Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions

Ameliorative Effect of Sesamin in Cisplatin-Induced Nephrotoxicity in Rats by Suppressing Inflammation, Oxidative/Nitrosative Stress, and Cellular Damage

(2020) B. ALI et al.   PHYSIOLOGICAL RESEARCH

Self-Nanoemulsifying Drug Delivery Systems for Enhancing Solubility, Permeability, and Bioavailability of Sesamin

(2020) Chih-Yuan Wang et al.   MOLECULES

Effects of sesamin on fatty acid and cholesterol metabolism, macrophage cholesterol homeostasis and serum lipid profile: A comprehensive review

(2020) Amin F. Majdalawieh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Health benefits of sesamin on cardiovascular disease and its associated risk factors

(2020) Sarah Dalibalta et al.   SAUDI PHARMACEUTICAL JOURNAL

Sesamin Catechol Glucuronides Exert Anti-inflammatory Effects by Suppressing Interferon β and Inducible Nitric Oxide Synthase Expression through Deconjugation in Macrophage-like J774.1 Cells

(2019) Naomi Abe-Kanoh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Using Turmeric Oil as a Solvent Improves the Distribution of Sesamin‐Sesamolin in the Serum and Brain of Mice

(2019) Kazuko Iwamoto et al.   LIPIDS

Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action

(2019) Amin F. Majdalawieh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A randomized, triple‐blind, placebo‐controlled clinical trial, evaluating the sesamin supplement effects on proteolytic enzymes, inflammatory markers, and clinical indices in women with rheumatoid arthritis

(2019) Bizhan Helli et al.   PHYTOTHERAPY RESEARCH

Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation

(2019) Xupeng Bai et al.   Oxidative Medicine and Cellular Longevity

Protective Effects of Sesamin Against UVB-Induced Skin Inflammation and Photodamage In Vitro and In Vivo

(2019) Lin et al.   Biomolecules

1,2-Bis[(3-Methoxyphenyl)Methyl]Ethane-1,2-Dicarboxylic Acid Reduces UVB-Induced Photodamage In Vitro and In Vivo

(2019) Wu et al.   Antioxidants

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

(2018) Georg Schett et al.   Nature Communications

(+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation

(2018) Yihang Zhao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds ( Sesamum indicum )

(2017) Amin F. Majdalawieh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

(2017) Puttaraju Srikantamurthy Yashaswini et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

(2017) Tran Duong Thuy et al.   Molecular Medicine Reports

Absorption, distribution, metabolism, and excretion of [14 C]sesamin in rats

(2017) Namino Tomimori et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chemical constituents from the fruits of Ligustrum japonicum and their inhibitory effects on T cell activation

(2017) Quynh-Mai Thi Ngo et al.   PHYTOCHEMISTRY

Development of sesamin-loaded solid dispersion with α-glycosylated stevia for improving physicochemical and nutraceutical properties

(2017) Hideyuki Sato et al.   Journal of Functional Foods

Sesamin prevents apoptosis and inflammation after experimental myocardial infarction by JNK and NF-κB pathways

(2017) Di Fan et al.   Food & Function

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Ex vivo model exhibits protective effects of sesamin against destruction of cartilage induced with a combination of tumor necrosis factor-alpha and oncostatin M

(2016) Manatsanan Khansai et al.   BMC Complementary and Alternative Medicine

The dangers of NSAIDs: look both ways

(2016) Abigail Davis et al.   BRITISH JOURNAL OF GENERAL PRACTICE

Sesamin inhibits lipopolysaccharide-induced inflammation and extracellular matrix catabolism in rat intervertebral disc

(2016) Kang Li et al.   CONNECTIVE TISSUE RESEARCH

Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy

(2016) Saif Ahmad et al.   JOURNAL OF NEUROIMMUNOLOGY

Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXRα and PPARα

(2016) Ruijuan Zhang et al.   NUTRITION RESEARCH

Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal Cancer

(2016) Zhiqi Wang et al.   Oxidative Medicine and Cellular Longevity

Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor-kappa B activation

(2016) Liangchang Li et al.   Experimental and Therapeutic Medicine

Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice

(2015) Li Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of sesamin against cytokine production from influenza type A H1N1-induced peripheral blood mononuclear cells: computational and experimental studies

(2015) Kanda Fanhchaksai et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Sesamin Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibition of TLR4 Signaling Pathways

(2015) Li Qiang et al.   INFLAMMATION

Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review

(2015) Amin F. Majdalawieh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sesamolin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt's lymphoma cells

(2015) Jeong Hwa Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of Sesamin Supplementation on Cardiovascular Risk Factors in Women with Rheumatoid Arthritis

(2015) B. Helli et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Sesamin attenuates mast cell-mediated allergic responses by suppressing the activation of p38 and nuclear factor-κB

(2015) LIANG CHANG LI et al.   Molecular Medicine Reports

Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells

(2015) PEIYUAN XU et al.   ONCOLOGY REPORTS

Sesamin Ameliorates Advanced Glycation End Products-Induced Pancreatic β-Cell Dysfunction and Apoptosis

(2015) Xiang Kong et al.   Nutrients

Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials

(2015) Ibrahim Jantan et al.   Frontiers in Plant Science

The Anti-Atherogenic Properties of Sesamin are Mediated via Improved Macrophage Cholesterol Efflux Through PPARγ1-LXRα and MAPK Signaling

(2015) Amin F. Majdalawieh et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

The lignan (+)-episesamin interferes with TNF-α-induced activation of VSMC via diminished activation of NF-ĸB, ERK1/2 and AKT and decreased activity of gelatinases

(2014) C. Freise et al.   Acta Physiologica

Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma

(2014) Xiang Kong et al.   BMC Complementary and Alternative Medicine

Influence of oral supplementation with sesamin on longevity of Caenorhabditis elegans and the host defense

(2014) Yukie Yaguchi et al.   EUROPEAN JOURNAL OF NUTRITION

Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke

(2014) Saif Ahmad et al.   NEUROTOXICOLOGY

Protective Effects of the Polyphenol Sesamin on Allergen-Induced TH2 Responses and Airway Inflammation in Mice

(2014) Ching-Huei Lin et al.   PLoS One

Sesamin suppresses macrophage-derived chemokine expression in human monocytes via epigenetic regulation

(2014) Chong-Chao Hsieh et al.   Food & Function

Antinociceptive and Anti-Inflammatory Activities of the Sesame Oil and Sesamin

(2014) Érika Monteiro et al.   Nutrients

Lignans of sesame: Purification methods, biological activities and biosynthesis – A review

(2013) Aejaz Ahmad Dar et al.   BIOORGANIC CHEMISTRY

Pharmacokinetics and safety of the sesame lignans, sesamin and episesamin, in healthy subjects

(2013) Namino Tomimori et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Inhibitory effects of epi-sesamin on endothelial protein C receptor shedding in vitro and in vivo

(2013) Sae-Kwang Ku et al.   INFLAMMATION RESEARCH

(+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPARγ and induction of iNOS

(2012) Christian Freise et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sesamin suppresses activation of microglia and p44/42 MAPK pathway, which confers neuroprotection in rat intracerebral hemorrhage

(2012) M. Ohnishi et al.   NEUROSCIENCE

Quercetin and Sesamin Protect Dopaminergic Cells from MPP+-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System

(2012) Julie Bournival et al.   Oxidative Medicine and Cellular Longevity

Chondroprotective and anti-inflammatory effects of sesamin

(2012) Thanyaluck Phitak et al.   PHYTOCHEMISTRY

Sequential Metabolism of Sesamin by Cytochrome P450 and UDP-Glucuronosyltransferase in Human Liver

(2011) K. Yasuda et al.   DRUG METABOLISM AND DISPOSITION

How is sesamin metabolised in the human liver to show its biological effects?

(2011) Kaori Yasuda et al.   Expert Opinion on Drug Metabolism & Toxicology

(+)-Episesamin exerts anti-neoplastic effects in human hepatocellular carcinoma cell lines via suppression of nuclear factor-kappa B and inhibition of MMP-9

(2011) Christian Freise et al.   INVESTIGATIONAL NEW DRUGS

Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation

(2011) Peiyuan F Hsieh et al.   Journal of Neuroinflammation

The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and α-Tocopherol in Rats Fed a High-Cholesterol Diet

(2011) Tomohiro Rogi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Metabolism of Sesamin by Cytochrome P450 in Human Liver Microsomes

(2010) K. Yasuda et al.   DRUG METABOLISM AND DISPOSITION

Sesamin Inhibits Macrophage-Induced Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 Expression and Proangiogenic Activity in Breast Cancer Cells

(2010) Chun-Chung Lee et al.   INFLAMMATION

Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

(2010) Amin Majdalawieh et al.   MEDIATORS OF INFLAMMATION

Sesamin Manifests Chemopreventive Effects through the Suppression of NF-κB–Regulated Cell Survival, Proliferation, Invasion, and Angiogenic Gene Products

(2010) Kuzhuvelil B. Harikumar et al.   MOLECULAR CANCER RESEARCH

Sesamin Modulates Tyrosine Hydroxylase, Superoxide Dismutase, Catalase, Inducible No Synthase and Interleukin-6 Expression in Dopaminergic Cells Under Mpp+-Induced Oxidative Stress

(2010) Vicky Lahaie-Collins et al.   Oxidative Medicine and Cellular Longevity

Angiogenic activity of sesamin through the activation of multiple signal pathways

(2009) Byung-Hee Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sesamin Mitigates Inflammation and Oxidative Stress in Endothelial Cells Exposed to Oxidized Low-Density Lipoprotein

(2009) Wen-Jane Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sesamin Inhibits Bacterial Formylpeptide-Induced Inflammatory Responses in a Murine Air-Pouch Model and in THP-1 Human Monocytes

(2009) Youhong Cui et al.   JOURNAL OF NUTRITION

Antihypertensive Effects of Sesamin in Humans

(2009) Takashi MIYAWAKI et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

HPTLC fingerprinting and quantification of lignans as markers in sesame oil and its polyherbal formulations

(2008) Divya Sukumar et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases

(2008) Q. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA