TRIP13 regulates DNA repair pathway choice through REV7 conformational change

Thyroid hormone receptor interactor 13 (TRIP13) overexpression associated with tumor progression and poor prognosis in lung adenocarcinoma

(2018) Wei Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

(2018) Rajat Gupta et al.   CELL

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

(2018) Harveer Dev et al.   NATURE CELL BIOLOGY

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells

(2018) Marco Barazas et al.   Cell Reports

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

(2018) Hind Ghezraoui et al.   NATURE

The shieldin complex mediates 53BP1-dependent DNA repair

(2018) Sylvie M. Noordermeer et al.   NATURE

53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

(2018) Zachary Mirman et al.   NATURE

Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex

(2018) Alessandro A. Rizzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An OB-fold complex controls the repair pathways for DNA double-strand breaks

(2018) Shengxian Gao et al.   Nature Communications

USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors

(2018) Kah Suan Lim et al.   MOLECULAR CELL

Mechanisms of DNA damage, repair, and mutagenesis

(2017) Nimrat Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Dynamic feature of mitotic arrest deficient 2–like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment–maintaining phosphoprotein (CAMP)

(2017) Kodai Hara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

(2017) Shawn Yost et al.   NATURE GENETICS

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mSignatureDB: a database for deciphering mutational signatures in human cancers

(2017) Po-Jung Huang et al.   NUCLEIC ACIDS RESEARCH

Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2

(2017) Alan M V West et al.   NUCLEIC ACIDS RESEARCH

multiplierz v2.0: A Python-based ecosystem for shared access and analysis of native mass spectrometry data

(2017) William M. Alexander et al.   PROTEOMICS

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Biallelic inactivation of REV7 is associated with Fanconi anemia

(2016) Dominique Bluteau et al.   JOURNAL OF CLINICAL INVESTIGATION

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

TRIP13 is expressed in colorectal cancer and promotes cancer cell invasion

(2016) Kenji Kurita et al.   Oncology Letters

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint

(2016) Hoi Tang Ma et al.   Cell Reports

Regulation of the Rev1-pol   complex during bypass of a DNA interstrand cross-link

(2015) M. Budzowska et al.   EMBO JOURNAL

The multifaceted roles of the HORMA domain in cellular signaling

(2015) Scott C. Rosenberg et al.   JOURNAL OF CELL BIOLOGY

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

(2015) Qiaozhen Ye et al.   eLife

Mutational signatures: the patterns of somatic mutations hidden in cancer genomes

(2014) Ludmil B Alexandrov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Thyroid Hormone Receptor Interacting Protein 13 (TRIP13) AAA-ATPase Is a Novel Mitotic Checkpoint-silencing Protein

(2014) Kexi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes

(2014) Corine M. Beaufort et al.   PLoS One

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

(2014) Andrés Cruz-García et al.   Cell Reports

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Structural Basis of Recruitment of DNA Polymerase ζ by Interaction between REV1 and REV7 Proteins

(2012) Sotaro Kikuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Ends Alter the Molecular Composition and Localization of Ku Multicomponent Complexes

(2012) Guillaume Adelmant et al.   MOLECULAR & CELLULAR PROTEOMICS

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

(2012) Orit Rozenblatt-Rosen et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1 -Mutated Mouse Mammary Tumors

(2012) Janneke E. Jaspers et al.   Cancer Discovery

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment

(2010) Go Itoh et al.   EMBO JOURNAL

Crystal Structure of Human REV7 in Complex with a Human REV3 Fragment and Structural Implication of the Interaction between DNA Polymerase ζ and REV1

(2010) Kodai Hara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation

(2010) Ryu-Suke Nozawa et al.   NATURE CELL BIOLOGY

Mouse TRIP13/PCH2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during Meiosis

(2010) Ignasi Roig et al.   PLoS Genetics

multiplierz: an extensible API based desktop environment for proteomics data analysis

(2009) Jignesh R Parikh et al.   BMC BIOINFORMATICS

mzAPI: a new strategy for efficiently sharing mass spectrometry data

(2009) Manor Askenazi et al.   NATURE METHODS