Article
Green & Sustainable Science & Technology
Rossella Vadala, Giovanna Lo Vecchio, Rossana Rando, Michelangelo Leonardi, Nicola Cicero, Rosaria Costa
Summary: The present study developed a cost-effective, energy-saving, and ecofriendly methodology for producing ethanol from citrus fruit waste. This involved pretreating the waste through physical means, followed by enzymatic hydrolysis and fermentation. The process resulted in the production of 40.1 g/L ethanol in 48 hours, and an additional fed batch step increased the ethanol yield to 52.3 g/L. The study successfully achieved its objectives of sustainability.
Review
Nutrition & Dietetics
Jasmine A. Evans, Patricia Mendonca, Karam F. A. Soliman
Summary: Neurodegenerative disorders are a serious health threat, and neuroinflammation and oxidative stress play critical roles in their onset, progression, and pathogenesis. Hesperetin, an aglycone of hesperidin found in citrus fruits, has been shown to have neuroprotective effects in experimental models of neurodegenerative diseases, and can modulate the release of cellular anti-inflammatory and antioxidative stress mediators.
Article
Plant Sciences
Raphael J. Eberle, Danilo S. Olivier, Marcos S. Amaral, Dieter Willbold, Raghuvir K. Arni, Monika A. Coronado
Summary: Hesperidin and Hesperetin exhibit inhibitory effects on DENV2, YFV, and WNV NS2B/NS3 proteases, suggesting the potential development of a new generation of anti-flavivirus drugs through selective optimization of these molecules.
Article
Chemistry, Applied
Meiyu Zheng, Shengmin Lu, Jianrong Xing
Summary: In this study, hesperidin hydrolysates (HHS) were found to have higher radical scavenging activities, higher reducing capacity, and stronger antioxidant activity compared to hesperidin (HDN). HHS also exhibited greater inhibition of NO production and pro-inflammatory cytokines in RAW 264.7 cells than HDN. Additionally, the minor components (MCS) showed synergistic effects with henperetin (HTN) on the above activities.
Article
Food Science & Technology
Paula de Paula Menezes Barbosa, Amanda Roggia Ruviaro, Gabriela Alves Macedo
Summary: The study showed that enzymatic-assisted extraction can effectively extract high amounts of flavanones from citrus pectin by-product, which is important for increasing resource utilization and development of waste products.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Review
Biochemistry & Molecular Biology
Adriana de Cassia Ortiz, Simone Ortiz Moura Fideles, Carlos Henrique Bertoni Reis, Marcia Zilioli Bellini, Eliana de Souza Bastos Mazuqueli Pereira, Joao Paulo Galletti Pilon, Miguel Angelo de Marchi, Claudia Rucco Penteado Detregiachi, Uri Adrian Prync Flato, Beatriz Flavia de Moraes Trazzi, Bruna Trazzi Pagani, Jose Burgos Ponce, Taiane Priscila Gardizani, Fulvia de Souza Veronez, Daniela Vieira Buchaim, Rogerio Leone Buchaim
Summary: Flavonoids are natural phytochemicals that have anti-inflammatory and antioxidant potential, and can positively impact bone health both in vitro and in vivo. They are considered to have therapeutic potential in controlling diseases such as osteoporosis and osteoarthritis.
Article
Plant Sciences
Congcong Zhang, Dingqi Zhang, Yongli Wang, Linzhang Zhang, Shenglan Qi, Qinqin Fang, Ying Xu, Jiamei Chen, Xuemei Cheng, Ping Liu, Changhong Wang, Wei Liu
Summary: This study investigated the pharmacokinetic characteristics and anti-liver fibrosis effect of Amy and its metabolite Pru. The results showed significant differences in the metabolism of Amy and Pru in rat plasma. In in vitro and in vivo experiments, Amy and Pru exhibited comparable anti-liver fibrosis effects. The deglycosylated activated metabolite Pru of Amy plays an important role in anti-liver fibrosis.
Article
Chemistry, Applied
Weidan Guo, Yu Xiao, Xiangjin Fu, Zhao Long, Yue Wu, Qinlu Lin, Kangzi Ren, Liwen Jiang
Summary: In this study, the effect of Douchi extract (DWE) on a-glucosidase and angiotensin-converting enzymes (ACE) was investigated. Peptidomics approach based on UPLC-MS/MS was used to identify several novel peptides with inhibitory activity against a-glucosidase and ACE. The results showed that DWE had high inhibition rates on a-glucosidase and moderate inhibition rates on ACE. Through peptidomics and molecular docking, new peptides with potential inhibitory activity against a-glucosidase and ACE were discovered.
Article
Chemistry, Medicinal
Chi Wang, Pei-Xu Chen, Qiong Xiao, Qiu-Ming Yang, Hui-Fen Weng, Yong-Hui Zhang, An-Feng Xiao
Summary: A non-toxic chitosan-based carrier was successfully constructed for tannase immobilization, achieving better environmental adaptability and stability with enhanced biological activities of tea extract through optimized activation and immobilization conditions.
Article
Chemistry, Medicinal
Yoshinori Fujimura, Takanori Yoshimoto, Konatsu Fujino, Ayaka Nezu, Yuki Marugame, Jaehoon Bae, Motofumi Kumazoe, Hirofumi Tachibana
Summary: Many patients with allergies are hesitant about taking anti-allergic medicines due to side effects and increased expenses. This study found that hesperetin, a compound found in citrus fruits, enhances the ability of a specific anti-allergic catechin to inhibit allergic reactions. It does this by activating a signaling pathway involving an enzyme called acid sphingomyelinase. Furthermore, orally administering another citrus compound called hesperidin also improved the inhibitory potency of a green tea rich in the anti-allergic catechin in mice. These findings suggest that hesperetin amplifies the effectiveness of the anti-allergic catechin in suppressing allergic reactions.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Kazuhiko Nakadate, Kiyoharu Kawakami, Noriko Yamazaki
Summary: Chronic obesity leads to various diseases, highlighting the urgency for treatment and prevention. This study investigated the combined effects of tea catechins and beta-cryptoxanthin from mandarin oranges on reducing obesity using obese mice induced by monosodium glutamate. The results showed that the mice consuming both tea catechins and beta-cryptoxanthin for 4 weeks experienced a significant decrease in body weight, with no difference compared to control mice. In addition, blood biochemical tests were normal, and histopathological analysis indicated a decrease in body fat percentage. Moreover, the abundance of pro-inflammatory M1 macrophages in adipose tissue was significantly reduced, while beneficial M2 macrophages increased and adiponectin levels, involved in suppressing metabolic syndrome, were elevated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Desai, Giuseppe Voza, Silvia Paiardi, Francesca Ilaria Teofilo, Giuseppe Caltagirone, Marta Ripoll Pons, Monia Aloise, Maria Kogan, Tobia Tommasini, Victor Savevski, Giulio Stefanini, Claudio Angelini, Michele Ciccarelli, Salvatore Badalamenti, Ana Lleo De Nalda, Alessio Aghemo, Maurizio Cecconi, Filippo Martinelli Boneschi, Antonio Voza
Summary: The study found that chronic intake of ACE-I was associated with a trend in reduction of mortality in COVID-19 patients, while factors such as increased age and cardiovascular comorbidities were important risk factors for death. Timely treatment with low-molecular-weight heparin in the Emergency Department was also shown to decrease in-hospital mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Agricultural Engineering
Poonam Sharma, Reena Vishvakarma, Krishna Gautam, Archana Vimal, Vivek Kumar Gaur, Alvina Farooqui, Sunita Varjani, Kaiser Younis
Summary: Sources and effects of citrus waste, applications of pectin, technological utilization, and socioeconomic and environmental perspectives.
BIORESOURCE TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Manuel Scherer, Andres G. Santana, Kyle Robinson, Steven Zhou, Hermen S. Overkleeft, Lorne Clarke, Stephen G. Withers
Summary: This study introduces a new class of transient GCase inactivators with improved stability in aqueous media, and validates through cellular research that treatment with these compounds can restore catalytic activity in Gaucher cells.
Article
Food Science & Technology
Xianying Fang, Yuan Dai, Jingqiu Wang, Guoqin Guo, Xiangyang Ge, Linguo Zhao
Summary: In this study, enzyme transformed PNS products (E-PNS) were prepared, and it was found that E-PNS exhibited significantly better anti-tumor activity than PNS. The E-PNS could inhibit the proliferation of 4T1 cells through cell apoptosis and suppress angiogenesis in tumor tissue. The study suggests that enzyme conversion has the potential to promote the application of P. notoginseng as functional food or food addition in cancer prevention and treatment.
Article
Food Science & Technology
Paula de Paula Menezes Barbosa, Amanda Roggia Ruviaro, Isabela Mateus Martins, Juliana Alves Macedo, Gisele LaPointe, Gabriela Alves Macedo
Summary: The study found that citrus pomace extracts and flavanones can inhibit the growth, motility, and adhesion ability of S. Typhimurium, reducing the risk of infection.
Article
Food Science & Technology
Paula de Paula Menezes Barbosa, Amanda Roggia Ruviaro, Gabriela Alves Macedo
Summary: The study showed that enzymatic-assisted extraction can effectively extract high amounts of flavanones from citrus pectin by-product, which is important for increasing resource utilization and development of waste products.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Food Science & Technology
Livia Dias de Queiros, Fernanda Furlan Goncalves Dias, Amanda Rejane Alves de Avila, Juliana Alves Macedo, Gabriela Alves Macedo, Juliana Maria Leite Nobrega de Moura Bell
Summary: The study evaluated the effects of enzymatic extraction strategies on the extractability, bioconversion, and bioaccessibility of biologically active isoflavones from full-fat soy flour. The results showed that enzyme combinations significantly increased the extraction and bioaccessibility of isoflavones, enhancing the antioxidant activity of the extracts.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Annayara C. F. Fernandes, Adina L. Santana, Natalia C. Vieira, Renata L. P. Gandra, Camila Rubia, Ian Castro-Gamboa, Juliana A. Macedo, Gabriela A. Macedo
Summary: Peanut skin extract containing 18 flavonoids demonstrated strong antioxidant potential, showing promising effects in preventing oxidative stress, reducing adipocyte differentiation, and ameliorating hepatic steatosis.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2021)
Article
Food Science & Technology
Julia Cristina Zuin, Renata Luana de Padua Gandra, Ana Paula Badan Ribeiro, Juliana Neves Rodrigues Ract, Juliana Alves Macedo, Gabriela Alves Macedo
Summary: One of the challenges in the food industry is to develop lipid bases with desired technological performance and lower caloric value. This research compares chemical and enzymatic interesterification as methods for obtaining structured low-calorie lipids and finds that interesterification improves the physical properties of the lipids, making them a potential alternative to fats in low-calorie foods.
FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Renata Luana de Padua Gandra, Julia Cristina Zuin, Debora Kono Taketa Moreira, Annayara Celestina Ferreira Fernandes, Alessandra Gambero, Ana Paula Badan Ribeiro, Gabriela Alves Macedo, Juliana Alves Macedo
Summary: The study evaluated the stability and effects of structured lipid nanoemulsion on obesity biomarkers, showing potential for its use as a fat substitute in low-calorie food products.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Camila Rubia Christofoletti, Annayara C. F. Fernandes, Renata L. P. Gandra, Isabela M. Martins, Alessandra Gambero, Gabriela A. Macedo, Juliana A. Macedo
Summary: The biotransformed extracts of wine waste show potential in attenuating oxidative stress and reducing inflammation in vitro. This suggests that utilizing these extracts could modulate metabolic syndrome parameters and provide environmental and economic advantages.
Article
Food Science & Technology
Gabriela A. Macedo, Paula de P. M. Barbosa, Fernanda F. G. Dias, Lauren M. Crawford, Selina C. Wang, Juliana M. L. N. De Moura Bell
Summary: The integration and optimization of microwave-assisted extraction (MEAE) and enzyme-assisted extraction have been shown to improve the extraction efficiency of bioactive phenolics from olive pomace, reducing processing time and costs. The selection of enzymes and adjustment of extraction conditions significantly affect the phenolic profile of the extracts.
Article
Food Science & Technology
Gabriela Alves Macedo, Cintia Rabelo e Paiva Caria, Paula de Paula Menezes Barbosa, Marina Rodrigues Mazine, Alessandra Gambero
Summary: This study evaluated the potential of enzymatic and microbial fermentation processes in improving the absorbability and antioxidant capacity of soy isoflavones. The results showed that enzymatic treatment followed by microbial fermentation effectively converted glycosylated isoflavones into aglycones, and increased the total phenolic content and antioxidant capacity. Furthermore, after in vitro digestion, the treated samples showed higher levels of isoflavones, total phenolic content, and antioxidant capacity.
Article
Biochemistry & Molecular Biology
Paula de Paula Menezes Barbosa, Amanda Roggia Ruviaro, Isabela Mateus Martins, Juliana Alves Macedo, Gisele LaPointe, Gabriela Alves Macedo
