Editorial Material
Multidisciplinary Sciences
Matthew B. Greenblatt, Shawon Debnath
Summary: As aging progresses, skeletal stem cells in mice lose their ability to generate bone-forming cells and instead promote the generation of bone-resorbing cells.
Review
Biochemistry & Molecular Biology
Elancheleyen Mahindran, Wan Safwani Wan Kamarul Zaman, Khairul Bariah Ahmad Amin Noordin, Yuen-Fen Tan, Fazlina Nordin
Summary: Population ageing is increasing globally due to advancements in medical treatments and technologies. This leads to a higher prevalence of age-related diseases, such as muscle loss, among the older population. Current interventions only slow down and control symptoms, and there is no treatment to prevent or reverse age-related muscle frailty. Mesenchymal stem cell-derived extracellular vesicle (MSC-EV) therapy shows promise in attenuating age-related muscle frailty, but further studies, including large-scale clinical trials, are needed to determine its effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rachel A. Oldershaw, Gavin Richardson, Phillippa Carling, W. Andrew Owens, David J. Lundy, Annette Meeson
Summary: This study compared cardiac stem cell-like cells from patients with bicuspid aortic valve disease and coronary artery disease. The results showed that stem cell-like cells from bicuspid aortic valve disease displayed a prematurely aged phenotype, with lower cell doubling rate, metabolic activity, shorter telomere lengths, and higher expression of p16.
Article
Chemistry, Multidisciplinary
Wenjin Cai, Jinglun Zhang, Yiqian Yu, Yueqi Ni, Yan Wei, Yihong Cheng, Litian Han, Leyi Xiao, Xiaoxin Ma, Hongjiang Wei, Yaoting Ji, Yufeng Zhang
Summary: Mitochondrial transfer from macrophages to mesenchymal stem cells regulates bone homeostasis, and abnormal transfer under osteoporotic conditions leads to metabolic remodeling in stem cells.
Review
Clinical Neurology
Meng Lu, Jindong Guo, Bowen Wu, Yuhui Zhou, Mishan Wu, Maryam Farzaneh, Seyed Esmaeil Khoshnam
Summary: Stroke is a leading cause of death and disability globally. Maintaining mitochondrial function is crucial for cell survival and neurological progress post ischemic stroke. Stem cell-mediated mitochondrial transfer shows promise as a therapeutic approach for ischemic stroke, where mesenchymal stem cells can transfer healthy mitochondria to damaged cells and rescue tissue degeneration caused by mitochondrial damage.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Medicine, Research & Experimental
Hyun Jik Lee, Chang Woo Chae, Ho Jae Han
Summary: Mesenchymal stem cell (MSC) transplantation has potential for treating diabetes mellitus (DM) and its complications. However, hyperglycemia can cause senescence and dysfunction in transplanted and resident MSCs due to mitochondrial dysfunction. Improving mitochondrial function could enhance the therapeutic efficacy of MSC transplantation in DM.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Konghuai Wang, Lu Zhou, Hanqing Mao, Jiayi Liu, Zhi Chen, Lu Zhang
Summary: Mitochondrial transfer has shown potential as a therapeutic strategy for tissue repair, but its role in protecting against pulpitis is unclear. This study found that hyperactivated NLRP3 inflammasomes and pyroptosis were present in pulpitis tissues, particularly in the odontoblast layer, and mitochondrial oxidative stress played a role in driving this pathology. Bone marrow mesenchymal stem cells (BMSCs) were found to donate their mitochondria to odontoblasts via tunnelling nanotubes (TNTs), reducing mitochondrial oxidative stress and pyroptosis. The transfer efficiency was enhanced by TNF-alpha secretion from pyroptotic odontoblasts, activating NF-kappa B signaling in BMSCs and promoting TNT formation.
CELL PROLIFERATION
(2023)
Review
Immunology
Claire Loussouarn, Yves-Marie Pers, Claire Bony, Christian Jorgensen, Daniele Noel
Summary: MSCs stimulate tissue repair by releasing EVs, which contain various molecules including miRNAs. These EVs impact the metabolism and oxidative stress of target cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Prakrit R. Kumar, Mona Saad, Charlotte Hellmich, Jayna J. Mistry, Jamie A. Moore, Shannon Conway, Christopher J. Morris, Kristian M. Bowles, Marc D. Moncrieff, Stuart A. Rushworth
Summary: Melanoma cells stimulate mitochondrial biogenesis in bone marrow-derived stromal cells, which leads to the transfer of mitochondria to melanoma cells. This study reveals metabolic interactions between melanoma and its microenvironment and provides new therapeutic approaches for melanoma treatment.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Wenjun Lv, Xiufen Peng, Yun Tu, Yisong Shi, Guanbin Song, Qing Luo
Summary: Weightlessness in space leads to detrimental effects on astronauts, including bone loss, muscle atrophy, and impaired immune defense. The study investigates the effects of simulated microgravity on mesenchymal stem cells (MSCs) and the potential therapeutic target for weightlessness-related cell senescence and aging. The results suggest that mitochondrial dysfunction mediates MSC senescence induced by simulated microgravity and inhibition of Yes-associated protein (YAP) alleviates MSC senescence through targeting mitochondrial dysfunction.
Review
Cell Biology
Yelei Cen, Guohua Lou, Jinjin Qi, Min Zheng, Yanning Liu
Summary: Mesenchymal stem cells (MSCs) show promise as an alternative treatment for liver disease due to their ability to regenerate, inhibit fibrosis, and regulate the immune system. Impaired mitochondrial function is a common feature in liver diseases, leading to ATP synthesis dysfunction, decreased respiratory chain activity, and altered mitochondrial dynamics. Recent evidence suggests that MSCs can not only replace damaged cells and have paracrine effects, but also regulate mitochondrial dysfunction in liver disease. This review comprehensively discusses the role of mitochondrial dysfunction in liver disease and how MSCs can target it, as well as recent advances in modifying MSCs to enhance their functions in treating liver disease.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Marta Cadenas-Martin, Francisco Arnalich-Montiel, Maria P. De Miguel
Summary: This study developed a protocol for deriving human limbal stem cells (LSCs) from adipose-derived mesenchymal stem cells (ADSCs) that is compatible with the standard carrier human amniotic membrane. The best protocol achieved optimal differentiation efficiency and will benefit patients with LSC deficiency, aiding in the restoration of vision.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Sebastien Gillotin, Vishal Sahni, Tjasa Lepko, Maya A. Hanspal, Jina E. Swartz, Zoi Alexopoulou, Fiona H. Marshall
Summary: Deficits in adult neurogenesis can lead to various neurological diseases, with recent studies exploring molecular mechanisms that could potentially lead to new therapeutic strategies. Understanding the role of adult neurogenesis is crucial for maintaining cognitive function and developing treatments for aging-related diseases, including neurodegeneration.
AGEING RESEARCH REVIEWS
(2021)
Article
Cell Biology
Naresh Polisetti, Guenther Schlunck, Thomas Reinhard
Summary: The expression pattern of PAX6 in limbal niche cells, such as mesenchymal stromal cells and melanocytes, is not well understood. This study shows that PAX6 is mainly expressed in limbal epithelial cells and plays a crucial role in maintaining their identity and fate.
Review
Biochemistry & Molecular Biology
Andromachi Pouikli, Peter Tessarz
Summary: This study highlights the coordinated control of bone-marrow mesenchymal stem cell (BM-MSC) proliferation and lineage commitment by metabolism and epigenetics, as well as the important role of metabolism in driving stem cell fate decisions through alterations of chromatin landscape. Age-associated changes in metabolism and the epigenome disturb the balance between stem cell proliferation and differentiation, leading to stem cell depletion, fat accumulation, and bone-quality related diseases. Understanding the dynamics of the metabolism-chromatin interplay is crucial for maintaining the stem cell pool and delaying aging.
Article
Medicine, General & Internal
Mi Zhou, Duo Huang, Yangyang Cheng, Yee Man Lau, Wing Hon Lai, Yuk-Ming Lau, JoJo Hai, Chu Pak Lau, Esther W. Chan, Wen Sheng Yue, Ming-Liang Zuo, Li Xue Yin, Yingqing Feng, Ning Tan, Jiyan Chen, Xin Li Li, Hung Fat Tse, Chi Ho Lee, Wing-Sun Chow, Chung Wah Siu, Chun Ka Wong
Summary: This study implemented screening for left ventricular dysfunction in patients with type 2 diabetes mellitus and found a small percentage of patients at high risk for heart failure. Male gender, prior stroke, chronic kidney disease, and newly detected atrial fibrillation were significantly associated with elevated NT-proBNP levels. The study suggests that NT-proBNP and ECG screening can aid in early detection of cardiovascular complications and improve long-term outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hok Shing Tang, Chi Ting Kwan, Jianlong He, Pan Pan Ng, Siu Han Jojo Hai, Fung Yu James Kwok, Ho Fung Sze, Man Hon So, Hong Yip Lo, Ho Tung Ambrose Fong, Eric Yuk Fai Wan, Chi-Ho Lee, Esther Yee Tak Yu, Yee Tak Alta Lai, Chun Yin Jonan Lee, Siu Ting Leung, Hiu Lam Chan, Hung Fat Tse, Dudley J. Pennell, Raad H. Mohiaddin, Roxy Senior, Andrew T. Yan, Kai-Hang Yiu, Ming-Yen Ng
Summary: This study evaluated the prognostic utility of feature tracking (FT) parameters derived from cardiac magnetic resonance imaging (MRI) and found that left ventricular global longitudinal strain (LV GLS) is a significant independent predictor of adverse outcomes in patients with dilated cardiomyopathy (DCM). LV GLS can be used as a clinical indicator for predicting the prognosis of DCM patients and strengthens the clinical implementation of FT in cardiac MRI.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Endocrinology & Metabolism
Jia-Yi Huang, Yi-Kei Tse, Hang-Long Li, Cong Chen, Chun-Ting Zhao, Ming-Ya Liu, Mei-Zhen Wu, Qing-Wen Ren, Si-Yeung Yu, Denise Hung, Xin-Li Li, Hung-Fat Tse, Gregory Y. H. Lip, Kai-Hang Yiu
Summary: This study evaluated the association between prediabetes and heart failure, as well as the association of heart failure with changes in glycemic status. The results showed that prediabetes was associated with an increased risk of heart failure, while reverting to normoglycemia was associated with a decreased risk of heart failure.
Article
Medicine, General & Internal
Si-Yeung Yu, Hang-Long Li, Yi-Kei Tse, Xue Li, Qing-Wen Ren, Mei-Zhen Wu, Pui-Fai Wong, Hung-Fat Tse, Gregory. Y. H. Lip, Kai -Hang Yiu
Summary: The study aimed to investigate the potential protective effects of statin use among patients with infective endocarditis (IE), considering underlying diseases and bacterial culture variables. The effects of pre-admission and in-hospital statin use on mortality were estimated through propensity score analytics. The results showed that both pre-admission and in-hospital statin use were associated with a lower risk of 1-year mortality.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Cardiac & Cardiovascular Systems
Yi Kei Tse, Hang Long Li, Si Yeung Yu, Mei Zhen Wu, Qing Wen Ren, Jiayi Huang, Hung Fat Tse, Jeroen J. Bax, Kai Hang Yiu
Summary: This study examines the predictors, changes, and prognostic implications of right ventricular (RV) remodelling in patients undergoing double-valve surgery. The study found that RV remodelling is strongly related to adverse outcomes and should be considered in risk assessment and decision-making for double-valve surgery.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Mei-zhen Wu, Tiew-Hwa Katherine Teng, Wan-Ting Tay, Qing-wen Ren, Jasper Tromp, Wouter Ouwerkerk, Chanchal Chandramouli, Jia-Yi Huang, Yap-Hang Chan, Kanako Teramoto, Si-Yeung Yu, Claire Lawson, Hang-Long Li, Yi-Kei Tse, Xin-li Li, Denise Hung, Hung-Fat Tse, Carolyn S. P. Lam, Kai-Hang Yiu
Summary: Cardiorenal complications are common in patients with new-onset type 2 diabetes and are associated with a higher risk of mortality. Close surveillance of these complications is crucial to reduce the burden of disease.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Huihuan Wu, Sha Tu, Zewei Zhuo, Rui Jiang, Ruijie Zeng, Qi Yang, Qizhou Lian, Weihong Sha, Hao Chen
Summary: The study aimed to determine the core target and potential mechanism of action of bisdemethoxycurcumin as a therapy for ulcerative colitis. Public databases were used to identify potential targets for bisdemethoxycurcumin and ulcerative colitis, and it was found that PI3K/Akt and MAPK pathways may be essential for the treatment of ulcerative colitis by bisdemethoxycurcumin.
Article
Endocrinology & Metabolism
Chi-Ho Lee, David Tak-Wai Lui, Raymond Hang-Wun Li, Michele Mae-Ann Yuen, Carol Ho-Yi Fong, Ambrose Pak-Wah Leung, Justin Chiu-Man Chu, Loey Lung-Yi Mak, Tai-Hing Lam, Jean Woo, Yu-Cho Woo, Aimin Xu, Hung-Fat Tse, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Man-Fung Yuen, Karen Siu-Ling Lam
Summary: This study investigated whether incorporating additional metabolic risk factors improved liver fibrosis risk stratification in non-diabetic overweight/obese MAFLD individuals. The results showed that abnormal AST and HOMA-IR levels were independently associated with higher liver fibrosis risk, and a sequential screening algorithm using these factors was developed for risk identification.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Calvin Ka-Lam Leung, Lok-Yee Lam, Kwan-Yu Li, Yundi Feng, Gaozhen Cao, Min Wu, Run Wang, Mei-Zhen Wu, Qing-Wen Ren, Si-Yeung Yu, Yi-Kei Tse, Hang-Long Li, Shuk-Yin Yu, Hung-Fat Tse, Bo Xu, Kai-Hang Yiu
Summary: This study evaluated the prognostic value of computational pressure-flow dynamics-derived FFR in patients with stable coronary artery disease. The results showed that PCI was associated with a lower risk of adverse cardiovascular events in ischemic patients, but not in non-ischemic patients. Adherent-to-caFFR treatment was also associated with a lower risk of adverse events.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Psychology, Clinical
Rui Jiang, Ruijie Zeng, Qiu Xinqi, Huihuan Wu, Zewei Zhuo, Qi Yang, Jingwei Li, Felix W. Leung, Qizhou Lian, Weihong Sha, Hao Chen
Summary: This study examined the causal relationship between inflammatory bowel disease (IBD) and anorexia nervosa (AN) using two-sample Mendelian randomization (MR) analysis. The results showed that genetically predicted IBD was significantly associated with an increased risk of AN, while there was no evidence of a causal effect of AN on IBD. These findings may have clinical benefits for early detection of AN and management of IBD patients.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Cardiac & Cardiovascular Systems
Xuxiao Ye, Caige Huang, Vincent Ka Chun Yan, Wei Kang, Min Fan, Gigi Kwan Chi Tsang, Clarissa Mung Yee Ho, Gregory Y. H. Lip, Kai-Hang Yiu, Hung-Fat Tse, Tiantian Ma, Xiwen Qin, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Carlos King Ho Wong, Eric Yuk Fai Wan, Xue Li, Cheuk Kwong Lee, Ivan Fan Ngai Hung, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: This study aimed to evaluate the risk of ischaemic stroke or systemic embolism and bleeding following COVID-19 vaccination in patients with atrial fibrillation (AF), with a focus on sex differences. The results showed that there was an increased risk of ischaemic stroke or systemic embolism in female patients with AF after receiving the first dose of BNT162b2 or CoronaVac. However, the risk was even higher after COVID-19 infection.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Marco Proietti, Tatjana Potpara, Moussa Mansour, Irina Savelieva, Hung Fat Tse, Andreas Goette, A. John Camm, Carina Blomstrom-Lundqvist, Dhiraj Gupta, Giuseppe Boriani
Summary: Stroke prevention in patients with atrial fibrillation has significantly improved with the introduction of non-vitamin K antagonist oral anticoagulants. Early rhythm control and cardiovascular risk factor management are also crucial in reducing the risk of stroke. Left atrial appendage occlusion or exclusion may be considered for patients who cannot undergo long-term oral anticoagulation. A holistic approach to atrial fibrillation management is recommended.
Article
Medicine, General & Internal
Eloi Marijon, Kumar Narayanan, Karen Smith, Sergio Barra, Cristina Basso, Marieke Blom, Lia Crotti, Andre D'Avila, Rajat Deo, Florence Dumas, Anastase Dzudie, Audrey Farrugia, Kaitlyn Greeley, Gerhard Hindricks, Wei Hua, Jodie Ingles, Taku Iwami, Juhani Junttila, Rudolph W. Koster, Jean-Benoit Le Polain De Waroux, Theresa M. Olasveengen, Marcus E. H. Ong, Michael Papadakis, Comilla Sasson, Sang Do Shin, Hung-Fat Tse, Zian Tseng, Christian Van Der Werf, Fredrik Folke, Christine M. Albert, Bo Gregers Winkel
Summary: Despite advancements in cardiovascular medicine, sudden cardiac death (SCD) remains a major challenge. Prevention efforts need to improve risk prediction and address arrhythmogenesis, while also strengthening community interventions and emergency medical systems. International collaboration and policy changes are crucial for further progress in tackling SCD.
Article
Cell & Tissue Engineering
Jingzhou Li, Fei Song, Ruolan Chen, Jinjuan Yang, Jie Liu, Li Huang, Fuyu Duan, Meng Kou, Boon Xuan Lian, Xiaoxia Zhou, Weimin Han, Liang Mao, Chan Wu, Weiyin Wu, Rui Wei, Hao Chen, Aimin Xu, Hung-Fat Tse, Qizhou Lian, Gang Li, Yan Wang
Summary: This study aimed to identify the active components of exosomes from bradykinin-pretreated cardiac-specific c-kit(+) cells and elucidate their underlying protective mechanisms in promoting angiogenesis against hindlimb ischemia.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Chi Ting Kwan, On Hang Samuel Ching, Pui Min Yap, Sau Yung Fung, Hok Shing Tang, Wan Wai Vivian Tse, Cheuk Nam Felix Kwan, Yin Hay Phoebe Chow, Nga Ching Yiu, Yung Pok Lee, Jessica Wing Ka Lau, Ambrose Ho Tung Fong, Qing-Wen Ren, Mei-Zhen Wu, Eric Yuk Fai Wan, Ka Chun Kevin Lee, Chun Yu Leung, Andrew Li, David Montero, Varut Vardhanabhuti, Jojo Siu Han Hai, Chung-Wah Siu, Hung-Fat Tse, Valentin Zingan, Xiaoxi Zhao, Haonan Wang, Dudley John Pennell, Raad Mohiaddin, Roxy Senior, Kai-Hang Yiu, Ming-Yen Ng
Summary: This study aimed to differentiate HFpEF patients from non-HFpEF patients and asymptomatic controls using intraventricular four-dimensional flow phase-contrast cardiovascular magnetic resonance. The results showed that CMR 4D flow derived LV direct flow and residual volume could effectively differentiate HFpEF patients from non-HFpEF patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)