Tau and DNA Damage in Neurodegeneration

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Bacterial DNA promotes Tau aggregation

(2020) George Tetz et al.   Scientific Reports

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy

(2020) Jin Zheng et al.   Acta Neuropathologica Communications

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

(2020) Sarah A. Kent et al.   ACTA NEUROPATHOLOGICA

Microbial involvement in Alzheimer disease development and progression

(2020) Hannah R. Bulgart et al.   Molecular Neurodegeneration

DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains

(2020) Nidheesh Thadathil et al.   MOLECULAR NEUROBIOLOGY

Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer

(2020) Stéphanie Papin et al.   Brain Sciences

Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons

(2019) D. Zada et al.   Nature Communications

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

(2019) Joy Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

DNA repair deficiency in neuropathogenesis: when all roads lead to mitochondria

(2019) Luis Bermúdez-Guzmán et al.   Translational Neurodegeneration

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

(2019) Niraj M. Shanbhag et al.   Acta Neuropathologica Communications

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

(2019) Allison J. Schaser et al.   Scientific Reports

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

(2019) Pascale Barbier et al.   Frontiers in Aging Neuroscience

Aberrant Accumulation of BRCA1 in Alzheimer Disease and Other Tauopathies

(2019) Masataka Nakamura et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression

(2019) Jorge Baquero et al.   Frontiers in Molecular Neuroscience

A resurrection of aducanumab for Alzheimer's disease

(2019) Lon Schneider   LANCET NEUROLOGY

Advances and considerations in AD tau-targeted immunotherapy

(2019) Alice Bittar et al.   NEUROBIOLOGY OF DISEASE

Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies

(2019) Masanori Kurihara et al.   Brain Sciences

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Tau mutations serve as a novel risk factor for cancer

(2018) Giacomina Rossi et al.   CANCER RESEARCH

Tau filaments in neurodegenerative diseases

(2018) Michel Goedert   FEBS LETTERS

Overactive BRCA1 Affects Presenilin 1 in Induced Pluripotent Stem Cell-Derived Neurons in Alzheimer’s Disease

(2018) Michalina Wezyk et al.   JOURNAL OF ALZHEIMERS DISEASE

Homologous recombination and the repair of DNA double-strand breaks

(2018) William Douglass Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease

(2018) Maja Jazvinšćak Jembrek et al.   PROGRESS IN NEUROBIOLOGY

Brain Energy and Oxygen Metabolism: Emerging Role in Normal Function and Disease

(2018) Michelle E. Watts et al.   Frontiers in Molecular Neuroscience

DNA Damage, Repair, and Cancer Metabolism

(2018) Marc-Olivier Turgeon et al.   Frontiers in Oncology

Hyperphosphorylation Results in Tau Dysfunction in DNA Folding and Protection

(2018) Yang Lu et al.   JOURNAL OF ALZHEIMERS DISEASE

Bacterial Infection and Alzheimer's Disease: A Meta-Analysis

(2018) Priya Maheshwari et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Protein Provides DNA with Thermodynamic and Structural Features which are Similar to those Found in Histone-DNA Complex

(2018) Sergio Camero et al.   JOURNAL OF ALZHEIMERS DISEASE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

The involvement of tau in nucleolar transcription and the stress response

(2018) Mahmoud B. Maina et al.   Acta Neuropathologica Communications

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions

(2018) Houda Benhelli-Mokrani et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways

(2018) Giorgio Ulrich et al.   Scientific Reports

Mechanisms of DNA damage, repair, and mutagenesis

(2017) Nimrat Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology

(2017) Noelia López-Sánchez et al.   NEUROBIOLOGY OF AGING

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease

(2017) Tatsuo Mano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging and neurodegeneration are associated with increased mutations in single human neurons

(2017) Michael A. Lodato et al.   SCIENCE

Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease

(2017) Chenjie Xia et al.   JAMA Neurology

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

The “Jekyll and Hyde” Actions of Nucleic Acids on the Prion-like Aggregation of Proteins

(2016) Jerson L. Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

DNA repair targeted therapy: The past or future of cancer treatment?

(2016) Navnath S. Gavande et al.   PHARMACOLOGY & THERAPEUTICS

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

(2016) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice

(2016) Michele Bellesi et al.   Scientific Reports

The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease

(2016) Laura Narciso et al.   NEURAL PLASTICITY

The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease

(2016) Antonio Currais et al.   Aging-US

Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds

(2016) Diana L. Castillo-Carranza et al.   JOURNAL OF ALZHEIMERS DISEASE

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin

(2016) Zeyni Mansuroglu et al.   Scientific Reports

Nuclear Magnetic Resonance Spectroscopy Characterization of Interaction of Tau with DNA and Its Regulation by Phosphorylation

(2015) Haoling Qi et al.   BIOCHEMISTRY

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

Neuronal cell cycle: the neuron itself and its circumstances

(2015) José M Frade et al.   CELL CYCLE

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome

(2015) C. Geeth Gunawardana et al.   MOLECULAR & CELLULAR PROTEOMICS

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

(2015) Marie Violet et al.   NEUROBIOLOGY OF DISEASE

Somatic mutation in single human neurons tracks developmental and transcriptional history

(2015) M. A. Lodato et al.   SCIENCE

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

(2015) Elsa Suberbielle et al.   Nature Communications

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

(2014) Tomohiro Umeda et al.   ACTA NEUROPATHOLOGICA

Tau promotes neurodegeneration through global chromatin relaxation

(2014) Bess Frost et al.   NATURE NEUROSCIENCE

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Visualizing the microtubule-associated protein tau in the nucleus

(2014) Jing Lu et al.   Science China-Life Sciences

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

(2014) Marie Violet et al.   Frontiers in Cellular Neuroscience

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

(2013) Elsa Suberbielle et al.   NATURE NEUROSCIENCE

Correction: Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease

(2013) Pavel Katsel et al.   PLoS One

Efficacy of Cyclin Dependent Kinase 4 Inhibitors as Potent Neuroprotective Agents against Insults Relevant to Alzheimer’s Disease

(2013) Priyankar Sanphui et al.   PLoS One

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Tau oligomers and tau toxicity in neurodegenerative disease

(2012) Sarah M. Ward et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Herpes simplex virus type 1 induces nuclear accumulation of hyperphosphorylated tau in neuronal cells

(2012) Gema Álvarez et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

A neuroprotective role for the DNA damage checkpoint in tauopathy

(2011) Vikram Khurana et al.   AGING CELL

Sublethal Doses of β-Amyloid Peptide Abrogate DNA-dependent Protein Kinase Activity

(2011) Alessio Cardinale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

A new function of microtubule-associated protein tau: Involvement in chromosome stability

(2010) Giacomina Rossi et al.   CELL CYCLE

A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation

(2010) Tracey A. Dobbs et al.   DNA REPAIR

A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration

(2010) Kanae Iijima-Ando et al.   HUMAN MOLECULAR GENETICS

TDP-43: A DNA and RNA binding protein with roles in neurodegenerative diseases

(2010) Sadaf T. Warraich et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Review: Cell cycle aberrations and neurodegeneration

(2010) D. J. Bonda et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity

(2009) Mansour Akbari et al.   DNA REPAIR

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

DNA repair deficiency and neurological disease

(2009) Peter J. McKinnon   NATURE REVIEWS NEUROSCIENCE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor

(2009) S. M. Morillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome

(2008) Karyn M. Austin et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA polymerase β-catalyzed-PCNA independent long patch base excision repair synthesis: a mechanism for repair of oxidatively damaged DNA ends in post-mitotic brain

(2008) Wei Wei et al.   JOURNAL OF NEUROCHEMISTRY

Huntingtin Modulates Transcription, Occupies Gene Promoters In Vivo, and Binds Directly to DNA in a Polyglutamine-Dependent Manner

(2008) C. L. Benn et al.   JOURNAL OF NEUROSCIENCE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON