Article
Environmental Sciences
Baek Kiook, Park Jong-Tae, Kwak Kyeongmin
Summary: The study found that urinary bisphenol S (BPS) played an important role in the diagnosis of asthma in Korean adolescent females. Compared to patients diagnosed with asthma after 60 months, high urinary BPS significantly increased the odds of lifetime asthma prevalence.
Review
Environmental Sciences
Miaoliang Wu, Fuhui Yan, Qian Liu, Ganzhong Liao, Yilin Shen, Zhi Bai, Xiaoshan Liu
Summary: Preeclampsia (PE) is a disease that occurs after 20 weeks of pregnancy and is characterized by new onset hypertension and albuminuria or other end-organ damage. It is a major complication of pregnancy that can increase morbidity and mortality in pregnant women and fetuses, causing significant social burden. Recent research suggests that exposure to environmental xenobiotic compounds, particularly endocrine disruptors, may contribute to the development of PE. However, the specific mechanisms underlying this relationship remain unclear. This paper reviews the role and potential mechanism of PE induced by exogenous chemicals and provides an outlook on the environmental etiology of PE.
Article
Environmental Sciences
Raquel Chamorro-Garcia, Nathalie Poupin, Marie Tremblay-Franco, Cecile Canlet, Riann Egusquiza, Roselyne Gautier, Isabelle Jouanin, Bassem M. Shoucri, Bruce Blumberg, Daniel Zalko
Summary: Metabolomics confirmed transgenerational obesogenic effects of environmentally relevant doses of TBT in male mice, while also showing impaired liver biotransformation capacity in females. This study demonstrates the transgenerational effects of EDC exposure and highlights the potential use of metabolomic fingerprints in identifying individuals susceptible to adverse health effects from ancestral exposure to obesogens.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Environmental Sciences
Juan P. Munoz, Tammy C. Bleak, Gloria M. Calaf
Summary: Glyphosate, a broad-spectrum herbicide introduced in 1974, has had a significant impact on the crop industry and is considered one of the most successful herbicides in history. However, recent studies have raised concerns about its safety, with conflicting opinions from international agencies regarding its effects on human health, particularly as an endocrine-disrupting chemical and carcinogen.
Article
Environmental Sciences
Niedson Correia de Lima Junior, Juliana Franco Camilo, Pamella Rodrigues do Carmo, Marcelle Novaes de Andrade, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Lycia de Brito Gitirana, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho, Leandro Miranda-Alves, Glaecir Roseni Mundstock Dias
Summary: Subacute exposure to lead acetate disrupts thyroid gland function in both sexes, leading to changes in learning and memory abilities.
ENVIRONMENTAL POLLUTION
(2021)
Editorial Material
Biochemistry & Molecular Biology
Borja Quiroga
Summary: BPA, a common component of plastics worldwide, has been shown to act as an endocrine disruptor with some hormonal functions. High levels of BPA are related to cardiovascular events and carcinogenesis pathways, and CKD patients have higher serum concentrations of BPA due to impaired renal function. Efforts to reduce BPA levels in these patients include developing BPA-free dialysis filters and other techniques.
Article
Environmental Sciences
David A. Geier, Mark R. Geier
Summary: A study using NHANES data found that 82% of the tested individuals in the United States had detectable concentrations of glyphosate in their urine. There was a significant inverse correlation between glyphosate concentrations and total testosterone and total estradiol concentrations, but no correlation with sex hormone binding globulin concentrations.
Article
Food Science & Technology
Camila Helena Facina, Silvana Gisele Pegorin Campos, Thalles Fernando Rocha Ruiz, Rejane Maira Goes, Patricia Simone Leite Vilamaior, Sebastiao Roberto Taboga
Summary: Curcumin and piperine can mitigate the detrimental effects of BPA on the prostate gland, reducing nuclear atypia and maintaining the homeostasis of prostate epithelial cells. The protective action of these phytotherapeutic agents is associated with weight loss, anti-inflammatory potential, and control of prostate epithelial cell homeostasis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Susana Santos, Chalana M. Sol, Charissa Van Zwol-Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande
Summary: Exposure to phthalates during pregnancy may lead to fetal growth restriction and preterm birth. Different trimester-specific exposures to phthalates may have varying effects on fetal growth and birth outcomes.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Pallavi Gautam, Anand Kumar Pandey, Suresh Kumar Dubey
Summary: The widely used insecticide, imidacloprid, has caused serious environmental concerns due to its residual presence. A study on soil microcosms investigated the biodegradation potential of Agrobacterium sp. InxBP2, which achieved 88% degradation of imidacloprid within 20 days. The findings of this study provide important insights into the mechanistic link between imidacloprid degradation genes/enzymes and Agrobacterium sp. InxBP2, and have implications for soil remediation strategies.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Eve Pellerin, Christophe Caneparo, Stephane Chabaud, Stephane Bolduc, Martin Pelletier
Summary: Bisphenols are endocrine-disrupting chemicals that have been linked to cancer progression, particularly prostate cancer. They are found in the urine of the vast majority of the population and could potentially impact the normal physiology and cancer development of the bladder.
ENVIRONMENTAL RESEARCH
(2021)
Review
Agriculture, Multidisciplinary
Jia Yu, Haoyang Zou, Tiehua Zhang, Jie Zhang
Summary: This review examines the molecular mechanisms by which non-phthalate plasticizers modulate nuclear receptor activity, emphasizing the importance of evaluating their endocrine-disrupting effects and laying the foundation for the development of safer alternatives within the plastic industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Eujung Kim, Minjung Song, Adam Gopal Ramu, Dongjin Choi
Summary: Bisphenol A (BPA), a common chemical used in plastic production, has emerged as a serious environmental concern due to its potential toxicity to plants. This study aimed to investigate the mechanism of BPA-induced root cells by examining the effects of BPA on the ultrastructure and function of soybean plant root tip cells. Changes in plant root cell tissues after BPA exposure were observed, and the accumulation of BPA in different plant parts was analyzed. The findings provide insight into how BPA can alter plant root growth.
Review
Biochemistry & Molecular Biology
Nicolas Monnin, Anne Julie Fattet, Isabelle Koscinski
Summary: Endometriosis is caused by ectopic endometrial tissue, and its chronic inflammation is associated with pain and fertility problems. Endometriotic implants produce their own estrogen through aromatase and are dependent on estrogen receptor beta (ESR beta) while being resistant to progesterone. The transcription factor SF1 promotes aromatase synthesis and its expression, along with ESR beta, is enhanced by demethylation. Local estrogen concentrations play a role in implantation and development of endometriotic implants, as well as potentially promoting genital cancer. Certain microbiota components, prenatal exposure to endocrine disruptors, and phthalates are associated with increased estrogen levels, while the impact of dioxin and tobacco on endometriosis is less clear.
Article
Environmental Sciences
Danielle Regina Gomes Ribeiro-Brasil, Italo Braga Castro, Marcelo Petracco, Rodrigo Moco Batista, Leandro Schlemmer Brasil, Johnata Azevedo Ferreira, Thais Angelica da Costa Borba, Marcelo Rollnic, Gilberto Fillmann, Lilian Lund Amado
Summary: In this study, the spatial distribution of Butyltins (BTs) in surface sediments and gastropod tissues in the Eastern Amazon estuarine system was quantified. The results indicate that BTs concentrations are associated with area use and local hydrodynamics in the region.
MARINE POLLUTION BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Slawomir Gonkowski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Nutrition & Dietetics
Michael Thoene, Ewa Dzika, Slawomir Gonkowski, Joanna Wojtkiewicz
Review
Biochemistry & Molecular Biology
Slawomir Gonkowski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Food Science & Technology
Slawomir Gonkowski, Magdalena Gajecka, Krystyna Makowska
Review
Agriculture, Dairy & Animal Science
Slawomir Gonkowski, Liliana Rytel, Krystyna Makowska, Jaroslaw Calka
Article
Environmental Sciences
Ignacy Gonkowski, Slawomir Gonkowski, Ewa Dzika, Joanna Wojtkiewicz
Summary: The study found that BPA has an impact on CB-positive enteric neuronal cells in the caecum, with low doses increasing cell numbers in certain plexuses and high doses increasing cell numbers in all plexuses. This indicates that CB in the ENS has adaptive and protective functions.
Article
Agriculture, Dairy & Animal Science
Krystyna Makowska, Slawomir Gonkowski
Summary: Bisphenol A (BPA), commonly used in plastics, can leach into food, water, and air, negatively affecting living organisms by impairing heart innervation, which may lead to adverse cardiovascular effects.
Article
Biochemistry & Molecular Biology
Krystyna Makowska, Kamila Szymanska, Jaroslaw Calka, Slawomir Gonkowski
Summary: Bisphenol A (BPA) is a harmful substance used in plastic manufacturing, primarily affecting the stomach and intestines through gastrointestinal intoxication, potentially increasing the co-localization of NRG1 with other substances in the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Slawomir Gonkowski, Manolis Tzatzarakis, Elena Vakonaki, Krystyna Makowska, Aristidis M. Tsatsakis, Joanna Wojtkiewicz
Summary: This study evaluated TCS concentration levels in residents of Olsztyn, northeastern Poland, using liquid chromatography-mass spectrometry. The results showed that TCS was present in the majority of samples, with concentration levels ranging from 37.9 pg/mg to 3386.5 pg/mg. The study revealed that people living in northeastern Poland are exposed to TCS to a large degree.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Krystyna Makowska, Julia Martin, Andrzej Rychlik, Irene Aparicio, Juan Luis Santos, Esteban Alonso, Slawomir Gonkowski
Summary: This study used hair analysis to evaluate the exposure of 30 dogs to BPA. The results showed that 93.33% of the samples had BPA concentrations above the detection limit, with levels ranging from 7.05 ng/g to 436 ng/g. Significant differences in BPA concentrations were found between dogs with different weights. The study suggests that dogs are highly exposed to BPA and that it may play a role in their health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Krystyna Makowska, Ewa Lepiarczyk, Slawomir Gonkowski
Summary: Bisphenol A (BPA), commonly used as a plasticizer, has a strong negative effect on living organisms and is being replaced by bisphenol S (BPS) in plastic production. This study compares the impact of BPA and BPS on enteric neurons for the first time using double immunofluorescence technique. Both BPA and BPS affect the number of enteric neurons containing various neuronal factors, with BPS showing a stronger impact on certain neuronal populations. The results indicate that long-term exposure to BPS, even in low doses, is not neutral for enteric neurons and may be more potent than BPA for certain neuronal populations.
Editorial Material
Environmental Sciences
Slawomir Gonkowski, Krystyna Makowska
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Krystyna Makowska, Slawomir Gonkowski
Summary: This study found that BPA can affect the function of the descending colon by altering the neurochemical characteristics of enteric neurons. This is of significant importance in understanding the impact of BPA on human health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Marta Wiszpolska, Ewa Lepiarczyk, Mateusz A. Mazdziarz, Lukasz Paukszto, Karol G. Makowczenko, Aleksandra Lipka, Elzbieta Lopienska-Biernat, Krystyna Makowska, Slawomir Gonkowski, Paulo Correia-de-Sa, Marta Majewska
Summary: This study investigated the changes in liver gene expression caused by oral exposure to BPA in mice. The findings suggest that BPA has a significant impact on gene expression in the liver, and this may be related to genes associated with important metabolism and malignant tumors in the liver.