Article
Medicine, Research & Experimental
Peng Deng, Zining Wang, Jinghong Chen, Shini Liu, Xiaosai Yao, Shaoyan Liu, Lizhen Liu, Zhaoliang Yu, Yulin Huang, Zhongtang Xiong, Rong Xiao, Jiuping Gao, Weiting Liang, Jieping Chen, Hui Liu, Jinghan Hong, Jason Yongsheng Chan, Peiyong Guan, Jianfeng Chen, Yali Wang, Jiaxin Yin, Jundong Li, Min Zheng, Chao Zhang, Penghui Zhou, Tiebang Kang, Bin Tean Teh, Qiang Yu, Zhixiang Zuo, Qingping Jiang, Jihong Liu, Ying Xiong, Xiaojun Xia, Jing Tan
Summary: In this study, RAD21 overexpression in ovarian cancer was found to be inversely correlated with IFN signature gene expression. RAD21 was shown to directly interact with YAP/TEAD4 and recruit NuRD complex to suppress IFN signaling. The study also demonstrated that RAD21 ablation enhanced the efficacy of anti-PD-1 treatment, suggesting RAD21 as a potential target and biomarker for precision immunotherapy in ovarian cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
[Anonymous]
Summary: Tumor immunology and cancer immunotherapy is a rapidly evolving field that has seen the implementation of various immunotherapies across different tumor types in the past decade. Novel strategies to overcome resistance and address the tumor microenvironment are currently the focus of research in this area. The Spanish Group for Cancer Immuno-Biotherapies (GeTICA) recently organized the IX Forum on Translational Immunology and Cancer Immunotherapy (FITCancer 9) in Madrid, which is the largest meeting dedicated to cancer immunotherapy and brings together clinicians, researchers, and experts in the field. This article presents abstracts from GeTICA members submitted to the forum.
Review
Medicine, General & Internal
Shufei Yu, Shuyang Zhang, Haiyan Xu, Guangjian Yang, Fei Xu, Liang Yang, Duo Chen, Guangyu An, Yan Wang
Summary: This meta-analysis investigates the efficacy of immune checkpoint inhibitors (ICIs) compared to chemotherapy in lung cancer patients with liver or brain metastases. The results show that ICIs are more effective than chemotherapy in these patients, with less benefit observed in patients with liver metastases and greater benefit observed in patients with brain metastases, specifically in non-small cell lung cancer patients.
Article
Gastroenterology & Hepatology
Carla Montironi, Florian Castet, Philipp K. Haber, Roser Pinyol, Miguel Torres-Martin, Laura Torrens Fontanals, Agavni Mesropian, Huan Wang, Marc Puigvehi, Miho Maeda, Wei Qiang Leow, Elizabeth Harrod, Patricia Taik, Jigjidsuren Chinburen, Erdenebileg Taivanbaatar, Enkhbold Chinbold, Manel Sole Arques, Michael Donovan, Swan Thung, Jaclyn Neely, Vincenzo Mazzaferro, Jeffrey Anderson, Sasan Roayaie, Myron Schwartz, Augusto Villanueva, Scott L. Friedman, Andrew Uzilov, Daniela Sia, Josep M. Llovet
Summary: This study characterizes the immunogenomic contexture of hepatocellular carcinoma (HCC) and defines inflamed and non-inflamed tumors. Two distinct patterns of CTNNB1 are associated with differential immune evasion and may help predict immune response in HCC.
Review
Immunology
Zihan Deng, Lisen Lu, Binghui Li, Xiujuan Shi, Honglin Jin, Weidong Hu
Summary: Inflammation is a critical feature in all stages of tumor development. Inflammasomes, as an important component of the inflammatory response and innate immune system, regulate infiltrating immune cell activity by signaling the secretion of different cytokines and chemokines. The expression patterns of inflammasomes vary across tumor types and stages, and understanding their specific effects is crucial for developing inflammasome-targeting drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Noel E. Donlon, Maria Davern, Fiona O'Connell, Andrew Sheppard, Aisling Heeran, Anshul Bhardwaj, Christine Butler, Ravi Narayanasamy, Claire Donohoe, James J. Phelan, Niamh Lynam-Lennon, Margaret R. Dunne, Stephen Maher, Jacintha O'Sullivan, John Reynolds, Joanne Lysaght
Summary: The study aimed to immunophenotype OAC patients' immune checkpoint (IC) expression with and without radiation and evaluate the effects of checkpoint blockade on cell viability.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Medicine, General & Internal
Amy L. Shaver, Nikita Nikita, Swapnil Sharma, Daniel S. Lefler, Atrayee Basu-Mallick, Jennifer M. Johnson, Meghan L. Butryn, Grace Lu-Yao
Summary: This study aims to investigate the influence of sex on the outcomes of cancer patients receiving ICI therapy and identify any knowledge gaps in this field.
Article
Medicine, General & Internal
Tao Yang, Lizheng Hao, Xinyu Yang, Changyong Luo, Guomi Wang, Caroline Lin Cai, Shuo Qi, Zhong Li
Summary: This study evaluated the association between pretreatment dNLR and prognosis of patients with NSCLC treated with ICIs through systematic review and meta-analysis. The results showed that higher dNLR levels significantly predicted poor overall survival and progression-free survival in NSCLC patients.
Review
Cell Biology
Guilhem Lalle, Julie Twardowski, Yenkel Grinberg-Bleyer
Summary: NF-kappa B plays a crucial role in immune responses to cancer and could be targeted by novel immunotherapies.
Review
Medicine, General & Internal
Miaoqi Chen, Ridesh Raj, Louis Fox, Charlotte Louise Moss, Gincy George, Sophia N. Karagiannis, Deborah Enting, Magdalene Joseph, Nicola Peat, Beth Russell, Mieke Van Hemelrijck
Summary: This scoping review aims to identify possible physical activity interventions, their efficacy and feasibility, and the potential underlying biological mechanisms responsible for their effects on cancer immunotherapy using immune checkpoint inhibitors (ICIs).
Article
Multidisciplinary Sciences
Goran Micevic, Andrew Daniels, Karine Flem-Karlsen, Koonam Park, Ronan Talty, Meaghan McGeary, Haris Mirza, Holly N. Blackburn, Esen Sefik, Julie F. Cheung, Noah I. Hornick, Lilach Aizenbud, Nikhil S. Joshi, Harriet Kluger, Akiko Iwasaki, Marcus W. Bosenberg, Richard A. Flavell
Summary: This study identifies a specific immune cell population with high IL-7R expression that plays a critical role in antitumor memory and can be enhanced through epigenetics to generate powerful antitumor immune responses. These findings have significant implications for preventing melanoma recurrence and developing new treatment options.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Youhuai Li, Mina Wang, Xueqiang Peng, Yingying Yang, Qishuang Chen, Jiaxing Liu, Qing She, Jichao Tan, Chuyuan Lou, Zehuan Liao, Xuexin Li
Summary: Messenger ribonucleic acid (mRNA) vaccines are a promising therapy for infectious diseases and cancer, particularly in the case of SARS-CoV2. Compared to conventional cancer vaccines, mRNA vaccines have advantages such as efficient immune response production, low side effects, and lower acquisition cost. This review discusses the development of cancer vaccines, mRNA cancer vaccines, their potential biological mechanisms, recent progress in tumor treatments, and future challenges and directions in the field.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Piotr Peczek, Monika Gajda, Kacper Rutkowski, Marta Fudalej, Andrzej Deptala, Anna M. Badowska-Kozakiewicz
Summary: Cancer cells can escape immune destruction and exploit tumor-associated inflammation, leading to tumor progression. Understanding the roles of immune cell populations and reshaping tumor-associated inflammation can improve cancer therapy efficacy. Increased tumor-associated inflammation can overcome cancer-derived immunosuppression, while specific methods like cancer vaccines and chimeric antigen receptor T cells can enhance the immune system's ability to destroy cancer cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Immunology
Julie M. Garcia, Cassandra E. Burnett, Kole T. Roybal
Summary: Synthetic biology tools, such as chimeric antigen receptors (CARs), have shown promise in targeting and improving immune cell responses to tumors, particularly in curing blood cancers. However, there are challenges in designing and translating these complex cell therapies for patients with immune refractory solid tumors. This article focuses on principles for engineering future cell therapies to increase clinical impact and provides an overview of the current state of synbio cell therapy design for cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Immunology
Anne Mette Askehoj Romer, Marie-Louise Thorseth, Daniel Hargbol Madsen
Summary: During tumor growth, the extracellular matrix undergoes remodeling, with a tumor-specific ECM of higher collagen density being associated with poor prognosis in cancer. Recent studies suggest that collagen can influence the function and phenotype of tumor-infiltrating immune cells, potentially affecting cancer progression and immunotherapy efficacy. Knowledge of collagen's immune modulatory functions may help improve current cancer therapies and develop new treatments.
FRONTIERS IN IMMUNOLOGY
(2021)