Article
Health Care Sciences & Services
Hee Young Cho, Han Sung Park, Eun Hee Ahn, Eun Ju Ko, Hyeon Woo Park, Young Ran Kim, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
Summary: The study revealed that PAI-1 rs1050955 and REN 10795 rs5707 alleles may decrease the risk of RPL, while the tPA rs4646972 genotype may increase the risk of RPL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Esra'a Abudouleh, Fatimah Alhamlan, Arwa A. Al-Qahtani, Marie Fe Bohol, Amal Al Hazzani, Khadija Khorfan, Morad Alkaff, Tarek Owaidah, Ahmed A. Al-Qahtani
Summary: This study investigated coagulation and fibrinolysis parameters in COVID-19 patients and their association with disease severity. The results showed significantly elevated levels of thrombin activatable fibrinolysis inhibitor, fibrinogen, and tissue plasminogen activator in severe patients. Additionally, patients in the ICU had significantly higher levels of plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombin activatable fibrinolysis inhibitor. These coagulation markers can serve as suitable prognostic indicators for hypofibrinolysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kseniya Rubina, Anna Shmakova, Aslan Shabanov, Yulii Andreev, Natalia Borovkova, Vladimir Kulabukhov, Anatoliy Evseev, Konstantin Popugaev, Sergey Petrikov, Ekaterina Semina
Summary: This study analyzed the clinical, laboratory, and CT scan characteristics associated with a high risk of COVID-19-related death in severely-ill patients in Russia. The findings suggest new prognostic factors that can be used as early predictors of a severe course of COVID-19 for prevention or timely treatment trials.
Review
Peripheral Vascular Disease
Andrianto, Makhyan Jibril Al-Farabi, Ricardo Adrian Nugraha, Bagas Adhimurda Marsudi, Yusuf Azmi
Summary: Biomarkers of endothelial dysfunction, including VWF antigen, t-PA, PAI-1, and sTM, are significantly associated with increased composite poor outcomes in patients with COVID-19, indicating the importance of endothelial dysfunction in COVID-19 patients.
MICROVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Jose-Ramon Blanco, Maria -Jesus Cobos-Ceballos, Francisco Navarro, Isabel Sanjoaquin, Francisco Arnaiz de las Revillas, Enrique Bernal, Luis Buzon-Martin, Miguel Viribay, Lourdes Romero, Simona Espejo-Perez, Borja Valencia, David Ibanez, Diego Ferrer-Pargada, Damian Malia, Fernando -Gustavo Gutierrez-Herrero, Julian Olalla, Bernabe Jurado-Gamez, Javier Ugedo
Summary: This study aimed to describe lung function in patients recovering from COVID-19 hospitalization and to identify biomarkers in serum and induced sputum samples from these patients. A total of 100 patients with respiratory function tests were included in the study, with 47% of patients experiencing severe COVID-19 symptoms and 48% of patients having normal CT results.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Anesthesiology
Mirjam Bachler, Johannes Boesch, Daniel P. Stuerzel, Tobias Hell, Andreas Giebl, Mathias Stroehle, Sebastian J. Klein, Volker Schaefer, Georg F. Lehner, Michael Joannidis, Claudius Thome, Dietmar Fries
Summary: Critically ill COVID-19 patients exhibit a hypercoagulable state with impaired fibrinolysis, characterized by increased clot firmness and decreased fibrinolytic response in whole blood coagulation tests. This hypofibrinolytic state may be at least partially due to a decreased fibrinolytic response.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Dentistry, Oral Surgery & Medicine
F. Pamuk, M. Lutfioglu, T. Paksoy, C. Z. Koyuncuoglu, N. G. Polat, E. Cifcibasi, S. Yildirim, A. Kantarci
Summary: The study found that low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment can modulate the plasminogen-activating system in severe periodontitis.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Pharmacology & Pharmacy
Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Krol, Salvador Pane, Tessa Luehmann
Summary: The study developed three polyethylene glycol (PEG)ylated tPA bioconjugates based on the recombinant human tPA drug Alteplase using site-specific conjugation strategies. These bioconjugates showed improved proteolytic activity, slower inhibition kinetics by PAI-1, and increased hydrodynamic size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Hematology
Ziyu Zhang, Wen Dai, Wen Zhu, Maya Rodriguez, Hayley Lund, Yuhe Xia, Yiliang Chen, Mary Rau, Ellen Anje Schneider, Mary Beth Graham, Shawn Jobe, Demin Wang, Weiguo Cui, Renren Wen, Sidney W. Whiteheart, Jeremy P. Wood, Roy Silverstein, Jeffery S. Berger, Lisa Baumann Kreuziger, Tessa J. Barrett, Ze Zheng
Summary: High Lp(a) concentration is associated with low endogenous tPA enzymatic activity and poor clinical outcomes in patients with COVID-19.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Victor M. Schuettfort, Benjamin Pradere, David D'Andrea, Nico C. Grossmann, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Pierre I. Karakiewicz, Reza Sari Motlagh, Satoshi Katayama, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Harun Fajkovica, Eva Comperat, Dmitry Enikeev, Shahrokh F. Shariat
Summary: Elevated preoperative plasma levels of uPA, SuPAR, and PAI-one were confirmed to be associated with aggressive disease features and worse survival outcomes in patients treated with RC for UCB. These biomarkers have the potential to identify patients who may benefit from intensified/multimodal therapy and improve the discriminatory power of predictive/prognostic models.
JOURNAL OF UROLOGY
(2021)
Article
Obstetrics & Gynecology
Esra Demirel, Reem Sabouni, Neelima Chandra, Ov D. Slayden, David F. Archer
Summary: The study investigates the distribution and concentrations of several receptors and activators within the primate endometrium during artificial menstrual cycles, showing similarities in their expression patterns suggesting overlapping pathways. These findings indicate potential interactions between the plasminogen activator system and steroid receptors in the endometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Cheryl L. Maier, Tania Sarker, Fania Szlam, Roman M. Sniecinski
Summary: Patients critically ill with COVID-19 have higher levels of fibrinogen in their plasma and show resistance to fibrinolysis induced by tPA, potentially reducing the clinical efficacy of thrombolytic therapy in COVID-19 patients.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Hematology
Abaher O. Al-Tamimi, Ayesha M. Yusuf, Manju N. Jayakumar, Abdul W. Ansari, Mona Elhassan, Fatema AbdulKarim, Meganathan Kannan, Rabih Halwani, Firdos Ahmad
Summary: This study assessed the levels of coagulation and platelet activation markers in COVID-19 patients and found that soluble P-selectin, sCD40L, fibrinogen, and PAI-1 were induced at the moderate stage, suggesting platelet and coagulation system activation before patients required intensive care.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Yu Zuo, Srilakshmi Yalavarthi, Sherwin Navaz, Claire Hoy, Alyssa Harbaugh, Kelsey Gockman, Melanie Zuo, Jacqueline A. Madison, Hui Shi, Yogendra Kanthi, Jason S. Knight
Summary: The presence of autoantibodies targeting neutrophil extracellular traps (NETs) in individuals hospitalized with severe COVID-19 may impair NET clearance, exacerbating SARS-CoV-2-mediated thromboinflammation.
Article
Rheumatology
Hui Shi, Yu Zuo, Sherwin Navaz, Alyssa Harbaugh, Claire K. Hoy, Alex A. Gandhi, Gautam Sule, Srilakshmi Yalavarthi, Kelsey Gockman, Jacqueline A. Madison, Jintao Wang, Melanie Zuo, Yue Shi, Michael D. Maile, Jason S. Knight, Yogendra Kanthi
Summary: This study found that circulating factors in the serum or plasma of COVID-19 patients contribute to endothelial cell activation and dysfunction. Particularly, the presence of circulating antiphospholipid antibodies is closely associated with the ability of COVID-19 serum to activate endothelial cells.
ARTHRITIS & RHEUMATOLOGY
(2022)