标题
Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives
作者
关键词
-
出版物
Drug Design Development and Therapy
Volume Volume 14, Issue -, Pages 5375-5392
出版商
Informa UK Limited
发表日期
2020-12-03
DOI
10.2147/dddt.s275007
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Metallointercalator [Ru(dppz)2(PIP)]2+ Renders BRCA Wild-Type Triple-Negative Breast Cancer Cells Hypersensitive to PARP Inhibition
- (2020) Nur Aininie Yusoh et al. ACS Chemical Biology
- A Dinuclear Ruthenium(II) Complex Excited by Near-Infrared Light through Two-Photon Absorption Induces Phototoxicity Deep within Hypoxic Regions of Melanoma Cancer Spheroids
- (2020) Ahtasham Raza et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Preclinical Anticancer Activity of an Electron‐Deficient Organoruthenium(II) Complex
- (2020) Joan J. Soldevila‐Barreda et al. ChemMedChem
- Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to In Vivo Studies
- (2020) Anna Notaro et al. JOURNAL OF MEDICINAL CHEMISTRY
- Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II
- (2020) Kai Xiong et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy
- (2020) Johannes Karges et al. Nature Communications
- Heterofunctional ruthenium(II) carbosilane dendrons, a new class of dendritic molecules to fight against prostate cancer
- (2020) Natalia Sanz del Olmo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- High in Vitro and in Vivo Tumor-Selective Novel Ruthenium(II) Complexes with 3-(2′-Benzimidazolyl)-7-fluoro-coumarin
- (2019) Qi-Pin Qin et al. ACS Medicinal Chemistry Letters
- Synthesis, Structure, Stability, and Inhibition of Tubulin Polymerization by RuII–p-Cymene Complexes of Trimethoxyaniline-Based Schiff Bases
- (2019) Sourav Acharya et al. INORGANIC CHEMISTRY
- Novel tetranuclear ruthenium(II) arene complexes showing potent cytotoxic and antimetastatic activity as well as low toxicity in vivo
- (2019) Mohamed Kasim Mohamed Subarkhan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Harnessing ruthenium(II) as photodynamic agents: Encouraging advances in cancer therapy
- (2018) Jiangping Liu et al. COORDINATION CHEMISTRY REVIEWS
- Controlling with light the interaction between trans-tetrapyridyl ruthenium complexes and an oligonucleotide
- (2018) Vincent H. S. van Rixel et al. DALTON TRANSACTIONS
- Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines
- (2018) Jakob Kljun et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433
- (2018) Susan Monro et al. CHEMICAL REVIEWS
- Anticancer activity of two novel ruthenium compounds in gastric cancer cells
- (2018) S. Ramírez-Rivera et al. LIFE SCIENCES
- Synthesis and Photobiological Activity of Ru(II) Dyads Derived from Pyrrole-2-carboxylate Thionoesters
- (2017) Deborah A. Smithen et al. INORGANIC CHEMISTRY
- Combination of ruthenium(II)-arene complex [Ru(η6-p-cymene)Cl2(pta)] (RAPTA-C) and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity
- (2017) Robert H. Berndsen et al. Scientific Reports
- X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism
- (2016) Aleksandar Bijelic et al. JOURNAL OF MEDICINAL CHEMISTRY
- Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy
- (2015) Huaiyi Huang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Water-Soluble Phosphorescent Ruthenium Complex with a Fluorescent Coumarin Unit for Ratiometric Sensing of Oxygen Levels in Living Cells
- (2015) Daiki Hara et al. BIOCONJUGATE CHEMISTRY
- Ruthenium(II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents
- (2015) Jiangping Liu et al. BIOMATERIALS
- Cisplatin binding to human serum albumin: a structural study
- (2015) Giarita Ferraro et al. CHEMICAL COMMUNICATIONS
- A luminescent ruthenium(ii) complex for light-triggered drug release and live cell imaging
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- Ruthenium complexes as antimicrobial agents
- (2015) Fangfei Li et al. CHEMICAL SOCIETY REVIEWS
- Duplex-Selective Ruthenium-Based DNA Intercalators
- (2015) Chad M. Shade et al. CHEMISTRY-A EUROPEAN JOURNAL
- Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells
- (2015) Leli Zeng et al. CHEMISTRY-A EUROPEAN JOURNAL
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- (2015) Jessica D. Knoll et al. COORDINATION CHEMISTRY REVIEWS
- Noble metals in medicine: Latest advances
- (2015) Serenella Medici et al. COORDINATION CHEMISTRY REVIEWS
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- (2015) Hiroshi Inaba et al. Biomaterials Science
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- (2014) Tanmaya Joshi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- (2014) N.C. Miltenburg et al. CANCER TREATMENT REVIEWS
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- (2014) Wenchao Xu et al. CHEMICAL COMMUNICATIONS
- Metallodrugs in Medicinal Inorganic Chemistry
- (2014) Katja Dralle Mjos et al. CHEMICAL REVIEWS
- Fusion of photodynamic therapy and photoactivated chemotherapy: a novel Ru(ii) arene complex with dual activities of photobinding and photocleavage toward DNA
- (2014) Yongjie Chen et al. DALTON TRANSACTIONS
- Syntheses and evaluation of drug-like properties of CO-releasing molecules containing ruthenium and group 6 metal
- (2014) Pengpeng Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes
- (2014) Leonor Côrte-Real et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Arene–Ruthenium(II) Acylpyrazolonato Complexes: Apoptosis-Promoting Effects on Human Cancer Cells
- (2014) Riccardo Pettinari et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery and Investigation of Anticancer Ruthenium–Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly
- (2014) Mun Juinn Chow et al. JOURNAL OF MEDICINAL CHEMISTRY
- Luminescent Ruthenium Complexes for Theranostic Applications
- (2014) Carolina R. Cardoso et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, Characterization, and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy
- (2014) Angelo Frei et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting Nucleus DNA with a Cyclometalated Dipyridophenazineruthenium(II) Complex
- (2014) Huaiyi Huang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery
- (2014) Anna K. Renfrew Metallomics
- Ruthenium Polypyridine Complexes Combined with Oligonucleotides for Bioanalysis: A Review
- (2014) Shuyu Zhang et al. MOLECULES
- RutheniumII Complexes bearing Fused Polycyclic Ligands: From Fundamental Aspects to Potential Applications
- (2014) Ludovic Troian-Gautier et al. MOLECULES
- Synthesis, labeling and bioanalytical applications of a tris(2,2′-bipyridyl)ruthenium(II)-based electrochemiluminescence probe
- (2014) Xiaoming Zhou et al. Nature Protocols
- Ruthenium(II)–Arene RAPTA Type Complexes Containing Curcumin and Bisdemethoxycurcumin Display Potent and Selective Anticancer Activity
- (2014) Riccardo Pettinari et al. ORGANOMETALLICS
- NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
- (2014) Robert Trondl et al. Chemical Science
- The studies on bioactivity in vitro of ruthenium(ii) polypyridyl complexes towards human lung carcinoma A549 cells
- (2014) Bing-Jie Han et al. RSC Advances
- Bioactive Luminescent Transition-Metal Complexes for Biomedical Applications
- (2013) Dik-Lung Ma et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- From One-Photon to Two-Photon Probes: “Caged” Compounds, Actuators, and Photoswitches
- (2013) Guillaume Bort et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The path for metal complexes to a DNA target
- (2013) Alexis C. Komor et al. CHEMICAL COMMUNICATIONS
- Kinetic and mechanistic studies on reactions of diruthenium(ii,iii) with biologically relevant reducing agents
- (2013) Rodrigo Luis Silva Ribeiro Santos et al. DALTON TRANSACTIONS
- Ruthenium complexes in different oxidation states: synthesis, crystal structure, spectra and redox properties
- (2013) Agnieszka Jabłońska-Wawrzycka et al. DALTON TRANSACTIONS
- Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells
- (2013) Eva Iniguez et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Studies of ruthenium(ii)-2,2′-bisimidazole complexes on binding to G-quadruplex DNA and inducing apoptosis in HeLa cells
- (2013) Yu Xia et al. NEW JOURNAL OF CHEMISTRY
- A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia
- (2013) Stuart J. Wong et al. ORAL ONCOLOGY
- Photoactivatable metal complexes: from theory to applications in biotechnology and medicine
- (2013) N. A. Smith et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- Dinuclear ruthenium(ii) antimicrobial agents that selectively target polysomes in vivo
- (2013) Fangfei Li et al. Chemical Science
- Sixty Years Young: The Diverse Biological Activities of Metal Polypyridyl Complexes Pioneered by Francis P. Dwyer
- (2012) Nathan L. Kilah et al. AUSTRALIAN JOURNAL OF CHEMISTRY
- Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization
- (2012) Percia Beatrice Arockiam et al. CHEMICAL REVIEWS
- Ruthenium(ii) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics
- (2012) Martin R. Gill et al. CHEMICAL SOCIETY REVIEWS
- The potential of organometallic complexes in medicinal chemistry
- (2012) Gilles Gasser et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Structure–Activity Relationships of Targeted RuII(η6-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands
- (2012) Andrea Kurzwernhart et al. JOURNAL OF MEDICINAL CHEMISTRY
- Detection of α-Synuclein Amyloidogenic Aggregates in Vitro and in Cells using Light-Switching Dipyridophenazine Ruthenium(II) Complexes
- (2012) Nathan P. Cook et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Molecular and Cellular Characterization of the Biological Effects of Ruthenium(II) Complexes Incorporating 2-Pyridyl-2-pyrimidine-4-carboxylic Acid
- (2012) Vanessa Pierroz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Distinct cellular fates for KP1019 and NAMI-A determined by X-ray fluorescence imaging of single cells
- (2012) Jade B. Aitken et al. Metallomics
- CO-Releasing Molecules: A Personal View
- (2012) Brian E. Mann ORGANOMETALLICS
- A ruthenium(ii) complex based turn-on electrochemiluminescence probe for the detection of nitric oxide
- (2011) Wenzhu Zhang et al. ANALYST
- Dual-Color Fluorescence and Homogeneous Immunoassay for the Determination of Human Enterovirus 71
- (2011) Lu Chen et al. ANALYTICAL CHEMISTRY
- Control of ligand-exchange processes and the oxidation state of the antimetastatic Ru(iii) complex NAMI-A by interactions with human serum albumin
- (2011) Michael I. Webb et al. DALTON TRANSACTIONS
- Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs
- (2011) Alberta Bergamo et al. DALTON TRANSACTIONS
- Pyridine Analogues of the Antimetastatic Ru(III) Complex NAMI-A Targeting Non-Covalent Interactions with Albumin
- (2011) Michael I. Webb et al. INORGANIC CHEMISTRY
- Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin
- (2011) Michael Groessl et al. Metallomics
- A Ruthenium−Rhodamine Complex as an Activatable Fluorescent Probe
- (2010) Josefina del Mármol et al. ANALYTICAL CHEMISTRY
- Interaction of [Ru(bpy)2(dppz)]2+ with human telomeric DNA: Preferential binding to G-quadruplexes over i-motif
- (2010) Shuo Shi et al. BIOCHIMIE
- Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry
- (2010) Michael Groessl et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Organometallic ruthenium-based antitumor compounds with novel modes of action
- (2010) Wee Han Ang et al. JOURNAL OF ORGANOMETALLIC CHEMISTRY
- Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure–activity relationships
- (2009) Claudio Luis Donnici et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Photodynamic therapy of actinic keratoses with 8% and 16% methyl aminolaevulinate and home-based daylight exposure: a double-blinded randomized clinical trial
- (2009) S.R. Wiegell et al. BRITISH JOURNAL OF DERMATOLOGY
- Ruthenium-Based Heterocyclic Carbene-Coordinated Olefin Metathesis Catalysts†
- (2009) Georgios C. Vougioukalakis et al. CHEMICAL REVIEWS
- Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine
- (2009) Nicola J. Farrer et al. DALTON TRANSACTIONS
- Areneruthenium complexes as anticancer agents
- (2009) Georg Süss-Fink DALTON TRANSACTIONS
- Platinum Anticancer Coordination Compounds: Study of DNA Binding Inspires New Drug Design
- (2009) Jan Reedijk EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
- Serum-protein interactions with anticancer Ru(III) complexes KP1019 and KP418 characterized by EPR
- (2009) Naniye Cetinbas et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- Recent developments in ruthenium anticancer drugs
- (2009) Aviva Levina et al. Metallomics
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- (2009) S. R. McWhinney et al. MOLECULAR CANCER THERAPEUTICS
- Recent Advances in Two-Photon Photodynamic Therapy
- (2008) Kazuya Ogawa et al. Anti-Cancer Agents in Medicinal Chemistry
- KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients
- (2008) Christian G. Hartinger et al. CHEMISTRY & BIODIVERSITY
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