MicroRNAs and long non-coding RNAs in the pathophysiological processes of diabetic cardiomyopathy: emerging biomarkers and potential therapeutics

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease

(2020) Cheng-Kai Huang et al.   CIRCULATION RESEARCH

Potential Clinical Implications of miR-1 and miR-21 in Heart Disease and Cardioprotection

(2020) Branislav Kura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

(2020) Yi Tan et al.   Nature Reviews Cardiology

High-mobility group AT-hook 1 promotes cardiac dysfunction in diabetic cardiomyopathy via autophagy inhibition

(2020) Qing-Qing Wu et al.   Cell Death & Disease

Non-coding RNA therapeutics for cardiac regeneration

(2020) Luca Braga et al.   CARDIOVASCULAR RESEARCH

HMGA1-Regulating microRNAs Let-7a and miR-26a are Downregulated in Human Seminomas

(2020) Marco De Martino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-coding RNAs are involved in the response to oxidative stress

(2020) Soudeh Ghafouri-Fard et al.   BIOMEDICINE & PHARMACOTHERAPY

Inflammatory state does not affect the antiplatelet efficacy of potent P2Y12 inhibitors in ACS

(2020) Benedikt S. Biesinger et al.   PLATELETS

MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

(2020) Karima Ait-Aissa et al.   Cardiovascular Diabetology

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

(2020) Ceren Eyileten et al.   MOLECULAR NEUROBIOLOGY

Platelets Promote Ang II (Angiotensin II)-Induced Atrial Fibrillation by Releasing TGF-β1 (Transforming Growth Factor-β1) and Interacting With Fibroblasts

(2020) Yang Liu et al.   HYPERTENSION

The Importance of Non-Coding RNAs in Neurodegenerative Processes of Diabetes-Related Molecular Pathways

(2020) Joanna Jarosz-Popek et al.   Journal of Clinical Medicine

MiR-30c/PGC-1β protects against diabetic cardiomyopathy via PPARα

(2019) Zhongwei Yin et al.   Cardiovascular Diabetology

Diabetic cardiomyopathy- A comprehensive updated review

(2019) Ghulam Murtaza et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Let‑7a‑5p may participate in the pathogenesis of diabetic nephropathy through targeting HMGA2

(2019) Tao Wang et al.   Molecular Medicine Reports

Early dysregulation of cardiac-specific microRNA-208a is linked to maladaptive cardiac remodelling in diabetic myocardium

(2019) Shruti Rawal et al.   Cardiovascular Diabetology

Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study

(2019) Chen Mao et al.   BMC Geriatrics

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases

(2019) Rafael M. da Costa et al.   Frontiers in Pharmacology

Downregulation of MALAT1 alleviates saturated fatty acid-induced myocardial inflammatory injury via the miR-26a/HMGB1/TLR4/NF-κB axis

(2019) Pengyu Jia et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement From the American Heart Association and the Heart Failure Society of America

(2019) Shannon M. Dunlay et al.   CIRCULATION

Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy

(2019) Isabella Evangelista et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA‐Seq analysis and functional characterization revealed lncRNA NONRATT007560.2 regulated cardiomyocytes oxidative stress and apoptosis induced by high glucose

(2019) Manli Yu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interfering with long chain noncoding RNA ANRIL expression reduces heart failure in rats with diabetes by inhibiting myocardial oxidative stress

(2019) Wenxin Dai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The long non-coding RNA SNHG1 promotes glioma progression by competitively binding to miR-194 to regulate PHLDA1 expression

(2019) Liang Liu et al.   Cell Death & Disease

Diabetic Cardiomyopathy

(2019) Stefania Paolillo et al.   Heart Failure Clinics

Crosstalk Between Long Non-coding RNAs, Micro-RNAs and mRNAs: Deciphering Molecular Mechanisms of Master Regulators in Cancer

(2019) Eduardo López-Urrutia et al.   Frontiers in Oncology

Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review

(2019) Justyna Pordzik et al.   Cardiovascular Diabetology

MicroRNAs fingerprint of bicuspid aortic valve

(2019) Jolanda Sabatino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Emerging role of microRNAs in dilated cardiomyopathy: evidence regarding etiology

(2019) Maria Calderon-Dominguez et al.   Translational Research

Transcatheter Aortic Valve Replacement Is Associated with Less Oxidative Stress and Faster Recovery of Antioxidant Capacity than Surgical Aortic Valve Replacement

(2019) Anna Komosa et al.   Journal of Clinical Medicine

Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

(2019) Burgos-Morón et al.   Journal of Clinical Medicine

Up-regulation of microRNA-203 inhibits myocardial fibrosis and oxidative stress in mice with diabetic cardiomyopathy through the inhibition of PI3K/Akt signaling pathway via PIK3CA

(2019) Xubin Yang et al.   GENE

Inhibition of microRNA‐150‐5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose‐treated cardiac fibroblasts

(2019) Hui Che et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LncRNA SNHG1 exerts a protective role in cardiomyocytes hypertrophy via targeting miR‐15a‐5p/HMGA1 axis

(2019) Si‐Min Yan et al.   CELL BIOLOGY INTERNATIONAL

MiR‐144 protects the heart from hyperglycemia‐induced injury by regulating mitochondrial biogenesis and cardiomyocyte apoptosis

(2019) Lichan Tao et al.   FASEB JOURNAL

Exosome-Mediated Transfer of lncRNA HOTTIP Promotes Cisplatin Resistance in Gastric Cancer Cells by Regulating HMGA1/miR-218 Axis

(2019) Jingyu Wang et al.   OncoTargets and Therapy

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

(2018) Shan-shan Zhou et al.   ACTA PHARMACOLOGICA SINICA

LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling

(2018) Lu Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Overexpression of miR-22 attenuates oxidative stress injury in diabetic cardiomyopathy via Sirt 1

(2018) Qinghui Tang et al.   Cardiovascular Therapeutics

Functional Classification and Experimental Dissection of Long Noncoding RNAs

(2018) Florian Kopp et al.   CELL

Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins: Pre-Specified Secondary End Points in ORION 1

(2018) Kausik K. Ray et al.   CIRCULATION

Diabetic Cardiomyopathy

(2018) Guanghong Jia et al.   CIRCULATION RESEARCH

Transcoronary concentration gradients of circulating microRNAs in heart failure

(2018) Salvatore De Rosa et al.   EUROPEAN JOURNAL OF HEART FAILURE

LncRNA SNHG1 regulates cerebrovascular pathologies as a competing endogenous RNA through HIF-1α/VEGF signaling in ischemic stroke

(2018) Lin Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-155—at the Critical Interface of Innate and Adaptive Immunity in Arthritis

(2018) Stefano Alivernini et al.   Frontiers in Immunology

Type 2 Diabetes Mellitus and Cardiovascular Disease: Genetic and Epigenetic Links

(2018) Salvatore De Rosa et al.   Frontiers in Endocrinology

MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin

(2018) Beibei Dai et al.   Cardiovascular Diabetology

LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells

(2018) Yibin Lin et al.   GENE

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR-34a in diabetic cardiomyopathy

(2018) Lu Gao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy

(2018) Fan Yang et al.   Cell Death & Disease

LncRNA HOTAIR improves diabetic cardiomyopathy by increasing viability of cardiomyocytes through activation of the PI3K/Akt pathway

(2018) Kun Qi et al.   Experimental and Therapeutic Medicine

MicroRNA-150 relieves vascular remodeling and fibrosis in hypoxia-induced pulmonary hypertension

(2018) Ying Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy

(2018) Tarun Pant et al.   BMC Cardiovascular Disorders

Diabetic cardiomyopathy

(2018) Matthew Meng Yang Lee et al.   HEART

Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control

(2018) Giulia Borghetti et al.   Frontiers in Physiology

MicroRNAs as Diagnostic and Prognostic Biomarkers in Ischemic Stroke—A Comprehensive Review and Bioinformatic Analysis

(2018) Ceren Eyileten et al.   Cells

Protective effect of 3H-1, 2-dithiole-3-thione on cellular model of Alzheimer's disease involves Nrf2/ARE signaling pathway

(2017) Lan Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity

(2017) Dawei Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

HMGA1 is a novel candidate gene for myocardial infarction susceptibility

(2017) Salvatore De Rosa et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Gold nanoparticle-based miR155 antagonist macrophage delivery restores the cardiac function in ovariectomized diabetic mouse model

(2017) Chengming Jia et al.   International Journal of Nanomedicine

Distinct but complementary contributions of PPAR isotypes to energy homeostasis

(2017) Vanessa Dubois et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-146a mediates inflammatory changes and fibrosis in the heart in diabetes

(2017) Biao Feng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

(2017) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelets redox balance assessment: Current evidence and methodological considerations

(2017) Anna Komosa et al.   VASCULAR PHARMACOLOGY

Differential methylation of lncRNA KCNQ1OT1 promoter polymorphism was associated with symptomatic cardiac long QT

(2017) Eliecer Coto et al.   Epigenomics

Serum microRNA-1 and microRNA-133a levels reflect myocardial steatosis in uncomplicated type 2 diabetes

(2017) D. de Gonzalo-Calvo et al.   Scientific Reports

miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb

(2017) Zeyu Chen et al.   Cell Reports

miR-503 Is Involved in the Protective Effect of Phase II Enzyme Inducer (CPDT) in Diabetic Cardiomyopathy via Nrf2/ARE Signaling Pathway

(2017) Ying Miao et al.   Biomed Research International

Mir30c Is Involved in Diabetic Cardiomyopathy through Regulation of Cardiac Autophagy via BECN1

(2017) Chen Chen et al.   Molecular Therapy-Nucleic Acids

MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1

(2016) Prince Jeyabal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipotoxicity in obesity and diabetes-related cardiac dysfunction

(2016) Igor Zlobine et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Long non-coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia-reperfusion injury

(2016) Zhi-hui Zhao et al.   CELL BIOLOGY INTERNATIONAL

Lack of miR-133a Decreases Contractility of Diabetic Hearts: A Role for Novel Cross Talk Between Tyrosine Aminotransferase and Tyrosine Hydroxylase

(2016) Shyam Sundar Nandi et al.   DIABETES

MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway

(2016) Wei Sang et al.   IMMUNOLOGY LETTERS

miR-30c and miR-181a synergistically modulate p53–p21 pathway in diabetes induced cardiac hypertrophy

(2016) Satish K. Raut et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Viral Vector-Based Targeting of miR-21 in Cardiac Nonmyocyte Cells Reduces Pathologic Remodeling of the Heart

(2016) Deepak Ramanujam et al.   MOLECULAR THERAPY

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes

(2016) Sahana Suresh Babu et al.   Scientific Reports

Crucial Role of miR-433 in Regulating Cardiac Fibrosis

(2016) Lichan Tao et al.   Theranostics

lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy

(2016) Xiangquan Li et al.   Scientific Reports

Inhibiting microRNA-144 abates oxidative stress and reduces apoptosis in hearts of streptozotocin-induced diabetic mice

(2015) Manli Yu et al.   CARDIOVASCULAR PATHOLOGY

miR-30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy

(2015) Satish K. Raut et al.   Cardiovascular Therapeutics

MicroRNA-34a Plays a Key Role in Cardiac Repair and Regeneration Following Myocardial InfarctionNovelty and Significance

(2015) Yanfei Yang et al.   CIRCULATION RESEARCH

Role of miRNAs in Coronary Artery Disease

(2015) Leixing Xie et al.   Current Signal Transduction Therapy

Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice

(2015) Dong Zheng et al.   DIABETOLOGIA

miR-146a targets Fos expression in human cardiac cells

(2015) Xavier Palomer et al.   Disease Models & Mechanisms

MicroRNA profiling unveils hyperglycaemic memory in the diabetic heart

(2015) Sarah Costantino et al.   EUROPEAN HEART JOURNAL

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes

(2015) Petar M. Seferović et al.   EUROPEAN HEART JOURNAL

MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure

(2015) Chris J. Watson et al.   EUROPEAN JOURNAL OF HEART FAILURE

Noncoding RNAs, cytokines, and inflammation-related diseases

(2015) José Luiz Marques-Rocha et al.   FASEB JOURNAL

MicroRNAs in cardiovascular disease: an introduction for clinicians

(2015) Simon P R Romaine et al.   HEART

Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells

(2015) Prasanth Puthanveetil et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-223 inhibits tissue factor expression in vascular endothelial cells

(2014) Sufang Li et al.   ATHEROSCLEROSIS

Micro-RNA 21Targets Dual Specific Phosphatase 8 to Promote Collagen Synthesis in High Glucose–Treated Primary Cardiac Fibroblasts

(2014) Shulei Liu et al.   CANADIAN JOURNAL OF CARDIOLOGY

2. Classification and Diagnosis of Diabetes

(2014)   DIABETES CARE

lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI

(2014) Miaojun Zhu et al.   FEBS Journal

Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes

(2014) Shali Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy

(2014) X Li et al.   Cell Death & Disease

Single Intracoronary Injection of Encapsulated Antagomir‐92a Promotes Angiogenesis and Prevents Adverse Infarct Remodeling

(2014) Neus Bellera et al.   Journal of the American Heart Association

MicroRNA-150 aggravates H2O2-induced cardiac myocyte injury by down-regulating c-myb gene

(2013) X. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

MicroRNAs: The Underlying Mediators of Pathogenetic Processes in Vascular Complications of Diabetes

(2013) Michael Anthony Ruiz et al.   Canadian Journal of Diabetes

Differential Expression of Dicer, miRNAs, and Inflammatory Markers in Diabetic Ins2+/− Akita Hearts

(2013) Vishalakshi Chavali et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Relationship Between Downregulation of miRNAs and Increase of Oxidative Stress in the Development of Diabetic Cardiac Dysfunction: Junctin as a Target Protein of miR-1

(2013) Samet Serdar Yildirim et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy

(2013) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection

(2013) B. G. Byrne et al.   mBio

CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC

(2012) Ada Congrains et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction During Acute Viral Myocarditis

(2012) Maarten F. Corsten et al.   CIRCULATION RESEARCH

MicroRNA Dysregulation in Diabetic Ischemic Heart Failure Patients

(2012) S. Greco et al.   DIABETES

Resveratrol induces nuclear factor-κB activity in human cardiac cells

(2012) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

(2012) C Freudlsperger et al.   ONCOGENE

PPAR and Oxidative Stress: Con() Catenating NRF2 and FOXO

(2012) Simone Polvani et al.   PPAR Research

MicroRNAs Involved in the Mitogen-Activated Protein Kinase Cascades Pathway During Glucose-Induced Cardiomyocyte Hypertrophy

(2011) E. Shen et al.   AMERICAN JOURNAL OF PATHOLOGY

Platelet TGF- 1 contributions to plasma TGF- 1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload

(2011) A. Meyer et al.   BLOOD

Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes

(2011) M. Balasubramanyam et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice

(2011) Bing Hu   Molecular Medicine Reports

The Interplay between NF-kappaB and E2F1 Coordinately Regulates Inflammation and Metabolism in Human Cardiac Cells

(2011) Xavier Palomer et al.   PLoS One

Nrf2 and PPARγ

(2010) Raju C. Reddy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism

(2010) Han Lu et al.   CARDIOVASCULAR RESEARCH

Reactive Oxygen Species and Antioxidants in the Pathophysiology of Cardiovascular Disease: Does the Actual Knowledge Justify a Clinical Approach?

(2010) Salvatore Rosa et al.   Current Vascular Pharmacology

Bcl-6 and NF- B cistromes mediate opposing regulation of the innate immune response

(2010) G. D. Barish et al.   GENES & DEVELOPMENT

Diabetic cardiomyopathy, causes and effects

(2010) Sihem Boudina et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Hypothesis: the “metabolic memory”, the new challenge of diabetes

(2009) Antonio Ceriello   DIABETES RESEARCH AND CLINICAL PRACTICE

miR133a regulates cardiomyocyte hypertrophy in diabetes

(2009) Biao Feng et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4

(2009) Yunhui Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ARC is a critical cardiomyocyte survival switch in doxorubicin cardiotoxicity

(2009) Junfeng An et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Overexpression of junctate induces cardiac hypertrophy and arrhythmia via altered calcium handling

(2008) Chang-Soo Hong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

(2008) Jonathan B. Johnnidis et al.   NATURE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark