标题
Addressing BBB Heterogeneity: A New Paradigm for Drug Delivery to Brain Tumors
作者
关键词
-
出版物
Pharmaceutics
Volume 12, Issue 12, Pages 1205
出版商
MDPI AG
发表日期
2020-12-14
DOI
10.3390/pharmaceutics12121205
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Intrathecal drug delivery in the era of nanomedicine
- (2020) M. Fowler et al. ADVANCED DRUG DELIVERY REVIEWS
- ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases
- (2020) Priya Kumthekar et al. CLINICAL CANCER RESEARCH
- Long-term complete response to intrathecal trastuzumab in a patient with leptomeningeal carcinomatosis due to her2- overexpressing breast cancer
- (2020) Francisco José Valdivia García et al. MEDICINE
- Evaluating infusate parameters for direct drug delivery to the brainstem: a comparative study of convection-enhanced delivery versus osmotic pump delivery
- (2020) Julian S. Rechberger et al. Neurosurgical Focus
- Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain
- (2020) William M. Pardridge Frontiers in Aging Neuroscience
- Antibodies for the Treatment of Brain Metastases, a Dream or a Reality?
- (2020) Marco Cavaco et al. Pharmaceutics
- PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study
- (2020) Gina P. Hoyos-Ceballos et al. Pharmaceutics
- Comparison of Absolute Protein Abundances of Transporters and Receptors among Blood–Brain Barriers at Different Cerebral Regions and the Blood–Spinal Cord Barrier in Humans and Rats
- (2020) Yasuo Uchida et al. MOLECULAR PHARMACEUTICS
- A HER2 Antibody Drug Conjugate Controls Growth of Breast Cancer Brain Metastases in Hematogenous Xenograft Models, with Heterogeneous Blood-Tumor Barrier Penetration Unlinked to a Passive Marker
- (2020) Brunilde Gril et al. NEURO-ONCOLOGY
- Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
- (2020) Mihalis S. Kariolis et al. Science Translational Medicine
- Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
- (2020) Julie C. Ullman et al. Science Translational Medicine
- Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma
- (2020) Gautham Gampa et al. Scientific Reports
- Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles
- (2020) David C. Luther et al. ADVANCED DRUG DELIVERY REVIEWS
- Intrathecal administration of anti-HER2 treatment for the treatment of meningeal carcinomatosis in breast cancer: A metanalysis with meta-regression
- (2020) Flora Zagouri et al. CANCER TREATMENT REVIEWS
- Synergistic drug combinations for a precision medicine approach to interstitial glioblastoma therapy
- (2020) Elizabeth G. Graham-Gurysh et al. JOURNAL OF CONTROLLED RELEASE
- Cerebrospinal fluid circulating tumor cells as a quantifiable measurement of leptomeningeal metastases in patients with HER2 positive cancer
- (2020) Rachna Malani et al. JOURNAL OF NEURO-ONCOLOGY
- New Insights into the Dysfunctions of Pericytes and Neurovascular Units in Neurodegenerative Diseases
- (2020) Qiang Liu et al. Neuroscience Bulletin
- PET, image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models
- (2020) Umberto Tosi et al. Science Advances
- Brain distribution and active efflux of three panRAF inhibitors: considerations in the treatment of melanoma brain metastases
- (2019) Gautham Gampa et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study
- (2019) Todd Mainprize et al. Scientific Reports
- Correlated MRI and Ultramicroscopy (MR-UM) of Brain Tumors Reveals Vast Heterogeneity of Tumor Infiltration and Neoangiogenesis in Preclinical Models and Human Disease
- (2019) Michael O. Breckwoldt et al. Frontiers in Neuroscience
- Vectors for Glioblastoma Gene Therapy: Viral & Non-Viral Delivery Strategies
- (2019) Breanne Caffery et al. Nanomaterials
- Quantitative Evaluation of Intraventricular Delivery of Therapeutic Neural Stem Cells to Orthotopic Glioma
- (2019) Margarita Gutova et al. Frontiers in Oncology
- Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma
- (2019) Ahmed Idbaih et al. CLINICAL CANCER RESEARCH
- Phase II study of systemic high dose methotrexate and intrathecal liposomal cytarabine for treatment of leptomeningeal carcinomatosis from breast cancer
- (2019) Maciej M. Mrugala et al. Clinical Breast Cancer
- MDNA55: A locally administered IL4 guided toxin as a targeted treatment for recurrent glioblastoma.
- (2019) Dina Randazzo et al. JOURNAL OF CLINICAL ONCOLOGY
- Established and Emerging Strategies for Drug Delivery Across the Blood-Brain Barrier in Brain Cancer
- (2019) Alessandro Parodi et al. Pharmaceutics
- A tumor‐targeting nanomedicine carrying the p53 gene crosses the blood–brain barrier and enhances anti‐PD‐1 immunotherapy in mouse models of glioblastoma
- (2019) Sang‐Soo Kim et al. INTERNATIONAL JOURNAL OF CANCER
- The anatomy and immunology of vasculature in the central nervous system
- (2019) Panagiotis Mastorakos et al. Science Immunology
- miRNA-26a expression influences the therapy response to carmustine wafer implantation in patients with glioblastoma multiforme
- (2019) Christoph Sippl et al. ACTA NEUROCHIRURGICA
- Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood-brain barrier
- (2019) Synnøve Nymark Aasen et al. MOLECULAR CANCER THERAPEUTICS
- The blood-brain barrier: Physiology and strategies for drug delivery
- (2019) Rucha Pandit et al. ADVANCED DRUG DELIVERY REVIEWS
- Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors
- (2019) Jongha Lee et al. Nature Communications
- Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice
- (2019) K. T. Householder et al. Scientific Reports
- Recurrent or Refractory High-Grade Gliomas Treated by Convection-Enhanced Delivery of a TGFβ2-Targeting RNA Therapeutic: A Post-Hoc Analysis with Long-Term Follow-Up
- (2019) Fatih M. Uckun et al. Cancers
- Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes
- (2019) Gyeungyun Kim et al. JOURNAL OF CONTROLLED RELEASE
- Blood-brain barrier shuttle peptides enhance AAV transduction in the brain after systemic administration
- (2018) Xintao Zhang et al. BIOMATERIALS
- Intrathecal trastuzumab in the management of HER2+ breast leptomeningeal disease: a single institution experience
- (2018) Nicholas B. Figura et al. BREAST CANCER RESEARCH AND TREATMENT
- The use of a smartphone-assisted ventricle catheter guide for Ommaya reservoir placement—experience of a retrospective bi-center study
- (2018) Sergey Ozerov et al. CHILDS NERVOUS SYSTEM
- Phase 0 Trial of AZD1775 in First-Recurrence Glioblastoma Patients
- (2018) Nader Sanai et al. CLINICAL CANCER RESEARCH
- Management of leptomeningeal metastasis in breast cancer
- (2018) Hazem I. Assi et al. CLINICAL NEUROLOGY AND NEUROSURGERY
- Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma
- (2018) Frederick F. Lang et al. JOURNAL OF CLINICAL ONCOLOGY
- Convection enhanced delivery of liposome encapsulated doxorubicin for brain tumour therapy
- (2018) Wenbo Zhan et al. JOURNAL OF CONTROLLED RELEASE
- Highly efficacious and specific anti-glioma chemotherapy by tandem nanomicelles co-functionalized with brain tumor-targeting and cell-penetrating peptides
- (2018) Yaqin Zhu et al. JOURNAL OF CONTROLLED RELEASE
- Tumor microenvironment after biodegradable BCNU wafer implantation: special consideration of immune system
- (2018) Ichiyo Shibahara et al. JOURNAL OF NEURO-ONCOLOGY
- Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinity
- (2018) Arsalan S. Haqqani et al. JOURNAL OF NEUROCHEMISTRY
- First-in-human evaluation of the Cleveland Multiport Catheter for convection-enhanced delivery of topotecan in recurrent high-grade glioma: results of pilot trial 1
- (2018) Michael A. Vogelbaum et al. JOURNAL OF NEUROSURGERY
- The distribution, clearance, and brainstem toxicity of panobinostat administered by convection-enhanced delivery
- (2018) William G. B. Singleton et al. Journal of Neurosurgery-Pediatrics
- Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration
- (2018) Denise Karaoglu Hanzatian et al. mAbs
- Efficacy of the MDM2 inhibitor SAR405838 in glioblastoma is limited by poor distribution across the blood-brain barrier
- (2018) Minjee Kim et al. MOLECULAR CANCER THERAPEUTICS
- Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection
- (2018) Elizabeth Graham-Gurysh et al. MOLECULAR PHARMACEUTICS
- Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
- (2018) Nir Lipsman et al. Nature Communications
- Current Strategies for Brain Drug Delivery
- (2018) Xiaowei Dong Theranostics
- Emerging trends in bispecific antibody and scaffold protein therapeutics
- (2018) Petra Verdino et al. Current Opinion in Chemical Engineering
- Passive immunotherapies for central nervous system disorders – current delivery challenges and new approaches.
- (2018) Niyanta N. Kumar et al. BIOCONJUGATE CHEMISTRY
- Intrathecal viral vector delivery of trastuzumab prevents or inhibits tumor growth of human HER2-positive xenografts in mice
- (2018) William T Rothwell et al. CANCER RESEARCH
- CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer
- (2018) Thanyanan Reungwetwattana et al. JOURNAL OF CLINICAL ONCOLOGY
- Characteristics and outcomes of elderly patients with diffuse gliomas: a multi-institutional cohort study by Kansai Molecular Diagnosis Network for CNS Tumors
- (2018) Takahiro Sasaki et al. JOURNAL OF NEURO-ONCOLOGY
- Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood–tumor barrier disruption
- (2018) Costas D. Arvanitis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Angiopep-2/IP10-EGFRvIIIscFv modified nanoparticles and CTL synergistically inhibit malignant glioblastoma
- (2018) Xuan Wang et al. Scientific Reports
- Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy
- (2018) Wen Liao et al. Acta Biomaterialia
- Boosting RNAi therapy for orthotopic glioblastoma with nontoxic brain-targeting chimaeric polymersomes
- (2018) Yanan Shi et al. JOURNAL OF CONTROLLED RELEASE
- Blood-Brain Barrier: From Physiology to Disease and Back
- (2018) Melanie D. Sweeney et al. PHYSIOLOGICAL REVIEWS
- Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening
- (2018) Hong-Chieh Tsai et al. Scientific Reports
- Targeted Theranostic Nanoparticles for Brain Tumor Treatment
- (2018) Maria Mendes et al. Pharmaceutics
- Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer
- (2018) Tovi Shapira-Furman et al. JOURNAL OF CONTROLLED RELEASE
- Angiogenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors
- (2017) En-Ling Chang et al. JOURNAL OF CONTROLLED RELEASE
- Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption
- (2017) Juyoung Park et al. JOURNAL OF CONTROLLED RELEASE
- Liposomal temozolomide drug delivery using convection enhanced delivery
- (2017) Mirjam M. Nordling-David et al. JOURNAL OF CONTROLLED RELEASE
- Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats
- (2017) Clark Zhang et al. JOURNAL OF CONTROLLED RELEASE
- Controlled release of liposome-encapsulated temozolomide for brain tumour treatment by convection-enhanced delivery
- (2017) Chung-Yin Lin et al. JOURNAL OF DRUG TARGETING
- Maximize surgical resection beyond contrast-enhancing boundaries in newly diagnosed glioblastoma multiforme: is it useful and safe? A single institution retrospective experience
- (2017) Federico Pessina et al. JOURNAL OF NEURO-ONCOLOGY
- Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies
- (2017) Arman Jahangiri et al. JOURNAL OF NEUROSURGERY
- New horizons for focused ultrasound (FUS) – therapeutic applications in neurodegenerative diseases
- (2017) Diane B. Miller et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence
- (2017) Jingwei Xue et al. Nature Nanotechnology
- Antibody–drug conjugates in glioblastoma therapy: the right drugs to the right cells
- (2017) Hui K. Gan et al. Nature Reviews Clinical Oncology
- Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data
- (2017) Jann N Sarkaria et al. NEURO-ONCOLOGY
- Convection-Enhanced Delivery
- (2017) A. M. Mehta et al. Neurotherapeutics
- Mathematical Modelling of Convection Enhanced Delivery of Carmustine and Paclitaxel for Brain Tumour Therapy
- (2017) Wenbo Zhan et al. PHARMACEUTICAL RESEARCH
- Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet
- (2017) P.E. Bunney et al. PHYSIOLOGY & BEHAVIOR
- Trastuzumab distribution in an in-vivo and in-vitro model of brain metastases of breast cancer
- (2017) Tori B. Terrell-Hall et al. Oncotarget
- Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma
- (2017) Kasper Bendix Johnsen et al. Scientific Reports
- Localized delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat brain using focused ultrasound
- (2016) Rohit S. Mulik et al. BIOMATERIALS
- Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery
- (2016) Benjamí Oller-Salvia et al. CHEMICAL SOCIETY REVIEWS
- Characterization of passive permeability at the blood–tumor barrier in five preclinical models of brain metastases of breast cancer
- (2016) Chris E. Adkins et al. CLINICAL & EXPERIMENTAL METASTASIS
- Alterations in Pericyte Subpopulations Are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer
- (2016) L. T. Lyle et al. CLINICAL CANCER RESEARCH
- Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity
- (2016) P. Ballard et al. CLINICAL CANCER RESEARCH
- Impact of Blood-Brain Barrier Integrity on Tumor Growth and Therapy Response in Brain Metastases
- (2016) M. Osswald et al. CLINICAL CANCER RESEARCH
- Simple and novel strategies to achieve shape and size control of magnetite nanoparticles intended for biomedical applications
- (2016) Pamela Azcona et al. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
- Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier
- (2016) David S. Hersh et al. CURRENT PHARMACEUTICAL DESIGN
- CSF, blood-brain barrier, and brain drug delivery
- (2016) William M. Pardridge Expert Opinion on Drug Delivery
- Concurrent radiotherapy and intrathecal methotrexate for treating leptomeningeal metastasis from solid tumors with adverse prognostic factors: A prospective and single-arm study
- (2016) Zhenyu Pan et al. INTERNATIONAL JOURNAL OF CANCER
- Growth inhibition in a brain metastasis model by antibody delivery using focused ultrasound-mediated blood-brain barrier disruption
- (2016) Thiele Kobus et al. JOURNAL OF CONTROLLED RELEASE
- ABCG2 and ABCB1 Limit the Efficacy of Dasatinib in a PDGF-B-Driven Brainstem Glioma Model
- (2016) R. K. Mittapalli et al. MOLECULAR CANCER THERAPEUTICS
- Very High Plasma Concentrations of a Monoclonal Antibody against the Human Insulin Receptor Are Produced by Subcutaneous Injection in the Rhesus Monkey
- (2016) Ruben J. Boado et al. MOLECULAR PHARMACEUTICS
- Systemic AAV9-IFNβ gene delivery treats highly invasive glioblastoma
- (2016) Dwijit GuhaSarkar et al. NEURO-ONCOLOGY
- OS7.2 A Phase II Study of ANG1005, a novel BBB/BCB Penetratant Taxane in Patients with Recurrent Brain Metastases and Leptomeningeal Carcinomatosis from Breast Cancer
- (2016) P. Kumthekar et al. NEURO-ONCOLOGY
- Updates in the management of brain metastases
- (2016) Nils D. Arvold et al. NEURO-ONCOLOGY
- Focused Ultrasound Enhances Central Nervous System Delivery of Bevacizumab for Malignant Glioma Treatment
- (2016) Hao-Li Liu et al. RADIOLOGY
- Clinical trial of blood-brain barrier disruption by pulsed ultrasound
- (2016) Alexandre Carpentier et al. Science Translational Medicine
- Long-Term Survivor with Intrathecal and Intravenous Trastuzumab Treatment in Metastatic Breast Cancer
- (2016) H. Pluchart et al. Targeted Oncology
- Gliadel wafer implantation combined with standard radiotherapy and concurrent followed by adjuvant temozolomide for treatment of newly diagnosed high-grade glioma: a systematic literature review
- (2016) Lynn S. Ashby et al. World Journal of Surgical Oncology
- Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report
- (2016) YING PAN et al. Oncology Letters
- Association of the Extent of Resection With Survival in Glioblastoma
- (2016) Timothy J. Brown et al. JAMA Oncology
- Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges
- (2016) Dinh Ha et al. Acta Pharmaceutica Sinica B
- Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood–brain barrier opening and brain-tumor drug delivery
- (2015) Ching-Hsiang Fan et al. Acta Biomaterialia
- Synthesis and characterization of maghemite nanoparticles for hyperthermia applications
- (2015) E.M. Múzquiz-Ramos et al. CERAMICS INTERNATIONAL
- Two Fatal Cases of Accidental Intrathecal Vincristine Administration: Learning from Death Events
- (2015) Thirachit Chotsampancharoen et al. CHEMOTHERAPY
- Breast Cancer Leptomeningeal Metastasis: The Results of Combined Treatment and the Comparison of Methotrexate and Liposomal Cytarabine As Intra–Cerebrospinal Fluid Chemotherapy
- (2015) Anna Niwińska et al. Clinical Breast Cancer
- The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma
- (2015) J. L. Pokorny et al. CLINICAL CANCER RESEARCH
- Convection-enhanced delivery of SN-38-loaded polymeric micelles (NK012) enables consistent distribution of SN-38 and is effective against rodent intracranial brain tumor models
- (2015) Rong Zhang et al. DRUG DELIVERY
- Drug and gene delivery across the blood–brain barrier with focused ultrasound
- (2015) Kelsie F. Timbie et al. JOURNAL OF CONTROLLED RELEASE
- Multimodality Brain Tumor Imaging: MR Imaging, PET, and PET/MR Imaging
- (2015) J. R. Fink et al. JOURNAL OF NUCLEAR MEDICINE
- Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment
- (2015) Vasileios Askoxylakis et al. JNCI-Journal of the National Cancer Institute
- Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors
- (2015) Suraj Dixit et al. Nanoscale
- Polymeric drug delivery for the treatment of glioblastoma
- (2015) S. D. Wait et al. NEURO-ONCOLOGY
- Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio
- (2015) Tianzhi Yang et al. PHARMACEUTICAL RESEARCH
- Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model
- (2015) Feng-Yi Yang et al. Oncotarget
- Leptomeningeal metastasis in breast cancer – a systematic review
- (2015) Brian J. Scott et al. Oncotarget
- LRP-1-mediated intracellular antibody delivery to the Central Nervous System
- (2015) Xiaohe Tian et al. Scientific Reports
- Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment
- (2015) Vasileios Askoxylakis et al. JNCI-Journal of the National Cancer Institute
- Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient
- (2015) Nu T. Lu et al. Journal for ImmunoTherapy of Cancer
- Epidemiologic and Molecular Prognostic Review of Glioblastoma
- (2014) J. P. Thakkar et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Prolonged survival upon ultrasound-enhanced doxorubicin delivery in two syngenic glioblastoma mouse models
- (2014) Zsofia Kovacs et al. JOURNAL OF CONTROLLED RELEASE
- Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood–brain barrier in rats
- (2014) Jaap Rip et al. JOURNAL OF DRUG TARGETING
- Concurrent intrathecal methotrexate and liposomal cytarabine for leptomeningeal metastasis from solid tumors: a retrospective cohort study
- (2014) Brian J. Scott et al. JOURNAL OF NEURO-ONCOLOGY
- Magnetic resonance imaging properties of convective delivery in diffuse intrinsic pontine gliomas
- (2014) Prashant Chittiboina et al. Journal of Neurosurgery-Pediatrics
- ANG4043, a Novel Brain-Penetrant Peptide-mAb Conjugate, Is Efficacious against HER2-Positive Intracranial Tumors in Mice
- (2014) A. Regina et al. MOLECULAR CANCER THERAPEUTICS
- P08.03 * 2B3-101, GLUTATHIONE PEGYLATED LIPOSOMAL DOXORUBICIN, IN PATIENTS WITH RECURRENT HIGH GRADE GLIOMAS AND BREAST CANCER BRAIN METASTASES
- (2014) D. Brandsma et al. NEURO-ONCOLOGY
- Pharmacokinetics, Brain Delivery, and Efficacy in Brain Tumor-Bearing Mice of Glutathione Pegylated Liposomal Doxorubicin (2B3-101)
- (2014) Pieter J. Gaillard et al. PLoS One
- Peptide Carrier-Mediated Non-Covalent Delivery of Unmodified Cisplatin, Methotrexate and Other Agents via Intravenous Route to the Brain
- (2014) Gobinda Sarkar et al. PLoS One
- Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells
- (2014) Stacey Watkins et al. Nature Communications
- Noninvasive and Targeted Drug Delivery to the Brain Using Focused Ultrasound
- (2013) Alison Burgess et al. ACS Chemical Neuroscience
- MGMT promoter methylation status and prognosis of patients with primary or recurrent glioblastoma treated with carmustine wafers
- (2013) A. Gutenberg et al. BRITISH JOURNAL OF NEUROSURGERY
- Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model
- (2013) T T Huang et al. CANCER GENE THERAPY
- T7 peptide-functionalized nanoparticles utilizing RNA interference for glioma dual targeting
- (2013) Yuyang Kuang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Brain Bioavailability of Human Intravenous Immunoglobulin and its Transport through the Murine Blood–Brain Barrier
- (2013) Isabelle St-Amour et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Local delivery of angiogenesis-inhibitor minocycline combined with radiotherapy and oral temozolomide chemotherapy in 9L glioma
- (2013) Hansen Bow et al. JOURNAL OF NEUROSURGERY
- Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors
- (2013) Neil Senzer et al. MOLECULAR THERAPY
- EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY
- (2013) C. Aaberg-Jessen et al. NEURO-ONCOLOGY
- Long-term cognitive function, neuroimaging, and quality of life in primary CNS lymphoma
- (2013) N. D. Doolittle et al. NEUROLOGY
- Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
- (2012) Fangqiong Tang et al. ADVANCED MATERIALS
- Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor
- (2012) Roger Prades et al. BIOMATERIALS
- O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and low MGMT-encoded protein expression as prognostic markers in glioblastoma patients treated with biodegradable carmustine wafer implants after initial surgery followed by radiotherapy w
- (2012) Emmanuèle Lechapt-Zalcman et al. CANCER
- Targeting the PI3K Pathway in the Brain--Efficacy of a PI3K Inhibitor Optimized to Cross the Blood-Brain Barrier
- (2012) L. Salphati et al. CLINICAL CANCER RESEARCH
- Ultrasound-mediated blood‐brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model
- (2012) Eun-Joo Park et al. JOURNAL OF CONTROLLED RELEASE
- Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (BBB)
- (2012) Jörg Kreuter JOURNAL OF MICROENCAPSULATION
- Examination of blood–brain barrier (BBB) integrity in a mouse brain tumor model
- (2012) Ngoc H. On et al. JOURNAL OF NEURO-ONCOLOGY
- Active Efflux of Dasatinib from the Brain Limits Efficacy against Murine Glioblastoma: Broad Implications for the Clinical Use of Molecularly Targeted Agents
- (2012) S. Agarwal et al. MOLECULAR CANCER THERAPEUTICS
- Investigation of the Role of FcγR and FcRn in mAb Distribution to the Brain
- (2012) Lubna Abuqayyas et al. MOLECULAR PHARMACEUTICS
- Insight into the Cooperation of P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) at the Blood–Brain Barrier: A Case Study Examining Sorafenib Efflux Clearance
- (2012) Sagar Agarwal et al. MOLECULAR PHARMACEUTICS
- Pharmacokinetic Analysis of 111In-Labeled Liposomal Doxorubicin in Murine Glioblastoma after Blood-Brain Barrier Disruption by Focused Ultrasound
- (2012) Feng-Yi Yang et al. PLoS One
- Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma
- (2012) Lisa H. Treat et al. ULTRASOUND IN MEDICINE AND BIOLOGY
- Choline-Derivate-Modified Nanoparticles for Brain-Targeting Gene Delivery
- (2011) Jianfeng Li et al. ADVANCED MATERIALS
- Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment
- (2011) Chien-Yu Ting et al. BIOMATERIALS
- Therapeutic effect of neural stem cells expressing TRAIL and bortezomib in mice with glioma xenografts
- (2011) Irina V. Balyasnikova et al. CANCER LETTERS
- Cell-mediated drug delivery
- (2011) Elena V Batrakova et al. Expert Opinion on Drug Delivery
- Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain
- (2011) Sagar Agarwal et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- Local drug delivery strategies for cancer treatment: Gels, nanoparticles, polymeric films, rods, and wafers
- (2011) Jesse B. Wolinsky et al. JOURNAL OF CONTROLLED RELEASE
- Tissue concentration of systemically administered antineoplastic agents in human brain tumors
- (2011) Marshall W. Pitz et al. JOURNAL OF NEURO-ONCOLOGY
- Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
- (2011) Yasuo Uchida et al. JOURNAL OF NEUROCHEMISTRY
- The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice
- (2011) Yao-Sheng Tung et al. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
- Engaging neuroscience to advance translational research in brain barrier biology
- (2011) Edward A. Neuwelt et al. NATURE REVIEWS NEUROSCIENCE
- Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer
- (2011) Kunal S. Taskar et al. PHARMACEUTICAL RESEARCH
- Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
- (2011) Y. J. Yu et al. Science Translational Medicine
- Epidemiology of Brain Metastases
- (2011) Lakshmi Nayak et al. Current Oncology Reports
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- (2010) P. R. Lockman et al. CLINICAL CANCER RESEARCH
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- (2010) Michael T. Milano et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
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- (2010) Sonia Partap et al. JOURNAL OF NEURO-ONCOLOGY
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- (2010) Richard Daneman et al. NATURE
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- (2010) P.-Y. Chen et al. NEURO-ONCOLOGY
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- (2010) S. Kunwar et al. NEURO-ONCOLOGY
- Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain
- (2010) H.-L. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) G. H. Bird et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Convection-Enhanced Delivery of a Synthetic Retinoid Am80, Loaded into Polymeric Micelles, Prolongs the Survival of Rats Bearing Intracranial Glioblastoma Xenografts
- (2010) Michiko Yokosawa et al. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
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- (2009) Philippe Metellus et al. CANCER
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- (2009) Lilyana Angelov et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2009) Amy Y. Grahn et al. JOURNAL OF NEURO-ONCOLOGY
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- (2009) N. Joan Abbott et al. NEUROBIOLOGY OF DISEASE
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- (2009) Fancy C. Thomas et al. PHARMACEUTICAL RESEARCH
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- (2009) Azeb Tadesse Argaw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recent Advances in Blood–Brain Barrier Disruption as a CNS Delivery Strategy
- (2008) Marc-André Bellavance et al. AAPS Journal
- Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma
- (2008) Sudhir H. Ranganath et al. BIOMATERIALS
- Stem and progenitor cell-mediated tumor selective gene therapy
- (2008) K S Aboody et al. GENE THERAPY
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- (2008) Nader Sanai et al. NEUROSURGERY
- Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium
- (2008) Nickolai Sheikov et al. ULTRASOUND IN MEDICINE AND BIOLOGY
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