Deep Learning Predicts Underlying Features on Pathology Images with Therapeutic Relevance for Breast and Gastric Cancer

Artificial intelligence as the next step towards precision pathology

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Deep learning for prediction of colorectal cancer outcome: a discovery and validation study

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Portrait of a cancer: mutational signature analyses for cancer diagnostics

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Detecting the mutational signature of homologous recombination deficiency in clinical samples

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Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy

(2019) Pengfei Zhao et al.   Journal of Hematology & Oncology

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

(2019) Jakob Nikolas Kather et al.   NATURE MEDICINE

Clinical-grade computational pathology using weakly supervised deep learning on whole slide images

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Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancers

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Biomarkers for Homologous Recombination Deficiency in Cancer

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Biomarkers for Homologous Recombination Deficiency in Cancer

(2018) Michal M Hoppe et al.   JNCI-Journal of the National Cancer Institute

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

(2018) Nicolas Coudray et al.   NATURE MEDICINE

Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial

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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

(2017) Paz Polak et al.   NATURE GENETICS

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

(2017) Helen Davies et al.   NATURE MEDICINE

signeR: an empirical Bayesian approach to mutational signature discovery

(2016) Rafael A. Rosales et al.   BIOINFORMATICS

Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

(2016) Maria Secrier et al.   NATURE GENETICS

DNA repair targeted therapy: The past or future of cancer treatment?

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Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

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The DNA damage response and cancer therapy

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

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DNA-damage repair; the good, the bad, and the ugly

(2008) Razqallah Hakem   EMBO JOURNAL