Electrophysiological properties of the mitochondrial permeability transition pores: Channel diversity and disease implication

Mechanisms for Ca2+-dependent permeability transition in mitochondria

(2020) Paolo Bernardi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A 20/20 view of ANT function in mitochondrial biology and necrotic cell death

(2020) Michael J. Bround et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome

(2020) Pawel Licznerski et al.   CELL

Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection

(2020) Michela Carraro et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration

(2020) Nelli Mnatsakanyan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

(2020) Massimo Bonora et al.   Biomolecules

The very low number of calcium-induced permeability transition pores in the single mitochondrion

(2020) Maria A. Neginskaya et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cryo-EM structure of the entire mammalian F-type ATP synthase

(2020) Gergely Pinke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial F-ATP synthase as the permeability transition pore

(2020) Christoph Gerle   PHARMACOLOGICAL RESEARCH

Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion

(2020) Stephen Hurst et al.   Cell Death & Disease

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore

(2019) Maria A. Neginskaya et al.   Cell Reports

Fondation Leducq Transatlantic Network of Excellence Targeting Mitochondria to Treat Heart Disease

(2019) Elizabeth Murphy et al.   CIRCULATION RESEARCH

Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase

(2019) Joe Carroll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

(2019) Jason Karch et al.   Science Advances

Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore

(2019) Andrea Urbani et al.   Nature Communications

A mitochondrial megachannel resides in monomeric F1FO ATP synthase

(2019) Nelli Mnatsakanyan et al.   Nature Communications

Osmotic regulation of the mitochondrial permeability transition pore investigated by light scattering, fluorescence and electron microscopy techniques

(2018) Artyom Y. Baev et al.   ANALYTICAL BIOCHEMISTRY

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the structural possibility of pore-forming mitochondrial F o F 1 ATP synthase

(2016) Christoph Gerle   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

F 1 F 0 ATP Synthase–Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline

(2016) Shijun Yan et al.   DIABETES

Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F1FO ATP synthase

(2015) Elizabeth A. Jonas et al.   PHARMACOLOGICAL RESEARCH

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration

(2013) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. Effect of the phosphorylation status of subunit c on pore opening

(2013) Tamara Azarashvili et al.   CELL CALCIUM

Calculation of ion currents across the inner membrane of functionally intact mitochondria

(2013) Daniel A Kane et al.   Channels

Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

(2013) Lan Guo et al.   PLoS One

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA