Non-coding RNAs as Regulators of Cellular Senescence in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease

Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

(2020) Yoshihiko Kobayashi et al.   NATURE CELL BIOLOGY

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

(2020) Maximilian Strunz et al.   Nature Communications

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

(2020) Marianna Feretzaki et al.   NATURE

The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability

(2019) Nicole Bettin et al.   Cells

lncRNA ZEB1-AS1 promotes pulmonary fibrosis through ZEB1-mediated epithelial–mesenchymal transition by competitively binding miR-141-3p

(2019) Weibin Qian et al.   Cell Death & Disease

Cellular functions of long noncoding RNAs

(2019) Run-Wen Yao et al.   NATURE CELL BIOLOGY

Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

(2019) Charlotte Hill et al.   Cell Death & Disease

Aging and Lung Disease

(2019) Soo Jung Cho et al.   Annual Review of Physiology

A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing

(2019) Yifei Zhou et al.   Nature Communications

Senescent cell turnover slows with age providing an explanation for the Gompertz law

(2019) Omer Karin et al.   Nature Communications

Identification of abnormally expressed lncRNAs induced by PM2.5 in human bronchial epithelial cells

(2018) Xing Li et al.   BIOSCIENCE REPORTS

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin

(2018) Juan J. Montero et al.   Nature Communications

Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis

(2017) Ana L. Mora et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Regulation of TERRA on telomeric and mitochondrial functions in IPF pathogenesis

(2017) Yulin Gao et al.   BMC Pulmonary Medicine

MicroRNA-29b inhibits supernatants from silica-treated macrophages from inducing extracellular matrix synthesis in lung fibroblasts

(2017) Ximeng Lian et al.   Toxicology Research

Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health

(2017) Johanna Heid et al.   Scientific Reports

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach

(2017) Griet Conickx et al.   Scientific Reports

MicroRNA-17-5p: At the Crossroads of Cancer and Aging - A Mini-Review

(2016) Hanna Dellago et al.   GERONTOLOGY

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Lipopolysaccharide promotes pulmonary fibrosis in acute respiratory distress syndrome (ARDS) via lincRNA-p21 induced inhibition of Thy-1 expression

(2016) Wen-qin Zhou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

(2016) J. R. Baker et al.   Scientific Reports

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Accelerated ageing of the lung in COPD: new concepts

(2015) Nicolas Mercado et al.   THORAX

Non-coding RNAs in the pathogenesis of COPD

(2015) Elise G De Smet et al.   THORAX

MicroRNA-218 inhibits bladder cancer cell proliferation, migration, and invasion by targeting BMI-1

(2015) Yidong Cheng et al.   TUMOR BIOLOGY

Decreased expression of long noncoding RNA MEG3 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer

(2015) Dan-dan Yin et al.   TUMOR BIOLOGY

Transcriptomic landscape of lncRNAs in inflammatory bowel disease

(2015) Aashiq H Mirza et al.   Genome Medicine

Regulation of Transcription by Long Noncoding RNAs

(2014) Roberto Bonasio et al.   Annual Review of Genetics

MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression

(2014) Santiyagu M Savarimuthu Francis et al.   BMC GENOMICS

Telomerase mutations in smokers with severe emphysema

(2014) Susan E. Stanley et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

(2014) Marta Bueno et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence

(2014) Izumi Horikawa et al.   Nature Communications

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke

(2013) Javier Milara et al.   THORAX

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

(2012) Nan Liu et al.   NATURE

Short telomere length, lung function and chronic obstructive pulmonary disease in 46 396 individuals

(2012) Line Rode et al.   THORAX

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Autophagy in Pulmonary Diseases

(2011) Stefan W. Ryter et al.   Annual Review of Physiology

Gene expression networks in COPD: microRNA and mRNA regulation

(2011) Michael E Ezzie et al.   THORAX

Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases

(2010) Ravindresh Chhabra et al.   Molecular Cancer

MicroRNA MiR-17 retards tissue growth and represses fibronectin expression

(2009) Sze Wan Shan et al.   NATURE CELL BIOLOGY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS