期刊
ELECTROCHIMICA ACTA
卷 191, 期 -, 页码 98-105出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2015.12.230
关键词
Electrochemical synthesis; Arylsulfonyl-4,4 '-biphenol; EC mechanism; Green chemistry; Antibacterial activity; Observed homogeneous rate constants
资金
- Bu-Ali Sina University Research Council
- Center of Excellence in Development of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS)
The electrochemical synthesis of arylsulfonyl-4,4'-biphenol (ASB) and bis-phenylsulfonyl-4,4'-biphenol (BASB) derivatives was carried out via the electrochemical oxidation of 4,4'-biphenol in the presence of arylsulfinic acids as nucleophiles using a carbon anode. Our data demonstrate that the arylsulfinic acids participate in Michael type addition reaction with the electrogenerated 4,4'-diphenoquinone, converts it to the arylsulfonyl-4,4'-biphenol or bis-phenylsulfonyl-4,4'-biphenol derivatives depends on electrode potential. The arylsulfonyl-4,4'-biphenols were evaluated for their in vitro antibacterial activity against Escherichia coli (E. coli) ATCC 35218 (Gram-negative) and Staphylococcus aureus (S. aureus) ATCC 6538 (Gram-positive). It was found that the tested compounds were more active against gram-positive than gram-negative bacteria. It was also found that the antimicrobial activity of ASB derivatives to vary in the order ASB-CH3 > ASB-Cl > ASB-H. Furthermore, based on the EC mechanism, the observed homogeneous rate constants (k(obs)) of the reaction of 4,4'-diphenoquinone with arylsulfinic acids were estimated by comparing the experimental cyclic voltammograms with the digital simulated results in various pH values. (C) 2016 Elsevier Ltd. All rights reserved.
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