CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-Target

Coronavirus puts drug repurposing on the fast track

(2020) Charlotte Harrison   NATURE BIOTECHNOLOGY

TRIP13 regulates DNA repair pathway choice through REV7 conformational change

(2020) Connor S. Clairmont et al.   NATURE CELL BIOLOGY

COVID-19 treatment by repurposing drugs until the vaccine is in sight

(2020) Mrudula Phadke et al.   DRUG DEVELOPMENT RESEARCH

Drug repositioning is an alternative for the treatment of coronavirus COVID-19

(2020) Marissa B. Serafin et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19)

(2020) Dae-Gyun Ahn et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Cellular thermal shift assay for the identification of drug–target interactions in the Plasmodium falciparum proteome

(2020) Jerzy Michal Dziekan et al.   Nature Protocols

Rapid repurposing of drugs for COVID-19

(2020) R. Kiplin Guy et al.   SCIENCE

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

(2020) Richard T. Eastman et al.   ACS Central Science

Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease

(2020) Mahmoud Kandeel et al.   LIFE SCIENCES

Harder, better, faster

(2020) Danielle Schultz et al.   Nature Chemistry

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

(2019) Jerzy M. Dziekan et al.   Science Translational Medicine

TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma

(2017) Yi Tao et al.   Oncotarget

Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit

(2017) Daniel Henry Marks et al.   Cell Reports

Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes

(2016) Ylva Terelius et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

(2016) Isabelle Becher et al.   Nature Chemical Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

(2014) Eisuke Murakami et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tracking cancer drugs in living cells by thermal profiling of the proteome

(2014) M. M. Savitski et al.   SCIENCE

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

The intracellular activation of lamivudine (3TC) and determination of 2′-deoxycytidine-5′-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells

(2003) Stephen Kewn et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY