Article
Endocrinology & Metabolism
Kai Zhang, Yang Wang, Shiyu Chen, Jiali Mao, Yue Jin, Hui Ye, Yan Zhang, Xiwang Liu, Chenchen Gong, Xuejun Cheng, Xiaoli Huang, Andreas Hoeft, Qixing Chen, Xuekun Li, Xiangming Fang
Summary: Sepsis-induced cardiomyopathy (SICM) is a common and highly fatal condition characterized by abnormal immune response. This study identifies a unique subpopulation of cardiac-resident macrophages, CD163(+)RETNLA(+) (Mac1), which play a crucial role in SICM and can be targeted for prevention. The study demonstrates that TREM2(hi) Mac1 cells actively scavenge dysfunctional mitochondria and their deficiency leads to impaired self-renewal capability, excessive inflammation, cardiac dysfunction, and reduced survival. Intrapericardial administration of TREM2(hi) Mac1 cells can prevent SICM, suggesting a potential therapeutic strategy.
Article
Materials Science, Multidisciplinary
S. Ranjani, Matheen Abdul, A. Antony Jenish, S. Hemalatha
Summary: Poly bio-silver nanoparticles (PBSNp) synthesized from the extracts of Piper nigrum, Piper longum and Zingiber officinale showed promising antibacterial efficacy, outperforming antibiotics in controlling microbial growth. PBSNp has the potential to be developed as an alternative biomaterial for controlling bacterial pathogens in the future.
Article
Immunology
Xueyi Chen, Ferdia Gallagher, Mark A. Sellmyer, Alvaro A. Ordonez, Andreas Kjaer, Michael Ohliger, David M. Wilson, Sanjay K. Jain
Summary: Bacterial infections remain a major global threat even after the discovery of penicillin nearly a century ago. The overuse of antibiotics has led to the selection of multidrug-resistant super-bugs, highlighting the urgent need for new clinical tools. Next-generation molecular imaging offers unique opportunities to identify and monitor bacterial infections in a noninvasive manner, overcoming the limitations of current tools.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biology
Victoria Prudent, Gaelle Demarre, Emilie Vazeille, Maxime Wery, Nicole Quenech'Du, Antinea Ravet, Julie Dauverd - Girault, Erwin van Dijk, Marie-Agnes Bringer, Marc Descrimes, Nicolas Barnich, Sylvie Rimsky, Antonin Morillon, Olivier Espeli
Summary: Patients with Crohn's disease exhibit abnormal colonization of the intestine by adherent invasive E. coli (AIEC), which adapt to phagolysosomal stress and form bacterial communities within macrophages through the production of an extrabacterial matrix. This study provides insights into the strategies that AIECs use to establish their replicative niche within macrophages.
COMMUNICATIONS BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Xiaomin Huang, Luoyuan Li, Zhongxing Chen, Haoyu Yu, Xinru You, Na Kong, Wei Tao, Xingtao Zhou, Jinhai Huang
Summary: Ocular bacterial infection, a common cause of blindness, has significant consequences for daily life. The rapid advancement of nanoscience and biomedicine has led to the increasing attention on multifunctional nanosystems as a potential solution to ocular bacterial infections. This review highlights the challenges faced by ocular medicine and encourages basic research and future clinical transformation based on ophthalmic antibacterial nanomedicine.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Guoyu Li, Zhenheng Lai, Anshan Shan
Summary: Due to the increase in multidrug-resistant bacterial isolates and lack of effective antimicrobial agents, antibiotic resistant bacterial infections have risen significantly. There is an urgent need to develop new antimicrobial drugs and formulations. Recent advancements in natural antimicrobial peptides (AMPs), such as AMP optimization, self-assembled AMPs, AMP hydrogels, and biomaterial-assisted delivery, have shown promise in treating bacterial infections. This review focuses on the development prospects and limitations of AMP-based biomaterials for animal model infections like abdominal, skin, and eye infections, aiming to inspire further innovation and accelerate their commercialization.
Article
Microbiology
Ivette A. Nunez, Ying Huang, Ted M. Ross
Summary: The study constructed human COBRA-2 HA H5N1 COBRA hemagglutinin sequences and updated the COBRA HA-based vaccines to induce protective antibodies against currently circulating H5Nx viruses, achieving positive results.
Review
Immunology
Elyza A. Do, Casey M. Gries
Summary: Potassium is essential for the survival and function of both host and pathogenic bacteria during infection, playing a critical role in nutrient uptake, virulence gene expression, antimicrobial resistance, and biofilm formation.
INFECTION AND IMMUNITY
(2021)
Review
Agriculture, Dairy & Animal Science
Nahed Yehia, Heba M. Salem, Yasser Mahmmod, Dalia Said, Mahmoud Samir, Sara Abdel Mawgod, Hend K. Sorour, Mona A. A. AbdelRahman, Samy Selim, Ahmed M. Saad, Mohamed T. El-Saadony, Rasha M. El-Meihy, Mohamed E. Abd El-Hack, Khaled A. El-Tarabily, Ali M. Zanaty
Summary: Many pathogens commonly infect birds through the respiratory tract, leading to respiratory disorders and significant financial losses in the poultry industry. Viral pathogens, such as avian influenza virus, Newcastle disease virus, infectious bronchitis virus, and avian pneumovirus, are particularly severe. Bacterial pathogens, including Mycoplasma gallisepticum, Staphylococcus, Bordetella avium, Pasteurella multocida, Riemerella anatipestifer, Chlamydophila psittaci, and Escherichia coli, also cause serious respiratory infections in poultry. This review provides an updated summary of the evidence for widespread poultry respiratory pathogens, along with possible control and prevention methods.
Article
Medicine, Research & Experimental
Reza Ranjbar, Saeed Niazi Vahdati, Sara Tavakoli, Reza Khodaie, Hossein Behboudi
Summary: Recent studies have shown the important role of short-chain fatty acids (SCFAs) in maintaining gut microbiota balance and regulating immune functions, especially in responding to bacterial infections.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Hu Yue, Zhongjin Yang, Yitao Ou, Shuli Liang, Wenmin Deng, Hao Chen, Cheng Zhang, Lei Hua, Wenhui Hu, Ping Sun
Summary: Tanshinones, derived from the roots of Salvia miltiorrhiza, are active ingredients widely used in traditional medicine for treating inflammatory diseases. This study identified 15 tanshinones that suppress the activation of NLRP3 inflammasome, with specific tanshinones showing potential mitochondrial protection via promoting autophagy and the AMP-activated protein kinase pathway. The findings suggest that tanshinones, particularly dihydrotanshinone I, may offer a pharmacological mechanism for effectively treating inflammatory diseases like septic and gouty inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Virology
Jenny-Helena Soellner, Thomas C. Mettenleiter, Bjoern Petersen
Summary: The livestock industry faces constant threats from viral diseases, but CRISPR/Cas technology can be used to generate disease-resistant livestock, develop vaccines, and enhance understanding of virus-host interactions. Targeting genes can help reduce disease outbreaks and decrease the risk of zoonotic diseases.
Article
Critical Care Medicine
Edwige Peju, Jean-Francois Llitjos, Julien Charpentier, Anne Francois, Nathalie Marin, Alain Cariou, Jean-Daniel Chiche, Jean-Paul Mira, Jerome Lambert, Matthieu Jamme, Frederic Pene
Summary: This study investigated the impact of blood product transfusions on the susceptibility to ICU-acquired infections in high-risk patients with septic shock, and found that transfusions of platelets and fresh frozen plasma were independently associated with the further occurrence of ICU-acquired infections.
CRITICAL CARE MEDICINE
(2021)
Review
Fisheries
Jose Luis Sanchez-Salgado, Mohamed Ali Pereyra, Juan Jose Alpuche-Osorno, Edgar Zenteno
Summary: Bacterial infections pose a high risk in crustacean production and lead to significant economic losses globally. Research on immune mechanisms against bacterial infections, particularly the identification and characterization of PRRs in crustaceans, has advanced significantly. PRRs recognize PAMPs in microorganisms, triggering signaling cascades and activating humoral and cellular mechanisms for pathogen elimination.
Review
Fisheries
Said Ben Hamed, Silvana Teresa Tapia-Paniagua, Miguel Angel Morinigo, Maria Jose Tavares Ranzani-Paiva
Summary: The use of antibiotic-medicated food in aquaculture has resulted in antibiotic resistance among several pathogens, raising public concern; scientists are now focusing on prophylactic strategies using vaccines, with advances in three main forms of vaccines.
AQUACULTURE RESEARCH
(2021)
Article
Chemistry, Physical
Irene de Lazaro, David J. Mooney
Summary: This text discusses the biological barriers that have hindered the clinical translation of cancer nanomedicines, and elaborates on new directions for the field that capitalize on a deeper understanding of the nano-bio interface.
Article
Nanoscience & Nanotechnology
Christina M. Tringides, Nicolas Vachicouras, Irene de Lazaro, Hua Wang, Alix Trouillet, Bo Ri Seo, Alberto Elosegui-Artola, Florian Fallegger, Yuyoung Shin, Cinzia Casiraghi, Kostas Kostarelos, Stephanie P. Lacour, David J. Mooney
Summary: This study introduces a fully viscoelastic microelectrode array for electrical stimulation and signal recording of heart and brain activities in vivo, utilizing an alginate matrix and carbon-based nanomaterials encapsulated in a viscoelastic hydrogel. The combination of viscoelastic materials enables the array to closely match the biomechanical properties of soft biological tissues, overcoming previous limitations. The use of hydrogels as outer layers and a hydrogel-based conductor enhanced with carbon nanomaterials allows for the fabrication of electrode arrays compatible with standard electrophysiology platforms.
NATURE NANOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Theresa M. Raimondo, David J. Mooney
Summary: Chronic inflammation plays a role in muscular dystrophies, with anti-inflammatory cytokine treatment shown to increase T-reg recruitment, muscle fiber area, contraction force, and velocity, offering potential benefits for diverse muscular dystrophies.
Review
Chemistry, Multidisciplinary
Christina M. Tringides, David J. Mooney
Summary: Surface electrode arrays are mainly made of rigid or elastic materials and ductile metal films, offering limited stretchability. They are often repurposed for different tissues without optimizing the materials and mechanical properties for the specific application. To improve tissue interfaces and reduce damage, it is important to characterize the biological environment and design technology accordingly for each specific organ.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Alexander J. Najibi, Ting-Yu Shih, David J. Mooney
Summary: Cryogel-based cancer vaccines can induce potent antigen-specific immune responses regardless of the distance to the draining lymph nodes. The vaccination location flexibility of scaffold-based vaccines demonstrates their ability to generate strong immune responses independent of draining lymph nodes.
Article
Engineering, Biomedical
Ting-Yu Shih, Alexander J. Najibi, Alexandra L. Bartlett, Aileen W. Li, David J. Mooney
Summary: Recent studies have developed injectable scaffold-based cancer vaccines that recruit and activate host dendritic cells, generating potent antitumor responses. A system utilizing ultrasound-triggered release of CpG-ODN at specific time points showed enhanced immune responses, providing a promising platform for studying the optimal timing of immunomodulatory agents delivery for cancer vaccination.
Meeting Abstract
Hematology
Kyle H. Vining, Anna E. Marneth, Kwasi Adu-Berchie, Christina M. Tringides, Joshua M. Grolman, Yutong Liu, Waihay J. Wong, Olga Pozdnyakova, Mariano Severgnini, Alexander Stafford, Georg N. Duda, Ann Mullally, Kai W. Wucherpfennig, David J. Mooney
Article
Environmental Sciences
Mythri Ambatipudi, Paola Carrillo Gonzalez, Kazi Tasnim, Jordan T. Daigle, Taisa Kulyk, Nicholas Jeffreys, Nishant Sule, Rafael Trevino, Emily M. He, David J. Mooney, Esther Koh
Summary: The COVID-19 pandemic has affected learning and necessitated assessing infection risk for reopening university spaces. A quantitative model incorporating various parameters allows for evaluation of infection probabilities and shows that in-person classes could be held with low risk under specific conditions. Development of a web application using this model may facilitate accurate assessments of infection risk in university spaces.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2021)
Article
Environmental Sciences
Esther Koh, Mythri Ambatipudi, DaLoria L. Boone, Julia B. W. Luehr, Alena Blaise, Jose Gonzalez, Nishant Sule, David J. Mooney, Emily M. He
Summary: The comfort of face masks is crucial for user compliance, with discomfort being the primary reason for noncompliance. Three critical predicting variables were identified through surveys and experiments to predict mask comfort. Machine learning algorithms were used to generate overall comfort scores for masks based on these predicting variables.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2022)
Correction
Biotechnology & Applied Microbiology
Nisarg J. Shah, Angelo S. Mao, Ting-Yu Shih, Matthew D. Kerr, Azeem Sharda, Theresa M. Raimondo, James C. Weaver, Vladimir D. Vrbanac, Maud Deruaz, Andrew M. Tager, David J. Mooney, David T. Scadden
NATURE BIOTECHNOLOGY
(2021)
Article
Cell Biology
Bo Ri Seo, Christopher J. Payne, Stephanie L. McNamara, Benjamin R. Freedman, Brian J. Kwee, Sungmin Nam, Irene de Lazaro, Max Darnell, Jonathan T. Alvarez, Maxence O. Dellacherie, Herman H. Vandenburgh, Conor J. Walsh, David J. Mooney
Summary: Mechanical stimulation can promote skeletal muscle repair by modulating inflammatory responses, with cyclic compressive loading in a specific force range improving functional recovery of severely injured muscle in mice. This improvement is partly due to the rapid clearance of neutrophil populations and neutrophil-mediated factors that may inhibit myogenesis. Insights from this research will contribute to the advancement of therapeutic strategies for tissue regeneration.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Fernanda Langellotto, Maxence O. Dellacherie, Chyenne Yeager, Hamza Ijaz, Jingyou Yu, Chi-An Cheng, Nikolaos Dimitrakakis, Benjamin T. Seiler, Makda S. Gebre, Tal Gilboa, Rebecca Johnson, Nadia Storm, Sarai Bardales, Amanda Graveline, Des White, Christina M. Tringides, Mark J. Cartwright, Edward J. Doherty, Anna Honko, Anthony Griffiths, Dan H. Barouch, David R. Walt, David J. Mooney
Summary: The study introduces a biomaterial COVID-19 vaccine based on mesoporous silica rods, which generates robust and durable immune responses. The vaccine, containing GM-CSF, MPLA, and SARS-CoV-2 viral protein antigens, can be rapidly deployed against emerging SARS-CoV-2 variants or new pathogens.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Benjamin R. Freedman, Andreas Kuttler, Nicolau Beckmann, Sungmin Nam, Daniel Kent, Michael Schuleit, Farshad Ramazani, Nathalie Accart, Anna Rock, Jianyu Li, Markus Kurz, Andreas Fisch, Thomas Ullrich, Michael W. Hast, Yann Tinguely, Eckhard Weber, David J. Mooney
Summary: A hydrogel with high-capacity drug storage function has been found to promote tissue healing in tendon injuries. This hydrogel has a tough structure on one side and an adhesive surface on the other, allowing it to support tendon gliding and strong adhesion. Through experiments, it has been shown that this hydrogel enhances healing and reduces scar formation in rat models of tendon rupture, and can sustainably release drugs. It has potential for biomedical applications.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Biology
Yiwei Li, Angelo Mao, Bo Seo, Xing Zhao, Satish Gupta, Maorong Chen, Yu Han, Ting-Yu Shih, David Mooney, Ming Guo
Summary: Current methods to obtain MSCs involve culture and expansion, but drawbacks include limited cell numbers and reduced stemness. A new method allows dedifferentiation of fat cells, but is laborious. This study presents a modified protocol using physical stimulation to enhance Wnt/β-catenin signaling for more efficient and simpler adipocyte dedifferentiation.