Article
Oncology
Ludmila Stepanovna Zubarovskaya, Ivan Sergeevich Moiseev, Maria Dmidrievna Vladovskaya, Natalia Borisovna Mikhailova, Elena Vladislavovna Morozova, Tatyana Alexandrovna Bykova, Yulia Yurievna Vlasova, Olesya Vladimirovna Paina, Ilya Viktorovich Kazantsev, Olga Alexandrovna Slesarchuk, Anna Gennadyevna Smirnova, Anna Alekseevna Osipova, Liliya Vladimirovna Stelmakh, Alexey Yurievich Polushin, Oleg Valerievich Goloshchapov, Maxim Pavlovich Bogomolny, Maria Arkadievna Estrina, Marina Olegovna Popova, Maxim Anatolievich Kucher, Alisa Georgievna Volkova, Alexander Leonidovich Alyansky, Dmitrii Eduardovich Pevtcov, Natalia Evgenievna Ivanova, Elena Vitalievna Babenko, Nikolai Nikolaevich Mamaev, Tatiana Leonidovna Gindina, Alina Alexandrovna Vitrishchak, Alexei Borisovich Chukhlovin, Elena Vladimirovna Semenova, Sergei Nicolaevich Bondarenko, Alexander Dmitrievich Kulagin, Boris Vladimirovich Afanasyev, Yvonne A. Efebera
Summary: In this single-center analysis, trends in hematopoietic cell transplantations between 1990 and 2022 were evaluated. The study showed improved event-free survival after autologous hematopoietic cell transplantation due to reduced relapse incidence. Additionally, an improvement in event-free survival after allogeneic hematopoietic cell transplantation was observed due to reduced non-relapse mortality. Different diseases showed varying degrees of improvement in survival rates after different types of transplantation.
Article
Obstetrics & Gynecology
T. Diesch-Furlanetto, A. Rovo, J. E. Galimard, G. Szinnai, A. Dalissier, P. Sedlacek, I Bodova, V. K. Roussou, B. E. Gibson, X. Poire, F. Fagioli, H. Pichler, M. Faraci, F. G. Gumy-Pause, J. H. Dalle, A. Balduzzi, P. Bader, S. Corbacioglu
Summary: The study found that insemination and conception after hematopoietic stem cell transplantation (HCT) in childhood or adolescence are possible, with some patients possibly requiring reproductive medicine support. Traditional HCT preparative regimens can lead to gonadal failure and pubertal development disorders. Reproductive health surveillance and fertility preservation counseling are crucial for these patients.
HUMAN REPRODUCTION
(2021)
Article
Biophysics
Moshe Yeshurun, Uri Rozovski, Liat Shargian, Oren Pasvolsky, Steffie van der Werf, Gloria Tridello, Nina Knelange, Malgorzata Mikulska, Jan Styczynski, Diana Averbuch, Rafael de la Camara
Summary: We conducted a study to describe the infection prevention practices among EBMT centers. Questionnaires were sent to all 553 centers and responses from 127 centers in 32 countries were obtained. The study revealed significant variations in antimicrobial prophylaxis practices, medications employed and duration of preventive therapy among the centers.
BONE MARROW TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
L. Nie, A. C. Nusantara, V. G. Damle, R. Sharmin, E. P. P. Evans, S. R. Hemelaar, K. J. van der Laan, R. Li, F. P. Perona Martinez, T. Vedelaar, M. Chipaux, R. Schirhagl
Summary: Relaxometry measurement inherited from diamond magnetometry can be used to detect free radicals in living cells with subcellular resolution. This quantum sensing technique based on defects in diamond allows nanoscale magnetic resonance measurements to detect metabolic activity in mitochondria.
Article
Hematology
Michael H. Albert, Mary A. Slatter, Andrew R. Gennery, Tayfun Gungor, Katerina Bakunina, Benyamin Markovitch, Sheree Hazelaar, Tiarlan Sirait, Virginie Courteille, Alessandro Aiuti, Olga Aleinikova, Dmitry Balashov, Maria Ester Bernardo, Ivana Bodova, Benedicte Bruno, Marina Cavazzana, Robert Chiesa, Alain Fischer, Fabian Hauck, Marianne Ifversen, Krzysztof Kalwak, Christoph Klein, Alexander Kulagin, Alphan Kupesiz, Baris Kuskonmaz, Caroline A. Lindemans, Franco Locatelli, Su Han Lum, Alexey Maschan, Roland Meisel, Despina Moshous, Fulvio Porta, Martin G. Sauer, Petr Sedlacek, Ansgar Schulz, Felipe Suarez, Tanja C. Vallee, Jacek H. Winiarski, Marco Zecca, Benedicte Neven, Paul Veys, Arjan C. Lankester
Summary: This study analyzed the data of 197 patients with Wiskott-Aldrich syndrome (WAS) who underwent HSCT treatment at European Society for Blood and Marrow Transplantation centers between 2006 and 2017. The study found that there was no significant impact on overall survival and chronic GVHD-free survival based on conditioning regimen, donor type, or period of HSCT. Patients aged under 5 years had a significantly better overall survival.
Article
Medicine, General & Internal
Andrea Lisco, Ana M. Ortega-Villa, Harry Mystakelis, Megan V. Anderson, Allyson Mateja, Elizabeth Laidlaw, Maura Manion, Gregg Roby, Jeanette Higgins, Safia Kuriakose, Magdalena A. Walkiewicz, Morgan Similuk, Jennifer W. Leiding, Alexandra F. Freeman, Virginia Sheikh, Irini Sereti
Summary: This study analyzes the clinical, genetic, immunologic, and prognostic characteristics of ICL patients. It finds that ICL is associated with increased susceptibility to viral, fungal, and mycobacterial diseases, reduced response to novel antigens, and increased risk of cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Chemistry, Analytical
Piia Liigand, Jaanus Liigand, Karl Kaupmees, Anneli Kruve
Summary: This study discusses the variation of ionization efficiency for different compounds and its influencing factors, analyzes the methodology used for measuring ionization efficiency, and the observed data trends. Suggestions are made to collectively collect and unify knowledge about the ionization processes through a GitHub repository.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biophysics
Simone Cesaro, Per Ljungman, Gloria Tridello, Malgorzata Mikulska, Lotus Wendel, Jan Styczynski, Dina Averbuch, Rafael de la Camara
Summary: The management of cytomegalovirus (CMV) infection was assessed through a survey, which showed that nearly half of the centers adopted letermovir prophylaxis. However, further research is needed to investigate the impact of letermovir prophylaxis on other important aspects of CMV management.
BONE MARROW TRANSPLANTATION
(2022)
Article
Environmental Sciences
Akiyoshi Ito, Shinji Wakamatsu, Tazuko Morikawa, Shinji Kobayashi
Summary: This paper aims to obtain information to contribute to further improve air quality in Japan. Analysis of air pollutant concentration trends over the past 30 years reveals a decrease in PM2.5 mass concentrations, with a need to reduce VOC emissions as precursors. A linear relationship between domestic anthropogenic emissions and atmospheric concentrations is found for NOx and SO2. Recent air pollution episodes and the impact of reduced economic activity due to COVID-19 on air pollution concentrations are also summarized.
Review
Medicine, General & Internal
Pamela Tozzo, Arianna Delicati, Renato Zambello, Luciana Caenazzo
Summary: The paper provides a comparative overview of molecular biology techniques for studying chimerism after bone marrow transplantation, highlighting the advantages and disadvantages of each method. While STR-PCR remains the gold standard option due to its high power of differentiation, other methods such as qPCR, dPCR, and NGS offer potential advantages in terms of sensitivity and earlier detection of chimerism.
Article
Cardiac & Cardiovascular Systems
Matilda Jerkeman, Pedram Sultanian, Peter Lundgren, Niklas Nielsen, Edvin Helleryd, Christian Dworeck, Elmir Omerovic, Per Nordberg, Annika Rosengren, Jacob Hollenberg, Andreas Claesson, Solveig Aune, Anneli Stromsoe, Annica Ravn-Fischer, Hans Friberg, Johan Herlitz, Araz Rawshani
Summary: The study analyzed trends in characteristics, management, and survival rates of out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA) in Sweden. The survival rate for OHCA increased by 2.2 times from 1990 to 2020, but showed no further improvement in the last decade. For IHCA, the survival rate increased by 1.2 times from 2004 to 2020, with rapid improvement in the last decade. Cardiac causes and shockable rhythms decreased by half, but there was no significant improvement in neurological outcomes.
EUROPEAN HEART JOURNAL
(2022)
Article
Biophysics
Jakob R. Passweg, Helen Baldomero, Christian Chabannon, Selim Corbacioglu, Rafael de la Camara, Harry Dolstra, Bertram Glass, Raffaella Greco, Mohamad Mohty, Benedicte Neven, Regis Peffault de Latour, Zinaida Peric, John A. Snowden, Ibrahim Yakoub-Agha, Anna Sureda, Nicolaus Kroeger
Summary: According to the annual report from the European Society for Blood and Marrow Transplantation (EBMT), there was a decrease in the number of hematopoietic stem cell transplants (HCT) in 2020 compared to the previous year. The decrease was more pronounced in allogeneic HCT for non-malignant disorders and autologous HCT for autoimmune diseases. However, the use of CAR-T cell therapies and non-myeloablative conditioning showed significant growth.
BONE MARROW TRANSPLANTATION
(2022)
Article
Environmental Sciences
Chris Pappas, Brenda Foos
Summary: The USDA's Pesticide Data Program (PDP) is a major global monitoring program for pesticide residues, celebrating its 30th anniversary in 2021. With over 42 million data points, the PDP database provides essential information on the pairing of pesticides with commodities through the analysis of nearly 310,000 food samples. Updated data from PDP is crucial for exposure and risk assessment.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Biophysics
Ibrahim Yakoub-Agha, Raffaella Greco, Francesco Onida, Rafael de la Camara, Fabio Ciceri, Selim Corbacioglu, Harry Dolstra, Bertram Glass, Michelle Kenyon, Donal P. McLornan, Benedicte Neven, Regis Peffault de Latour, Zinaida Peric, Annalisa Ruggeri, John A. Snowden, Anna Sureda, Isabel Sanchez-Ortega
Summary: Clinical patient care for hematopoietic cell transplantation and cellular therapy varies between countries and centers. To harmonize clinical practices, European guidelines will be developed by the EBMT PH&G committee through workshops with experts. These guidelines aim to provide clear and practical recommendations in the absence of international consensus.
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Ville E. J. Sirvio, Jari V. Rasanen, Joonas H. Kauppila
Summary: The prognosis of esophageal cancer has improved in Finland over the last 30 years, with significant increases in survival rates for patients undergoing esophagectomy. However, the prognosis for patients not undergoing surgery remains poor.
Article
Oncology
Joanna Zaleska, Paulina Kwasnik, Magdalena Paziewska, Joanna Purkot, Aleksandra Szabelak, Mateusz Jurek, Natalia Masny, Izabela Dziatkiewicz, Bartosz Pronobis-Szczylik, Agnieszka Piebiak, Agnieszka Szymczyk, Katarzyna Jarosz-Chudzik, Lukasz Bolkun, Katarzyna Kozlowska, Jaroslaw Piszcz, Edyta Subocz, Janusz Halka, Michal Bator, Elzbieta Kalicinska, Tomasz Wrobel, Lidia Usnarska-Zubkiewicz, Justyna Rybka, Izabela Deren-Wagemann, Marta Szyca-Smieszniak, Jaroslaw Dybko, Iwona Hus, Bartosz Pula, Edyta Cichocka, Marcin Rymko, Dorota Zdunczyk, Mateusz Ziarkiewicz, Grzegorz Wladyslaw Basak, Lars Bullinger, Krzysztof Giannopoulos
Summary: Multiple myeloma and chronic lymphocytic leukemia patients have increased susceptibility to COVID-19 due to impaired immune function. This study evaluated the efficacy of mRNA COVID-19 vaccines in these patients and found that vaccination can induce specific CD8+ T cell responses, but they do not correlate positively with serological responses.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biophysics
Anne Banet, Ali Bazarbachi, Myriam Labopin, Nicolas Stocker, Remy Dulery, Florent Malard, Zoe Van de Wyngaert, Alexis Genthon, Mara Memoli, Ollivier Legrand, Agnes Bonnin, Tounes Ledraa, Ramdane Belhocine, Simona Sestili, Jean El-Cheikh, Mohamad Mohty, Eolia Brissot
Summary: Total body irradiation (TBI)-based conditioning regimens are commonly used in acute lymphoblastic leukemia (ALL) patients, but studies have shown comparable outcomes with thiotepa-based conditioning regimen. In this retrospective study, we evaluated the outcome of adult ALL patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HCT) with a thiotepa-busulfan-fludarabine (TBF) myeloablative conditioning regimen. The results showed promising overall survival and acceptable toxicity in these patients.
BONE MARROW TRANSPLANTATION
(2023)
Letter
Hematology
Michele Wieczorek, Myriam Labopin, Luca Castagna, Eolia Brissot, Gerard Socie, Anna Maria Raiola, Emanuele Angelucci, Arancha Bermudez Rodriguez, Ibrahim Yakoub-Agha, Mahmoud Aljurf, Charles Crawley, Jean Baptiste Mear, Maurizio Musso, Renato Fanin, Daniele Avenoso, Pascal Turlure, Cristina Tecchio, Jaime Sanz, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Biophysics
Remy Dulery, Claire Goudet, Daniele Mannina, Antonio Bianchessi, Angela Granata, Samia Harbi, Valerio Maisano, Christian Chabannon, Florent Malard, Eolia Brissot, Simona Sestili, Anne Banet, Zoe van de Wyngaert, Ramdane Belhocine, Stephane Ederhy, Luca Castagna, Stefania Bramanti, Didier Blaise, Mohamad Mohty, Sabine Fuerst, Raynier Devillier
Summary: Comparing the outcomes of PT-Cy at 80 mg/kg and 100 mg/kg in elderly patients undergoing haploidentical HCT, it was found that reducing the PT-Cy dose to 80 mg/kg improved hematological recovery and reduced the incidence of hemorrhagic cystitis.
BONE MARROW TRANSPLANTATION
(2023)
Article
Clinical Neurology
Giacomo Boffa, Alessio Signori, Luca Massacesi, Alice Mariottini, Elvira Sbragia, Salvatore Cottone, Maria Pia Amato, Claudio Gasperini, Lucia Moiola, Stefano Meletti, Anna Maria Repice, Vincenzo Brescia Morra, Giuseppe Salemi, Francesco Patti, Massimo Filippi, Giovanna De Luca, Giacomo Lus, Mauro Zaffaroni, Patrizia Sola, Antonella Conte, Riccardo Nistri, Umberto Aguglia, Franco Granella, Simonetta Galgani, Luisa Maria Caniatti, Alessandra Lugaresi, Silvia Romano, Pietro Iaffaldano, Eleonora Cocco, Riccardo Saccardi, Emanuele Angelucci, Maria Trojano, Giovanni Luigi Mancardi, Maria Pia Sormani, Matilde Inglese
Summary: This study compared the effects of autologous hematopoietic stem cell transplantation (AHSCT) with other anti-inflammatory disease-modifying therapies (DMTs) on long-term disability worsening in active secondary progressive multiple sclerosis (SPMS). The results showed that AHSCT was associated with a slower disability progression and a higher likelihood of disability improvement compared to standard immunotherapy.
Letter
Biophysics
Marie Robin, Luuk Gras, Linda Koster, Riccardo Saccardi, Juergen Finke, Edouard Forcade, Montserrat Rovira, Guido Kobbe, Peter Remenyi, Jane Apperley, Arghirescu Smaranda, Jacques-Olivier Bay, Jochen Casper, Liesbeth. C. C. de Wreede, Sebastian Giebel, Giovanni Grillo, Inmaculada Heras, Victoria Potter, Johanna Tischer, Ilze Trociukas, David Nachbaur, Joanna Drozd-Sokolowska, Kavita Raj, Carmelo Gurnari, Ibrahim Yakoub-Agha, Francesco Onida, Christof Scheid, Donal McLornan
BONE MARROW TRANSPLANTATION
(2023)
Article
Biophysics
Ibrahim Yakoub-Agha, Raffaella Greco, Francesco Onida, Rafael de la Camara, Fabio Ciceri, Selim Corbacioglu, Harry Dolstra, Bertram Glass, Michelle Kenyon, Donal P. McLornan, Benedicte Neven, Regis Peffault de Latour, Zinaida Peric, Annalisa Ruggeri, John A. Snowden, Anna Sureda, Isabel Sanchez-Ortega
Summary: Clinical patient care for hematopoietic cell transplantation and cellular therapy varies between countries and centers. To harmonize clinical practices, European guidelines will be developed by the EBMT PH&G committee through workshops with experts. These guidelines aim to provide clear and practical recommendations in the absence of international consensus.
BONE MARROW TRANSPLANTATION
(2023)
Article
Biophysics
Arnon Nagler, Myriam Labopin, Ryszard Swoboda, Alexander Kulagin, Andrea Velardi, Jaime Sanz, Helene Labussiere-Wallet, Victoria Potter, Juergen Kuball, Simona Sica, Elena Parovichnikova, Wolfgang Bethge, Natacha Maillard, Uwe Platzbecker, Friedrich Stoelzel, Fabio Ciceri, Mohamad Mohty
Summary: This study evaluated the outcome of second transplantation (HSCT2) for the treatment of primary graft failure (pGF) in 243 patients with acute leukemia. The median age was 44.8 years. 73.7% of patients achieved engraftment after HSCT2. The 5-year nonrelapse mortality was 51.6%, relapse incidence was 18.8%, leukemia-free survival was 29.6%, and overall survival was 30.7%.
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Philipp Berning, Norbert Schmitz, Maud Ngoya, Herve Finel, Ariane Boumendil, Fengrong Wang, Xiao-Jun Huang, Olivier Hermine, Laure Philippe, Lucile Couronne, Arnaud Jaccard, Daihong Liu, Depei Wu, Hans Christian Reinhardt, Yves Chalandon, Eva Wagner-Drouet, Mi Kwon, Xi Zhang, Ben Carpenter, Ibrahim Yakoub-Agha, Gerald Wulf, Javier Lopez-Jimenez, Jaime Sanz, Helene Labussiere-Wallet, Avichai Shimoni, Peter Dreger, Anna Sureda, Won Seog Kim, Bertram Glass
Summary: In this study, researchers conducted a retrospective analysis of data from 135 patients with natural killer/T-cell lymphomas (NKTCL) who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). The results showed that allo-HSCT can achieve long-term survival in NKTCL patients.
Article
Immunology
Chiara Oltolini, Andrea Acerbis, Giorgio Orofino, Sara Racca, Maddalena Noviello, Stefania Dispinseri, Nicola Clementi, Simona Piemontese, Elisabetta Xue, Fabio Giglio, Maria Teresa Lupo Stanghellini, Elisa Diral, Alessandro Bruno, Elena Tassi, Valeria Beretta, Ilaria Marzinotto, Gabriella Scarlatti, Vito Lampasona, Anna Ardemagni, Michela Sampaolo, Chiara Bonini, Consuelo Corti, Jacopo Peccatori, Antonella Castagna, Fabio Ciceri, Raffaella Greco
Summary: This report describes a case of a 34-year-old patient with active SARS-CoV-2 infection and high-risk leukemia who underwent allogeneic hematopoietic stem cell transplantation. Timely anti-SARS-CoV-2 preventive therapies and prompt management of transplant-related complications resulted in a favorable outcome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Sjoerd J. F. Hermans, Jurjen Versluis, Myriam Labopin, Sebastian Giebel, Yvette van Norden, Ivan Moiseev, Didier Blaise, Jose L. Diez Martin, Ellen Meijer, Montserrat Rovira, Goda Choi, Anna Maria Raiola, Yener Koc, Peter Remenyi, Jan Vydra, Nicolaus Kroeger, Simona Sica, Massimo Martino, Gwendolyn van Gorkom, Patrice Chevallier, Alessandro Busca, Concepcion Herrera Arroyo, Eolia Brissot, Zinaida Peric, Arnon Nagler, Roni Shouval, Fabio Ciceri, Jan J. Cornelissen, Mohamad Mohty
Summary: PTCY-based GVHD prophylaxis reduces the incidence of GVHD and nonrelapse mortality after alloSCT. We developed a novel PTCY-specific NRM-risk model that better predicts 2-year NRM compared to existing models.
Article
Hematology
Radwan Massoud, Hassan Naim, Evgeny Klyuchnikov, Dietlinde Janson, Christine Wolschke, Francis Ayuk, Nicolaus Kroeger
Summary: This study compared transplant outcomes between patients with refractory-T-NHL and Chemosensitive-T-NHL who underwent allo-SCT. While there were no differences in engraftment between the two groups, trends for improved survival were observed in the Chemosensitive-T-NHL group, showing the curative potential of allo-SCT in patients with T-NHL.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Kai Rejeski, Raffaella Greco, Francesco Onida, Isabel Sanchez-Ortega, Chiara Bonini, Anna Sureda, John G. Gribben, Ibrahim Yakoub-Agha, Marion Subklewe
Summary: The pathophysiology of hematological toxicity after CAR-T cell therapy is not fully understood and its grading and management are not well-defined. This study conducted a survey of experienced clinicians to gather insights on the grading, risk-stratification, diagnostic work-up, and management of immune effector cell-associated hematotoxicity (ICAHT) in order to inform guideline development. The survey revealed significant variability in cytopenia grading, a preference for pre-CAR-T bone marrow studies in high-risk patients, and a need for ruling out viral infections, substrate deficiency, and coincident sHLH/MAS in patients with severe hematotoxicity.
Letter
Medicine, General & Internal
Magdalena Rajner, Marcin Jasinski, Ewa Karakulska-Prystupiuk, Urszula Ambroziak, Wieslaw W. Jedrzejczak, Grzegorz W. Basak
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)