Article
Biochemistry & Molecular Biology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Maria Teresa Schiaffino, Alejandro del Castillo, Barbara Alonso, Miguel A. A. Vega, Amaya Puig-Kroger, Antonio Castrillo, Angel L. Corbi
Summary: Monocyte-derived macrophages play a role in inflammatory diseases and their functions are influenced by the extracellular environment. Liver X Receptors (LXRs) control cholesterol metabolism and macrophage differentiation. Inhibition of LXRs can promote the anti-inflammatory gene and functional profile of human macrophages in a MAFB-dependent manner.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Sebastian J. Theobald, Alexander Simonis, Theodoros Georgomanolis, Christoph Kreer, Matthias Zehner, Hannah S. Eisfeld, Marie-Christine Albert, Jason Chhen, Susanne Motameny, Florian Erger, Julia Fischer, Jakob J. Malin, Jessica Graeb, Sandra Winter, Andromachi Pouikli, Friederike David, Boris Boell, Philipp Koehler, Kanika Vanshylla, Henning Gruell, Isabelle Suarez, Michael Hallek, Gerd Faetkenheuer, Norma Jung, Oliver A. Cornely, Clara Lehmann, Peter Tessarz, Janine Altmueller, Peter Nuernberg, Hamid Kashkar, Florian Klein, Manuel Koch, Jan Rybniker
Summary: Our study reveals that the SARS-CoV-2 spike protein induces inflammasome formation and IL-1 beta release in macrophages from COVID-19 patients, but not in healthy individuals. Furthermore, macrophages isolated from convalescent COVID-19 patients show robust S-protein-driven inflammasome activation, indicating innate immune memory after recovery.
EMBO MOLECULAR MEDICINE
(2021)
Review
Oncology
Holden T. Maecker
Summary: Understanding the interaction of SARS-CoV-2 infection with the host immune system, induction of antibody and T cell responses, importance of innate immune responses, and impact of baseline immune profiles and changes on predicting disease progression are crucial for the development of immune monitoring tools for COVID-19.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Sheng-Kang Chiu, Kuo-Wang Tsai, Chia-Chao Wu, Cai-Mei Zheng, Chung-Hsiang Yang, Wan-Chung Hu, Yi-Chou Hou, Kuo-Cheng Lu, You-Chen Chao
Summary: COVID-19 is characterized by significant immune dysfunction, requiring the development of effective treatments; various types of COVID-19 vaccines are under development and optimization, increasing public immunity may enhance vaccine effectiveness; Vitamin D supplementation may help mitigate the progression of COVID-19, but its role in vaccine efficacy remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Daniel D. Bikle
Summary: The major cause of morbidity and mortality in Covid-19 is the cytokine storm in the lungs, which leads to inflammation and cell damage in the lungs, resulting in death.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Immunology
Ellen McKenna, Richard Wubben, Johana M. Isaza-Correa, Ashanty M. Melo, Aisling Ui Mhaonaigh, Niall Conlon, James S. O'Donnell, Cliona Ni Cheallaigh, Tim Hurley, Nigel J. Stevenson, Mark A. Little, Eleanor J. Molloy
Summary: This article discusses the immunological characteristics of severe COVID-19 patients, the antiviral and pathological roles of neutrophils in SARS-CoV-2 infection, the contribution of neutrophils to complications of COVID-19, and potential therapeutic strategies targeting neutrophil-mediated inflammatory responses in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biology
Sindhu Mohandas, Prasanna Jagannathan, Timothy J. Henrich, Zaki A. Sherif, Christian Bime, Erin Quinlan, Michael A. Portman, Marila Gennaro, Jalees Rehman, RECOVER Mechanist Pathways Task Force
Summary: With over 500 million cases of COVID-19 worldwide, there is increasing concern about the long-term effects known as long COVID. Exaggerated immune responses play a crucial role in the severity and outcomes of both the initial infection and long COVID. This review explores the mechanisms behind immune dysregulation in severe COVID-19 and the limited data on the immunopathology of long COVID, highlighting the need for further research to understand its distinct and heterogeneous immunopathology.
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Emanuel Sarinho, Ekaterini Goudouris, Dirceu Sole
Summary: The BCG vaccine is effective in protecting against severe tuberculosis and may offer some non-specific protection against other infectious diseases, although the duration of this protection is uncertain. Careful consideration should be given before revaccinating with BCG to avoid serious risks to patients with immunodeficiencies.
Article
Immunology
Hiroyuki Saiga, Masaki Ueno, Takashi Tanaka, Tsuneyasu Kaisho, Katsuaki Hoshino
Summary: This study reveals that MafB acts as a negative regulator of type I IFN production in pDCs by interfering with the complex formation of IRF-7 and Spi-B. Decreased MafB expression and degradation in the early phase of immune responses lead to increased type I IFN production. MafB is also involved in resistance against psoriasis-like skin inflammation.
INTERNATIONAL IMMUNOLOGY
(2022)
Article
Cell Biology
Kylie B. R. Belchamber, Onn S. Thein, Jon Hazeldine, Frances S. Grudzinska, Aduragbemi A. Faniyi, Michael J. Hughes, Alice E. Jasper, Kay Por Yip, Louise E. Crowley, Sebastian T. Lugg, Elizabeth Sapey, Dhruv Parekh, David R. Thickett, Aaron Scott
Summary: COVID-19 infection is associated with dysfunctional neutrophil functions, including increased migration, NETosis, and impaired phagocytosis and ROS generation, along with altered phenotype and impaired antimicrobial responses. Targeting neutrophil function may help modulate COVID-19 severity.
Review
Virology
Saade Abdalkareem Jasim, Roaa Salih Mahdi, Dmitry Olegovich Bokov, Mazin A. A. Najm, Guzal N. Sobirova, Zarnigor O. Bafoyeva, Ahmed Taifi, Ola Kamal A. Alkadir, Yasser Fakri Mustafa, Rasoul Mirzaei, Sajad Karampoor
Summary: The interaction between the immune system and SARS-CoV-2 is crucial for understanding COVID-19 pathogenesis and developing therapeutic tools. Different immune components play various roles in viral infections, and characterizing the immune reactions is essential for defining the pathogenicity of COVID-19. Furthermore, investigating the roles of other immune mediators in the immunopathogenesis of COVID-19 is necessary.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Immunology
Gurpreet Kaur, Sanpreet Singh, Sidhanta Nanda, Mohammad Adeel Zafar, Jonaid Ahmad Malik, Mohammad Umar Arshi, Taruna Lamba, Javed Naim Agrewala
Summary: The BCG vaccine, used against Mycobacterium tuberculosis, is known to induce non-specific heterologous immunity and may have a role in protecting against COVID-19. However, the effectiveness of vaccines against COVID-19 remains uncertain.
Review
Immunology
Patricia Lamadrid, Marta Alonso-Pena, David San Segundo, Mayte Arias-Loste, Javier Crespo, Marcos Lopez-Hoyos
Summary: This study focuses on the association between COVID-19 and MAFLD, highlighting that patients with metabolic syndrome are more susceptible to severe COVID-19. The role of the immune system in both diseases is discussed, providing potential therapeutic targets and prognostic biomarkers for further research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sharvan Sehrawat, Barry T. Rouse
Summary: The dose and presentation of the infecting virus play a crucial role in determining the outcomes of COVID-19 infection, with higher doses potentially leading to more severe consequences. Further research and testing are needed to explore practical maneuvers and untested procedures that aim to increase the threshold dose required to break through resistance barriers.
MICROBES AND INFECTION
(2021)
Article
Immunology
Lizbeth Estrada-Capetillo, Laura Aragoneses-Fenoll, Angeles Dominguez-Soto, Sara Fuentelsaz-Romero, Concha Nieto, Miriam Simon-Fuentes, Barbara Alonso, Pilar Portoles, Angel L. Corbi, Jose M. Rojo, Amaya Puig-Kroger
Summary: CD28 expression is not limited to T lymphocytes but also exists in macrophages with regulatory functions. Defective CD28 expression in mouse macrophages affects gene expression profile and functionality. Therefore, CD28 expression may serve as a hallmark of anti-inflammatory macrophages and a potential target for immunotherapy.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Victor D. Cuevas, Miriam Simon-Fuentes, Emmanuel Orta-Zavalza, Rafael Samaniego, Paloma Sanchez-Mateos, Maria Escribese, Francisco J. Cimas, Matilde Bustos, Mario Perez-Diego, Alberto Ocana, Angeles Dominguez-Soto, Miguel A. Vega, Angel L. Corbi
Summary: During inflammatory responses, monocytes can differentiate into monocyte-derived macrophages with distinct transcriptional profiles, which are partially regulated by IL-10. This specific gene expression signature may provide potential targets for macrophage-centered therapeutic strategies.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Immunology
Miriam Simon-Fuentes, Silvia Sanchez-Ramon, Lidia Fernandez-Paredes, Barbara Alonso, Kissy Guevara-Hoyer, Miguel A. Vega, Angel L. Corbi, Angeles Dominguez-Soto
Summary: Common variable immunodeficiency disorders (CVID) is a primary immune deficiency characterized by hypogammaglobulinemia and impaired antibody responses. Intravenous Immunoglobulin (IVIg), a preparation of highly purified poly-specific IgG, exerts immunoregulatory and anti-inflammatory actions on peripheral blood monocytes, leading to an acquisition of an anti-inflammatory gene profile and altered proportions of monocyte subsets. CD14+ MDSC-like cells may contribute to the immunoregulatory effects of IVIg in CVID and other inflammatory disorders.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Alejandra Comins-Boo, Lorena Valdeolivas, Fernando Perez-Pla, Ignacio Cristobal, Nabil Subhi-Issa, Angeles Dominguez-Soto, Lydia Pilar-Suarez, Pilar Gasca-Escorial, Marta Calvo-Urrutia, Miguel Fernandez-Arquero, Miguel Angel Herraiz, Angel Corbi, Silvia Sanchez-Ramon
Summary: This study aimed to evaluate the role of monocyte subsets and cytokines in RPL and RIF women. The study found that CX3CR1+ and CCR5+ intermediate monocytes were significantly higher in RPL and RIF, and there was a significant positive correlation between CX3CR1+ intermediate monocytes and IL-17A. The combination of specific monocyte subsets and cytokines could aid in identifying RPL and RIF women with a pro-inflammatory profile.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Maria Teresa Schiaffino, Alejandro del Castillo, Barbara Alonso, Miguel A. A. Vega, Amaya Puig-Kroger, Antonio Castrillo, Angel L. Corbi
Summary: Monocyte-derived macrophages play a role in inflammatory diseases and their functions are influenced by the extracellular environment. Liver X Receptors (LXRs) control cholesterol metabolism and macrophage differentiation. Inhibition of LXRs can promote the anti-inflammatory gene and functional profile of human macrophages in a MAFB-dependent manner.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Alba Garrido-Trigo, Ana M. Corraliza, Marisol Veny, Isabella Dotti, Elisa Melon-Ardanaz, Aina Rill, Helena L. Crowell, Angel Corbi, Victoria Gudino, Miriam Esteller, Iris alvarez-Teubel, Daniel Aguilar, M. Carme Masamunt, Emily Killingbeck, Youngmi Kim, Michael Leon, Sudha Visvanathan, Domenica Marchese, Ginevra Caratu, Albert Martin-Cardona, Maria Esteve, Julian Panes, Elena Ricart, Elisabetta Mereu, Holger Heyn, Azucena Salas
Summary: Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. Single-cell technologies are applied to explore the transcriptional states within tissues and spatially localize macrophages and neutrophils subsets, revealing further macrophage diversity based on tissue localization and communication network involving macrophages and inflammatory fibroblasts. The cellular complexity of these diseases and myeloid and stromal compartments are important for understanding patient-to-patient heterogeneity.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Miriam Simon-Fuentes, Cristina Herrero, Lucia Acero-Riaguas, Concha Nieto, Fatima Lasala, Nuria Labiod, Joanna Luczkowiak, Barbara Alonso, Rafael Delgado, Maria Colmenares, Angel L. Corbi, Angeles Dominguez-Soto
Summary: This study investigates the expression and function of Toll-like receptor 7 (TLR7) in monocyte-derived macrophages. TLR7 activation leads to the production of type I interferon and reprograms the gene transcription profile of these cells, inducing the expression of neutrophil-attracting chemokines. The results suggest that aberrant TLR7 signaling is associated with delayed resolution of inflammation following viral infection.
JOURNAL OF INNATE IMMUNITY
(2023)