SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial–mesenchymal transition

(2019) Zhou Yang et al.   Cancer Cell International

SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species

(2019) Weiping Yu et al.   OncoTargets and Therapy

Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance

(2017) Mingze Chang et al.   ONCOLOGY REPORTS

Migraine and Cerebrovascular Atherosclerosis in Patients With Ischemic Stroke

(2017) Hendrikus J.A. van Os et al.   STROKE

Angiogenesis in the atherosclerotic plaque

(2017) Caroline Camaré et al.   Redox Biology

Reactive Oxygen Species/Hypoxia-Inducible Factor-1α/Platelet-Derived Growth Factor-BB Autocrine Loop Contributes to Cocaine-Mediated Alveolar Epithelial Barrier Damage

(2016) Lu Yang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia-Inducible Factor-1α Expression in Macrophages Promotes Development of AtherosclerosisHighlights

(2016) Annemarie Aarup et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption

(2016) Kuo-Liang Hou et al.   BIOFACTORS

LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56

(2016) Abhinav K. Jain et al.   MOLECULAR CELL

Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice

(2016) Zhiping Liu et al.   Translational Research

Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice

(2016) Zhu-Qin Zhang et al.   Scientific Reports

C-reactive protein can upregulate VEGF expression to promote ADSC-induced angiogenesis by activating HIF-1α via CD64/PI3k/Akt and MAPK/ERK signaling pathways

(2016) JiaYuan Chen et al.   Stem Cell Research & Therapy

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Novel mechanism of cardiac protection by valsartan: synergetic roles of TGF-β1 and HIF-1α in Ang II-mediated fibrosis after myocardial infarction

(2015) Xizhong Sui et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oxidative Stress and Early Atherosclerosis: Novel Antioxidant Treatment

(2014) Dimitris Tousoulis et al.   CARDIOVASCULAR DRUGS AND THERAPY

Alternatively Spliced Tissue Factor Promotes Plaque Angiogenesis Through the Activation of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Signaling

(2014) Chiara Giannarelli et al.   CIRCULATION

The Effects of CoCl2 on HIF-1α Protein under Experimental Conditions of Autoprogressive Hypoxia Using Mouse Models

(2014) Yan-Bo Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence

(2012) Anna Cardus et al.   CARDIOVASCULAR RESEARCH

Intraplaque neovascularization and hemorrhage

(2012) Dave Koole et al.   Journal of Cardiovascular Medicine

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE