Review
Microbiology
Yihan Chai, Zhengze Huang, Xuqiu Shen, Tianyu Lin, Yiyin Zhang, Xu Feng, Qijiang Mao, Yuelong Liang
Summary: The microbiota in various parts of the human body, particularly in the oral cavity, gastrointestinal tract, and pancreatic tissue, plays a crucial role in the occurrence and development of cancer, such as pancreatic cancer (PC). Recent research has shown that the microbiota influences PC carcinogenesis through altered immune responses, activatin oncogenic signaling, enhancing oncogenic metabolic pathways, altering cancer cell proliferation, and triggering chronic inflammation that suppresses tumor immunity. Diagnostics and treatments based on or in combination with the microbiota offer novel insights to improve efficiency compared with existing therapies.
Article
Environmental Sciences
Madjid Djouina, Cecile Vignal, Alexandre Dehaut, Segolene Caboche, Nell Hirt, Christophe Waxin, Charlotte Himber, Delphine Beury, David Hot, Laurent Dubuquoy, David Launay, Guillaume Duflos, Mathilde Body-Malapel
Summary: The aim of this study was to investigate the effects of intestinal exposure to polyethylene (PE) microplastics on gut homeostasis. Mice were orally exposed to PE microbeads of two different sizes, and it was found that ingestion of PE microbeads led to intestinal disturbances and significant alterations of crucial intestinal markers. This highlights the need for further research on the health impact of microplastic exposure in humans.
ENVIRONMENTAL RESEARCH
(2022)
Article
Neurosciences
Heping Xu, Mei Chen
Summary: This article discusses the immune response in retinal degenerative diseases and classifies them into dry and wet forms based on whether the blood-retinal barrier is breached. The immune response in dry degeneration is regulated by neurons, while the wet form involves infiltrating immune cells and potential effects from the gut microbiome.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Food Science & Technology
Zhuqing Xing, Jiaying Li, Yating Zhang, Ang Gao, Heran Xie, Zifan Gao, Xuan Chu, Yumeng Cai, Chunkai Gu
Summary: This study compared the nutritional properties of plant-based meat alternatives (PMAs) and meat both before and after in vitro simulation of gastrointestinal digestion. The results showed differences in molecular weight, composition, and bioactivity between PMAs and meat-derived peptides (MDPs). PMAs contained a higher proportion of high-biological-scoring peptides, indicating stronger antibacterial and antioxidant activities. The findings provide a theoretical basis for understanding the nutritional characteristics of PMAs.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Samantha Gonzalez Delgado, Idalia Garza-Veloz, Fabiola Trejo-Vazquez, Margarita L. Martinez-Fierro
Summary: This study aims to integrate scientific data on the role of the intestinal microbiota in regulating gut serotonin signaling and reuptake and its involvement in the pathogenesis of IBD. It is found that the use of selective serotonin reuptake inhibitors as an adjuvant therapy can improve disease activity and extraintestinal manifestations in IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yu-Chen Wang, Yang Cao, Calvin Pan, Zhiqiang Zhou, Lili Yang, Aldons J. Lusis
Summary: This study utilized single-cell RNA sequencing and statistical modeling to investigate the dynamic properties and underlying cellular mechanisms of intestinal cells. It identified new cell subsets and developmental trajectories in different layers of intestinal cells. The high-fat high-sucrose Western diet led to changes in immune cell populations and nutrient absorption function in enterocytes, as well as revealed novel interactions and communication hubs among intestinal cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Food Science & Technology
David Julian McClements, Jochen Weiss, Amanda J. Kinchla, Alissa A. Nolden, Lutz Grossmann
Summary: The modern food system is experiencing changes in consumption patterns driven by various factors, such as ethical, health, and environmental concerns, which are increasing the sales of meat analog foods and prompting increased research and development activities in plant-based meats. This review describes methods employed by scientists to analyze and characterize the properties of meat alternatives, proposing standardized methods for future use. Methods for determining the properties of plant-based meat, such as composition, microstructure, texture, water-holding capacity, cooking resilience, and sensory attributes, are discussed to guide further studies and method selection.
Review
Food Science & Technology
Qianli Huang, Huijuan Zhang, Li Zhang, Baocai Xu
Summary: This study investigates the bacterial microbiota in meat products, evaluating their diversity and the impact of environmental factors. The research finds that different types of processed meat products and different meats have varying effects on the bacterial microbiota. Furthermore, the examination of co-occurrence patterns reveals the underlying reasons for the frequent coexistence of certain species.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Cheng Liu, Jialu Shi, Jin Wang, Yue Dai, Vijaya Raghavan
Summary: With the increasing health needs of people, plant-based meat products have gained attention as an alternative to red meat. However, the heavy processing and use of additives in many plant-based meat products on the market categorize them as ultra-processed foods. An experimental study found that compared to low-processed red meat, ultra-processed plant-based meat and red meat led to significant weight gain and the presence of intestinal and liver inflammation in mice. Additionally, plant-based meat and red meat had different effects on gut microbiota, which in turn affected body weight and the occurrence of inflammation. This suggests that plant-based meat is healthier than red meat, but overprocessing reduces its benefits, emphasizing the need to improve processing methods and reduce the use of additives.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Microbiology
Xue-Ling Xu, Yue Zhao, Ming-Ming Chen, Yan Li, Yao Li, Su-Jun Wu, Jin-Long Zhang, Xiao-Sheng Zhang, Kun Yu, Zheng-Xing Lian
Summary: This study found that Toll-like receptor 4 (TLR4) recognizes bacterial ligands in the intestine and interacts with the immune system, counteracting Salmonella Typhimurium invasion and intestinal inflammation by regulating the composition of the intestinal microbiota and enhancing anti-inflammatory metabolites.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Nutrition & Dietetics
Perla Lopes de Freitas, Joao Paulo Nascimento Miranda, Lucas Martins Franca, Antonio Marcus de Andrade Paes
Summary: This narrative review aims to gather up-to-date information on the relationship between (poly)phenol intake, their modulatory effect on gut microbiota diversity, and consequent metabolic outcomes, serving as a supportive tool for future experimental design and clinical trials.
Review
Food Science & Technology
Perla Lopes de Freitas, Marcus Vinicius Camara Barros, Romulo Brenno Lopes Froes, Lucas Martins Franca, Antonio Marcus de Andrade Paes
Summary: The gut microbiota plays an important role in host neuroendocrine pathways and can contribute to the development of chronic diseases. Dysbiosis, or the imbalance between beneficial and pathogenic bacteria, is a key factor in the development of obesity, diabetes, metabolic syndrome, and Alzheimer's disease. Dietary supplementation with (poly)phenols can help restore the balance of the gut microbiota and improve metabolic disorders. This review discusses the modulation of the gut microbiota by (poly)phenols and their effects on host metabolism.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Immunology
Nicolas Ortiz-Lopez, Catalina Fuenzalida, Maria Soledad Dufeu, Araceli Pinto-Leon, Alejandro Escobar, Jaime Poniachik, Juan Pablo Roblero, Lucia Valenzuela-Perez, Caroll J. Beltran
Summary: Non-alcoholic fatty liver disease (NAFLD) is a liver-damaging manifestation of metabolic syndrome with increasing prevalence, requiring diverse therapeutic approaches due to chronic low-grade inflammation being a central mechanism in its development. Immune response modulation may be a key focus in current research on NAFLD treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Sang-Kap Han, Yeon-Jeong Shin, Dong-Yeon Lee, Kyung Min Kim, Seo-Jin Yang, Du Seong Kim, Ji-Whi Choi, Seunghun Lee, Dong-Hyun Kim
Summary: Oral administration of HDB1258 can enhance immune response by increasing NK cell cytotoxicity and macrophage phagocytosis in healthy mice, while suppressing systemic inflammation in mice with LPS-induced inflammation by modulating gut microbiota and IL-10 to TNF-alpha expression ratio in immune cells.
Review
Clinical Neurology
Qin Huang, Jian Xia
Summary: Research on the gut-brain axis in the context of stroke reveals significant disturbances in the dysbiotic gut microbiome, intestinal dysfunction, enteric nervous system, gut permeability, and immune cells activation in the gut. These disruptions can lead to infiltration of pro-inflammatory cells or bacterial toxins into brain tissue through the impaired blood-brain barrier, exacerbating brain infarction.
NEUROLOGICAL SCIENCES
(2021)
Article
Cell Biology
Raed Madhi, Milladur Rahman, Dler Taha, Matthias Morgelin, Henrik Thorlacius
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Raed Madhi, Milladur Rahman, Matthias Morgelin, Henrik Thorlacius
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Medicine, Research & Experimental
Johan Linders, Raed Madhi, Milladur Rahman, Matthias Morgelin, Sara Regner, Max Brenner, Ping Wang, Henrik Thorlacius
LABORATORY INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Kevin Brulois, Anusha Rajaraman, Agata Szade, Sofia Nordling, Ania Bogoslowski, Denis Dermadi, Milladur Rahman, Helena Kiefel, Edward O'Hara, Jasper J. Koning, Hiroto Kawashima, Bin Zhou, Dietmar Vestweber, Kristy Red-Horse, Reina E. Mebius, Ralf H. Adams, Paul Kubes, Junliang Pan, Eugene C. Butcher
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Anwar Algaber, Amr Al-Haidari, Raed Madhi, Milladur Rahman, Ingvar Syk, Henrik Thorlacius
SCIENTIFIC REPORTS
(2020)
Article
Surgery
Johan Linders, Raed Madhi, Matthias Morgelin, Ben C. King, Anna M. Blom, Milladur Rahman
Summary: The study revealed that C3 plays a crucial role in the recruitment of neutrophils and the formation of NETs in acute pancreatitis. Lack of C3 resulted in reduced NETs in pancreatic tissue, along with decreased levels of MPO in the lung, and plasma IL-6, MMP-9, and CXCL2. Targeting C3 could be a potential strategy to alleviate local damage and remote organ dysfunction in AP.
EUROPEAN SURGICAL RESEARCH
(2021)
Retraction
Medicine, Research & Experimental
Raeh Madhi, Milladur Rahman, Dler Taha, Johan Linders, Mohammed Merza, Yongzhi Wang, Matthias Morgelon, Henrik Thorlacius
Article
Oncology
Mattias Lepsenyi, Nader Algethami, Amr A. Al-Haidari, Anwar Algaber, Ingvar Syk, Milladur Rahman, Henrik Thorlacius
Summary: This study aimed to investigate the mechanisms regulating colon cancer cell adhesion and spread to peritoneal wounds after abdominal surgery. The results showed that the CXCL2-CXCR2 signaling axis and alpha V integrin play key roles in mediating colon cancer cell adhesion and growth on peritoneal wound sites.
CLINICAL & EXPERIMENTAL METASTASIS
(2021)
Review
Biochemistry & Molecular Biology
Umama Khan, Sabrina Chowdhury, Md Morsaline Billah, Kazi Mohammed Didarul Islam, Henrik Thorlacius, Milladur Rahman
Summary: This review highlights the roles of neutrophil extracellular traps (NETs) in colorectal cancer (CRC) progression and metastasis, as well as the potential of targeting NETs as a therapeutic strategy for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Avin Hawez, Dler Taha, Anwar Algaber, Raed Madhi, Milladur Rahman, Henrik Thorlacius
Summary: The study found that miR-155 regulates pulmonary formation of NETs in abdominal sepsis via up-regulation of PAD4 and histone 3 citrullination, suggesting that targeting miR-155 could be an effective approach to reduce pulmonary damage in abdominal sepsis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Oncology
Anwar Algaber, Raed Madhi, Avin Hawez, Carl-Fredrik Ronnow, Milladur Rahman
Summary: The study demonstrated that miR-340-5p can attenuate colon cancer cell migration and invasion by targeting FHL2 expression, suggesting its potential as a therapeutic target for colon cancer metastasis.
Article
Biochemistry & Molecular Biology
Milladur Rahman, Zhiyi Ding, Carl-Fredrik Ronnow, Henrik Thorlacius
Summary: Different subsets of lung endothelial cells, capillary endothelial cells (capEC) and post capillary venules (PCV), play distinct roles in regulating important physiological processes during sepsis-induced lung injury. CapEC are enriched with genes related to regulation of coagulation, vascular permeability, wound healing, and lipid metabolic processes after sepsis, while PCV are enriched with genes related to chemotaxis, cell-cell adhesion, chemokine biosynthesis, actin filament process regulation, and neutrophil homeostasis after sepsis. Targeting specific differentially expressed genes (DEGs) or transcription factors may be useful in protecting against sepsis-induced lung damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhiyi Ding, Feifei Du, Richard Garland Averitt, Gabriel Jakobsson, Carl-Fredrik Ronnow, Milladur Rahman, Alexandru Schiopu, Henrik Thorlacius
Summary: Blocking S100A9 function can attenuate neutrophil infiltration and edema formation in sepsis-induced lung injury, inhibit the up-regulation of Mac-1 on neutrophils, and decrease the levels of CXC chemokines in circulation and lungs. These findings suggest that targeting S100A9 could be a useful strategy to protect against excessive inflammation and lung damage in sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Avin Hawez, Zhiyi Ding, Dler Taha, Raed Madhi, Milladur Rahman, Henrik Thorlacius
Summary: This study demonstrates the pivotal role of c-Abl kinase in NET formation and lung damage during sepsis, suggesting that targeting c-Abl kinase may be an effective strategy to alleviate inflammation in sepsis. Inhibition of c-Abl kinase not only reduces NET formation and lung injury, but also decreases levels of CXC chemokines and IL-6, highlighting its potential as a therapeutic target for sepsis-induced inflammation.
LABORATORY INVESTIGATION
(2022)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)