Article
Food Science & Technology
Yanrong Ren, Shiwen Hu, Hongzheng Pu, Ying Zhou, Mingzhu Jiang, Yuanyuan Li, Chaofang Deng, Jie Gao, Minxuan Xu, Chenxu Ge
Summary: The study explored the regulatory potential of Jug in treating depression in vivo and in vitro, showing that Jug has neuroprotective and anti-inflammatory effects by improving AMPK activation, which may be a novel therapeutic strategy for depression treatment.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Clinical Neurology
Wei Shi, Shan Zhang, Yujia Lu, Yaning Wang, Jingjie Zhao, Li Li
Summary: The study using a mouse model found that exposure to chronic unpredictable mild stress (CUMS) can induce depression-like behaviors and decrease Th17 cell counts.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Sule Aydin, Zeynep Gul Yazici, Cansu Kilic, Birce Ercelen Ozozturk, Fatma Sultan Kilic
Summary: This study investigated the effects of Topiramate (TPM) on depression, anxiety, learning, memory, and neurobiological changes in rats exposed to chronic unpredictable mild stress (CUMS). The findings showed that TPM had different effects on cognition and neurobiological changes in rats under CUMS at different doses.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Sosorburam Batsukh, Seyeon Oh, Kyoungmin Rheu, Bae-Jin Lee, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun
Summary: This study found that rice germ with 30% GABA (RG) can reduce neuroinflammation induced by chronic unpredictable mild stress (CUMS) and the associated depressive-like behavior.
Article
Behavioral Sciences
Kari Bosch, Giulia Sbrini, Irene Burattini, Desiree Nieuwenhuis, Francesca Calabrese, Dirk Schubert, Marloes J. A. G. Henckens, Judith R. Homberg
Summary: The study found that CUMS induced acute disruptions of circadian locomotor rhythm and reduced sucrose preference in rats. These effects persisted for up to four weeks after stress cessation, while repeated testing also had an impact on results.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Linling Xu, Huimin Sun, Chujie Qu, Jun Shen, Changhua Qu, Hao Song, Tian Li, Jiaxin Zheng, Junjian Zhang
Summary: This study demonstrates that environmental enrichment (EE) can have neuroprotective effects on depression and cognitive impairment by inducing autophagy-mediated inflammation inhibition. Autophagy-mediated inflammation inhibition reduces the release of proinflammatory cytokines, thereby improving depressive-like behaviors and cognitive decline.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Fatimah R. Al-Ramadhan, Mahmoud M. A. Abulmeaty, Mohammed Alquraishi, Suhail Razak, Maha H. Alhussain
Summary: Depression is a psychiatric disorder that negatively affects a person's thoughts, feelings, and actions. Research has shown a positive link between vitamin D deficiency and depression. This study aimed to investigate the effects of vitamin D3 (VD3) on a rat model of chronic unpredictable mild stress (CUMS). The results demonstrated that VD3 had a protective effect against anxiety and depressive behaviors induced by CUMS in rats.
Article
Neurosciences
Ali Abbaszade-Cheragheali, Farimah Beheshti, Samaneh Kakhki, Seyed Reza Khatibi, Fatemeh Dehnokhalaji, Elham Akbari, Hashem Fathi, Saeid Safari Farimani
Summary: Crocin showed the potential to improve anxiety and depression induced by UCMS in rats by reducing brain oxidative stress, inflammatory mediators, and corticosterone levels.
NEUROSCIENCE LETTERS
(2022)
Article
Psychiatry
Ning Jiang, Haixia Wang, Hong Huang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xinmin Liu
Summary: Medicinal plant species in Shen yuan prescription demonstrate potent antidepressant-like effects, reversing depressive-like behaviors in rats by regulating neurotransmitter levels, suppressing neuroinflammation, and activating BDNF/TrkB pathway, among other mechanisms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Hossein Bakhtiari-Dovvombaygi, Saeed Izadi, Mostafa Zare Moghaddam, Milad Hashemzehi, Mahmoud Hosseini, Hassan Azhdari-Zarmehri, Hossein Dinpanah, Farimah Beheshti
Summary: The study demonstrated that vitamin D can protect rats from anxiety and depression-like behaviors induced by chronic mild stress by reducing brain oxidative stress and inhibiting neuroinflammation.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yang Du, Yan-Li Wang, Lei Chen, Qi-En Li, Yong Cheng
Summary: Major depressive disorder is a common neuropsychiatric disease that leads to disabilities. The limitations of current treatments have prompted the exploration of novel strategies for its cure. Rannasangpei (RSNP), a traditional Tibetan medicine, and its active ingredient crocin-1 have shown potential therapeutic effects in various diseases. In this study, RSNP and crocin-1 were found to ameliorate depressive-like behaviors in a mouse model of depression induced by chronic unpredictable mild stress. These effects were attributed to the reduction of oxidative stress, inflammatory response, and apoptotic pathway, as well as the increase in astrocyte number and brain-derived neurotrophic factor levels in the hippocampus.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Chorpeth Chalermwongkul, Charinya Khamphukdee, Juthamart Maneenet, Supawadee Daodee, Orawan Monthakantirat, Chantana Boonyarat, Yutthana Chotritthirong, Suresh Awale, Anake Kijjoa, Yaowared Chulikhit
Summary: Major depressive disorder (MDD) is a prevalent worldwide disease with unclear etiology. Herbal medicine is gaining interest as an alternative antidepressant, and Oroxylum indicum extract containing baicalin and baicalein shows potential as an effective treatment for MDD by normalizing the HPA axis function and improving neurogenesis.
Article
Clinical Neurology
Xujiao Song, Weihao Wang, Shanshan Ding, Xingyue Liu, Yan Wang, Hao Ma
Summary: Puerarin was found to alleviate depression-like behaviors induced by chronic stress in mice, and it reversed the changes in gut microbiota characterized by pathological microbial flora. The results suggest that the antidepressant mechanism of puerarin may closely interact with restoring beneficial microflora.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Shu Yang, Li Yi, Xiaodi Xia, Xiaolu Chen, Xiao Hou, Longjie Zhang, Fang Yang, Jiaxin Liao, Zhijie Han, Yixiao Fu
Summary: This study used a rat model to investigate transcriptome changes in the amygdala-hippocampal neural network under chronic unpredictable mild stress (CUMS), and identified depression-related modules. Differential gene expression and enrichment analyses revealed candidate genes associated with neuronal myelination in the amygdala and synaptic transmission in the hippocampus. Furthermore, central genes were identified in both the amygdala and hippocampus modules through module hub gene statistics, differential gene expression, and protein-protein interaction networks.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Food Science & Technology
Yingyu Zhang, Yuan Sun, Yupei Liu, Jiameng Liu, Jing Sun, Yajuan Bai, Bei Fan, Cong Lu, Fengzhong Wang
Summary: This study found that Polygonum sibiricum polysaccharides (PSP) significantly reversed depression-like behavior induced by chronic unpredictable mild stress (CUMS). PSP also regulated neurotransmitter levels, reduced neuroinflammation, and normalized gut microbiota and short-chain fatty acid levels. These findings suggest the potential of PSP in preventing and treating depression.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Agriculture, Multidisciplinary
Bo Ren, Tian Yuan, Xinglin Zhang, Luanfeng Wang, Junru Pan, Yan Liu, Beita Zhao, Weiyang Zhao, Zhigang Liu, Xuebo Liu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Luanfeng Wang, Bo Ren, Qian Zhang, Chuanqi Chu, Zhenting Zhao, Jianbin Wu, Weiyang Zhao, Zhigang Liu, Xuebo Liu
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Food Science & Technology
Luanfeng Wang, Bo Ren, Yan Hui, Chuanqi Chu, Zhenting Zhao, Yuyu Zhang, Beita Zhao, Renjie Shi, Junli Ren, Xiaoshuang Dai, Zhigang Liu, Xuebo Liu
MOLECULAR NUTRITION & FOOD RESEARCH
(2020)
Article
Agriculture, Multidisciplinary
Beita Zhao, Bing Xia, Xiaohan Li, Li Zhang, Xiaoning Liu, Renjie Shi, Rongwei Kou, Zhigang Liu, Xuebo Liu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Hongbo Zhang, Wentong Zhang, Duo Yun, Ling Li, Weiyang Zhao, Yitong Li, Xuebo Liu, Zhigang Liu
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Article
Cell Biology
Xiaoning Liu, Xiang Li, Bing Xia, Xin Jin, Qianhui Zou, Zhenhua Zeng, Weiyang Zhao, Shikai Yan, Ling Li, Shufen Yuan, Shancen Zhao, Xiaoshuang Dai, Fei Yin, Enrique Cadenas, Rui Hai Liu, Beita Zhao, Min Hou, Zhigang Liu, Xuebo Liu
Summary: Maternal obesity has been found to be associated with lower cognition and sociality in children. The study demonstrated a causal relationship between microbiota and behavioral changes, and showed that microbiota-derived short-chain fatty acids can alleviate behavioral deficits in offspring of obese dams. High dietary fiber intake may be a promising intervention for maternal obesity-induced cognitive and social dysfunctions.
Article
Biochemistry & Molecular Biology
Bo Ren, Luanfeng Wang, Lin Shi, Xin Jin, Yan Liu, Rui Hai Liu, Fei Yin, Enrique Cadenas, Xiaoshuang Dai, Zhigang Liu, Xuebo Liu
Summary: Methionine restriction has shown protective effects against age-related cognitive decline in mice through preserving synaptic ultrastructure, increasing mitochondrial biogenesis, and reducing brain MDA levels. The role of FGF21 in this process is crucial.
Article
Immunology
Qing Liu, Yujia Xi, Qianxu Wang, Jinhui Liu, Peiran Li, Xue Meng, Kai Liu, Weixuan Chen, Xuebo Liu, Zhigang Liu
Summary: The study demonstrated that prebiotic mannan oligosaccharide (MOS) significantly improved cognitive function and mental symptoms, reduced anxiety and obsessive behaviors, and enhanced neuroprotection in the 5xFAD transgenic AD mice model. MOS treatment also balanced brain oxidative status, suppressed neuroinflammatory responses, alleviated HPA-axis disorders, and prevented gut barrier damage.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Agriculture, Multidisciplinary
Qing Liu, Tianzhi Xie, Yujia Xi, Ling Li, Fengfeng Mo, Xuebo Liu, Zhigang Liu, Jin-Ming Gao, Tian Yuan
Summary: The study showed that sesamol has significant neuroprotective effects on Alzheimer's disease (AD) mice, improving memory and learning abilities, reducing neuronal damage and protein accumulation, and acting through the microbiota-gut-brain axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Lei Wang, Weixuan Chen, Yujie Tian, Xiaorong Duan, Yi Yuan, Na Wang, Chao Xu, Xuebo Liu, Zhigang Liu
Summary: Sesamol can suppress the production of harmful components in edible oil and improve the effects of deep-fried food on liver lipid metabolism and gut homeostasis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ying Lan, Qingyang Sun, Zhiyuan Ma, Jing Peng, Mengqi Zhang, Chi Wang, Xiaotian Zhang, Xianfang Yan, Lili Chang, Xinglin Hou, Ruixue Qiao, Aiziguli Mulati, Yuan Zhou, Qiang Zhang, Zhigang Liu, Xuebo Liu
Summary: Seabuckthorn polysaccharide (SP) has shown significant amelioration effects on obesity induced by a high-fat diet (HFD) in mice. The effects of SP are mediated through modulation of the gut microbiota and its metabolites, leading to reductions in body weight gain, serum lipid levels, and liver triglyceride levels. SP regulates liver lipid metabolism by influencing the composition of the gut microbiome and increasing the production of short-chain fatty acids (SCFAs). These findings suggest that SP could be a potential nutraceutical for alleviating obesity by targeting the gut-liver axis.
Article
Nutrition & Dietetics
Bo Ren, Luanfeng Wang, Aiziguli Mulati, Yan Liu, Zhigang Liu, Xuebo Liu
Summary: Dietary methionine restriction (MR) reduces inflammatory factors in aged mice, decreases gut permeability, and increases tight junction protein levels; moreover, MR promotes short-chain fatty acid production and dampens oscillations of inflammation-related microbes.
FRONTIERS IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Yihang Zhao, Mengzhen Jia, Weixuan Chen, Zhigang Liu
Summary: This review focuses on the mechanisms by which intermittent fasting (IF) improves mitochondrial function in brain aging and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. IF activates adaptive cellular stress responses and signaling pathways, enhancing mitochondrial function by promoting energy metabolism and reducing oxidant production.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Zhigang Liu, Ling Li, Shaobo Ma, Jin Ye, Hongbo Zhang, Yitong Li, Ali Tahir Sair, Junru Pan, Xiaoning Liu, Xiang Li, Shikai Yan, Xuebo Liu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Liping Wei, Caicai Zhao, Shan Dong, Shundi Yao, Bing Ji, Beita Zhao, Zhigang Liu, Xuebo Liu, Yutang Wang
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)