Article
Orthopedics
Xuancheng Zhang, Zhengzhe Han, Kang Han, He Zhang, Jinghuan Huang, Xiaoqiao Huangfu, Jinzhong Zhao
Summary: This study developed a patch loaded with MSC-Exos using a dynamic wet-spinning system and found that it significantly promoted tenocyte proliferation and migration activities in vitro. In vivo, the patch showed improved tendon maturing scores, reduced fatty infiltration, and enhanced biomechanical properties compared to controls.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mingda Li, Jie Jia, Shanshan Li, Baocheng Cui, Jiao Huang, Zhaoming Guo, Kun Ma, Li Wang, Changhao Cui
Summary: This study explored the effects of tendon stem cell-derived exosomes (TSC-exo) on tendon stem cells (TSCs), finding that TSC-exo were enriched in transforming growth factor beta (TGF beta) which accelerated the proliferation and migration of TSCs. Additionally, TGF beta carried by TSC-exo activated the TGF beta-Smad2/3 and ERK1/2 signaling pathways in TSCs, ultimately regulating the downstream molecule MMP2.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Surgery
Yichong Zhang, Jianhai Chen, Mingtai Ma, Jiabao Ju, Baoguo Jiang, Peixun Zhang
Summary: In this study of 75 patients with rotator cuff tears, it was found that proximal humeral migration is negatively correlated with tear size, pain level, and fatty degeneration grade. Tear size was identified as an independent predictor of humeral upward migration.
FRONTIERS IN SURGERY
(2022)
Article
Rehabilitation
Alan Z. Grusky, Amos Song, Peter Kim, Gregory D. Ayers, Laurence D. Higgins, John E. Kuhn, Keith M. Baumgarten, Elizabeth Matzkin, Nitin B. Jain
Summary: In a cohort of patients with shoulder pain, older age, involvement of the dominant shoulder, and a higher body mass index were found to be independently associated with rotator cuff tears. Further research is needed to understand the mechanisms behind these associations.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Orthopedics
SeongJu Choi, Gotak Kim, Younghun Lee, Byung-Guk Kim, Inseok Jang, Jae Hwa Kim
Summary: Patch augmentation for large and massive rotator cuff tears can effectively prevent retears, but the clinical outcomes are not superior to only performing rotator cuff repair surgery.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Oncology
Noam Cohen, Dhanashree Mundhe, Sarah K. Deasy, Omer Adler, Nour Ershaid, Tamar Shami, Oshrat Levi-Galibov, Rina Wassermann, Ruth Scherz-Shouval, Neta Erez
Summary: Metastatic cancer is difficult to cure and is the main cause of cancer-related deaths. In this study, the researchers found that cancer-associated fibroblasts play a crucial role in creating a favorable microenvironment for metastasis by mediating inflammation. They also discovered that a protein called Activin A is secreted from breast tumors and promotes fibrosis in the lung, which enhances metastasis. This new mechanism could potentially be targeted for therapeutic intervention to inhibit metastatic relapse.
Article
Orthopedics
Tae-Hwan Yoon, Sung-Jae Kim, Yun-Rak Choi, Ju-Cheol Shin, Sager-Holyl Alruwaili, Yong-Min Chun
Summary: Both anterosuperior rotator cuff tears and rotator cuff tears with subscapularis involvement showed significant improvement in clinical outcomes and structural integrity after arthroscopic repair, with no significant differences between the two groups in terms of postoperative outcomes and re-tear rates. Therefore, it would not be necessary to differentiate treatment protocols between these tear configurations based on the findings of this study.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Biotechnology & Applied Microbiology
Devon E. Anderson, Katherine G. Broun, Paromita Kundu, Xingyu Jing, Xiang Tang, Christopher Lu, Alexander Kotelsky, Sandeep Mannava, Whasil Lee
Summary: The aim of this study was to investigate the mechanotransduction of glenohumeral articular chondrocytes mediated by PIEZO1 in the altered biomechanical environment following a massive rotator cuff tear (RCT), and to identify potential therapeutic targets to attenuate cartilage degeneration after rotator cuff repair. The results showed that in the early stage of cuff tear arthropathy (CTA), the expression and activity of PIEZO1 were not increased but rather downregulated. This may be due to the decreased axial loading after glenohumeral joint decoupling in RCT limbs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Bei Pu, Xu Zhang, Tengfeng Yan, Yuntao Li, Baohui Liu, Zhihong Jian, Omer Kamal Mahgoub, Lijuan Gu, Xiaoxing Xiong, Ning Zou
Summary: Recent studies have shown that MICAL2 plays a role in promoting proliferation and migration of glioblastoma through the TGF-beta/p-Smad2/EMT-like signaling pathway. Knockdown of MICAL2 can inhibit the growth and invasion abilities of glioblastoma cells. High MICAL2 expression predicts poor prognosis in GBM patients, making it a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Orthopedics
Laura Gatto, Ashen Fernando, Minoo Patel, Angus Yeung, David C. Ackland
Summary: This study evaluated the influence of rotator cuff tears and subacromial impingement syndrome, and found that acromioplasty can alleviate subacromial contact pressure. These findings provide a basis for its use as an intervention for SAI syndrome and as an adjunct to rotator cuff repairs.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Ji-Hye Lee, Yun Hee Kim, Sung-Min Rhee, Jikhyon Han, Hyeon Jang Jeong, Joo Hyun Park, Joo Han Oh, Saewha Jeon
Summary: The study demonstrated that human dermal fibroblasts, with properties comparable to tenocytes, effectively enhanced the healing of chronic rotator cuff tears in rabbits. Specifically, in the HF-LD and HF-HD groups, collagen fibers were more continuous and better oriented, with a more mature interface between the tendon and bone. Moreover, biomechanical strength was significantly increased in the HF-HD group compared to the saline control group.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Review
Medicine, General & Internal
Edoardo Giovannetti de Sanctis, Edoardo Franceschetti, Ferdinando De Dona, Alessio Palumbo, Michele Paciotti, Francesco Franceschi
Summary: In comparing the effectiveness of corticosteroid injections and other drugs in treating partial rotator cuff tears, PRP injections have been found to be significantly more effective in both functional improvement and pain control in the long term. The small number of studies on prolotherapy limits our ability to draw conclusions on its outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Yao Zhang, Shuai Lu, Gang Yu, Chongyang Wang, Qichun Zhao
Summary: This study found that NAMPT can improve age-related degenerative RCT in aged mice and prevent postoperative retears, possibly by reversing mitochondrial dysfunction.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Medicine, General & Internal
Saadiq F. El-Amin, Nicola Maffulli, Matthew C. Mai, Hugo C. Rodriguez, Victoria Jaso, Dylan Cannon, Ashim Gupta
Summary: This study used MRI measurements to evaluate the relationship between the coracoid, glenoid, and humerus, as well as coracoid shape and rotator cuff fatty infiltration, in order to assess the association with anterosuperior rotator cuff tears. The results showed that there was a correlation between coracoid shape and ASCT, and certain MRI measurements were significantly different in ASCT patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Erick M. Marigi, Carl Tams, Joseph J. King, Matthew M. Crowe, Jean-David Werthel, Josef Eichinger, Thomas Wright, Richard J. Friedman, Bradley S. Schoch
Summary: The effect of a prior rotator cuff repair (RCR) on the outcomes and complications of primary reverse shoulder arthroplasty (RSA) was evaluated. Patients who had a prior RCR were compared with case-matched controls. The study found that RSA after a prior RCR improves pain and function without increasing complications or revision surgery, but it may slightly decrease postoperative shoulder function compared to patients without a prior RCR.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Cell & Tissue Engineering
Jinghui Xu, Zhenxiao Ren, Tianzuo Niu, Siyuan Li
Summary: This study discovers that MSCs-EVs attenuate inflammation and oxidative stress in spinal cord injury (SCI) by delivering miR-26b-5p to target the KDM6A/NOX4 axis, facilitating recovery.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Shant Nepal, Jinyan Si, Shohei Ishikawa, Masaki Nishikawa, Yasuyuki Sakai, Aya M. Akimoto, Hiroyuki Okada, Shinsuke Ohba, Ung-il Chung, Takamasa Sakai, Hironori Hojo
Summary: In this study, we evaluated the potential of oligo-tetra-PEG gel (Oligo gel) as a growth factor-releasing scaffold. Compared to tetra-PEG hydrogel (Tetra gel), Oligo gel underwent a higher degree of gel-gel phase separation, demonstrating better protein release and osteogenic potential, and achieving superior regeneration in a mouse calvarial defect model. Therefore, Oligo gel is considered a promising therapeutic biomaterial.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Yasuhiro Homma, Sayuri Uchino, Masashi Nagao, Takanori Wakayama, Shin Fukusato, Tomonori Baba, Taiji Watari, Koju Hayashi, Yoshitomo Saita, Muneaki Ishijima
Summary: This study investigates the safety and feasibility of locoregional PRP injection for iliopsoas impingement after THA, and finds that it is both safe and feasible.
REGENERATIVE THERAPY
(2024)
Article
Cell & Tissue Engineering
Taichi Tenkumo, Benedikt Kruse, Kathrin Kostka, Viktoriya Sokolova, Toru Ogawa, Nobuhiro Yoda, Oleg Prymak, Osamu Suzuki, Keiichi Sasaki, Matthias Epple
Summary: This study evaluated the bone-healing effects of a triple-functionalized CaP paste in the rat femoral head. The results showed that the paste significantly accelerated bone healing after 21 days and increased the levels of bone formation-related markers at the protein and gene levels.
REGENERATIVE THERAPY
(2024)
