Design and Syntheses of New Antibiotics Inspired by Nature’s Quest for Iron in an Oxidative Climate

In Vitro Characterization of ETX1317, a Broad-Spectrum β-Lactamase Inhibitor That Restores and Enhances β-Lactam Activity against Multi-Drug-Resistant Enterobacteriales, Including Carbapenem-Resistant Strains

(2020) Alita A. Miller et al.   ACS Infectious Diseases

Extraction and Detection of Structurally Diverse Siderophores in Soil

(2020) Vineeta Rai et al.   Frontiers in Microbiology

Hydroxamate siderophores: Natural occurrence, chemical synthesis, iron binding affinity and use as Trojan horses against pathogens

(2020) Danah Al Shaer et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Platform to Discover Protease-Activated Antibiotics and Application to Siderophore–Antibiotic Conjugates

(2020) Jonathan H. Boyce et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phenotypic Adaptation of Pseudomonas aeruginosa in the Presence of Siderophore-Antibiotic Conjugates during Epithelial Cell Infection

(2020) Quentin Perraud et al.   Microorganisms

Synthetic sideromycins (skepticism and optimism): selective generation of either broad or narrow spectrum Gram-negative antibiotics

(2019) Yun-Ming Lin et al.   BIOMETALS

Antibiotic repurposing: bis-catechol- and mixed ligand (bis-catechol-mono-hydroxamate)-teicoplanin conjugates are active against multidrug resistant Acinetobacter baumannii

(2019) Manuka Ghosh et al.   JOURNAL OF ANTIBIOTICS

A Synthetic Dual Drug Sideromycin Induces Gram-Negative Bacteria To Commit Suicide with a Gram-Positive Antibiotic

(2018) Rui Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Trojan-Horse Strategy Including a Bacterial Suicide Action for the Efficient Use of a Specific Gram-Positive Antibiotic on Gram-Negative Bacteria

(2018) Isabelle J. Schalk   JOURNAL OF MEDICINAL CHEMISTRY

Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin–Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity

(2018) Wilma Neumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer

(2018) Nicole Scherr et al.   Nature Communications

Methodology for Monobactam Diversification: Syntheses and Studies of 4-Thiomethyl Substituted β-Lactams with Activity against Gram-Negative Bacteria, Including Carbapenemase Producing Acinetobacter baumannii

(2017) Serena Carosso et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo

(2017) Manuka Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial and β-Lactamase Inhibitory Activity of Monocyclic β-Lactams

(2017) Lena Decuyper et al.   MEDICINAL RESEARCH REVIEWS

Siderophore Cephalosporin Cefiderocol Utilizes Ferric Iron Transporter Systems for Antibacterial Activity againstPseudomonas aeruginosa

(2016) Akinobu Ito et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam

(2016) David Yuxin Wang et al.   Future Medicinal Chemistry

Siderophore–fluoroquinolone conjugates containing potential reduction-triggered linkers for drug release: synthesis and antibacterial activity

(2015) Cheng Ji et al.   BIOMETALS

Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli

(2014) Tengfei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bactericidal Activity of an Imidazo[1, 2-a]pyridine Using a Mouse M. tuberculosis Infection Model

(2014) Yong Cheng et al.   PLoS One

Fate of ferrisiderophores after import across bacterial outer membranes: different iron release strategies are observed in the cytoplasm or periplasm depending on the siderophore pathways

(2013) Isabelle J. Schalk et al.   AMINO ACIDS

Adaptation-Based Resistance to Siderophore-Conjugated Antibacterial Agents by Pseudomonas aeruginosa

(2013) Andrew P. Tomaras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure and Biosynthesis of Fimsbactins A-F, Siderophores fromAcinetobacter baumanniiandAcinetobacter baylyi

(2013) Anna Proschak et al.   CHEMBIOCHEM

Biscatecholate–Monohydroxamate Mixed Ligand Siderophore–Carbacephalosporin Conjugates are Selective Sideromycin Antibiotics that Target Acinetobacter baumannii

(2013) Timothy A. Wencewicz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evolution of multicellularity coincided with increased diversification of cyanobacteria and the Great Oxidation Event

(2013) B. E. Schirrmeister et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis

(2013) Garrett C. Moraski et al.   ACS Medicinal Chemistry Letters

Exploiting bacterial iron acquisition: siderophore conjugates

(2012) Cheng Ji et al.   Future Medicinal Chemistry

Iron Transport-Mediated Drug Delivery: Practical Syntheses and In Vitro Antibacterial Studies of Tris-Catecholate Siderophore–Aminopenicillin Conjugates Reveals Selectively Potent Antipseudomonal Activity

(2012) Cheng Ji et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Scaffolds and Evaluation of Enterobactin–Cargo Conjugate Uptake

(2012) Tengfei Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis

(2012) Raúl E. Juárez-Hernández et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Syntheses of Siderophore–Drug Conjugates Using a Convergent Thiol–Maleimide System

(2012) Raúl E. Juárez-Hernández et al.   ACS Medicinal Chemistry Letters

Design, Synthesis, and Study of a Mycobactin−Artemisinin Conjugate That Has Selective and Potent Activity against Tuberculosis and Malaria

(2011) Marvin J. Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

(2011) Garrett C. Moraski et al.   ACS Medicinal Chemistry Letters

Structure–activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters

(2010) Garrett C. Moraski et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemistry and biology of siderophores

(2010) Robert C. Hider et al.   NATURAL PRODUCT REPORTS

Siderophores as drug delivery agents: application of the “Trojan Horse” strategy

(2009) Ute Möllmann et al.   BIOMETALS

Sideromycins: tools and antibiotics

(2009) Volkmar Braun et al.   BIOMETALS

Syntheses and Biological Activity of Amamistatin B and Analogs

(2008) Kelley A. Fennell et al.   JOURNAL OF ORGANIC CHEMISTRY

Traversing the coordination chemistry and chemical biology of hydroxamic acids

(2007) Rachel Codd   COORDINATION CHEMISTRY REVIEWS