Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation

Biallelic correction of sickle cell disease‐derived iPSCs confirmed at the protein level through serum‐free iPS‐sac/erythroid differentiation

(2020) Juan J. Haro‐Mora et al.   Stem Cells Translational Medicine

Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells

(2020) Chris Sebastiaan Vink et al.   Cell Reports

βT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex Vivo Anti-sickling Activity in Human Erythroid Cells

(2020) Selami Demirci et al.   Molecular Therapy-Methods & Clinical Development

Ex vivo HSC expansion challenges the paradigm of unidirectional human hematopoiesis

(2019) Luena Papa et al.   Annals of the New York Academy of Sciences

Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing

(2019) Yang Zeng et al.   CELL RESEARCH

Robust generation of erythroid and multilineage hematopoietic progenitors from human iPSCs using a scalable monolayer culture system

(2019) Juan Pablo Ruiz et al.   Stem Cell Research

Blood Development: Hematopoietic Stem Cell Dependence and Independence

(2018) Elaine Dzierzak et al.   Cell Stem Cell

Gene therapy for sickle cell disease: An update

(2018) Selami Demirci et al.   CYTOTHERAPY

The hematopoietic stem cell niche: from embryo to adult

(2018) Xin Gao et al.   DEVELOPMENT

Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor

(2018) Yu-Ting Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curative therapies: Allogeneic hematopoietic cell transplantation from matched related donors using myeloablative, reduced intensity, and nonmyeloablative conditioning in sickle cell disease

(2018) Gregory M.T. Guilcher et al.   SEMINARS IN HEMATOLOGY

Haematopoietic stem and progenitor cells from human pluripotent stem cells

(2017) Ryohichi Sugimura et al.   NATURE

Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition

(2017) Carolina Guibentif et al.   Cell Reports

Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development

(2016) Jonathan Henninger et al.   NATURE CELL BIOLOGY

β-Globin-Expressing Definitive Erythroid Progenitor Cells Generated from Embryonic and Induced Pluripotent Stem Cell-Derived Sacs

(2016) Atsushi Fujita et al.   STEM CELLS

Efficient Generation of β-Globin-Expressing Erythroid Cells Using Stromal Cell-Derived Induced Pluripotent Stem Cells from Patients with Sickle Cell Disease

(2016) Naoya Uchida et al.   STEM CELLS

Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo

(2015) Kathleen E. McGrath et al.   Cell Reports

Concise Review: Evidence for CD34 as a Common Marker for Diverse Progenitors

(2014) Laura E. Sidney et al.   STEM CELLS

Generation of Engraftable Hematopoietic Stem Cells From Induced Pluripotent Stem Cells by Way of Teratoma Formation

(2013) Nao Suzuki et al.   MOLECULAR THERAPY

Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy

(2012) D. Malide et al.   BLOOD

Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence

(2012) M. Yoshimoto et al.   BLOOD

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells

(2012) G. Amabile et al.   BLOOD

The role of HOX genes in normal hematopoiesis and acute leukemia

(2012) R A Alharbi et al.   LEUKEMIA

Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions

(2012) Jeanette Beers et al.   Nature Protocols

Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells

(2011) J. S. Merzaban et al.   BLOOD

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells

(2011) Kyung-Dal Choi et al.   Nature Protocols

Hematopoiesis in 3 dimensions: human and murine bone marrow architecture visualized by confocal microscopy

(2010) T. Takaku et al.   BLOOD

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Generation of T Cells from Human Embryonic Stem Cell-Derived Hematopoietic Zones

(2009) F. Timmermans et al.   JOURNAL OF IMMUNOLOGY