Severe Acute Respiratory Syndrome Coronavirus-2 Induces Cytokine Storm and Inflammation During Coronavirus Disease 19: Perspectives and Possible Therapeutic Approaches

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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COVID-19: combining antiviral and anti-inflammatory treatments

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Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

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(2020) Andrea Du Toit   NATURE REVIEWS MICROBIOLOGY

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Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

(2020) Yajing Fu et al.   VIROLOGICA SINICA

Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More

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Tocilizumab: A Therapeutic Option for the Treatment of Cytokine Storm Syndrome in COVID-19

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Extensive Partnership, Collaboration, and Teamwork is Required to Stop the COVID-19 Outbreak

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

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The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

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Consider TLR5 for new therapeutic development against COVID‐19

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Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

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Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

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Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

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Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Effective treatment of severe COVID-19 patients with tocilizumab

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COVID-19 treatment: close to a cure? A rapid review of pharmacotherapies for the novel coronavirus (SARS-CoV-2)

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Molecular Pathogenesis, Immunopathogenesis and Novel Therapeutic Strategy Against COVID-19

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SARS‐CoV ‐2 multifaceted interaction with the human host. Part II : Innate immunity response, immunopathology, and epigenetics

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The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions

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Clinical evaluation of Shufeng Jiedu Capsules combined with umifenovir (Arbidol) in the treatment of common-type COVID-19: a retrospective study

(2020) Jing Chen et al.   Expert Review of Respiratory Medicine

Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases

(2020) Zixin Shu et al.   Frontiers of Medicine

Severe COVID-19: what have we learned with the immunopathogenesis?

(2020) Bruno Bordallo et al.   Advances in Rheumatology

Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV

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Human Coronavirus: Host-Pathogen Interaction

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Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

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Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2

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Mechanisms and Management of Chimeric Antigen Receptor T-Cell Therapy-Related Toxicities

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Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

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Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

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Control of adaptive immunity by the innate immune system

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Analysis of Influence of Baicalin Joint Resveratrol Retention Enema on the TNF-α, SIgA, IL-2, IFN-γ of Rats with Respiratory Syncytial Virus Infection

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Natural products: A continuing source of novel drug leads

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Interspecies transmission and emergence of novel viruses: lessons from bats and birds

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Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris

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Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model

(2012) Yiwu Yan et al.   CELL RESEARCH

Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response

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Inhibitory activities of baicalin against renin and angiotensin-converting enzyme

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Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

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Toll-like receptors and innate immunity

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Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

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Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2

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