Article
Chemistry, Multidisciplinary
Qian-You Wang, Zhi-Bing Sun, Meng Zhang, Shu-Na Zhao, Peng Luo, Chun-Hua Gong, Wen-Xiao Liu, Shuang-Quan Zang
Summary: A robust copper tetrazolate metal-organic framework (MOF) catalyst has been developed for efficient detoxification of chemical warfare agents (CWAs). The catalyst, with a dicopper unit similar to the active sites of natural enzymes, demonstrated high efficiency in hydrolyzing phosphate ester bonds and decomposing hydrogen peroxide, effectively detoxifying nerve agent and sulfur mustard simulants. The study provides a new perspective for designing advanced catalysts for CWA detoxification.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Food Science & Technology
Shengnan Wei, Zhenyue Su, Xiangong Bu, Xuening Shi, Bo Pang, Liang Zhang, Juan Li, Chao Zhao
Summary: A colorimetric assay aptasensor for the detection of Salmonella typhimurium was developed using gold nanoparticles embedded spherical covalent organic framework with peroxidase-like activity and the affinity and specificity of S. typhimurium-aptamer. The aptasensor showed a low detection limit and good recovery rates, and can be combined with a smartphone-based image analysis system for point-of-care testing.
NPJ SCIENCE OF FOOD
(2022)
Article
Chemistry, Applied
Eun Jeong, Joong-Kwon Kim, Jungho Jin, Hyung-il Lee
Summary: A transparent cellulose nanofiber film was used for the colorimetric detection of a nerve agent mimic in the vapor phase. The film showed selective detection behavior and maintained its transparency during the detection process. It is a biodegradable sensor that can be disposed of after use.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Analytical
Dongbao Tang, Ziwei Duan, Luxuan Liu, Zhaoyuan Jia, Lijun Lang, Yuyu Tan
Summary: This study presents a hand-powered portable centrifuge driven by pulling a rope. The experiments show that the revolutions per minute (RPM) of the centrifuge are directly proportional to the length of the rope and the frequency of pulling, while inversely proportional to the load. The performance of the portable centrifuge in separating and washing microspheres equals that of traditional centrifuges. The researchers believe this centrifuge will have meaningful applications in resource-poor environments.
Article
Environmental Sciences
Shaoxiong Wu, Lianyuan Wang, Haiyan Zhu, Ling Yuan, Jian Li, Liang Ge, Hongpeng Zhang, Ting Miao, Zhenxing Cheng
Summary: This study developed a novel rapid quantitative determination method for VX by optimizing reaction conditions based on the mechanism of the Schoenemann reaction. With the use of sodium perborate, benzidine hydrochloride, and acetone, VX and GD in ethanol or water solutions could be quantitatively analyzed within 15 min at 60°C. This colorimetry system can be developed as a portable device for fieldwork applications in water samples.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Article
Biophysics
Lei Wang, Na Rong, Xinge Xi, Maohua Wang, Xiaoting Huo, Jing Yuan, Wuzhen Qi, Yanbin Li, Jianhan Lin
Summary: A novel lab-in-centrifugal-tube colorimetric biosensor was developed for the detection of Salmonella typhimurium. The biosensor utilized immune nickel nanowires for bacterial separation, gold@platinum nanozymes for signal amplification, and a smartphone App for color change analysis. The biosensor demonstrated rapid and sensitive detection of Salmonella typhimurium in pork samples, with a low detection limit and high recovery rate.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Pharmacology & Pharmacy
Alex S. Cornelissen, Efrain E. Garcia, Robert E. Raulli, Judith Laney, Marloes J. A. Joosen
Summary: Most research on medical countermeasures for nerve agent exposure focuses on immediate treatment in military scenarios, but this study developed a guinea pig model to evaluate delayed treatment efficacy. Scopolamine showed promising beneficial effects as a standalone treatment for survival and recovery, warranting further investigation on physiological improvements relevant to recovery and residual injury.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Zahra Khoshbin, Marzieh Moeenfard, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: A simple aptasensor embedded in a micropipette tip is developed for label-free monitoring of acrylamide. The aptasensor utilizes the formation of a triple-helix molecular switch structure to induce the aggregation of gold nanoparticles. A smartphone imaging readout strategy enables the quantification of acrylamide based on the color change of the solution inside the micropipette tip. This aptasensor shows good selectivity and can successfully quantify acrylamide in various food samples.
Article
Engineering, Environmental
So -young Park, Rini Sharma, Hyung-il Lee
Summary: In this study, two colorimetric thin polymeric films were designed to detect and quantify VX mimic demeton-S in contaminated areas. These films showed high selectivity and reusability, making them suitable for on-site measurements.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Multidisciplinary Sciences
Veronika Holisova, Martin Urban, Zuzana Konvickova, Marek Kolencik, Pavel Mancik, Jiri Slabotinsky, Gabriela Kratosova, Daniela Placha
Summary: By using Tilia sp. bract leachate as the reducing agent, stable Au NPs were successfully phytosynthesized and utilized as catalysts for soman nerve agent degradation, showcasing long-term stability and high degradation efficiency.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Environmental
Yanchao Lyu, Lucia Morillas-Becerril, Fabrizio Mancin, Paolo Scrimin
Summary: Gold nanoparticles passivated with thiolated molecules can efficiently hydrolyze nerve agent simulants, exhibiting enzyme-like catalytic behavior with half-lives in the order of a few minutes at 25 degrees C and pH 8. This nanozyme catalyst involves a single metal ion and recognizes substrates mainly through hydrophobic interactions, providing a promising solution for detoxification after contamination with organophosphorus nerve agents.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Analytical
Chungen Qian, Jiashuo Li, Zheng Pang, Han Xie, Chao Wan, Shunji Li, Xin Wang, Yujin Xiao, Xiaojun Feng, Yiwei Li, Peng Chen, Bi-Feng Liu
Summary: This paper proposes a hand-powered centrifugal micropipette-tip strategy for all-in-one immunoassay of SARS-CoV-2. The strategy enables sensitive and reliable quantification of the virus within 25 minutes. With the advantages of free washing, free fabrication, free instrument, and without the optical device, the proposed strategy shows great potential for quantitative point-of-care diagnostics for SARS-CoV-2.
Article
Food Science & Technology
Chengnan Xu, Mei Lin, Tianyu Wang, Zhoulin Yao, Weiqing Zhang, Xianju Feng
Summary: An instruments-free colorimetric assay was developed for the detection of acetamiprid using hybridization chain reaction (HCR)-based amplification strategy. The assay exhibited high sensitivity with a detection limit of 1.74 μM and excellent selectivity. A smartphone readout-based strategy was proposed for visual quantification of acetamiprid, showing promising application potential for on-site detection.
Article
Pharmacology & Pharmacy
Liao Shen, Yadan Zhang, Qimei Cai, Jun Yang, Yongan Wang, Dongqin Quan
Summary: In this study, PEGylated liposomes loading HI-6 were prepared and evaluated in vitro and in vivo. The results showed that PEG-LP-HI-6 significantly extended the half-life and mean retention time of HI-6 in vivo, and increased the AUC of HI-6. PEG-LP-HI-6 also increased drug concentrations in the CNS. In vivo treatment experiments demonstrated that PEG-LP-HI-6 could prolong survival time and alleviate neurotoxic symptoms.
Article
Chemistry, Analytical
Euna Ko, Won Hur, Seong Eun Son, Gi Hun Seong, Do Kyoung Han
Summary: A sensitive on-site mercury sensing platform was developed for simple and effective monitoring of mercury levels in the field. The platform integrates a nanozyme-based mercury detection system with a colorimetric device, allowing for real-time and efficient monitoring of mercury levels with high accuracy and applicability, making it suitable for a wide range of field measurements.
Article
Chemistry, Analytical
Fumiki Takahashi, Naoto Yamamoto, Miyuki Todoriki, Jiye Jin
Article
Biochemistry & Molecular Biology
Fumiki Takahashi, Masaru Kobayashi, Atsushi Kobayashi, Kanya Kobayashi, Hideki Asamura
Article
Electrochemistry
Hirosuke Tatsumi, Keita Sato, Manami Yoshimura, Mariko Sakamaki, Mizuki Sunagawa, Fumiki Takahashi, Jiye Jin
Summary: In this experiment, a stream of electron conductor powder was used to measure the Volta potential difference. The real potential of the solvation of Cl- ion was determined and compared with values obtained using the Kenrick method with mercury jet electrode.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)