Article
Nutrition & Dietetics
Nosheen Malik, Sana Javaid, Waseem Ashraf, Farhan Siddique, Muhammad Fawad Rasool, Faleh Alqahtani, Tanveer Ahmad, Muhammad Asad Abrar, Imran Imran
Summary: The medicinal properties of Syzygium cumini and its effects on age-related neurological changes have been explored in this study. Supplementing young mice with Syzygium cumini fruit pulp has shown significant protection against anxiety-like behavior and improved cognitive abilities in aged mice. The beneficial effects may be attributed to the antioxidant and anticholinergic effects of the phytocompounds present in Syzygium cumini.
Article
Neurosciences
Savannah M. Rocha, Kelly S. Kirkley, Debotri Chatterjee, Tawfik A. Aboellail, Richard J. Smeyne, Ronald B. Tjalkens
Summary: Parkinson's disease is the most common neurodegenerative movement disorder worldwide, with a higher prevalence in men. The cause of the disease is largely unknown, but environmental exposures and neuroinflammation are linked to the misfolding of proteins and disease progression. Activated microglia play a role in promoting neuroinflammation in Parkinson's disease, but the interaction between environmental agents and specific innate immune signaling pathways in microglia is not well understood.
Article
Biology
Eva M. Szego, Laura Malz, Nadine Bernhardt, Angela Roesen-Wolff, Bjoern H. Falkenburger, Hella Luksch
Summary: This study demonstrates that chronic activation of the STING pathway is sufficient to cause degeneration of dopaminergic neurons, which could be significant in Parkinson's disease and other neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Naserddine Hamadi, Omur Gulsum Deniz, Ahlam Said Abi Issa, Azim Ullah Shamsul Islam, Naheed Amir, Saeed Tariq Minhas, Nather Madjid, Fatima Khelifi-Touhami, Suleyman Kaplan, Abdu Adem
Summary: The development of animal models to study cell death in the brain is a delicate task. One of the models, that was discovered in the late eighties, is the induction of neurodegeneration through glucocorticoid withdrawal by adrenalectomy in albino rats. In this study, the impact of short-term adrenalectomy on hippocampal neuronal populations in Wistar rats was investigated using stereological technique and ultrastructural examination. The levels of insulin-like growth factor-1 (IGF-1) and beta-nerve growth factor (beta-NGF) were measured to understand the underlying mechanisms of degeneration in these neurons. The cognitive behavior of Wistar rats after short-term adrenalectomy was also examined.
Article
Neurosciences
Alexia Polissidis, Effrosyni Koronaiou, Georgia Nikolopoulou, Catherine Viel, Maria Nikatou, Marios Bogiongko, S. Pablo Sardi, Maria Xilouri, Kostas Vekrellis, Leonidas Stefanis
Summary: Mutations in the GBA1 gene are strongly associated with Parkinson's disease (PD). The interaction between GCase and AS may play a crucial role in the neurodegenerative process of PD.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Lih-Geeng Chen, Shyr-Yi Lin, Yi-Shan Lee, Ching-Chiung Wang, Wen-Chi Hou
Summary: Agricultural waste from water caltrop hulls was extracted and shown to have AChE inhibitory activities, free radical scavenging activities, and anti-non-enzymatic protein glycation effects. Several compounds with strong AChE inhibitory activities and anti-amyloid 13 peptide aggregation effects were identified. Additionally, treatment with the extracted compounds or water caltrop hull extracts improved learning behavior in mice with induced amnesia.
Review
Biochemistry & Molecular Biology
Ritu Soni, Prashant Delvadia, Amit Joharapurkar, Jigna Shah
Summary: Parkinson's disease (PD) is a common progressive disorder characterized by deposition of inclusion bodies on dopaminergic neurons in the brain. The major component of these inclusion bodies is α-synuclein aggregates, which gradually propagate PD pathology. Underexplored molecular targets could potentially aid in the development of novel therapeutics for PD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Matteo Senesi, Victoria Lewis, Paul A. Adlard, David I. Finkelstein, Jee Hyun Kim, Steven J. Collins
Summary: Research suggests that neurotoxic PrPSc may be produced during the late stages of prion disease in a mouse model, and different types of behavioral tests across the time course of disease progression can help detect cognitive deficits more effectively.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Juciano Gasparotto, Nauana Somensi, Carolina Saibro Girardi, Reykla Ramon Bittencourt, Laura Martinewski de Oliveira, Laura Piloneto Hoefel, Ingrid Matsubara Scheibel, Daniel Oppermann Peixoto, Jose Claudio Fonseca Moreira, Tiago Fleming Outeiro, Daniel Pens Gelain
Summary: RAGE is a transmembrane receptor associated with chronic inflammation in non-transmissible diseases and may play a crucial role in neuroinflammation in Parkinson's disease.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Margaux Teil, Marie-Laure Arotcarena, Benjamin Dehay
Summary: NHP models play a crucial role in studying synucleinopathy, providing insights into its pathogenicity and contributing to the development of therapeutic strategies for the disease.
Review
Biochemistry & Molecular Biology
Davide Decandia, Francesca Gelfo, Eugenia Landolfo, Francesca Balsamo, Laura Petrosini, Debora Cutuli
Summary: Alzheimer's disease (AD) is a growing epidemic with significant social and economic burden. Inflammation and neurodegeneration play a major role in AD pathogenesis. This review focuses on the effects of dietary supplementation in AD-like animal models, specifically in relation to neuroinflammation induced by lipopolysaccharide (LPS) injection. Various compounds, such as curcumin and krill oil, have been found to counteract cognitive decline and neuroinflammatory responses in rodents. Overall, dietary interventions offer potential neuroprotection and immune regulation in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Tiago F. Outeiro, Peter Heutink, Erwan Bezard, Angela M. Cenci
Summary: Parkinson's disease is primarily characterized by movement disorders associated with the loss of dopaminergic neurons. However, it is now understood as a complex condition with multiple nonmotor features, involving various protein inclusions. Familial forms of PD have provided insights into the molecular pathways leading to neurodegeneration, adding complexity to the issue. Models using patient-derived cells and animal models, combined with current technological tools, are proposed to expand understanding and identify therapeutic strategies for PD.
MOVEMENT DISORDERS
(2021)
Article
Food Science & Technology
Chi Heung Cho, Young Sung Jung, Jong Min Kim, Tae Gyu Nam, Sang-Hoon Lee, Hye Sung Cho, Myoung Chong Song, Ho Jin Heo, Dae-Ok Kim
Summary: The Actinidia eriantha cv. Bidan extract (AEE) showed neuroprotective effects by reducing reactive oxygen species levels and suppressing apoptotic cell death, resulting in improvements in learning and spatial memory in Aβ1-42-treated mice. AEE also increased endogenous antioxidant systems in mouse brain tissue and contained caffeic acid derivatives, suggesting its potential to improve cognitive function as a source of antioxidant phenolics.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Behavioral Sciences
Ewa Zwierzynska, Boguslawa Pietrzak
Summary: Lacosamide does not impair memory and learning processes, with temporary disruption of emotional memory observed only after a single high dose administration.
EPILEPSY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Maria Elena Quintanilla, Paola Morales, Daniela Santapau, Alba Avila, Carolina Ponce, Pablo Berrios-Carcamo, Belen Olivares, Javiera Gallardo, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel, Fernando Ezquer
Summary: Chronic opioid use leads to brain changes associated with dependence, and studying animal models can help identify these changes at the cellular and molecular level. Polydrug use and dependence are shared across substances. Using animals bred for alcohol preference, researchers found that they also developed opioid dependence and exhibited similar cortical abnormalities seen in opioid addicts. This study is valuable for future evaluations of treatment approaches for this condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
S. Mursalimov, A. Glagoleva, E. Khlestkina, O. Shoeva
Summary: The study discovered that melanin synthesis in barley seeds is controlled by two genes, Blp1 and Alm1, with Blp1 regulating melanin synthesis and Alm1 controlling chlorophyll synthesis. Although different genetic systems are responsible for these traits, they are localized in the same organelle. Cytological analysis revealed that husk cells have more developed internal structures, and melanin biosynthesis may depend on the presence of plastids with well-developed internal membranes.
Article
Agronomy
Anastasiya Glagoleva, Tatjana Kukoeva, Sergey Mursalimov, Elena Khlestkina, Olesya Shoeva
Summary: This study explored the effects of combined accumulation of anthocyanins and melanins in barley, and found that their presence positively influences the color and anthocyanin content of the grain. Additionally, the presence of pigments does not decrease plant productivity. These findings will contribute to the understanding of genetic mechanisms underlying pigment biosynthesis and breeding strategies for enriching barley varieties with polyphenols.
Review
Cell Biology
Tarun Minocha, Hareram Birla, Ahmad A. A. Obaid, Vipin Rai, P. Sushma, Chandan Shivamallu, Mahmoud Moustafa, Mohammed Al-Shehri, Ahmed Al-Emam, Maria A. A. Tikhonova, Sanjeev Kumar Yadav, Burkhard Poeggeler, Divakar Singh, Sandeep Kumar Singh
Summary: Alzheimer's disease is a serious progressive neurodegenerative disorder in the elderly, and flavonoids have shown neuroprotective effects and potential as a source for AD treatment.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Pharmacology & Pharmacy
Alexander B. Pupyshev, Tatyana P. Klyushnik, Anna A. Akopyan, Sandeep Kumar Singh, Maria A. Tikhonova
Summary: Trehalose is a promising approach for the treatment of neurodegenerative diseases through its induction of autophagy. It has anti-inflammatory, antioxidant, and neuroprotective effects, reducing the accumulation of abnormal proteins. Trehalose activates lysosome and autophagosome biogenesis pathways. However, further research is needed to understand its pharmacodynamics. Trehalose has demonstrated potential in treating diseases such as Alzheimer's, Parkinson's, and Huntington's in animal models.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Maria A. Tikhonova, Nikolai A. Maslov, Alim A. Bashirzade, Eugenyi V. Nehoroshev, Vladislav Y. Babchenko, Nadezhda D. Chizhova, Elena O. Tsibulskaya, Anna A. Akopyan, Evgeniya V. Markova, Yi-Ling Yang, Kwok-Tung Lu, Allan V. Kalueff, Lyubomir I. Aftanas, Tamara G. Amstislavskaya
Summary: Researchers developed a laser-induced brain injury model in zebrafish, which successfully replicated behavioral and neuroanatomical changes observed in traumatic brain injury (TBI). The model showed similarities to mammalian TBI models, validating its effectiveness. The study also examined the changes in neurons and brain-derived neurotrophic factor (BDNF) after the injury, as well as the activation of microglia and the levels of hypoxia-inducible factor 1-alpha (Hif1a).
Article
Plant Sciences
Elena Antonova, Nadezhda S. Shimalina, Anna M. Korotkova, Ekaterina Kolosovskaya, Sophia Gerasimova, Elena K. Khlestkina
Summary: The genes NUD and WIN1 play a regulatory role in cuticle organization in barley. Mutations in these genes may affect plant adaptation mechanisms and lead to alterations in root system and leaf morphology and color.
Article
Biochemistry & Molecular Biology
B. R. Kuluev, E. V. Mikhailova, A. R. Kuluev, A. A. Galimova, E. A. Zaikina, E. K. Khlestkina
Summary: This review discusses recent advances in genomic editing of cultivated plants in the Triticeae tribe, with a focus on bread wheat and barley. It also examines the tools and methods commonly used in this field, as well as approaches to overcome the low regenerative capacity observed in Triticeae plants.
Article
Genetics & Heredity
K. Strygina, A. G. Elatskova, Yu A. Elatskov, G. A. Tekhanovich, E. K. Khlestkina
Summary: Studying the genes related to dwarf watermelon plants is crucial for accelerating selection processes. By analyzing the unique VIR collection of melon crops and selection forms at the Kuban experimental station of VIR, potentially new genes determining dwarfism in watermelon were identified.
RUSSIAN JOURNAL OF GENETICS
(2022)
Article
Agronomy
Elena Gordeeva, Olesya Shoeva, Sergey Mursalimov, Irina Adonina, Elena Khlestkina
Summary: This study successfully created black-grained substitution lines in the genetic background of bread wheat using marker-assisted technology, allowing for the simultaneous accumulation of anthocyanins in the aleurone and pericarp layers with a high total anthocyanin content. Although chromosome substitution had a positive effect on the main spike length, it negatively affected other yield-related traits.
Article
Agriculture, Multidisciplinary
Olesya Yu. Shoeva, Marina A. Mukhanova, Shakhira Zakhrabekova, Mats Hansson
Summary: In this study, the molecular function of the Ant13 locus in barley was determined. It was found that Ant13 encodes a regulatory protein that plays a crucial role in the transcriptional activation of structural genes involved in flavonoid biosynthesis. Additionally, the mutants deficient in the Ant13 locus exhibited decreased root and shoot growth and yield-related parameters.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Editorial Material
Neurosciences
Maria A. A. Tikhonova, Hung-Ming Chang, Sandeep Kumar Singh
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Irina V. Rozanova, Yuriy N. Grigoriev, Vadim M. Efimov, Alexander V. Igoshin, Elena K. Khlestkina
Summary: This study conducted a genome-wide association study on 94 barley varieties and identified 64 SNP markers significantly associated with spike productivity traits. Among them, 23 SNP markers were validated and 14 markers on chromosomes 2H, 4H and 5H were suggested for marker-assisted breeding programs.
Article
Plant Sciences
Ekaterina A. Krylova, Aleksandra S. Mikhailova, Yulia N. Zinchenko, Irina N. Perchuk, Mayya P. Razgonova, Elena K. Khlestkina, Marina O. Burlyaeva
Summary: This study focused on the pigmentation of legumes and their connection to flavonoids. By using various methods and analyses, the relationship between the genes in the MYB cluster on chromosome 5 and anthocyanin pigmentation was explored. The results showed that there is a correlation between the color of the seed coat and the anthocyanin content in Vigna unguiculata.
Article
Biochemistry & Molecular Biology
Daria V. Mikhailova, Oksana G. Shevchenko, Denis A. Golubev, Elena Y. Platonova, Nadezhda V. Zemskaya, Olesya Yu. Shoeva, Elena I. Gordeeva, Sergey A. Patov, Mikhail V. Shaposhnikov, Elena K. Khlestkina, Alexey Moskalev
Summary: This study examines the antioxidant and geroprotective properties of wheat bran extracts with high anthocyanin levels. The results show that the extracts with anthocyanins have higher radical scavenging and membrane protective activities, and can extend the lifespan of Drosophila. However, other metabolites in wheat bran may also contribute to its antioxidant and geroprotective potential.