Article
Fisheries
Yu Liang, Ke-Cheng Zhu, Ying-Zhe You, Hua-Yang Guo, He-Dong Chen, Bao-Suo Liu, Nan Zhang, Yan-Bin Dai, Fan-Rong Zeng, Huan-Yang Lin, Dian-Chang Zhang
Summary: This study identified the TNF-α and IFN-γ genes of yellowfin seabream and determined their evolutionary relationships and gene expressions. The results showed that the expression of TNF-α and IFN-γ in yellowfin seabream is greatly affected by density stress. The optimal transportation density is 125 per bag for 4-5 cm fry or 1200 per bag for 1-2 cm fry.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Jian Zhang, Yao Lu, Yangming Mao, Yue Yu, Tianyu Wu, Wei Zhao, Yeqian Zhu, Pengcheng Zhao, Fengxiang Zhang
Summary: Exosomes derived from MSCs activated with IFN-gamma exhibit enhanced cardioprotective effects by upregulating miR-21 and directly targeting BTG2 to promote angiogenesis and reduce apoptosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Danielle M. Wiese, Catherine A. Wood, Barry N. Ford, Lorena R. Braid
Summary: This study compared the response of mesenchymal stromal cells (MSCs) from different donors and sources to cytokine activation. The results showed that the dynamic responses of licensed MSCs attenuated the heterogeneity between unstimulated populations and provided new insights into standardized assays.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Megan Fahey, Maureen Bennett, Matthew Thomas, Kaylee Montney, Irene Vivancos-Koopman, Brenna Pugliese, Lindsay Browning, Lawrence J. Bonassar, Michelle Delco
Summary: MSCs can transfer mitochondria to stressed chondrocytes in order to promote healing after cartilage injury.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ya-Chu Tsai, Hsun-Hao Chang, Sheng-Chieh Chou, Thomas W. Chu, Yu-Jou Hsu, Chien-Yu Hsiao, Yuan-Hsin Lo, Nan-Lin Wu, Der-Chen Chang, Chi-Feng Hung
Summary: Alpha-boswellic acid has shown efficacy in reducing inflammation, improving skin hydration, and reducing cytokine expression, suggesting its potential as a component in the development of anti-atopic dermatitis drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Eui Jeong Han, Hyun-Soo Kim, Kyungsook Jung, Kalu Kapuge Asanka Sanjeewa, Kalahe Hewage Iresha Nadeeka Madushani Herath, WonWoo Lee, Youngheun Jee, You-Jin Jeon, Jeongjun Lee, Taehee Kim, Ilekuttige Priyan Shanura Fernando, Ginnae Ahn
Summary: The study demonstrated that Sargassum horneri 70% ethanol extracts (SHE) has significant anti-inflammatory effects in both TNF-alpha/IFN-gamma-induced inflammation in HaCaT keratinocytes and TPA-induced ear edema in mice. Further research could potentially develop SHE as a food supplement/nutricosmetic to enhance protective effects against inflammatory skin diseases.
Article
Cell & Tissue Engineering
Chenyang Liu, Yan Xu, Yichi Lu, Pan Du, Xiaoxiao Li, Chengchun Wang, Peng Guo, Ling Diao, Guozhong Lu
Summary: The study demonstrates that S-IT MSCs can effectively induce M2 polarization of macrophages via IL-6 dependent signaling pathways and accelerate wound healing. Results show that S-IT MSCs significantly enhance the ability of M2 phenotype to promote vascularization and collagen deposition, ultimately improving wound healing quality.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Margherita Boieri, Emanuela Marchese, Quan Minh Pham, Marjan Azin, Lauren E. Steidl, Anna Malishkevich, Shadmehr Demehri
Summary: Research shows that TSLP-activated CD4(+) T cells have antitumor effects in advanced breast cancer by inducing cancer cells into a senescent-like state. Inflammatory CD4(+) T cells release interferon-gamma and tumor necrosis factor-alpha, which directly affects cancer cell receptors, driving them into senescence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Nermeen M. El Bakary, Asmaa Z. Alsharkawy, Zeinab A. Shouaib, Emad M. S. Barakat
Summary: This study evaluates the immune-stimulating and pro-apoptotic effects of chrysin on tumor growth and cell susceptibility to ionizing radiation. The results show that chrysin can significantly reduce tumor proliferation and improve tumor cell sensitivity to radiation therapy.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Immunology
Sarra Ait Djebbara, Saria Mcheik, Pauline Percier, Noria Segueni, Antoine Poncelet, Carine Truyens
Summary: We previously found that recombinant rTcMIP can stimulate the release of IFN-γ, CCL2, and CCL3, which are important for type 1 adaptive immune response. Additionally, it can enhance antibody response and promote Th1-related antibody production. In this study, we investigated the pathways and mechanism of action of rTcMIP using cord and adult blood cells, as well as isolated NK cells and monocytes. We discovered that rTcMIP activates TLR1/2 and TLR4 independently of CD14 and induces IFN-γ production by IL-15-primed NK cells, and TNF-α secretion by monocytes and myeloid dendritic cells through the MyD88 pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Suhaila Nafee Darogha
Summary: The research evaluated the relationship between serum levels and gene polymorphism of IFN-γ and TNF-α in Kurdish patients with T2DM. Significant differences were found in serum levels of IFN-γ between T2DM patients and the control group, while TNF-α levels did not differ significantly. Specific genotypes of IFN-γ and TNF-α showed significantly higher frequencies in T2DM patients.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Parasitology
Samuel Cota Teixeira, Rafaela J. Silva, Janice B. Lopes-Maria, Angelica O. Gomes, Mariana B. Angeloni, Marise L. Fermino, Maria C. Roque-Barreira, Neide M. Silva, Deise A. O. Silva, Jose R. Mineo, Eloisa A. V. Ferro, Bellisa F. Barbosa
Summary: TGF-beta 1 and IFN-gamma play different roles in regulating ICAM-1 expression, which may interfere with the adhesion/invasion of T. gondii to BeWo and HeLa cells, modulating susceptibility to infection.
Article
Biochemistry & Molecular Biology
Changying Liao, Zuolong Wang, Hongmei Li, Fengrong Zhao, Ling Ling
Summary: This study aimed to investigate the effect of combined treatment of deacetylated chitosan and two microscopes on IFN-gamma and ICAM-1 levels in tubal obstruction infertility. The results showed that the combined use of chitosan and endoscopy had better therapeutic effects, reducing the levels of IFN-gamma and ICAM-1, and decreasing the occurrence of pelvic adhesion.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Alyaa Farid, Merna Haytham, Abdelrahman Essam, Gehan Safwat
Summary: The study demonstrated that the aqueous extract of Siwa dates had significant protective effects against radiation-induced liver damage, oxidative stress, inflammation, and DNA damage.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2021)
Review
Rheumatology
Fabrizio De Benedetti, Giusi Prencipe, Claudia Bracaglia, Emiliano Marasco, Alexei A. Grom
Summary: Interferon-gamma (IFN gamma) plays a crucial role in immune responses and its overproduction is associated with hyperinflammation. Research has identified relevant biomarkers related to IFN gamma and shown promising results of IFN gamma-neutralizing agents in the treatment of specific diseases.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Article
Oncology
Itzen Aguiniga-Sanchez, Frida Montserrat Melendez-Ibarra, Edgar Ledesma-Martinez, Benny Weiss-Steider, Guadalupe Rosario Fajardo-Orduna, Rosalva Rangel-Corona, Sac-Nicte Garcia-Gervasio, Maria Guadalupe Ramirez-Padilla, Jose Luis Lara-Castaneda, Edelmiro Santiago-Osorio
Summary: The combination of sodium caseinate with cytarabine or daunorubicin shows synergistic effects in eliminating leukemic cells, promoting survival, and preserving normal hematopoietic cells in both in vitro and in leukemic mice models.
JOURNAL OF ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nadia Flores-Huerta, Macrina B. Silva-Cazares, Lourdes A. Arriaga-Pizano, Jessica L. Prieto-Chavez, Cesar Lopez-Camarillo
Summary: Breast cancer stem cells (bCSC), as a small subset of tumor cells with self-renewal properties and tumorigenic characteristics, play a key role in the development of breast cancer. Studies have shown that non-coding RNAs such as lncRNAs and miRNAs play important roles in regulating the stemness of bCSC.
Review
Biochemistry & Molecular Biology
Guadalupe Rosario Fajardo-Orduna, Edgar Ledesma-Martinez, Itzen Aguiniga-Sanchez, Maria de Lourdes Mora-Garcia, Benny Weiss-Steider, Edelmiro Santiago-Osorio
Summary: AML, the most common type of leukemia in older adults, originates from the clonal expansion of undifferentiated hematopoietic progenitor cells. Despite significant advances in understanding the molecular panorama of AML and the development of therapies targeting mutations, drug resistance remains the main obstacle to treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Sandra Rosas-Madrigal, Maria Teresa Villarreal-Molina, Jose Flores-Rivera, Veronica Rivas-Alonso, Luis Rodrigo Macias-Kauffer, Graciela Ordonez, Maria del Carmen Chima-Galan, Victor Acuna-Alonzo, Gaston Macin-Perez, Rodrigo Barquera, Julio Granados, Ricardo Valle-Rios, Teresa Corona, Alessandra Carnevale, Sandra Romero-Hidalgo
Summary: This study identified an association between TMPO gene variation and NMOSD risk, as well as a significant interaction with the previously associated HLA-class II gene variant. Individuals carrying both risk alleles had a 3.9-fold increased risk of NMOSD, highlighting the potential contribution of specific genetic variants to the disease in admixed Latin American populations.
FRONTIERS IN GENETICS
(2021)
Review
Medicine, Research & Experimental
Arturo Cerbulo Vazquez, Lourdes Arriaga-Pizano, Eduardo Ferat-Osorio
Summary: Sepsis, caused by pathogen invasion and unregulated response, poses a threat to patient lives with increasing incidence and high mortality rates globally. Understanding the role of cells and inflammatory mediators in host responses is crucial for developing medical treatments to regulate immune responses.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Computer Science, Interdisciplinary Applications
Lourdes Andrea Arriaga-Pizano, Marcos Angel Gonzalez-Olvera, Eduardo Antonio Ferat-Osorio, Jesica Escobar, Ana Luisa Hernandez-Perez, Cristina Revilla-Monsalve, Constatino Lopez-Macias, Jose Israel Leon-Pedroza, Graciela Libier Cabrera-Rivera, Uriel Guadarrama-Aranda, Ron Leder, Ana Gabriela Gallardo-Hernandez
Summary: The study proposed using a neural network to diagnose sepsis by utilizing common laboratory tests and vital signs with high sensitivity and specificity. The neural network system designed could accurately identify patients with sepsis, utilizing minimal resources and improving patient outcomes.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Immunology
Mariana Lopez-Filloy, Flor J. Cortez, Tarik Gheit, Omar Cruz y Cruz, Fernando Cruz-Talonia, Monserrat Chavez-Torres, Cristina Arteaga-Gomez, Ismael Mancilla-Herrera, Juan J. Montesinos, Victor Adrian Cortes-Morales, Cecilia Aguilar, Massimo Tommasino, Sandra Pinto-Cardoso, Leticia Rocha-Zavaleta
Summary: Cervical ectopy, a benign condition in the lower genital tract, is common among reproductive-age women. Although it is considered a physiological condition, some women experience symptoms that require medical intervention. While cervical ectopy is not linked to cervical cancer, it may facilitate the acquisition of sexually transmitted diseases. This study examined the presence of HPV and its impact on the cervicovaginal microenvironment in women with symptomatic cervical ectopy. The results showed that HPV infection and dysbiotic vaginal communities were associated with delayed recovery of the cervical epithelium and increased risk of STD acquisition.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Edgar Sanchez-Ramirez, Thi Phuong Lien Ung, Alejandro Alarcon del Carmen, Ximena del Toro-Rios, Guadalupe R. Fajardo-Orduna, Lilia G. Noriega, Victor A. Cortes-Morales, Armando R. Tovar, Juan Jose Montesinos, Ricardo Orozco-Solis, Chiara Stringari, Lorena Aguilar-Arnal
Summary: This study reveals the role of NAD(+) and SIRT1 in adipogenic differentiation, demonstrating that NAD(+) inhibits adipocyte commitment while SIRT1 is essential for terminal differentiation of pre-adipocytes and regulates subcellular compartmentalization of redox metabolism.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Cell Biology
Victor Adrian Cortes-Morales, Luis Chavez-Sanchez, Leticia Rocha-Zavaleta, Sandra Espindola-Garibay, Alberto Monroy-Garcia, Marta Elena Castro-Manrreza, Guadalupe Rosario Fajardo-Orduna, Teresa Apresa-Garcia, Marcos Gutierrez-de la Barrera, Hector Mayani, Juan Jose Montesinos
Summary: This study found that MSCs derived from cervical cancer (CeCa-MSCs) have the ability to promote M2 macrophage polarization, unlike MSCs derived from normal cervix (NCx-MSCs). CeCa-MSCs increase the production of anti-inflammatory molecules (IL-10 and IL-1RA) to regulate antitumor immune responses.
Article
Medicine, Research & Experimental
Ruth Lizzeth Madera-Sandoval, Arturo Cerbulo-Vazquez, Lourdes Andrea Arriaga-Pizano, Graciela Libier Cabrera-Rivera, Edna Basilio-Galvez, Patricia Esther Miranda-Cruz, Maria Teresa Garcia de la Rosa, Jessica Lashkmin Prieto-Chavez, Silvia Vanessa Rivero-Arredondo, Alonso Cruz-Cruz, Daniela Rodriguez-Hernandez, Maria Eugenia Salazar-Rios, Enrique Salazar-Rios, Esli David Serrano-Molina, Roberto Carlos De Lira-Barraza, Abel Humberto Villanueva-Compean, Alejandra Esquivel-Pineda, Ruben Ramirez-Montes de Oca, Omar Unzueta-Marta, Guillermo Flores-Padilla, Juan Carlos Anda-Garay, Luis Alejandro Sanchez-Hurtado, Salvador Calleja-Alarcon, Laura Romero-Gutierrez, Rafael Torres-Rosas, Laura C. Bonifaz, Rosana Pelayo, Edna Marquez-Marquez, Constantino I. I. I. Roberto Lopez-Macias, Eduardo Ferat-Osorio
Summary: The difficulty in predicting fatal outcomes in patients with COVID-19 impacts the burden on hospitals and their services. This study found that comorbidities such as hypertension and chronic renal failure were more common in deceased patients. The presence of mixed hypercytokinemia and a higher neutrophil-lymphocyte ratio were associated with increased risk of death.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Guadalupe Rosario Fajardo-Orduna, Edgar Ledesma-Martinez, Itzen Aguiniga-Sanchez, Benny Weiss-Steider, Edelmiro Santiago-Osorio, Erik A. C. Wiemer, Ignacio Camacho-Arroyo, Jorge Melendez-Zajgla, Mahara A. Valverde Ramirez, Mauricio Rodriguez-Dorantes
Summary: Leukemias of the AML, CML, and CLL types are the most common blood cancers worldwide, posing a major global public health problem. Drug resistance, one of the main obstacles in leukemia treatment, may involve the epigenetic regulator SIRT1, which has been found to play a role in both promoting and inhibiting tumor development. This review explores the role of SIRT1 in drug-resistant leukemia and its potential as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Omar Escobar-Chavarria, Alejandro Benitez-Guzman, Itzel Jimenez-Vazquez, Jacobo Carrisoza-Urbina, Lourdes Arriaga-Pizano, Sara Huerta-Yepez, Guillermina Baay-Guzman, Jose A. Gutierrez-Pabello
Summary: The necrotic cell death induced by Mycobacterium bovis and the inflammasome activation in bovine macrophages help control bacterial growth.
Article
Cardiac & Cardiovascular Systems
Maria Jose Garces-Hernandez, Karen Pedraza-Escudero, Nayely Garibay-Nieto, Joselin Hernandez-Ruiz, Jessica Lakshmi Prieto-Chavez, Lourdes Andrea Arriaga-Pizano, Erendira Villanueva-Ortega, Galileo Escobedo, Aaron Noe Manjarrez-Reyna, Juan Carlos Lopez-Alvarenga, Jose Luis Perez-Hernandez, Gloria Queipo-Garcia
Summary: The expression of CCR2(+) monocyte subsets is significantly associated with subclinical atherosclerosis risk in boys, while in girls, no such association is observed.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)