Article
Oncology
Bei Pu, Xu Zhang, Tengfeng Yan, Yuntao Li, Baohui Liu, Zhihong Jian, Omer Kamal Mahgoub, Lijuan Gu, Xiaoxing Xiong, Ning Zou
Summary: Recent studies have shown that MICAL2 plays a role in promoting proliferation and migration of glioblastoma through the TGF-beta/p-Smad2/EMT-like signaling pathway. Knockdown of MICAL2 can inhibit the growth and invasion abilities of glioblastoma cells. High MICAL2 expression predicts poor prognosis in GBM patients, making it a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Pedro Garcia-Gomez, Irene Golan, Mahsa S. Dadras, Artur Mezheyeuski, Claudia Bellomo, Kalliopi Tzavlaki, Anita Moren, Jordi Carreras-Puigvert, Laia Caja
Summary: This study investigates the crucial roles of TGF beta and ROS in GSC biology, revealing the key regulatory function of NOX4 in GSCs.
MOLECULAR ONCOLOGY
(2022)
Article
Orthopedics
Hong-Bin Yu, Jing Xiong, Hui-Zhen Zhang, Qin Chen, Xu-Yong Xie
Summary: Treating tendon fibrosis with TGF beta 1-transfected TSCs may be an effective approach.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Review
Medicine, Research & Experimental
Li Jiang, Jingwei Lu, Yixuan Chen, Kexin Lyu, Longhai Long, Xiaoqiang Wang, Tianzhu Liu, Sen Li
Summary: Tendon injury is a common disorder caused by overuse or trauma. Mesenchymal stem cells (MSCs), known for their proliferative capacity and ability to regenerate, have shown promise in treating various diseases including tendon injury. They can differentiate into specific cells and secrete biologically active molecules to promote tissue repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Cell & Tissue Engineering
Sophia K. Theodossiou, Jett B. Murray, LeeAnn A. Hold, Jeff M. Courtright, Anne M. Carper, Nathan R. Schiele
Summary: The study found that Akt signaling plays a role in TGF beta 2-induced tenogenesis, and that tenogenesis of MSCs can still be initiated by TGF beta 2 during inhibition of Smad3.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Wei Liao, Yong Liu, Chaoyu Ma, Liwen Wang, Guo Li, Shruti Mishra, Saranya Srinivasan, Kenneth Ka-Ho Fan, Haijing Wu, Qianwen Li, Ming Zhao, Xun Liu, Erika L. Demel, Xin Zhang, Yuanzheng Qiu, Qianjin Lu, Nu Zhang
Summary: The stepwise induction of CD69 and CD103 distinguishes different differentiation stages of mucosal Trms, while the majority of non-mucosal Trm do not have CD103 expression. CD69 expression alone is not sufficient to accurately define Trm cells in highly vascularized non-mucosal tissues, such as the kidney. The downregulation of IL-18 receptor (IL-18R) is associated with tissue residency, with IL-18R(lo) exclusively identifying tissue-resident cells and IL-18R(hi) population containing both tissue-resident and migratory cells. Additionally, local cytokines and transcription factors play essential roles in regulating the downregulation of IL-18R during kidney Trm differentiation, allowing for the identification of kidney-resident CD8(+) T cells and the underlying molecular mechanisms.
Review
Medicine, Research & Experimental
Pengfei Gao, Chanjuan Liu, Hui Dong, Qi Li, Yunfang Chen
Summary: The research shows that TGF-beta can promote the proliferation and osteogenesis of dental pulp stem cells, but it has no significant effect on the number of mineralized nodules.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Kai Song, Tao Jiang, Pin Pan, Yao Yao, Qing Jiang
Summary: This study investigates the effects of exosomes from tendon derived stem cells (TDSC-Exos) on tendon repair and explores the underlying mechanism involving microRNAs (miRNAs). The results show that TDSC-Exos can enhance tendon repair through the regulation of miR-144-3p, which promotes tenocyte proliferation and migration. This suggests that TDSC-Exos could be a promising strategy for treating tendon injuries.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
John P. Gleeson, Namit Chaudhary, Katherine C. Fein, Rose Doerfler, Patricia Hredzak-Showalter, Kathryn A. Whitehead
Summary: Breast milk contains cells that are beneficial for infant development, but little is known about these cells. This study characterized the cells in mature breast milk from healthy donors and identified the main cell population as epithelial cells, with several subpopulations including previously unidentified ones. These findings provide insights into the potential applications of breast milk cells in maternal and infant medicine.
Article
Cell Biology
Amy H. Lee, Deepraj Ghosh, Ivy L. Koh, Michelle R. Dawson
Summary: Radiation-induced fibrosis is a common side effect of radiotherapy, which causes cell cycle arrest and senescence in normal cells. Bone marrow-derived Mesenchymal Stem Cells (MSCs) accumulate in tumor sites and acquire senescence due to radiation effects. Senescent cells develop a potent senescence-associated secretory phenotype (SASP), leading to hyperactive secretion of cytokines, growth factors, and exosomes (EXOs).
Article
Orthopedics
Rouhollah Mousavizadeh, Charlie M. Waugh, Erin DeBruin, Robert G. McCormack, Vincent Duronio, Alex Scott
Summary: This study reveals that oxLDL, commonly found in patients with hypercholesterolemia, has mechanistic effects on tendon cells, leading to matrix remodeling. The findings suggest a potential link between high cholesterol and tendon damage.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Oncology
Bikash Chandra Jena, Siddik Sarkar, Lipsa Rout, Mahitosh Mandal
Summary: TGF-beta is considered as a crucial mediator of cell growth and cancer cell progression through both SMAD-dependent and independent pathways. In the tumor microenvironment, cancer-associated fibroblasts (CAFs) play a prominent role in tumor progression and chemoresistance, with TGF-beta facilitating the crosstalk between CAFs and tumor cells. Targeting the TGF-beta and CAFs interaction in clinical trials is essential for developing successful anti-cancer therapies.
Article
Cell & Tissue Engineering
Matteo Mazzella, Keegan Walker, Christina Cormier, Michael Kapanowski, Albi Ishmakej, Azeem Saifee, Yashvardhan Govind, G. Rasul Chaudhry
Summary: This study investigated the self-renewal mechanism of primitive (p) MSCs and found that the Wnt pathway is associated with self-renewal potential, while senescence is linked to the TGF beta pathway. Transcriptomic and MNase-seq analysis revealed distinct gene expressions and nucleosome occupancies in pMSCs grown in xeno-free and fetal bovine serum medium, providing insights into the complex molecular mechanisms governing the self-renewal and senescence of MSCs.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Orthopedics
Hongyu Zhang, Yuemei Huang, Qiuting Wen, Yan Li, Lin Guo, Na Ge
Summary: This study found that INHBA silencing plays a crucial role in osteosarcoma through TGF-beta 1-regulated proliferation, migration, and invasion.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell Biology
Zhi Wang, Yichuan Zhang, Cheng Zhao, Yangle Li, Xiheng Hu, Longxiang Wu, Minfeng Chen, Shiyu Tong
Summary: The study showed that miR-223-3p aggravates the uncontrolled proliferation and migration of BPH-1 cells by targeting MAP1B. The EMT and MAPK signaling pathways may be involved in this process.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)