期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 10, 期 37, 页码 7584-7593出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26077h
关键词
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资金
- University of Notre Dame
- NIH [AI 054193]
- National Science Foundation [CHE-0741793]
Three analogs of mycobactin T, the siderophore secreted by Mycobacterium tuberculosis (Mtb) were synthesized and screened for their antibiotic activity against Mtb H(37)Rv and a broad panel of Gram-positive and Gram-negative bacteria. The synthetic mycobactins were potent (MIC90 0.02-0.88 mu M in 7H12 media) and selective Mtb inhibitors, with no inhibitory activity observed against any other of the microorganisms tested. The maleimide-containing analog 40 represents a versatile platform for the development of mycobactin-drug conjugates, as well as other applications.
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