CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

Dimers Aren’t Forever: CD80 Breaks up with PD-L1

(2019) David M. Sansom et al.   IMMUNITY

Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression

(2018) Benjamin J. Schmiedel et al.   CELL

A genome-wide association study identifies six novel risk loci for primary biliary cholangitis

(2017) Fang Qiu et al.   Nature Communications

Transancestral mapping and genetic load in systemic lupus erythematosus

(2017) Carl D. Langefeld et al.   Nature Communications

1,25(OH)2D3Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept

(2015) David H. Gardner et al.   JOURNAL OF IMMUNOLOGY

A Transendocytosis Model of CTLA-4 Function Predicts Its Suppressive Behavior on Regulatory T Cells

(2015) Tie Zheng Hou et al.   JOURNAL OF IMMUNOLOGY

Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

(2015) B. Lo et al.   SCIENCE

Confusing signals: Recent progress in CTLA-4 biology

(2015) Lucy S.K. Walker et al.   TRENDS IN IMMUNOLOGY

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity

(2014) E. M. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

(2014) Desirée Schubert et al.   NATURE MEDICINE

An obligate cell-intrinsic function for CD28 in Tregs

(2013) Ruan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by inducedCD28deletion

(2012) Tea Gogishvili et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells

(2011) Leona Gabryšová et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

Enhancement of Suboptimal CD8 Cytotoxic T Cell Effector Function In Vivo Using Antigen-Specific CD80 Defective T Cells

(2010) I. Puliaeva et al.   JOURNAL OF IMMUNOLOGY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

(2009) L. E. Jeffery et al.   JOURNAL OF IMMUNOLOGY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE