Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms
出版年份 2020 全文链接
标题
Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms
作者
关键词
-
出版物
Cancers
Volume 12, Issue 12, Pages 3781
出版商
MDPI AG
发表日期
2020-12-16
DOI
10.3390/cancers12123781
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Overcoming tamoxifen resistance in oestrogen receptor‐positive breast cancer using the novel thiosemicarbazone anti‐cancer agent, DpC
- (2020) Sundus N. Maqbool et al. BRITISH JOURNAL OF PHARMACOLOGY
- Unique targeting of androgen‐dependent and ‐independent AR signaling in prostate cancer to overcome androgen resistance
- (2020) Syer C. Lim et al. FASEB JOURNAL
- The metastasis suppressor NDRG1 down-regulates the epidermal growth factor receptor via a lysosomal mechanism by up-regulating mitogen-inducible gene 6
- (2019) Sharleen V. Menezes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents
- (2019) Angelica M. Merlot et al. CURRENT MEDICINAL CHEMISTRY
- Two mechanisms involving the autophagic and proteasomal pathways process the metastasis suppressor protein, N-myc downstream regulated gene 1
- (2019) Sumit Sahni et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer
- (2019) Kyung Chan Park et al. FREE RADICAL BIOLOGY AND MEDICINE
- Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding.
- (2019) Kyung Chan Park et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1
- (2018) Kyung Chan Park et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- In vitro assessment of the role of DpC in the treatment of head and neck squamous cell carcinoma
- (2018) Ye‑Xing Xu et al. Oncology Letters
- The Metastasis Suppressor, NDRG1, Attenuates Oncogenic TGF-β and NF-ĸB Signaling to Enhance Membrane E-Cadherin Expression in Pancreatic Cancer Cells
- (2018) Sharleen V Menezes et al. CARCINOGENESIS
- Cancer treatment and survivorship statistics, 2016
- (2016) Kimberly D. Miller et al. CA-A CANCER JOURNAL FOR CLINICIANS
- The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms
- (2016) Zhu-Ling Guo et al. Journal of Hematology & Oncology
- Zinc(II)–Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity
- (2016) Alexandra E. Stacy et al. JOURNAL OF MEDICINAL CHEMISTRY
- A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC
- (2016) Nicole A Seebacher et al. Cell Death & Disease
- Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)
- (2015) Patric J. Jansson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways
- (2015) Zaklina Kovacevic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery
- (2015) Neetu Saxena et al. JNCI-Journal of the National Cancer Institute
- Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathways
- (2015) WEI MA et al. Molecular Medicine Reports
- The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the “Triad of Death” in cancer by Di-2-pyridylketone thiosemicarbazones
- (2015) Patric J. Jansson et al. PHARMACOLOGICAL RESEARCH
- Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
- (2015) Malin Wickström et al. Nature Communications
- SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery
- (2015) Neetu Saxena et al. JNCI-Journal of the National Cancer Institute
- The Anticancer Agent Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Prosurvival Autophagy by Two Mechanisms
- (2014) Elaine Gutierrez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of -catenin through mechanisms involving FRAT1 and PAK4
- (2014) R. Jin et al. JOURNAL OF CELL SCIENCE
- Quantitative Analysis of the Anti-Proliferative Activity of Combinations of Selected Iron-Chelating Agents and Clinically Used Anti-Neoplastic Drugs
- (2014) Eliska Potuckova et al. PLoS One
- LOX/COX inhibitors enhance the antineoplastic effects of all-trans retinoic acid in osteosarcoma cell lines
- (2014) Miroslava Krzyzankova et al. TUMOR BIOLOGY
- Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells
- (2013) K M Dixon et al. BRITISH JOURNAL OF CANCER
- Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors
- (2013) J. Sun et al. CARCINOGENESIS
- The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways
- (2012) Zaklina Kovacevic et al. ANTIOXIDANTS & REDOX SIGNALING
- The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα
- (2012) Jack C. Yalowich et al. BIOCHEMICAL PHARMACOLOGY
- N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis
- (2012) Wen Liu et al. EMBO Molecular Medicine
- Transcriptional and translational regulation of COX-2 expression by cadmium in C6 glioma cells
- (2012) YU-KYOUNG PARK et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- The Iron Chelators Dp44mT and DFO Inhibit TGF-β-induced Epithelial-Mesenchymal Transition via Up-Regulation of N-Myc Downstream-regulated Gene 1 (NDRG1)
- (2012) Zhiqiang Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo
- (2012) David B. Lovejoy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cells
- (2012) Caroline Happold et al. JOURNAL OF NEUROCHEMISTRY
- Metronomic Chemotherapy with the COMBAT Regimen in Advanced Pediatric Malignancies: A Multicenter Experience
- (2012) D. Zapletalova et al. ONCOLOGY
- Targeting apoptosis pathways by Celecoxib in cancer
- (2011) Verena Jendrossek CANCER LETTERS
- Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes
- (2011) D. B. Lovejoy et al. CANCER RESEARCH
- The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms
- (2011) Zaklina Kovacevic et al. CARCINOGENESIS
- Redox control of iron regulatory protein 2 stability
- (2011) Anja Hausmann et al. FEBS LETTERS
- Targeting DNA repair and the cell cycle in glioblastoma
- (2011) Brian M. Alexander et al. JOURNAL OF NEURO-ONCOLOGY
- Novel Thiosemicarbazone Iron Chelators Induce Up-Regulation and Phosphorylation of the Metastasis Suppressor N-myc Down-Stream Regulated Gene 1: A New Strategy for the Treatment of Pancreatic Cancer
- (2011) Z. Kovacevic et al. MOLECULAR PHARMACOLOGY
- Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on Celecoxib-induced apoptosis
- (2009) Justine Rudner et al. BIOCHEMICAL PHARMACOLOGY
- The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase II in Breast Cancer Cells
- (2009) V. A. Rao et al. CANCER RESEARCH
- MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance
- (2009) S. Yip et al. CLINICAL CANCER RESEARCH
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