Amyloid β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer’s Disease-Related Models

Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death

(2020) Song Han et al.   Cells

The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses

(2020) Yongquan Hu et al.   Autophagy

Amyloid β Oligomers Increase ER-Mitochondria Ca2+ Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca2+ Remodeling

(2019) Maria Calvo-Rodriguez et al.   Frontiers in Cellular Neuroscience

Metabolic implications of organelle–mitochondria communication

(2019) Isabel Gordaliza‐Alaguero et al.   EMBO REPORTS

Impaired adult neurogenesis is an early event in Alzheimer’s disease neurodegeneration, mediated by intracellular Aβ oligomers

(2019) Chiara Scopa et al.   CELL DEATH AND DIFFERENTIATION

The Charcot–Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress

(2019) Christina Wolf et al.   Cells

The regulation of autophagy by calcium signals: Do we have a consensus?

(2018) Martin D. Bootman et al.   CELL CALCIUM

The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis

(2018) Yan G. Zhao et al.   CURRENT BIOLOGY

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca 2+ Transfer

(2018) Riccardo Filadi et al.   CURRENT BIOLOGY

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

(2018) Estela Area-Gomez et al.   Cell Death & Disease

Amyloid-β Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes

(2018) Bernadette Schreiner et al.   JOURNAL OF ALZHEIMERS DISEASE

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients

(2018) Nuno Santos Leal et al.   Acta Neuropathologica Communications

On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis

(2017) Estela Area-Gomez et al.   FASEB JOURNAL

ER–mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release

(2017) Janos Steffen et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases

(2017) Yi Liu et al.   Translational Neurodegeneration

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation

(2016) Tina Garofalo et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

The coming of age of the mitochondria–ER contact: a matter of thickness

(2016) M Giacomello et al.   CELL DEATH AND DIFFERENTIATION

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

(2016) Dolores Del Prete et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production

(2016) Nuno Santos Leal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease

(2016) I Celardo et al.   Cell Death & Disease

Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2

(2016) Riccardo Filadi et al.   Cell Reports

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

(2016) Antonio Piras et al.   Acta Neuropathologica Communications

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

(2014) Yu-Jen Chang et al.   FEBS Journal

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Amino Acid Starvation Has Opposite Effects on Mitochondrial and Cytosolic Protein Synthesis

(2014) Mark A. Johnson et al.   PLoS One

Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum

(2014) Giovanni Meli et al.   Nature Communications

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells

(2012) Jean E. Vance et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Mitochondria-associated ER membranes in Alzheimer disease

(2012) Eric A. Schon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitofusin-2 Independent Juxtaposition of Endoplasmic Reticulum and Mitochondria: An Ultrastructural Study

(2012) Pierre Cosson et al.   PLoS One

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers

(2010) Sam Gandy et al.   ANNALS OF NEUROLOGY

Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot–Marie–Tooth neuropathy type 2A

(2010) Romain Cartoni et al.   BRAIN

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

AMPK-independent induction of autophagy by cytosolic Ca2+ increase

(2010) Antje Grotemeier et al.   CELLULAR SIGNALLING

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

(2010) Mauro Fa et al.   Jove-Journal of Visualized Experiments

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Direct in Vivo Intracellular Selection of Conformation-sensitive Antibody Domains Targeting Alzheimer's Amyloid-β Oligomers

(2009) Giovanni Meli et al.   JOURNAL OF MOLECULAR BIOLOGY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin 2: A Mitochondria-Shaping Protein with Signaling Roles Beyond Fusion

(2007) Olga Martins de Brito et al.   ANTIOXIDANTS & REDOX SIGNALING