Article
Biotechnology & Applied Microbiology
Atieh Abedin-Do, Ze Zhang, Yvan Douville, Mirelle Methot, Julien Bernatchez, Mahmoud Rouabhia
Summary: The prevalence of diabetes is increasing worldwide. This study engineered a diabetic human skin equivalent (DHSE) using fibroblasts and keratinocytes extracted from the skin of diabetic patients and demonstrated that exposure to low-intensity electrical stimulation (ES) can promote diabetic cell activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Geriatrics & Gerontology
Grace T. Yu, Dileep D. Monie, Sundeep Khosla, Tamar Tchkonia, James L. Kirkland, Saranya P. Wyles
Summary: This study found that cellular senescence plays an important role in the pathogenesis of diabetic foot ulcers. Gene expression analysis showed upregulated cellular senescence markers and downregulated TP53 in diabetic foot ulcers compared to uninvolved skin. Protein-protein interaction network analysis revealed significant perturbations in diabetic foot ulcer tissues, suggesting the involvement of cellular senescence in this condition.
Article
Dermatology
Alexey Lyundup, Maxim Balyasin, Nadezhda Maksimova, Marina Kovina, Mikhail E. Krasheninnikov, Tatiana G. Dyuzheva, Sergey A. Yakovenko, Svetlana A. Appolonova, Helgi B. Schioth, Ilya D. Klabukov
Summary: Some dermal malignancies can mimic diabetic foot ulcers, leading to misdiagnosis. Older age is associated with a higher risk of being misdiagnosed as DFU, and clinicians should maintain a high level of awareness in elderly patients with diabetes.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Hak Jun Kim, Woo Jong Kim, Hong Seop Lee, Yeong Yoon Koh, Young Bin Shin, Eui Dong Yeo
Summary: The degree of blood vessel stenosis does not significantly affect skin perfusion pressure (SPP) in diabetic foot wounds, but SPP is significantly associated with the rate of decrease in wound size.
Article
Dermatology
Irena Pastar, Jelena Marjanovic, Liang Liang, Rivka C. Stone, Olga Kashpur, Ivan Jozic, Cheyanne R. Head, Avi Smith, Behzad Gerami-Naini, Jonathan A. Garlick, Marjana Tomic-Canic
Summary: By studying the miR-regulated changes triggered by cell reprogramming, it was found that iPSC reprogramming is an effective approach for erasing the non-healing miR-mediated epigenetic signature in diabetes, promoting a pro-healing cellular phenotype.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Endocrinology & Metabolism
Bruno Verges, Roxane Brands, Coralie Fourmont, Jean-Michel Petit, Isabelle Simoneau, Alexia Rouland, Pauline Legris, Benjamin Bouillet, Jean-Christophe Chauvet-Gelinier
Summary: This study investigated the association between Type A personality and diabetic foot ulcer (DFU). The findings showed that Type A personality traits were significantly less common in T2D patients with DFU, while Type B personality traits were more prevalent. Type A personality may have a protective effect, while Type B personality may favor the development of DFU.
DIABETES & METABOLISM
(2021)
Article
Dermatology
Alvis Chiu, Dhavan Sharma, Feng Zhao
Summary: Diabetic foot ulcers (DFU) pose a significant problem and hinder natural wound healing processes. This review highlights recent advancements in tissue engineering for treatment, including FDA-approved approaches and cutting-edge experimental technologies. It emphasizes the need for new adjuvant therapies and explores the potential of genetic modification.
ADVANCES IN WOUND CARE
(2023)
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell & Tissue Engineering
Shou Jin Phang, Bavani Arumugam, Umah Rani Kuppusamy, Mh Busra Fauzi, Mee Lee Looi
Summary: This review focuses on different in vitro research models used in diabetic foot ulcer (DFU) investigations, such as the 2D scratch wound assay, 3D skin model, and 3D angiogenesis model, along with their limitations. Current efforts and challenges include applying these models in a hyperglycemic context to provide insights into DFU modeling.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Ching-Wen Lin, Chien-Min Hung, Wan-Jiun Chen, Jui-Ching Chen, Wen-Yen Huang, Chia-Sing Lu, Ming-Liang Kuo, Shyi-Gen Chen
Summary: Diabetic foot ulcers are costly and problematic complications of diabetes. The chronicity of these ulcers presents a challenge in treatment. Modulating the activity of M1 and M2 macrophages seems to be an effective approach in improving the healing process of DFUs.
Article
Endocrinology & Metabolism
Mingyang Jiang, Fu Gan, Meishe Gan, Huachu Deng, Xuxu Chen, Xintao Yuan, Danyi Huang, Siyi Liu, Baoyu Qin, Yanhong Wei, Shanggui Su, Zhandong Bo
Summary: This study identified 12 risk factors associated with diabetic foot ulcer in patients with type 2 diabetes mellitus and established a reliable prediction model.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Health Care Sciences & Services
Alvaro Astasio-Picado, Alba angel Babiano, Miriam Lopez-Sanchez, Rocio Ruiz Lozano, Paula Cobos-Moreno, Beatriz Gomez-Martin
Summary: This article provides evidence on the effectiveness and safety of ozone therapy in the treatment of wounds in patients with diabetic foot. It compares ozone therapy with other treatment methods and presents the findings of a literature review.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Sohail Akhtar, Mujahid Latif, Omer Shabbir Ahmed, Aqsa Sarwar, Ayisham Alina, Muhammad Imran Khan
Summary: This study explores the prevalence of foot ulcers among diabetic patients in Punjab, Pakistan and identifies associated factors. The results indicate a relatively high prevalence of foot ulcers in Punjab, highlighting the need for better strategies and preventive measures to address this epidemic.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Gauthier Borderie, Ninon Foussard, Alice Larroumet, Laurence Blanco, Kamel Mohammedi, Eric Ducasse, Caroline Caradu, Vincent Rigalleau
Summary: In individuals with diabetic kidney disease, there is a relationship between DKD and later occurrence of diabetic foot ulcers, while normoalbuminuric DKD is not related to diabetic foot ulcers.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Sungmin Nam, David Mooney
Summary: Polymeric tissue adhesives are versatile materials widely used in wound management, offering relative ease of use and rapid application while also acting as hemostats. Despite facing challenges, advancements in tissue adhesives may provide new possibilities for wound care.
Article
Chemistry, Multidisciplinary
Benjamin R. Freedman, Oktay Uzun, Nadja M. Maldonado Luna, Anna Rock, Charles Clifford, Emily Stoler, Gabrielle Ostlund-Sholars, Christopher Johnson, David J. Mooney
Summary: The development of degradable tough adhesive hydrogels with excellent mechanical and adhesive properties provides a foundation for various in vivo applications, allowing for on-demand removal without causing harm to underlying skin tissue. These new formulations show equivalent performance to nondegradable counterparts, complete degradation within weeks to months in vivo, and minimal fibrous encapsulation and no signs of organ toxicity after implantation.
ADVANCED MATERIALS
(2021)
Article
Cell Biology
Simon Matoori, Aristidis Veves, David J. Mooney
Summary: The study reviews current treatment options for foot ulcers related to diabetes and discusses the development of wound dressings tailored to the diabetic wound environment.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Physical
Irene de Lazaro, David J. Mooney
Summary: This text discusses the biological barriers that have hindered the clinical translation of cancer nanomedicines, and elaborates on new directions for the field that capitalize on a deeper understanding of the nano-bio interface.
Article
Nanoscience & Nanotechnology
Christina M. Tringides, Nicolas Vachicouras, Irene de Lazaro, Hua Wang, Alix Trouillet, Bo Ri Seo, Alberto Elosegui-Artola, Florian Fallegger, Yuyoung Shin, Cinzia Casiraghi, Kostas Kostarelos, Stephanie P. Lacour, David J. Mooney
Summary: This study introduces a fully viscoelastic microelectrode array for electrical stimulation and signal recording of heart and brain activities in vivo, utilizing an alginate matrix and carbon-based nanomaterials encapsulated in a viscoelastic hydrogel. The combination of viscoelastic materials enables the array to closely match the biomechanical properties of soft biological tissues, overcoming previous limitations. The use of hydrogels as outer layers and a hydrogel-based conductor enhanced with carbon nanomaterials allows for the fabrication of electrode arrays compatible with standard electrophysiology platforms.
NATURE NANOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Michael Super, Edward J. Doherty, Mark J. Cartwright, Benjamin T. Seiler, Fernanda Langellotto, Nikolaos Dimitrakakis, Des A. White, Alexander G. Stafford, Mohan Karkada, Amanda R. Graveline, Caitlin L. Horgan, Kayla R. Lightbown, Frank R. Urena, Chyenne D. Yeager, Sami A. Rifai, Maxence O. Dellacherie, Aileen W. Li, Collin Leese-Thompson, Hamza Ijaz, Amanda R. Jiang, Vasanth Chandrasekhar, Justin M. Scott, Shanda L. Lightbown, Donald E. Ingber, David J. Mooney
Summary: Injectable biomaterial vaccines designed to magnetically capture pathogen-associated molecular patterns protect mice and pigs against septic shock from lethal bacterial infections.
NATURE BIOMEDICAL ENGINEERING
(2022)
Review
Chemistry, Multidisciplinary
Christina M. Tringides, David J. Mooney
Summary: Surface electrode arrays are mainly made of rigid or elastic materials and ductile metal films, offering limited stretchability. They are often repurposed for different tissues without optimizing the materials and mechanical properties for the specific application. To improve tissue interfaces and reduce damage, it is important to characterize the biological environment and design technology accordingly for each specific organ.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Alexander J. Najibi, Ting-Yu Shih, David J. Mooney
Summary: Cryogel-based cancer vaccines can induce potent antigen-specific immune responses regardless of the distance to the draining lymph nodes. The vaccination location flexibility of scaffold-based vaccines demonstrates their ability to generate strong immune responses independent of draining lymph nodes.
Review
Dermatology
Georgios Theocharidis, Stavroula Tekkela, Aristidis Veves, John A. McGrath, Alexandros Onoufriadis
Summary: Single-cell technologies, particularly single-cell RNA sequencing, have revolutionized research in skin biology by enabling the assessment of cell-to-cell variation and elucidation of cellular heterogeneity in human diseases. These technologies have found wide applications in inflammatory skin disorders, fibrotic skin diseases, wound healing complications, and cutaneous neoplasms.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Peng Wang, Georgios Theocharidis, Ioannis S. Vlachos, Konstantinos Kounas, Antonio Lobao, Bin Shu, Biaoliang Wu, Julin Xie, Zhicheng Hu, Shaohai Qi, Bing Tang, Jiayuan Zhu, Aristidis Veves
Summary: This study investigated the efficacy and mechanisms of epidermal stem cells and their derived exosomes in improving diabetic foot ulceration. The results showed that both epidermal stem cells and their exosomes were effective in promoting diabetic wound healing, and exosome treatment may be a promising alternative to stem cell therapies.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Environmental Sciences
Esther Koh, Mythri Ambatipudi, DaLoria L. Boone, Julia B. W. Luehr, Alena Blaise, Jose Gonzalez, Nishant Sule, David J. Mooney, Emily M. He
Summary: The comfort of face masks is crucial for user compliance, with discomfort being the primary reason for noncompliance. Three critical predicting variables were identified through surveys and experiments to predict mask comfort. Machine learning algorithms were used to generate overall comfort scores for masks based on these predicting variables.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2022)
Article
Multidisciplinary Sciences
Georgios Theocharidis, Beena E. Thomas, Debasree Sarkar, Hope L. Mumme, William J. R. Pilcher, Bhakti Dwivedi, Teresa Sandoval-Schaefer, Ruxandra F. Sirbulescu, Antonios Kafanas, Ikram Mezghani, Peng Wang, Antonio Lobao, Ioannis S. Vlachos, Biraja Dash, Henry C. Hsia, Valerie Horsley, Swati S. Bhasin, Aristidis Veves, Manoj Bhasin
Summary: This study utilizes single-cell RNA sequencing to reveal the distribution of specific populations of fibroblasts and macrophages in diabetic foot ulceration (DFU) patients and identifies their crucial roles in wound healing.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Benjamin R. Freedman, Andreas Kuttler, Nicolau Beckmann, Sungmin Nam, Daniel Kent, Michael Schuleit, Farshad Ramazani, Nathalie Accart, Anna Rock, Jianyu Li, Markus Kurz, Andreas Fisch, Thomas Ullrich, Michael W. Hast, Yann Tinguely, Eckhard Weber, David J. Mooney
Summary: A hydrogel with high-capacity drug storage function has been found to promote tissue healing in tendon injuries. This hydrogel has a tough structure on one side and an adhesive surface on the other, allowing it to support tendon gliding and strong adhesion. Through experiments, it has been shown that this hydrogel enhances healing and reduces scar formation in rat models of tendon rupture, and can sustainably release drugs. It has potential for biomedical applications.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Georgios Theocharidis, Hyunwoo Yuk, Heejung Roh, Liu Wang, Ikram Mezghani, Jingjing Wu, Antonios Kafanas, Mauricio Contreras, Brandon Sumpio, Zhuqing Li, Enya Wang, Lihong Chen, Chuan Fei Guo, Navin Jayaswal, Xanthi-Leda Katopodi, Nikolaos Kalavros, Christoph S. Nabzdyk, Ioannis S. Vlachos, Aristidis Veves, Xuanhe Zhao
Summary: A polymer patch that adheres to diabetic wounds and contracts in a pre-programmed manner has shown to promote wound closure and re-epithelialization in mouse and human skin, in mini-pigs and in humanized mice. The patch consists of a dried adhesive layer of crosslinked polymer networks and a pre-stretched hydrophilic elastomer backing, utilizing a hydration-based shape-memory mechanism. In preclinical trials, the patch enhanced the healing of diabetic wounds by promoting faster re-epithelialization and angiogenesis, and enriching the fibroblast populations with a pro-regenerative phenotype.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Biology
Yiwei Li, Angelo Mao, Bo Seo, Xing Zhao, Satish Gupta, Maorong Chen, Yu Han, Ting-Yu Shih, David Mooney, Ming Guo
Summary: Current methods to obtain MSCs involve culture and expansion, but drawbacks include limited cell numbers and reduced stemness. A new method allows dedifferentiation of fat cells, but is laborious. This study presents a modified protocol using physical stimulation to enhance Wnt/β-catenin signaling for more efficient and simpler adipocyte dedifferentiation.