TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma

Improved Mycobacterium tuberculosis clearance after restoration of IFN‐γ + TNF‐α + CD4 + T cells: Impact of PD‐1 inhibition in active tuberculosis patients

(2020) Divya Kamboj et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mendelian susceptibility to mycobacterial disease: recent discoveries

(2020) Jacinta Bustamante   HUMAN GENETICS

CytoMAP: A Spatial Analysis Toolbox Reveals Features of Myeloid Cell Organization in Lymphoid Tissues

(2020) Caleb R. Stoltzfus et al.   Cell Reports

Tuberculosis following programmed cell death receptor-1 (PD-1) inhibitor in a patient with non-small cell lung cancer. Case report and literature review

(2020) Aasir M. Suliman et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Ultra-low Dose Aerosol Infection of Mice with Mycobacterium tuberculosis More Closely Models Human Tuberculosis

(2020) Courtney R. Plumlee et al.   Cell Host & Microbe

ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets

(2019) Henrique Borges da Silva et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Bacillus Calmette–Guérin–Induced T Cells Shape Mycobacterium tuberculosis Infection before Reducing the Bacterial Burden

(2019) Jared L. Delahaye et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design

(2018) Joel D. Ernst   Cell Host & Microbe

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

(2018) Scott G Hansen et al.   NATURE MEDICINE

Disseminated nontuberculous mycobacterial disease in a cat caused by Mycobacterium sp. strain MFM001

(2018) Hideki Kayanuma et al.   VETERINARY MICROBIOLOGY

Nitric Oxide Modulates Macrophage Responses toMycobacterium tuberculosisInfection through Activation of HIF-1α and Repression of NF-κB

(2017) Jonathan Braverman et al.   JOURNAL OF IMMUNOLOGY

Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques

(2017) K D Kauffman et al.   Mucosal Immunology

In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control ofMycobacterium tuberculosis

(2017) Uma S. Gautam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

(2017) Kelly L. Walton et al.   Frontiers in Pharmacology

Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model

(2017) Hayley C. Warsinske et al.   Frontiers in Immunology

Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis

(2016) Smita Srivastava et al.   Cell Host & Microbe

TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections

(2016) Gavin M. Lewis et al.   JOURNAL OF CLINICAL INVESTIGATION

CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

(2016) Shunsuke Sakai et al.   PLoS Pathogens

Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance

(2015) Elizabeth M. Steinert et al.   CELL

ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis

(2015) Albanus O. Moguche et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transforming growth factor-β signaling is constantly shaping memory T-cell population

(2015) Chaoyu Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-to-Cell Transfer of M. tuberculosis Antigens Optimizes CD4 T Cell Priming

(2014) Smita Srivastava et al.   Cell Host & Microbe

Cutting Edge: Control of Mycobacterium tuberculosis Infection by a Subset of Lung Parenchyma-Homing CD4 T Cells

(2014) S. Sakai et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Subverts the TLR-2 - MyD88 Pathway to Facilitate Its Translocation into the Cytosol

(2014) Md. Aejazur Rahman et al.   PLoS One

Immunity and Immunopathology in the Tuberculous Granuloma

(2014) Antonio J. Pagán et al.   Cold Spring Harbor Perspectives in Medicine

Predictors of mortality among TB-HIV Co-infected patients being treated for tuberculosis in Northwest Ethiopia: a retrospective cohort study

(2013) Balewgizie Sileshi et al.   BMC INFECTIOUS DISEASES

Pathogen-Specific Treg Cells Expand Early during Mycobacterium tuberculosis Infection but Are Later Eliminated in Response to Interleukin-12

(2013) Shahin Shafiani et al.   IMMUNITY

Cutting Edge: Direct Recognition of Infected Cells by CD4 T Cells Is Required for Control of Intracellular Mycobacterium tuberculosis In Vivo

(2013) S. Srivastava et al.   JOURNAL OF IMMUNOLOGY

TGF- : Guardian of T Cell Function

(2013) S. A. Oh et al.   JOURNAL OF IMMUNOLOGY

TGF-β Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function

(2013) Anna Śledzińska et al.   PLOS BIOLOGY

Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes

(2012) Michael Y. Gerner et al.   IMMUNITY

IFN-  from CD4 T Cells Is Essential for Host Survival and Enhances CD8 T Cell Function during Mycobacterium tuberculosis Infection

(2012) A. M. Green et al.   JOURNAL OF IMMUNOLOGY

The Mycobacterium tuberculosis Stress Response Factor SigH Is Required for Bacterial Burden as Well as Immunopathology in Primate Lungs

(2012) Smriti Mehra et al.   JOURNAL OF INFECTIOUS DISEASES

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

(2012) Nu Zhang et al.   NATURE IMMUNOLOGY

Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice

(2011) Adrian G. Rosas-Taraco et al.   TUBERCULOSIS

Duration of antigen receptor signaling determines T-cell tolerance or activation

(2010) S. D. Katzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

(2010) E. Lazar-Molnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Host-Dependent Survival Factors for Intracellular Mycobacterium tuberculosis through an siRNA Screen

(2010) Shilpi Jayaswal et al.   PLoS Pathogens

Cell-Mediated Immune Responses in Tuberculosis

(2009) Andrea M. Cooper   Annual Review of Immunology

The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection

(2009) J. Muse Davis et al.   CELL

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

(2009) Roberto Tinoco et al.   IMMUNITY

Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells

(2009) Shomyseh Sanjabi et al.   IMMUNITY

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

(2009) P. L. Lin et al.   INFECTION AND IMMUNITY

MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells

(2009) R. J. Salmond et al.   JOURNAL OF IMMUNOLOGY

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

(2009) H. E. Volkman et al.   SCIENCE

Evasion and subversion of antigen presentation byMycobacterium tuberculosis

(2009) A. Baena et al.   TISSUE ANTIGENS

TGF-β: A Master of All T Cell Trades

(2008) Ming O. Li et al.   CELL

Delayed protection by ESAT-6–specific effector CD4+T cells after airborneM. tuberculosisinfection

(2008) Alena M. Gallegos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes

(2008) W. W. Reiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA