期刊
BIOMATERIALS
卷 269, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120626
关键词
Phenolic-amine chemistry; Bivalirudin; Tannic acid; Anti-inflammation; Re-endothelialization; Cardiovascular stent
资金
- National Natural Science Foundation of China [82072072]
- International Cooperation Project by Science and Technology Department of Sichuan Province [2019YFH0103]
- Fundamental Research Funds for the Central Universities [2682020ZT82, 2682020ZT76]
In this study, a plant-inspired phenolic-amine chemistry strategy was developed to enhance the antithrombogenicity, anti-inflammatory properties, and rapid re-endothelialization of cardiovascular stents. The combined functions of tannic acid and bivalirudin showed promising results in reducing intimal hyperplasia and addressing clinical complications associated with restenosis and late stent thrombosis.
Antithrombogenicity, anti-inflammation, and rapid re-endothelialization are central requirements for the longterm success of cardiovascular stents. In this work, a plant-inspired phenolic-amine chemistry strategy was developed to combine the biological functions of a plant polyphenol, tannic acid (TA), and the thrombin inhibitor bivalirudin (BVLD) for tailoring the desired multiple surface functionalities of cardiovascular stents. To realize the synergistic modification of TA and BVLD on a stent surface, an amine-bearing coating of plasma polymerized allylamine was firstly prepared on the stent surface, followed by the sequential conjugation of TA and BVLD in alkaline solution based on phenolic-amine chemistry (i.e., Michael addition reaction). TA and BVLD were successfully immobilized onto the stent surface with considerable amounts of 330 +/- 12 and 930 +/- 80 ng/cm(2), respectively. The abundant phenolic hydroxyl groups of TA imparted the stent with ability to suppress inflammation. Meanwhile, BVLD provided an antithrombogenic and endothelial-friendly microenvironment. As a result, the combined functions of the TA and BVLD facilitate the rapid stent re-endothelialization for reduced intimal hyperplasia in vivo, and may be a promising strategy to address the clinical complications associated with restenosis and late stent thrombosis.
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