Article
Chemistry, Organic
Bruno Lainer, Dawid Lichosyt, Maiia Aleksandrova, Pawel Dydio
Summary: In this study, an enantioselective synthesis of secondary benzylic alcohols and diarylmethanols was achieved through sequential catalysis, allowing for various alcohols and aryl nucleophiles with tolerance to a range of functional groups.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Hui Chen, Tianhua Tang, Christian A. Malapit, Yoo Seok Lee, Matthew B. Prater, N. Samali Weliwatte, Shelley D. Minteer
Summary: Petroleum hydrocarbons are a major energy source and an important feedstock for the chemical industry. The deep conversion of inert hydrocarbons to more valuable chemicals is a significant challenge. In this study, a multistep bioelectrocatalytic system was developed to achieve the one-pot deep conversion of heptane to N-heptylhepan-1-imine. This system successfully realized the conversion of inert hydrocarbons to imines, providing a new methodology for the comprehensive conversion and utilization of inert hydrocarbons.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
Man-Bo Li, Jan-E Backvall
Summary: Palladium-catalyzed oxidations involving cascade processes have challenges in achieving high palladium efficiency and selectivity, but using heterogeneous palladium catalysts immobilized on amino-functionalized support materials has shown promising results in addressing these issues. The catalysts exhibit high activity, selectivity, and efficient recycling ability, and have been applied in various oxidative cascade reactions to access important compounds for medicinal chemistry and functional materials.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Organic
Jian Zhang, Xinzhe Shi, Henri Doucet
Summary: This study explores a Pd-catalyzed annulative pi-extension reaction of 1-arylpyrroles using 1,2-dihalobenzenes as coupling partners, leading to the selective synthesis of pyrrolo[1,2-f]phenanthridines. The higher reactivity of the pyrrole C2-H bond allows for successful access to substituted pyrrolo[1,2-f]phenanthridines.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jun-Jie Tian, Wei Sun, Rui-Rui Li, Gui-Xiu Tian, Xiao-Chen Wang
Summary: A borane/gold(I) co-catalytic system was designed and applied in C-H functionalization reactions and cycloaddition reactions between tertiary amines and alpha-alkynylenones, efficiently introducing a furan ring into the amine molecule.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Ramandeep Kaur, Nidhi Jain
Summary: This review presents recent advances in inter- and intramolecular asymmetric sp(3) C-H bond functionalization utilizing ruthenium, rhodium, and iridium catalysts, and provides insights into the mechanistic aspects of these transformations.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Organic
Yi-Xin Xu, Yu-Qing Liang, Zhong-Jian Cai, Shun-Jun Ji
Summary: A novel chelation-assisted C-H arylation reaction of benzo[h]quinoline is described in this study. The reaction, using [RuCl2(p-cymene)]2 as the catalyst and cheap and easily accessible arylsulfonyl chlorides as the arylation source, exhibits simple reaction conditions, a broad substrate scope, and good functional group tolerance. The successful application of bioactive-molecule-based sulfonyl chlorides further emphasizes the potential utility and importance of this desulfitative C-H arylation protocol.
Article
Chemistry, Organic
Zakhar M. Rubanov, Vitalij V. Levin, Alexander D. Dilman
Summary: This paper describes a method for converting aldehydes to ketones by first forming aldimines, and then utilizing acid-promoted Minisci-type reaction with alkyl radicals generated from esters of N-hydroxylphthalimide under photoredox conditions. Aminyl radical cations formed after the addition of the iminium ions are believed to be key intermediates.
Article
Chemistry, Organic
Mengzhu Guo, Fengying Dong, Xiangcong Yin, Lubin Xu, Liang Wang, Shuai-Shuai Li
Summary: In this study, medicinally significant 3-monosubstituted tetrahydroquinolines and 1,2-dihydroquinolines were controllably constructed via a redox-neutral vinylogous cascade condensation/[1,5]-hydride transfer/cyclization process in ethanol, showcasing novel features such as green solvent and metal-free conditions. Additionally, the electrophilicity and nucleophilicity of alpha,alpha-dicyanoalkenes were effectively utilized as hydride acceptors and gamma-exclusive nucleophiles.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Ya-Ting Wen, Xiang-Tao Kong, Hong-Chao Liu, Cui-Tian Wang, Wan-Xu Wei, Bin Wang, Xue-Yuan Liu, Yong-Min Liang
Summary: An innovative 1,5-HAT cascade strategy has been proposed for nickel-catalyzed distal arylation via cross-electrophile coupling. It selectively activates the remote C(sp(3))-H bond through specific migration and uses Ar-I as the available electrophile for constructing the C(sp(3))-C(sp(2)) bond. The method shows broad applicability for benzylic and aliphatic N-fluorocarboxamides with yields up to 80%. Control experiments suggest that this reaction may be initiated by a radical process.
Article
Chemistry, Applied
Paula Andrade-Sampedro, Jon M. Matxain, Arkaitz Correa
Summary: The development of catalytic tools for the late-stage modification of amino acids within a peptide framework is challenging but important. The researchers reported a Ru-catalyzed C(sp(2))-H hydroxylation method for di- and tripeptides containing tyrosine, using a carbamate as a removable directing group and PhI(OCOCF3)(2) (PIFA) as an oxidant. This method is reliable, scalable, and enables the synthesis of L-DOPA peptidomimetics without racemization. Density Functional Theory calculations support the proposed catalytic cycle involving Ru(II)/Ru(IV).
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Jianxiao Li, Dan He, Bowen Wang, Wenfang Xiong, Chaorong Qi, Huanfeng Jiang
Summary: In this paper, a novel and versatile reaction method for the synthesis of alkyl substituted alpha-methylene-gamma-lactones from unactivated alkenes has been reported. This reaction is enabled by Lewis acids and palladium catalysts, and exhibits high yields and excellent Z/E selectivities. The downstream functionalization of (Z)-gamma-lactones allows for the preparation of various valuable complex molecules, and has potential utility in organic synthesis and pharmaceutical chemistry.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Chinky Binnani, Sumangla Arora, Bhanu Priya, Puneet Gupta, Sanjay K. Singh
Summary: A class of 2-hydroxypyridine based ligands have been explored to enhance the catalytic activity of [(eta(6)-p-cymene)RuCl2](2) catalyst for ortho-C-H bond activation/arylation reaction in water. Among the studied ligands, 5-trifluoromethyl-2-hydroxypyridine (L6) showed significant enhancement in the catalytic activity of Ru(II) catalyst for ortho C-H bond arylation of 2-phenylpyridine. NMR and mass investigations suggested the involvement of ligand coordinated Ru(II) species in the C-H bond activation reaction. DFT calculations confirmed the important role of 2-hydroxypyridine based ligands in Ru(II) catalyzed C-H bond arylation of 2-phenylpyridine with lower energy barrier.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Gabriela A. Correa, Susana L. H. Rebelo, Baltazar de Castro
Summary: Sustainable functionalization of renewable aromatics is crucial for the transition to a circular, fossil-free economy. In this study, typical stable aromatic compounds were successfully functionalized using a green catalytic system at room temperature. The results demonstrated unusual initial epoxidation of the aromatic ring, with high yields obtained for various products.
Review
Chemistry, Organic
Ming Zhang, Zukang Zhong, Lihua Liao, Ai Qin Zhang
Summary: This review introduces the application of a transient directing strategy in cyclization reactions via C-H activation. Different types of cyclization reactions can be achieved using various catalysts with good selectivity. The synthesized cyclic compounds have potential applications in pharmaceutical chemistry, material chemistry, and synthetic chemistry.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Applied
Shengdong Wang, Haiyun Huang, Svetlana Tsareva, Christian Bruneau, Cedric Fischmeister
ADVANCED SYNTHESIS & CATALYSIS
(2019)
Article
Chemistry, Multidisciplinary
Shengdong Wang, Haiyun Huang, Thierry Roisnel, Christian Bruneau, Cedric Fischmeister
Article
Chemistry, Organic
Yu-Chao Yuan, Marion Goujon, Christian Bruneau, Thierry Roisnel, Rafael Gramage-Doria
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Physical
Luciana Sarmento Fernandes, Dalmo Mandelli, Wagner A. Carvalho, Cedric Fischmeister, Christian Bruneau
CATALYSIS COMMUNICATIONS
(2020)
Article
Chemistry, Physical
Gabriel M. Vieira, Artur V. Granato, Elena V. Gusevskaya, Eduardo N. dos Santos, Pierre H. Dixneuf, Cedric Fischmeister, Christian Bruneau
APPLIED CATALYSIS A-GENERAL
(2020)
Review
Chemistry, Physical
Hallouma Bilel, Naceur Hamdi, Cedric Fischmeister, Christian Bruneau
Article
Chemistry, Organic
Harikrishnan Jayaprakash, Liwei Guo, Shengdong Wang, Christian Bruneau, Cedric Fischmeister
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Editorial Material
Chemistry, Inorganic & Nuclear
Jean-Francois Soule, Christian Bruneau, Christophe Darcel
Review
Chemistry, Multidisciplinary
Salekh M. Masoud, Dania V. Vorobyeva, Dmitry A. Petropavlovskikh, Christian Bruneau, Sergey N. Osipov
Summary: This review summarizes literature data on methods for introducing fluorine atoms and fluoralkyl groups into different ligands to construct metathesis-active ruthenium carbene complexes, analyzing their influence on catalytic activity. The choice of fluorinated substituents in NHC ligands aims to increase ruthenium atom electrophilicity and enhance complex activity; introducing polyfluoroalkyl groups can help solve the issue of catalyst recovery.
RUSSIAN CHEMICAL REVIEWS
(2021)
Article
Chemistry, Physical
Luciana Sarmento Fernandes, Dalmo Mandelli, Wagner A. Carvalho, Elsa Caytan, Cedric Fischmeister, Christian Bruneau
Summary: The direct functionalization of sterically demanding alpha,alpha-disubstituted double bonds in beta-pinene, (-)-limonene and (-)-limonene terpenoids has been achieved through cross metathesis with internal olefins. This clean transformation provides a new method for accessing functionalized bulky cyclic terpenes, where the terminal double bond generates a trisubstituted olefin.
APPLIED CATALYSIS A-GENERAL
(2021)
Article
Biochemistry & Molecular Biology
Thalita S. Galhardo, Anderson K. Ueno, Thais A. Costa-Silva, Andre G. Tempone, Wagner A. Carvalho, Cedric Fischmeister, Christian Bruneau, Dalmo Mandelli, Joao Henrique G. Lago
Summary: In this study, compounds isolated from N. leucantha were used as starting material to synthesize two new derivatives, which showed activity against trypanosome and no toxicity to mammalian cells. Mechanism study revealed that the derivatives caused depolarization of the parasite's plasma membrane and collapse of mitochondrial membrane potential. Therefore, this compound could be a potential candidate for future drug design in the treatment of Chagas disease.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Physical
Thalita S. Galhardo, Anderson K. Ueno, Wagner A. Carvalho, Thais A. Costa-Silva, Marina M. Goncalves, Mariana B. Abiuzi, Andre G. Tempone, Joao Henrique G. Lago, Dalmo Mandelli, Cedric Fischmeister, Christian Bruneau
Summary: Ruthenium-catalyzed cross metathesis of biseugenol with electron-deficient olefins resulted in the synthesis of derivatives 3a-3e in good yields and excellent conversion rates. The antitrypanosomal activity of these compounds against Trypanosoma cruzi was evaluated, and compounds 3b and 3d showed similar IC50 values to biseugenol, but with reduced toxicities and similar selectivity indexes to the standard drug benznidazol.
Article
Chemistry, Physical
Naba Abuhafez, Herve Ruffin, Raghu Kamaraj, Christian Bruneau, Rafael Gramage-Doria
Summary: A new method for the synthesis of 1,3-diene building blocks using ruthenium-catalyzed oxidative homo- and cross-coupling is reported, which mainly produces the E,E isomer. This methodology also allows for the synthesis of adipic acid ester derivatives in a one-pot fashion after in situ ruthenium-catalyzed hydrogenation.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Physical
Massimo Christian D'Alterio, Yu-Chao Yuan, Christian Bruneau, Giovanni Talarico, Rafael Gramage-Doria, Albert Poater
CATALYSIS SCIENCE & TECHNOLOGY
(2020)
Review
Chemistry, Inorganic & Nuclear
Pegah Hajivand, Johannes Carolus Jansen, Emilio Pardo, Donatella Armentano, Teresa F. Mastropietro, Amirreza Azadmehr
Summary: VOCs in human breath can be used as biomarkers for diseases, and MOFs have been extensively studied as gas sensors for VOCs. This review provides a comprehensive summary of the latest MOF-derived composites used as VOCs biomarkers' sensors, and discusses the structural and functional characteristics of MOFs, sensing properties, and the potential of bio-MOFs in VOCs sensing.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shudi Liu, Liangwei Zhang, Heejeong Kim, Jinyu Sun, Juyoung Yoon
Summary: Chromium is a strategic and critical transition metal element with extensive applications. Efficient detection methods, such as fluorescence and colorimetry, have been developed for monitoring its concentrations. However, existing reviews on fluorescent probes for chromium lack comprehensive coverage. This review aims to consolidate information and promote the development of novel fluorescent probes for chromium detection.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rehab H. Elattar, Samah F. El-Malla, Amira H. Kamal, Fotouh R. Mansour
Summary: Metal complexes have strong analysis potential and can be used to measure analytes lacking essential chemical properties. Their analytical methods based on different mechanisms offer superior performance.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Nem Singh, Miae Won, Yunjie Xu, Changyu Yoon, Jiyoung Yoo, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Hypoxia is a common occurrence in the tumor microenvironment and poses challenges for cancer treatment. The introduction of covalent organic frameworks (COFs) offers promising prospects for addressing hypoxia-related issues. This article explores the role of COFs in enhancing oxygen delivery, generating reactive oxygen species, optimizing drug delivery, and enabling hypoxia-specific imaging, as well as outlining their applications in various hypoxia-targeting therapeutic modalities.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Priyadarshi Roy Chowdhury, Himani Medhi, Krishna G. Bhattacharyya, Chaudhery Mustansar Hussain
Summary: This review critically analyzes the production of waste-derived layered double hydroxides (LDH) and their utility in electrochemical water splitting for the generation of green hydrogen as sustainable energy. It highlights the importance of waste-derived LDH and discusses the challenges and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Rajamanickam Sivakumar, Nae Yoon Lee
Summary: This article reviews the progress in imaging reactive oxygen, nitrogen, and sulfur species (RONSS) using luminescent metal complex-based probes. This technology is selective and sensitive, which is of great significance for studying the impact of RONSS in cells and tissues and preventing diseases.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Xinyang Li, Binbin Ding, Pan Zheng, Ping'an Ma, Jun Lin
Summary: The main goal of immunotherapy is to enhance the response and cytotoxicity of tumor-specific T cells by turning cold tumors into hot tumors. However, metabolic reprogramming in the tumor microenvironment can depress the cytotoxicity of T cells and hinder the effectiveness of immunotherapy. This review discusses the role of metabolic reprogramming in the interplay between cancer cells and immune cells in the tumor microenvironment and explores the use of nanomaterials to modulate metabolic pathways and improve immunotherapy outcomes.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Kingsley Poon, Abhishek Gupta, William S. Price, Hala Zreiqat, Gurvinder Singh
Summary: Progress in the development of manganese oxide nanoparticles (MONPs) has provided an alternative for early-stage diagnosis of life-threatening diseases and therapeutic delivery of drugs and genes. The synthesis and characterization of MONPs have enabled the production of multi-functional targeted nanoparticles in various sizes and shapes. The integration of diagnosis and therapeutic capabilities within a single entity, known as nanotheranostics, is promising for real-time monitoring of disease progression and evaluating therapeutic treatment efficacy.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Reza Abedi-Firoozjah, Hadiseh Ebdali, Mahya Soltani, Parastoo Abdolahi-Fard, Mahshid Heydari, Elham Assadpour, Maryam Azizi-Lalabadi, Fuyuan Zhang, Seid Mahdi Jafari
Summary: With the increasing awareness of food safety, there is a growing demand for efficient and affordable sensing methods for the detection of pathogens and toxins in food products. Nanosensors offer promising solutions with their quick and reliable detection capabilities, although challenges remain in their fabrication and practical application.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Demei Sun, Xuesong Feng, Xinyuan Zhu, Youfu Wang, Jinghui Yang
Summary: Metal organic cages (MOCs) with precise and tunable nano structures show great potential in cancer therapy. Their diverse functions and ultrasmall size make them excellent nanoagents for different anticancer strategies, demonstrating outstanding anticancer performances.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Li Li, Yang-Tao Yu, Ning-Ning Zhang, Shu-Hao Li, Jian-Ge Zeng, Yang Hua, Hong Zhang
Summary: This article summarizes recent advances in POM-based hybrid photochromic materials (PCHPMs), including structure types, new photochromic mechanisms, and applications. It can provide valuable guidance for researchers investigating POM-based hybrid photochromic materials.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Chien Ing Yeo, Clariss Hui Peng Goh, Edward R. T. Tiekink, Jactty Chew
Summary: This review article provides an overview of the antibacterial activity of gold complexes, with a focus on gold(I) and gold(III) complexes. It also summarizes the repurposing of Auranofin for antibacterial purposes and the associated mechanism(s) of action.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Sangharaj Diyali, Nilankar Diyali, Bhaskar Biswas
Summary: This study discusses the recent progress in the design and development of catalysts, focusing on the factors influencing overpotential, catalytic rate, and stability, as well as the mechanisms of the hydrogen evolution reaction in acidic and alkaline media. Moreover, it outlines the challenges in future design of robust and active electrocatalysts.
COORDINATION CHEMISTRY REVIEWS
(2024)
Review
Chemistry, Inorganic & Nuclear
Shaik Gouse Peera, Rahul S. Menon, Sumanta Kumar Das, Akram Alfantazi, K. Karuppasamy, Chao Liu, Akhila Kumar Sahu
Summary: Doped carbon materials, especially F-doped carbon catalysts, have gained significant attention as metal-free catalysts for oxygen reduction reactions and as corrosion-resistant supports for Pt and non-Pt nanoparticles. F-doped carbon materials possess unique properties and greatly improve the activity and durability of the ORR compared to N-doped carbon materials. The high electronegativity of F-doping can efficiently modify the electronic band structure of carbon materials, favoring the ORR. This review systematically discusses the effect of F-doping/F co-doping on the electrocatalytic reduction of O2 in acidic and alkaline conditions, the stability and durability of fuel cell catalysts, and provides guidelines for working with F-doped carbons. Future research directions on F-doped carbons are also proposed to bridge the gap between laboratory-scale assessments and commercial applications.
COORDINATION CHEMISTRY REVIEWS
(2024)