Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in sciatic nerve ligated Wistar rats

d-Ribose-l-cysteine attenuates lipopolysaccharide-induced memory deficits through inhibition of oxidative stress, release of proinflammatory cytokines, and nuclear factor-kappa B expression in mice

(2020) Osagie Emokpae et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Twin studies of the covariation of pain with depression and anxiety: A systematic review and re-evaluation of critical needs

(2020) Waqas Ullah Khan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Depression Prevalence in Neuropathic Pain and Its Impact on the Quality of Life

(2020) Farah Cherif et al.   Pain Research & Management

Combination strategy of PARP inhibitor with antioxidant prevent bioenergetic deficits and inflammatory changes in CCI-induced neuropathy

(2017) Prashanth Komirishetty et al.   NEUROPHARMACOLOGY

EZH2 regulates spinal neuroinflammation in rats with neuropathic pain

(2017) Ruchi Yadav et al.   NEUROSCIENCE

Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-κB/MLCK pathway in a mouse endotoxemia model

(2017) Jie Han et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dexmedetomidine attenuates neuropathic pain in chronic constriction injury by suppressing NR2B, NF-κB, and iNOS activation

(2017) Feng Liang et al.   SAUDI PHARMACEUTICAL JOURNAL

Activity-triggered tetrapartite neuron–glial interactions following peripheral injury

(2016) Ke Ren et al.   CURRENT OPINION IN PHARMACOLOGY

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

(2016) Wen-Shan Gui et al.   Molecular Pain

Morin Mitigates Chronic Constriction Injury (CCI)-Induced Peripheral Neuropathy by Inhibiting Oxidative Stress Induced PARP Over-Activation and Neuroinflammation

(2016) Prashanth Komirishetty et al.   NEUROCHEMICAL RESEARCH

Ananas comosus Effect on Perineal Pain and Wound Healing After Episiotomy: A Randomized Double-Blind Placebo-Controlled Clinical Trial

(2016) Samira Golezar   Iranian Red Crescent Medical Journal

Interleukin-10 levels in rat models of nerve damage and neuropathic pain

(2015) Junad Khan et al.   NEUROSCIENCE LETTERS

Anti-allodynic Effects of Obtusifolin and Gluco-Obtusifolin against Inflammatory and Neuropathic Pain

(2014) Zhi-Wei He et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C

(2014) Xisheng Yan et al.   GLIA

Perioperative Bromelain Reduces Pain and Swelling and Improves Quality of Life Measures After Mandibular Third Molar Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2014) Omer Waleed Majid et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Emotional consequences of neuropathic pain: Insight from preclinical studies

(2014) Ipek Yalcin et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Modulating the delicate glial–neuronal interactions in neuropathic pain: Promises and potential caveats

(2014) Vinod Tiwari et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Suppression of bone marrow–derived microglia in the amygdala improves anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice

(2014) Atsushi Sawada et al.   PAIN

Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain

(2014) Abhilasha Ahlawat et al.   INFLAMMOPHARMACOLOGY

Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling

(2013) Wei Dou et al.   BRITISH JOURNAL OF NUTRITION

Endogenous Interleukin-1β in Neuropathic Rats Enhances Glutamate Release from the Primary Afferents in the Spinal Dorsal Horn through Coupling with PresynapticN-Methyl-d-aspartic Acid Receptors

(2013) Xisheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

(2013) Steven Biesmans et al.   MEDIATORS OF INFLAMMATION

Discovering cytokines as targets for chemotherapy-induced painful peripheral neuropathy

(2012) Xiao-Min Wang et al.   CYTOKINE

Spinal Interleukin-10 Therapy to Treat Peripheral Neuropathic Pain

(2012) Erin D. Milligan et al.   NEUROMODULATION

Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1

(2010) Yong-Jing Gao et al.   GLIA

The Role of Glia and the Immune System in the Development and Maintenance of Neuropathic Pain

(2010) Ricardo Vallejo et al.   Pain Practice

Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway

(2009) Kulpreet Bhui et al.   CANCER LETTERS

A Key Role for gp130 Expressed on Peripheral Sensory Nerves in Pathological Pain

(2009) M. Andratsch et al.   JOURNAL OF NEUROSCIENCE

Bromelain treatment decreases neutrophil migration to sites of inflammation

(2008) David J. Fitzhugh et al.   CLINICAL IMMUNOLOGY

Ameliorative effects of Ocimum sanctum in sciatic nerve transection-induced neuropathy in rats

(2008) A. Muthuraman et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1 , Interleukin-6, and Tumor Necrosis Factor-  in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord

(2008) Y. Kawasaki et al.   JOURNAL OF NEUROSCIENCE

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

IL-1β signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2

(2007) Wendy Kleibeuker et al.   BRAIN BEHAVIOR AND IMMUNITY