The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders

Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex

(2019) Jie Liu et al.   CELL DEATH AND DIFFERENTIATION

Maternal exposure to cadmium impairs cognitive development of male offspring by targeting the Coronin-1a signaling pathway

(2019) Jianfeng Feng et al.   CHEMOSPHERE

De novo variants in PAK1 lead to intellectual disability with macrocephaly and seizures

(2019) Susanne Horn et al.   BRAIN

Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease

(2019) Julie C. Lauterborn et al.   BRAIN PATHOLOGY

PAK3 mutations responsible for severe intellectual disability and callosal agenesis inhibit cell migration

(2019) Kévin Duarte et al.   NEUROBIOLOGY OF DISEASE

CDC42 binds PAK4 via an extended GTPase-effector interface

(2018) Byung Hak Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Entorhinal Cortical Projections to the Dentate Gyrus Underlies Social Memory Retrieval

(2018) Celeste Leung et al.   Cell Reports

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease

(2018) Xianjun Dong et al.   NATURE NEUROSCIENCE

PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior

(2018) Yan Wang et al.   Cell Reports

Activating Mutations in PAK1, Encoding p21-Activated Kinase 1, Cause a Neurodevelopmental Disorder

(2018) Frederike L. Harms et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The intellectual disability protein PAK3 regulates oligodendrocyte precursor cell differentiation

(2017) Majistor Raj Luxman Maglorius Renkilaraj et al.   NEUROBIOLOGY OF DISEASE

AutDB: a platform to decode the genetic architecture of autism

(2017) Wayne Pereanu et al.   NUCLEIC ACIDS RESEARCH

Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

(2017) Alexander Pyronneau et al.   Science Signaling

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

(2017) Alexander Pyronneau et al.   Science Signaling

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

PAK5 is auto-activated by a central domain that promotes kinase oligomerization

(2016) B. Tabanifar et al.   BIOCHEMICAL JOURNAL

The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex

(2016) Daniel Pensold et al.   CEREBRAL CORTEX

Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?

(2016) Zhen Yan et al.   JOURNAL OF NEUROSCIENCE

Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1–PAK3 signaling in neuroplasticity

(2016) M J Kim et al.   MOLECULAR PSYCHIATRY

Advancing the understanding of autism disease mechanisms through genetics

(2016) Luis de la Torre-Ubieta et al.   NATURE MEDICINE

A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons

(2016) Dong Kong et al.   NEURON

Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP

(2016) Bo Hu et al.   PLoS Genetics

p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus

(2016) Shuting Xia et al.   eLife

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

(2016) Kate M. Byrne et al.   Cell Systems

Specification of Dendritogenesis Site in Drosophila aCC Motoneuron by Membrane Enrichment of Pak1 through Dscam1

(2015) Daichi Kamiyama et al.   DEVELOPMENTAL CELL

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

(2015) Laura Civiero et al.   JOURNAL OF NEUROCHEMISTRY

Oligodendroglial Maturation Is Dependent on Intracellular Protein Shuttling

(2015) P. Gottle et al.   JOURNAL OF NEUROSCIENCE

Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation

(2015) Natasha K. Hussain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neto-Mediated Intracellular Interactions Shape Postsynaptic Composition at the Drosophila Neuromuscular Junction

(2015) Cathy I. Ramos et al.   PLoS Genetics

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway

(2015) Nikhil Tyagi et al.   Oncotarget

Aβ Selectively Impairs mGluR7 Modulation of NMDA Signaling in Basal Forebrain Cholinergic Neurons: Implication in Alzheimer's Disease

(2014) Zhenglin Gu et al.   JOURNAL OF NEUROSCIENCE

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

(2014) Andrei I Molosh et al.   NATURE NEUROSCIENCE

Temporal Specification and Bilaterality of Human Neocortical Topographic Gene Expression

(2014) Mihovil Pletikos et al.   NEURON

PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence

(2014) A. Hayashi-Takagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GIT1 and βPIX Are Essential for GABA A Receptor Synaptic Stability and Inhibitory Neurotransmission

(2014) Katharine R. Smith et al.   Cell Reports

NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1

(2013) Wei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pathogenesis of Abeta Oligomers in Synaptic Failure

(2013) Senthilkumar Sivanesan et al.   Current Alzheimer Research

Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression

(2013) Xiaojing Dai et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The genetic and neuroanatomical basis of social dysfunction: Lessons from neurofibromatosis type 1

(2013) Natalie A. Pride et al.   HUMAN BRAIN MAPPING

Mechanisms of cell migration in the nervous system

(2013) Jonathan A. Cooper   JOURNAL OF CELL BIOLOGY

PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and A 

(2013) D. Arsenault et al.   JOURNAL OF NEUROSCIENCE

The Neural Cell Adhesion Molecule (NCAM) Associates with and Signals through p21-Activated Kinase 1 (Pak1)

(2013) S. Li et al.   JOURNAL OF NEUROSCIENCE

Postsynaptic Density Scaffold SAP102 Regulates Cortical Synapse Development through EphB and PAK Signaling Pathway

(2013) Y. Murata et al.   JOURNAL OF NEUROSCIENCE

Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism

(2013) L. J. Duffney et al.   JOURNAL OF NEUROSCIENCE

The translation of translational control by FMRP: therapeutic targets for FXS

(2013) Jennifer C Darnell et al.   NATURE NEUROSCIENCE

Neurofibromatosis Type 1 and Autism Spectrum Disorder

(2013) S. Garg et al.   PEDIATRICS

Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6

(2013) Jia Gao et al.   PLoS One

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

(2013) B. M. Dolan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonautonomous Regulation of Neuronal Migration by Insulin Signaling, DAF-16/FOXO, and PAK-1

(2013) Lisa M. Kennedy et al.   Cell Reports

Abnormalities of the Duo/Ras-Related C3 Botulinum Toxin Substrate 1/p21-Activated Kinase 1 Pathway Drive Myosin Light Chain Phosphorylation in Frontal Cortex in Schizophrenia

(2012) María D. Rubio et al.   BIOLOGICAL PSYCHIATRY

Symptomatology of autism spectrum disorder in a population with neurofibromatosis type 1

(2012) KARIN S WALSH et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Behaviour in children with neurofibromatosis type 1: cognition, executive function, attention, emotion, and social competence

(2012) ANNUKKA LEHTONEN et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Alteration of Synaptic Network Dynamics by the Intellectual Disability Protein PAK3

(2012) A. Dubos et al.   JOURNAL OF NEUROSCIENCE

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

(2012) Aditi Bhattacharya et al.   NEURON

Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking

(2012) T. I. Strochlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

(2012) B. H. Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

(2011) Max R. Banko et al.   MOLECULAR CELL

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling

(2011) S.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Autistic and psychiatric findings associated with the 3q29 microdeletion syndrome: Case report and review

(2010) Fabiola Quintero-Rivera et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Does Cognitive Impairment Explain Behavioral and Social Problems of Children with Neurofibromatosis Type 1?

(2010) Stephan C. J. Huijbregts et al.   BEHAVIOR GENETICS

Social information processing in children and adolescents with neurofibromatosis type 1

(2010) STEPHAN HUIJBREGTS et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

A FOXO-Pak1 transcriptional pathway controls neuronal polarity

(2010) L. de la Torre-Ubieta et al.   GENES & DEVELOPMENT

NOS1AP Associates with Scribble and Regulates Dendritic Spine Development

(2010) L. Richier et al.   JOURNAL OF NEUROSCIENCE

Physiological Activation of Synaptic Rac>PAK (p-21 Activated Kinase) Signaling Is Defective in a Mouse Model of Fragile X Syndrome

(2010) L. Y. Chen et al.   JOURNAL OF NEUROSCIENCE

p21-Activated Kinases 1 and 3 Control Brain Size through Coordinating Neuronal Complexity and Synaptic Properties

(2010) W. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Guiding Neuronal Cell Migrations

(2010) O. Marin et al.   Cold Spring Harbor Perspectives in Biology

Axon Growth and Guidance: Receptor Regulation and Signal Transduction

(2009) Michael O'Donnell et al.   Annual Review of Neuroscience

Dissecting Activation of the PAK1 Kinase at Protrusions in Living Cells

(2009) Maria Carla Parrini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Modifier of Cell Adhesion Reveals a Pathway Leading to Axonal Degeneration

(2009) Q. Chen et al.   JOURNAL OF NEUROSCIENCE

Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis

(2009) Matthew B. Johnson et al.   NEURON

A tale of two Paks

(2008) Luis E. Arias-Romero et al.   BIOLOGY OF THE CELL

Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning

(2008) Yijun Cui et al.   CELL

PAK signalling in neuronal physiology

(2008) Patricia Kreis et al.   CELLULAR SIGNALLING

The p21-Activated Kinase Is Required for Neuronal Migration in the Cerebral Cortex

(2008) Frédéric Causeret et al.   CEREBRAL CORTEX

Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration

(2008) F. J. Martini et al.   DEVELOPMENT

Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion

(2008) Tanya Nekrasova et al.   DEVELOPMENTAL BIOLOGY

A novel splice mutation in PAK3 gene underlying mental retardation with neuropsychiatric features

(2008) Imen Rejeb et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis

(2008) Qiu-Lan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1)

(2008) Suhail Asrar et al.   NEUROPHARMACOLOGY

UnPAKing the class differences among p21-activated kinases

(2008) Jeyanthy Eswaran et al.   TRENDS IN BIOCHEMICAL SCIENCES

Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664

(2007) Thuy-Vi V. Nguyen et al.   JOURNAL OF NEUROCHEMISTRY