Article
Environmental Sciences
Ariana Smies, Jeremy Wales, Maureen Hennenfent, Laura Lyons, Caleigh Dunn, Jooke Robbins, Bruce P. Lee, Alexandre Zerbini, Rupak M. Rajachar
Summary: A study found that using polydopamine surface coatings can reduce the adhesion of model bacteria on satellite telemetry tags, thereby reducing the chances of infection. These coatings release low doses of hydrogen peroxide and remain effective even when bacteria develop resistance to it.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Liru Tan, Tang Zhu, Yuchan Huang, Huixin Yuan, Ludi Shi, Zijuan Zhu, Pingping Yao, Caizhen Zhu, Jian Xu
Summary: This study successfully develops a green strategy to accelerate and control dopamine polymerization using ozone. The resulting polydopamine coatings exhibit highly homogeneous morphology, good hydrophilicity, and exceptional stability.
Article
Biophysics
Xiao Meng, Hao Xiong, Fangling Ji, Xiaorong Gao, Lulu Han, Zhenlin Wu, Lingyun Jia, Jun Ren
Summary: This study presents a simple surface treatment strategy to form antimicrobial coatings on medical plastics. The method involves activating the surface and using lysozyme to inhibit bacterial colonization and biofilm formation. This lysozyme-based antimicrobial coating is effective and can be applied to various medical plastics.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Saeed Behzadinasab, Myra D. Williams, Mete Aktuglu, Joseph O. Falkinham III, William A. Ducker
Summary: Antimicrobial coatings can effectively reduce the spread of infectious agents. Fast killing can be achieved by using a porous coating that allows the contaminated liquid to penetrate into the pores and come into rapid contact with active material. The use of a porous scaffold combined with an antimicrobial coating has shown significant improvement in the inactivation of microorganisms compared to a non-porous coating. This study demonstrates the importance of porous antimicrobial coatings in preventing the transmission of infectious agents.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Katrina Browne, Rajesh Kuppusamy, Renxun Chen, Mark D. P. Willcox, William R. Walsh, David StC Black, Naresh Kumar
Summary: Prevention and treatment of biofilm-mediated infections on medical devices are still unmet clinical needs. This study presents a versatile and simple polydopamine surface coating technique using a new class of antibiotics-antimicrobial peptidomimetics to prevent biofilm formation on implantable medical devices. The study assessed the anti-biofilm activity of peptidomimetics, characterizes their surface chemistry, quantifies their antibacterial activity, and evaluates the biocompatibility of the coated materials. Results showed that the peptidomimetic coatings completely eradicated S. aureus on surfaces and had variable activity against Gram-negative bacteria. The study provides a simple and effective antibacterial coating strategy for biomaterials to reduce biofilm-mediated infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
M. Borgolte, O. Riester, I. Quint, F. Blendinger, V. Bucher, S. Laufer, R. Csuk, L. Scotti, H. -p. Deigner
Summary: Chitosan derivatives with benzophenone groups were cross-linked by UV light to form coatings for PEEK substrates used in lumbar cages. The coated surface showed excellent antimicrobial properties against clinically relevant strains of bacteria and significantly reduced biofilm formation. The coatings exhibited good biocompatibility, low cytotoxicity, and strong antioxidant properties.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nitee Kumari, Sumit Kumar, Mamata Karmacharya, Sateesh Dubbu, Taewan Kwon, Varsha Singh, Keun Hwa Chae, Amit Kumar, Yoon-Kyoung Cho, In Su Lee
Summary: The new magneto-catalytic platform MTex is able to effectively diffuse into biofilms and kill bacteria, providing key antifouling efficacy through its unique surface topography.
Article
Biophysics
Chan Yeon Kim, Yoonyoung Kim, Min Young Lee, Seong Ah Jo, Seung-Woo Kim, Sung Min Kang, Young-Kwan Kim, Kyungtae Kang
Summary: This manuscript explores the impact of differently functionalized surfaces on the formation of solution-dispersed polydopamine (pDA). The study reveals that charged and polar surfaces, particularly those with -NH2 groups, significantly accelerate pDA formation in solution. It is also found that both dispersed forms and film forms of pDA are formed at solid-liquid interfaces. The research suggests that surface functional groups play a facilitative role in pDA formation and highlights the overlooked functions of amyloid fibers in melanogenesis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Zhen Hong Chang, Leow Hui Ting Lyly, Yeit Haan Teow, Swee Pin Yeap, Jing Yao Sum
Summary: Membrane modification with polydopamine can enhance membrane selectivity and compatibility. This study investigated the polymerization mechanism of dopamine on porous membranes and its impact on membrane performance. The results showed that polydopamine coating slightly reduced the membrane's pore size and formed aggregates on both the membrane surface and inner pores. The membrane's pore size significantly influenced the penetration and polymerization of dopamine.
Article
Infectious Diseases
Guilherme Melo Esteves, Joao Esteves, Marta Resende, Luzia Mendes, Andreia S. Azevedo
Summary: Dental implants are a great solution for replacing missing teeth, and antimicrobial coatings show promise in controlling bacterial infections and improving success rates. New materials have been developed to prevent biofilm adhesion to titanium implants, but more research is needed to determine the optimal coating material.
Article
Materials Science, Multidisciplinary
Yu Fang, Jing Wang, Ling-Yun Zou, Hong-Lin Qian, Ke-Feng Ren, You-Xiang Wang, Jian Ji
Summary: This study presents a method for accelerating the in-situ generation of PDA coating based on a photosensitizer-entrapped substrate, which allows for coating preparation even in acidic conditions. Laser irradiation induces sustained reactive oxygen species (ROS) production, promoting the preparation of PDA coating with advantages in thickness and functionality.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Chemistry, Physical
Li Tan, Xianming Lu, Ning Liu, Qi-Long Yan
Summary: The study successfully enhanced the thermostability of NBTTP and NPTTP crystals through PDA and GO coating, making them suitable for high-performance energetic materials. The major gaseous products of NBTTP composites are CO2, C2H2, N2O, -C=N, CO, NO, and H2O, while volatile hydrocarbon products appear in NPTTP composites, responsible for slower reaction rates.
APPLIED SURFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Shiva Kamini Divakarla, Theerthankar Das, Chandralekha Chatterjee, Mihail Ionescu, Zeljko Pastuovic, Jun-Hyeog Jang, Hala Al-khoury, Harald Loppnow, Seiji Yamaguchi, Thomas Groth, Wojciech Chrzanowski
Summary: Emerging and re-emerging infections pose a global threat, driven by antimicrobial resistance and poor infection control practices. This study combines gallium (Ga) and defensin (De) to enhance antimicrobial activity and reduce inflammation in polymer-based implantable devices. The treated surfaces effectively kill bacteria and reduce inflammation, making them promising for implantable device integration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Feng Xiong, Shuo Wei, Han Sheng, Xiang Han, Wei Jiang, Zhuojun Zhang, Biyun Li, Hongyun Xuan, Ye Xue, Huihua Yuan
Summary: The development of a new multi-functional poly(L)-lactide (PLLA) nanofibrous scaffold with excellent antibacterial and reactive oxygen species (ROS) scavenging capability is crucial in tissue engineering. In this study, polydopamine (PDA)/PLLA nanofibers were successfully prepared using electrospinning and post in-situ polymerization techniques. The PDA/PLLA composite demonstrated enhanced mechanical strength, hydrophilicity, oxidation resistance, and near-infrared photothermal effect, making it a promising antibacterial material for tissue engineering applications. The in vitro ROS scavenging ability of PDA also suggests its potential for damaged tissue repair. These findings highlight the versatility and biomedical applications of the PDA/PLLA nanofibrous scaffold.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biophysics
Jan Svoboda, Martin Kral, Marcela Dendisova, Pavel Matejka, Ognen Pop-Georgievski
Summary: This study investigated the growth of polydopamine on different substrates and found that the chemical nature of the substrate influences the structure of the resulting polydopamine in the early stages of layer formation. However, a unified chemical structure was observed at later stages of layer formation regardless of the substrate type. Various surface-sensitive techniques were utilized in this research to analyze the effects of polymerization time and substrate on polydopamine structure.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Heerak Chugh, Amardeep Awasthi, Yashi Agarwal, Rajesh K. Gaur, Gagan Dhawan, Ramesh Chandra
Summary: COVID-19 is an infectious respiratory disease caused by SARS-CoV-2, which utilizes spike proteins to invade host cells and trigger a series of pathological responses. Vaccine development and drug repurposing are currently the main strategies for the prevention and treatment of the pandemic.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Alex Muthengi, Virangika K. Wimalasena, Hailemichael O. Yosief, Melissa J. Bikowitz, Logan H. Sigua, Tingjian Wang, Deyao Li, Zied Gaieb, Gagan Dhawan, Shuai Liu, Jon Erickson, Rommie E. Amaro, Ernst Schonbrunn, Jun Qi, Wei Zhang
Summary: The development of a new CBP/EP300 bromodomain inhibitor UMB298 through a two-step synthesis route, along with the establishment of structure-activity relationships, allows for selective targeting of CBP/EP300.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Zeba Ahmadi, Harekrushna Jena, Mahak Singh, Gagan Dhawan, Pradeep Kumar
Summary: A series of amphiphilic retinoyl-bPEI conjugates were synthesized, showing promising potential in targeted gene delivery for hepatocellular carcinoma in the future due to their improved transfection efficiency and anticancer properties.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Yingjie Yu, Aiyao Liu, Gagan Dhawan, Haibo Mei, Wei Zhang, Kunisuke Izawa, Vadim A. Soloshonok, Jianlin Han
Summary: This review profiles thirteen new fluorine-containing drugs recently approved by the US FDA in 2020, covering a range of therapeutic areas including Alzheimer's disease, migraine, and various cancers. The approved drugs feature different types of fluorine groups, such as aromatic fluorine (Ar-F), aromatic Ar-CF3, aliphatic CHF and CF2. For each compound, the review provides details on biological activity, medicinal chemistry discovery, and synthetic approaches.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Samvedna Saini, Manusmriti Agarwal, Amartya Pradhan, Savitha Pareek, Ashish K. Singh, Gagan Dhawan, Uma Dhawan, Yatender Kumar
Summary: Cross-reactive and broadly neutralizing antibodies are crucial for developing effective universal vaccines against rapidly evolving viral pathogens like SARS-CoV-2. Our study demonstrates that mutations in the framework regions of the antibody CR3022 can enhance its cross-reactivity to emerging SARS-CoV-2 variants by improving flexibility and conformational changes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Jingrui He, Ziyi Li, Gagan Dhawan, Wei Zhang, Alexander E. Sorochinsky, Greg Butler, Vadim A. Soloshonok, Jianlin Han
Summary: This review article presents nine newly approved fluorine-containing drugs by the US Food and Drug Administration (FDA) in 2021. These small molecule drugs feature aromatic fluo-rine, trifluoromethyl, and chlorodifluoro groups. The therapeutic areas of these fluorine-containing drugs include multiple myeloma, lymphoma, HIV, chronic heart failure, chronic myeloid leukemia, (ANCA)-associated vasculitis, migraines, von Hippel-Lindau disease, and non-small cell lung cancer. The review also discusses the brief biological activities and synthetic methods for each of these nine drugs.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biochemistry & Molecular Biology
H. Jena, Z. Ahmadi, P. Kumar, G. Dhawan
Summary: In this study, low molecular weight branched polyethylenimine (LMW bPEIs 1.8 kDa) were successfully conjugated with a disulfide bond containing hydrophobic moiety, 3-(2-pyridyldithio) propionic acid (PDPA), to improve the transfection efficacy of nucleic acid carriers. The resulting PDPP nanostructures self-assemble into core-shell structures, which can efficiently bind and transport plasmid DNA, as well as release a hydrophobic drug in response to a reductive microenvironment. These nanostructures have great potential as the next-generation delivery system.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Nishtha Agrawal, Sanjesh Saini, Madhu Khanna, Gagan Dhawan, Uma Dhawan
Summary: This study investigated the effect of UPR pathways on the pathogenesis of chikungunya virus infection and observed that the virus can modulate UPR. Inhibition of the IRE1 and ATF6 branches significantly suppressed chikungunya virus replication. This study provides a novel perspective for designing antivirals against chikungunya virus.
INDIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Immunology
Nishtha Agrawal, Madhu Khanna, Gagan Dhawan
Summary: This study analyzed the expression of reference genes (GAPDH, GUSB, HPRT, Beta-actin, 18S rRNA) during chikungunya virus infection using quantitative PCR, and evaluated the stability of these commonly used genes with three bioinformatics softwares. The results showed significant variation in the expression of reference genes during chikungunya virus infection, with GAPDH and 18S rRNA being the most stable. The analysis by bioinformatics softwares further validated the results of quantitative PCR. This study is the first to identify and validate the most suitable reference gene for normalization of qPCR data during chikungunya based gene expression analysis, which can serve as a reference for researchers working on different aspects of chikungunya virus infections.
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nana Wang, Haibo Mei, Gagan Dhawan, Wei Zhang, Jianlin Han, Vadim A. Soloshonok
Summary: The strategic fluorination in pharmaceutical drugs allows us to manipulate their stability, bio-absorption, and overall efficiency. Additionally, natural and tailor-made amino acids serve as essential frameworks for the development of bioactive molecules. This review article highlights these prevalent trends in recently approved drugs.
Review
Biotechnology & Applied Microbiology
Gupta Romasha, Dhawan Gagan, Kumar Bipul, Gautam K. Hemant
Summary: Increase in antibiotic resistance is a global concern, especially in the treatment of acne due to antibiotic overprescription. The development of bioinformatics tools and machine learning algorithms can help predict and combat antibiotic resistance more effectively.
RESEARCH JOURNAL OF BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Madhu Khanna, Nishtha Agrawal, Ramesh Chandra, Gagan Dhawan
Summary: The unfolded protein response (UPR) is an evolutionarily conserved pathway triggered in response to disruption of endoplasmic reticulum (ER) homeostasis, with the main purpose of relieving ER stress and preventing cell death. Understanding the role of UPR in disease progression can help design therapeutic drugs targeting UPR pathways for disease amelioration.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Indu Singh, Seema Gupta, Hemant K. Gautam, Gagan Dhawan, Pradeep Kumar
Summary: The study synthesized biogenic AgNPs with antimicrobial, antioxidant, and antibiofilm properties using a green approach. These nanoparticles showed immense potential in various biomedical applications.
Article
Chemistry, Multidisciplinary
Heerak Chugh, Pramod Kumar, Neeraj Kumar, Rajesh K. Gaur, Gagan Dhawan, Ramesh Chandra
Summary: In this study, the binding of Noscapine with human hemoglobin was investigated using various experimental methods, which showed a feasible interaction and formation of a binding complex between the two molecules. This interaction led to a change in the secondary structure of Hb and was further verified to be stable at the molecular level through docking studies.
NEW JOURNAL OF CHEMISTRY
(2021)