Article
Immunology
Yinon Levy, Ron Alcalay, Anat Zvi, Efi Makdasi, Eldar Peretz, Tal Noy-Porat, Theodor Chitlaru, Michal Mandelboim, Ohad Mazor, Ronit Rosenfeld
Summary: This study examined the antibody response in transgenic mice infected with SARS-CoV-2 and identified six common immunogenic epitopes of the spike protein. The findings have important implications for predicting the efficacy of immune countermeasures against emerging SARS-CoV-2 variants.
Letter
Medicine, General & Internal
Jingyou Yu, Ai-ris Y. Collier, Marjorie Rowe, Fatima Mardas, John D. Ventura, Huahua Wan, Jessica Miller, Olivia Powers, Benjamin Chung, Mazuba Siamatu, Nicole P. Hachmann, Nehalee Surve, Felix Nampanya, Abishek Chandrashekar, Dan H. Barouch
Summary: Although immunity from two doses of BNT162b2 vaccine diminishes over time, a booster dose significantly enhances the neutralizing antibodies against both the BA.1 and BA.2 variants.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Chemistry, Medicinal
Hua-Rui Gong, Ye-fan Hu, Xuechen Li, Thomas Yau, Bao-Zhong Zhang, Jian-Dong Huang
Summary: This study investigates the infection enhancement effect of a multiple epitope-based vaccine on the Omicron strain of SARS-CoV-2. The results show that while the vaccine enhances infection for Omicron, it does not have the same effect on the ancestral SARS-CoV-2 or Delta strains. Furthermore, the study identifies a conserved epitope that has neutralizing activity against the three strains. This research provides up-to-date epitope information for guiding the development of better vaccines or antibody-based therapies against future variants.
ACS INFECTIOUS DISEASES
(2022)
Letter
Medicine, General & Internal
Xin Zhao, Rong Zhang, Shitong Qiao, Xiao Wang, Weibing Zhang, Wenjing Ruan, Lianpan Dai, Pengcheng Han, George F. Gao
Summary: This study found that neutralization against the SARS-CoV-2 omicron subvariants was reduced with both the inactivated and ZF2001 vaccines in China. However, heterologous boosting and a longer interval between doses resulted in higher neutralization levels.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Letter
Medicine, General & Internal
Xin Zhao, Rong Zhang, Shitong Qiao, Xiao Wang, Weibing Zhang, Wenjing Ruan, Lianpan Dai, Pengcheng Han, George F. Gao
Summary: This study indicates that neutralization against the SARS-CoV-2 omicron subvariants was reduced with both the inactivated and ZF2001 vaccines in China. However, heterologous boosting and a longer interval between doses resulted in higher neutralization levels.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Immunology
Agata Lopes-Ribeiro, Patricia de Melo Oliveira, Henrique Morais Retes, Edel Figueiredo Barbosa-Stancioli, Flavio Guimaraes da Fonseca, Moriya Tsuji, Jordana Grazziela Alves Coelho-dos-Reis
Summary: This study investigated the presence of MHC-I immunodominant viral peptides in coronavirus subfamilies and SARS-CoV-2 Variants of Concern (VOCs) using in silico and in vitro tools. The results showed that HLA-A*02 haplotype had the highest number of immunodominant epitopes but with the lowest combined prediction score. Furthermore, it was observed that the mutations on the VOCs are promoting escape from HLA-A2-mediated antigen presentation, indicating an immune evasion process.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jianying Liu, Yang Liu, Hongjie Xia, Jing Zou, Scott C. Weaver, Kena A. Swanson, Hui Cai, Mark Cutler, David Cooper, Alexander Muik, Kathrin U. Jansen, Ugur Sahin, Xuping Xie, Philip R. Dormitzer, Pei-Yong Shi
Summary: Serum samples from individuals vaccinated with the BNT162b2 vaccine can neutralize various SARS-CoV-2 variants, indicating mass immunization as a central strategy to end the global COVID-19 pandemic.
Article
Immunology
Bernard Vanhove, Stephane Marot, Ray T. So, Benjamin Gaborit, Gwenaelle Evanno, Isabelle Malet, Guillaume Lafrogne, Edwige Mevel, Carine Ciron, Pierre-Joseph Royer, Elsa Lheriteau, Francois Raffi, Roberto Bruzzone, Chris Ka Pun Mok, Odile Duvaux, Anne-Genevieve Marcelin, Vincent Calvez
Summary: Amino acid substitutions and deletions in the Spike protein of SARS-CoV-2 variants can reduce the effectiveness of monoclonal antibodies, while polyclonal antibodies like XAV-19 show potential for maintaining neutralization capacities by targeting multiple epitopes. XAV-19, a swine glyco-humanized polyclonal neutralizing antibody, demonstrates potent neutralization capacities against different variants of SARS-CoV-2, covering various epitopes on the RBD region. Ongoing clinical trials are evaluating the efficacy and safety of XAV-19 in COVID-19 patients with promising results.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Pia Gattinger, Katarzyna Niespodziana, Karin Stiasny, Sabina Sahanic, Inna Tulaeva, Kristina Borochova, Yulia Dorofeeva, Thomas Schlederer, Thomas Sonnweber, Gerhard Hofer, Renata Kiss, Bernhard Kratzer, Doris Trapin, Peter A. Tauber, Arno Rottal, Ulrike Kormoczi, Melanie Feichter, Milena Weber, Margarete Focke-Tejkl, Judith Loffler-Ragg, Bernhard Muhl, Anna Kropfmuller, Walter Keller, Frank Stolz, Rainer Henning, Ivan Tancevski, Elisabeth Puchhammer-Stockl, Winfried F. Pickl, Rudolf Valenta
Summary: The study analyzed the polyclonal antibody response to SARS-CoV-2 in a large population of patients with mild and severe COVID-19. It found that S- and RBD-specific antibody responses were mainly IgG(1) and correlated with virus neutralization activity, with conformational RBD epitopes being crucial for high virus-neutralizing activity. These results are important for understanding protective antibody responses and vaccine design to induce SARS-CoV-2-neutralizing antibodies.
Article
Biochemistry & Molecular Biology
Constantinos Kurt Wibmer, Frances Ayres, Tandile Hermanus, Mashudu Madzivhandila, Prudence Kgagudi, Brent Oosthuysen, Bronwen E. Lambson, Tulio de Oliveira, Marion Vermeulen, Karin van der Berg, Theresa Rossouw, Michael Boswell, Veronica Ueckermann, Susan Meiring, Anne von Gottberg, Cheryl Cohen, Lynn Morris, Jinal N. Bhiman, Penny L. Moore
Summary: The SARS-CoV-2 virus in the B.1.351 variant discovered in South Africa can evade neutralization by most antibodies when expressed, but does not affect binding by convalescent plasma. This suggests the potential for reinfection with antigenically distinct variants and predicts reduced efficacy of spike-based vaccines.
Article
Multidisciplinary Sciences
Hualong Xiong, Hui Sun, Siling Wang, Lunzhi Yuan, Liqin Liu, Yuhe Zhu, Jinlei Zhang, Yang Huang, Ruoyao Qi, Yao Jiang, Jian Ma, Ming Zhou, Yue Ma, Rao Fu, Siping Yan, Mingxi Yue, Yangtao Wu, Min Wei, Yizhen Wang, Tingting Li, Yingbin Wang, Zizheng Zheng, Hai Yu, Tong Cheng, Shaowei Li, Quan Yuan, Jun Zhang, Yi Guan, Qingbing Zheng, Tianying Zhang, Ningshao Xia
Summary: Antibody therapeutics for COVID-19 have been successful, but the emergence of the Omicron variant poses a challenge. Researchers have generated a panel of cross-neutralizing antibodies that can neutralize various variants of concern, with antibody X17 exhibiting strong neutralization against the Omicron variant. The antibodies bind to specific regions on the spike proteins of the viruses, enhancing resistance to viral evasion and providing effective protection against certain variants in animal models. These findings are important for the development of antibody therapeutics and broad-spectrum vaccines.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Medicine, General & Internal
John P. Evans, Panke Qu, Cong Zeng, Yi-Min Zheng, Claire Carlin, Joseph S. Bednash, Gerard Lozanski, Rama K. Mallampalli, Linda J. Saif, Eugene M. Oltz, Peter J. Mohler, Richard J. Gumina, Shan-Lu Liu
Summary: The study found that the Delta variant has high resistance to immune responses elicited by vaccines or previous infections, while the BA.3 variant does not show broad cross-resistance.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Charline Herrscher, Sebastien Eymieux, Christophe Gaborit, Helene Blasco, Julien Marlet, Karl Stefic, Philippe Roingeard, Leslie Grammatico-Guillon, Christophe Hourioux
Summary: This study used ELISA and peptides to investigate the immune response to SARS-CoV-2 infection. It found that patients with severe disease had higher antibody titers corresponding to multiple specific epitopes, which could potentially serve as a biological signature of disease characteristics.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
John P. Evans, Cong Zeng, Panke Qu, Julia Faraone, Yi-Min Zheng, Claire Carlin, Joseph S. Bednash, Tongqing Zhou, Gerard Lozanski, Rama Mallampalli, Linda J. Saif, Eugene M. Oltz, Peter J. Mohler, Kai Xu, Richard J. Gumina, Shan-Lu Liu
Summary: Recent reports show that SARS-CoV-2 Omicron variant sub-lineages BA.1, BA.1.1, and BA.2 have raised concerns about their ability to escape vaccine-induced and infection-induced immunity. A study finds that all Omicron sub-lineages, especially BA.1 and BA.1.1, exhibit significant immune escape, but this can be largely overcome by mRNA vaccine booster doses. The findings highlight the importance of booster vaccine doses for protection against all Omicron variants and provide insights into the immunity from natural infection against Omicron sub-lineages.
CELL HOST & MICROBE
(2022)
Article
Biochemistry & Molecular Biology
Anna Albecka, Dean Clift, Marina Vaysburd, Tyler Rhinesmith, Sarah L. Caddy, David M. Favara, Helen E. Baxendale, Leo C. James
Summary: The humoral immune response to SARS-CoV-2 results in antibodies against spike (S) and nucleoprotein (N). A new in vitro method called EDNA has been developed to quantitatively measure N-antibody activity in unpurified serum from SARS-CoV-2 convalescents. The study found that N antibodies can neutralize SARS-CoV-2 intracellularly and cell-autonomously, but require the cytosolic Fc receptor TRIM21.
Article
Food Science & Technology
Li Tao, Jingyi Wang, Qiyuan Zhu, Jingwei Zhang, Yufei Li, Shixin Song, Lei Yu
Summary: This study investigated the effects of fermentation on probiotic-rich mung bean, chickpea, and tiger skin kidney bean powders. The results showed that fermentation reduced the particle size and increased the specific surface area of the bean powders, improving their dissolution rate and flowability. This study provides a technical foundation for the deep processing of bean resources.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Meteorology & Atmospheric Sciences
Ping Li, Siyao Yue, Xiaoyang Yang, Di Liu, Qiang Zhang, Wei Hu, Shengjie Hou, Wanyu Zhao, Hong Ren, Gang Li, Yuanguan Gao, Junjun Deng, Qiaorong Xie, Yele Sun, Zifa Wang, Pingqing Fu
Summary: This study collected PM2.5 samples over a one-year period at the Shangdianzi station in North China to analyze its chemical and optical characteristics. The major chemical components of PM2.5 were identified, and the sources of water-soluble organic matter and water-insoluble organic matter were determined. Additionally, different types of fluorescent components were identified and their intensity varied with seasons, indicating the main impact of burning sources. This study provides insights into the chemical and optical characteristics of ambient aerosols in the background atmosphere.
ADVANCES IN ATMOSPHERIC SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fuxin Zhang, Ruixi Zhou, Tao Yang, Kailing Yang, Saisai Xin, Jingwei Zhang, Yuqiu Li, Guanqun Zhan, Zengjun Guo
Summary: Four undescribed biflavonoid alkaloids, sinenbiflavones A-D, were isolated from Cephalotaxus sinensis using a MS/MS-based molecular networking guided strategy. Their structures were elucidated by series of spectroscopic methods (HR-ESI-MS, UV, IR, 1D, and 2D NMR). Sinenbiflavones A-D are the first examples of amentoflavone-type (C-3'-C-8'') biflavonoid alkaloids. Meanwhile, sinenbiflavones B and D are the unique C-6-methylated amentoflavone-type biflavonoid alkaloids. Sinenbiflavone D showed weak SARS-CoV-2 3CL(pro) inhibitory activity with 43% inhibition rate at 40 mu M.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Environmental Sciences
Jian Li, Tim J. Daniell, Ming-Kang Jin, Rui-Ying Chang, Tao Wang, Jing Zhang, Xiao-Ru Yang, Yong-Guan Zhu
Summary: The spread of antibiotic-resistance genes (ARGs) has become a significant threat to human health. However, little is known about the profile and drivers of ARGs in the phyllosphere, which is an important habitat for microorganisms. In this study, leaf samples were collected from different stages of plant community succession to investigate the development of phyllosphere ARGs in natural habitats. The results showed that the presence of ARGs in the phyllosphere is influenced by environmental factors such as plant community composition, host leaf properties, and the phyllosphere microbiome.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Di Liu, Shaofeng Xu, Yunchao Lang, Shengjie Hou, Lianfang Wei, Xiaole Pan, Yele Sun, Zifa Wang, Kimitaka Kawamura, Pingqing Fu
Summary: This study investigated the source, formation, and seasonality of biogenic secondary organic aerosol (BSOA) in Beijing, China from April 2017 to January 2018. BSOA tracers derived from isoprene, monoterpene, and sesquiterpene were measured and showed significant seasonal variations. Isoprene SOA tracers correlated with biomass burning and long-range transport, while sesquiterpene SOA tracer was associated with local biomass burning. These results suggest that BSOA tracers are promising for understanding the source, formation, and seasonality of BSOA.
ENVIRONMENTAL POLLUTION
(2023)
Article
Automation & Control Systems
Xiaohong Chen, Xu Yang, Jing-wei Zhang, Hao Tang, Qing-hua Zhang, Ya-chen Wang, Zi-feng Jiang, Yan-ling Liu
Summary: Ink classification is the task of distinguishing unknown inks into different groups, while ink source prediction is the ability to predict the manufacturer or model of an unknown ink. This study presents an approach to predict the source of black inks using real-time mass spectrometry analysis and assesses the strength of the prediction using likelihood ratios. The results demonstrate the effectiveness of the proposed method in predicting ink source and calibrating the likelihood ratio.
JOURNAL OF CHEMOMETRICS
(2023)
Article
Plant Sciences
Peng Wei, Tongtong Liu, Junzhi Zhang, Kunqun Shi, Jingwei Zhang, Shijia Liu
Summary: This study aimed to investigate the anti-ulcerative colitis (UC) effects of Baitouweng decoction (BTW) and the underlying mechanisms. The results showed that BTW significantly improved clinical symptoms and histopathological tissue damage in UC mice. It also reduced the release of proinflammatory cytokines and alleviated oxidative stress by regulating the Leu-related mTORC1 pathway. These findings suggest the potential therapeutic value of BTW in the treatment of UC.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Engineering, Multidisciplinary
Hanrui Yang, Huanhuan Lv, Jingwei Zhang, Weiliang Huang, Shibo Xu, Shengxi Jiao
Summary: Long-term operation of cables and equipment under abnormal currents can lead to insulation aging and reduced equipment lifespan. Detecting the current-carrying status of power cables accurately and early detection of potential failures is crucial for the safe and economical operation of power equipment. This paper proposes a method based on temperature information to detect the current-carrying status and provide early fault warnings. The method analyzes the current-carrying state evaluation based on the relationship between temperature and current, according to IEC 61000-3-7 and IEC 60038 standards, and establishes an early fault warning model. The feasibility of the method is verified using cable connectors and lightning arresters in a power ring network cabinet as examples, showing distinct characteristic information of relative temperature variation curves under different current carrying states, such as the slopes at hour 9 and hour 2, and the maximum temperature. The total duration of abnormal current operation can be calculated and early fault warnings can be achieved.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Article
Cell Biology
Ya-ru Huang, Xi-xiu Xie, Jing Yang, Xiao-ying Sun, Xiao-yun Niu, Cheng-gang Yang, Ling-jie Li, Lun Zhang, Dan Wang, Chun-yu Liu, Sheng-jie Hou, Chen-yang Jiang, Yu-ming Xu, Rui-tian Liu
Summary: In this study, it was found that the levels of ArhGAP11A significantly increase in patients with AD and APP/PS1 mice. By reducing ArhGAP11A level in neurons, both AD generation and ADo neurotoxicity can be inhibited through the RhoA/ROCK/Erk signaling pathway. Furthermore, specific reduction of ArhGAP11A level significantly reduces AD production, plaque deposition, and improves neuronal damage, neuroinflammation, and cognitive deficits in APP/PS1 mice.
Article
Green & Sustainable Science & Technology
Tiansheng Xia, Xiujuan Fan, Jingwei Zhang, Tingting Liu
Summary: Packaging design plays a crucial role in influencing consumers' perception of the health of low-fat foods. This study developed a sequential mediation model to examine the impact of packaging complexity on consumers' purchase intentions. The results showed that increasing consumers' conceptual fluency and brand attitude could lead to higher purchase intentions. The study also highlighted the mediating role of brand attitude between packaging complexity and purchase intention.
Article
Chemistry, Applied
Li Tao, Jingyi Wang, Yihua Wei, Boyu Xiong, Jingwei Zhang, Wenfei Lan, Lei Yu
Summary: An efficient decolorization method for ginseng residue oligosaccharides (GROs) was developed using ultrasound-assisted D392 macroporous resin. The decolorization effects and color differences of activated carbon adsorption, hydrogen peroxide oxidation, and resin adsorption were compared. The ultrasound-assisted decolorization showed the best effect, reducing the decolorization time to 80 minutes and achieving the removal of most pigments.
Article
Chemistry, Multidisciplinary
Ziming Lin, Taomei Deng, Yinuo Liu, Shuangyang Zheng, Guangji Wang, Hua He, Jingwei Zhang
Summary: Poor tumor penetration is a major obstacle for the clinical translation of nanomedicines. This study investigates the impact of physicochemical properties and tumor-associated environments on the intratumoral penetration of liposomes. The results show that factors such as zeta potential, membrane fluidity, and size of liposomes influence their penetration in different areas of the tumor. The study provides guidance for the precise design and optimization of anti-tumor liposomes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Jingwei Zhang, Peng Zhou, Boyang Shi, Penghan Li, Guowei Wang
Summary: In this study, a facile strategy for preparing higher-order morphologies using a living anionic polymerization-mediated polymerization-induced cooperative assembly (LAP PICA) process was reported. The morphological transition from spherical micelles to worms, jellyfish, vesicles, sponges, and ordered mesophases of Im3m cubosomes and p6mm hexosomes was observed and demonstrated. Morphological distribution diagrams were also depicted to unveil the effect of LAP PICA on morphologies and provide guiding principles for preparing a variety of morphologies. Furthermore, a relevant morphological transition mechanism via LAP PICA was proposed.
Article
Materials Science, Multidisciplinary
Jingwei Zhang, Yonghua Han, Li Zhang, Hancheng Zhu, Ting Song, Duanting Yan, Meng Zhang, Chao Wang, Xintong Zhang
Summary: Cs3Cu2I5 has attracted widespread attention due to its low cost, high photo-luminescence quantum yield, green and non-toxic properties. By introducing Mn2+ into Cs3Cu2I5 through solid-state ball milling method, the crystal structure of Cs3Cu2I5 was minimally affected. Copper ions and manganese ions were found to exist stably as Cu+ and Mn2+ respectively. Mn2+ doping led to the emergence of a new emission peak at 560 nm, achieving dual color luminescence. The material also exhibited excellent thermal stability, making it suitable for solid-state lighting and anti-counterfeiting applications.
MATERIALS RESEARCH BULLETIN
(2023)
Article
Engineering, Manufacturing
Jingwei Zhang, Yin-Da Wang, Yunqiu Wu, Kai Kang, Wen-Yan Yin
Summary: To improve the performance of on-chip interconnects, a transfer learning-based deep neural network (TL-DNN) is proposed for the inverse and fully-automatic design. The TL-DNN surrogate model consists of two DNNs, where the first DNN maps performance parameters to geometric parameters, and the second DNN is trained using electromagnetic solver space datasets. The proposed method achieves a high testing accuracy of 93.67% and requires only 6.15 hours of modeling time compared to other design methods.
IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
(2023)
