Metabolic Engineering for Glycyrrhetinic Acid Production in Saccharomyces cerevisiae

Microbial Chassis Development for Natural Product Biosynthesis

(2020) Xianhao Xu et al.   TRENDS IN BIOTECHNOLOGY

RNA-Seq based transcriptome analysis reveals the molecular mechanism of triterpenoid biosynthesis in Glycyrrhiza glabra

(2020) Zhiqiang Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glycyrrhetinic acid and its derivatives as potential alternative medicine to relieve symptoms in non‐hospitalized COVID‐19 patients

(2020) Hong Ding et al.   JOURNAL OF MEDICAL VIROLOGY

Synthesis, anti-microbial and anti-inflammatory activities of 18β-glycyrrhetinic acid derivatives

(2020) Yang Yang et al.   BIOORGANIC CHEMISTRY

Discovery and engineering of colchicine alkaloid biosynthesis

(2020) Ryan S. Nett et al.   NATURE

Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae

(2020) Hongting Tang et al.   Metabolites

Metabolic engineering for increased lipid accumulation in Yarrowia lipolytica – A Review

(2020) Jinpeng Wang et al.   BIORESOURCE TECHNOLOGY

Advances in Metabolic Engineering of Saccharomyces cerevisiae for Cocoa Butter Equivalent Production

(2020) Mengge Wang et al.   Frontiers in Bioengineering and Biotechnology

Recent advances in improving metabolic robustness of microbial cell factories

(2020) Tian Jiang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering Plant Secondary Metabolism in Microbial Systems

(2019) Michael E Pyne et al.   PLANT PHYSIOLOGY

Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

(2019) Xiaozhou Luo et al.   NATURE

Enhanced β-Amyrin Synthesis in Saccharomyces cerevisiae by Coupling An Optimal Acetyl-CoA Supply Pathway

(2019) Hu Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Identification of genes involved in shea butter biosynthesis from Vitellaria paradoxa fruits through transcriptomics and functional heterologous expression

(2019) Yongjun Wei et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Efficient production of glycyrrhetinic acid in metabolically engineered Saccharomyces cerevisiae via an integrated strategy

(2019) Caixia Wang et al.   Microbial Cell Factories

Functional specialization of UDP ‐glycosyltransferase 73P12 in licorice to produce a sweet triterpenoid saponin, glycyrrhizin

(2019) Yuhta Nomura et al.   PLANT JOURNAL

Diversity of O-Glycosyltransferases Contributes to the Biosynthesis of Flavonoid and Triterpenoid Glycosides in Glycyrrhiza uralensis

(2019) Kuan Chen et al.   ACS Synthetic Biology

Synthesis and biological activity of glycyrrhetinic acid derivatives as antitumor agents

(2019) Fei Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modulation of saturation and chain length of fatty acids in Saccharomyces cerevisiae for production of cocoa butter-like lipids

(2018) David Bergenholm et al.   BIOTECHNOLOGY AND BIOENGINEERING

Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system from legume plants

(2018) Ming Zhu et al.   METABOLIC ENGINEERING

Expression of cocoa genes in Saccharomyces cerevisiae improves cocoa butter production

(2018) Yongjun Wei et al.   Microbial Cell Factories

Distribution patterns for metabolites in medicinal parts of wild and cultivated licorice

(2018) Chengcheng Wang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene

(2018) Tian Ma et al.   METABOLIC ENGINEERING

18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration

(2017) Saisai Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Immunomodulatory and anticancer potential of Gan cao (Glycyrrhiza uralensis Fisch.) polysaccharides by CT-26 colon carcinoma cell growth inhibition and cytokine IL-7 upregulation in vitro

(2016) Peter Amwoga Ayeka et al.   BMC Complementary and Alternative Medicine

Engineering Cellular Metabolism

(2016) Jens Nielsen et al.   CELL

Draft genome assembly and annotation of Glycyrrhiza uralensis , a medicinal legume

(2016) Keiichi Mochida et al.   PLANT JOURNAL

Refactoring β-amyrin synthesis inSaccharomyces cerevisiae

(2015) Genlin Zhang et al.   AICHE JOURNAL

18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulation

(2015) Ayman M. Mahmoud et al.   Genes and Nutrition

Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts

(2015) Pingping Wang et al.   METABOLIC ENGINEERING

Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts

(2015) Wei Wei et al.   Molecular Plant

Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones

(2015) Juan Guo et al.   NEW PHYTOLOGIST

Complete biosynthesis of opioids in yeast

(2015) S. Galanie et al.   SCIENCE

18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulation

(2015) Ayman M. Mahmoud et al.   Genes and Nutrition

Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases

(2014) Stefan Schwarz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Production of bioactive ginsenoside compound K in metabolically engineered yeast

(2014) Xing Yan et al.   CELL RESEARCH

Producing aglycons of ginsenosides in bakers' yeast

(2014) Zhubo Dai et al.   Scientific Reports

Metabolic engineering of Saccharomyces cerevisiae for production of ginsenosides

(2013) Zhubo Dai et al.   METABOLIC ENGINEERING

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Glycyrrhiza uralensis Transcriptome Landscape and Study of Phytochemicals

(2013) Jordan A. Ramilowski et al.   PLANT AND CELL PHYSIOLOGY

The Protective Effect of Glycyrrhetinic Acid on Carbon Tetrachloride-Induced Chronic Liver Fibrosis in Mice via Upregulation of Nrf2

(2013) Shaoru Chen et al.   PLoS One

Engineering Microbial Cells for the Biosynthesis of Natural Compounds of Pharmaceutical Significance

(2013) Philippe Jeandet et al.   Biomed Research International

Advances in Omics and Bioinformatics Tools for Systems Analyses of Plant Functions

(2011) K. Mochida et al.   PLANT AND CELL PHYSIOLOGY

Triterpene Functional Genomics in Licorice for Identification of CYP72A154 Involved in the Biosynthesis of Glycyrrhizin

(2011) Hikaru Seki et al.   PLANT CELL

Synthesis and antitumour activity of glycyrrhetinic acid derivatives

(2010) Stefan Schwarz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

EST analysis reveals putative genes involved in glycyrrhizin biosynthesis

(2010) Ying Li et al.   BMC GENOMICS

Synthesis, anti-inflammatory, and antioxidant activities of 18β-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors

(2009) Dravidum Maitraie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Engineering triterpene production in Saccharomyces cerevisiae-β-amyrin synthase from Artemisia annua

(2008) James Kirby et al.   FEBS Journal

Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)

(2008) Qingying Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

Review of Pharmacological Effects ofGlycyrrhiza sp. and its Bioactive Compounds

(2008) Marjan Nassiri Asl et al.   PHYTOTHERAPY RESEARCH

Licorice  -amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin

(2008) H. Seki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel process for extraction of natural sweetener from licorice (Glycyrrhiza glabra) roots

(2008) Mamata Mukhopadhyay et al.   SEPARATION AND PURIFICATION TECHNOLOGY