Review
Oncology
Jennifer Sun, Chaelee Park, Nicole Guenthner, Shannon Gurley, Luna Zhang, Berit Lubben, Ola Adebayo, Hannah Bash, Yixuan Chen, Mina Maksimos, Barbara Muz, Abdel Kareem Azab
Summary: MM is a cancer of plasma cells in the bone marrow, with the tumor microenvironment playing a critical role in disease progression. TAMs in the TME have been found to support tumor survival and chemoresistance, highlighting the importance of exploring macrophage-targeted immunotherapy in MM treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Chunxiao Li, Xiaofei Xu, Shuhua Wei, Ping Jiang, Lixiang Xue, Junjie Wang
Summary: Macrophages play a crucial role in the tumor microenvironment, where they can be polarized into tumor-associated macrophages (TAMs). The abundance of TAMs in tumors is closely linked with poor prognosis, leading to investigations into therapeutic strategies targeting TAMs. These strategies include inhibiting macrophage recruitment to tumors, repolarizing TAMs towards an anti-tumor phenotype, and inducing macrophage-mediated destruction of cancer cells. As tumor immunotherapy gains more importance, new anti-tumor strategies focusing on TAMs are being discussed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu
Summary: Tumor-associated macrophages (TAMs) play a significant role in tumor immunotherapies, with potential therapeutic value in enhancing treatment outcomes.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Oncology
Iva Truxova, David Cibula, Radek Spisek, Jitka Fucikova
Summary: Epithelial ovarian cancer (EOC) ranks among the top causes of cancer-related death in women due to early dissemination of malignant cells to the peritoneum. Despite improvements in medical therapies, EOC remains insensitive to immune checkpoint inhibitors, mainly due to a tumor microenvironment characterized by poor immune cell infiltration and immune suppression by tumor-associated macrophages (TAMs). TAMs have emerged as potential therapeutic targets to reverse immunosuppression and enhance the effectiveness of immunotherapy. This review focuses on the biological features of TAMs and their relevance as targets for treating EOC, including therapies that modulate TAM recruitment, polarization, survival, and function in the EOC tumor microenvironment for better combinatorial regimens with immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Rebecca Adams, Gabriel Osborn, Bipashna Mukhia, Roman Laddach, Zena Willsmore, Alicia Chenoweth, Jenny L. C. Geh, Alastair D. MacKenzie Ross, Ciaran Healy, Linda Barber, Sophia Tsoka, Victoria Sanz-Moreno, Katie E. Lacy, Sophia N. Karagiannis
Summary: The application of monoclonal antibodies in the treatment of melanoma has significantly improved clinical management over the last decade, but more than half of patients do not benefit from treatment. Targeting tumor-associated macrophages (TAMs) and exploring new treatment strategies based on their diversity and plasticity hold promise for enhancing treatment success.
Review
Oncology
Yifan Tan, Min Wang, Yang Zhang, Shengyang Ge, Fan Zhong, Guowei Xia, Chuanyu Sun
Summary: Macrophages are crucial innate immune cells that can promote tumor progression in the tumor microenvironment. Targeting tumor-associated macrophages has become a significant focus in cancer therapy due to their association with cancer advancement and poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Physical
Siyuan Chen, Furong Qin, Manni Wang, Yuquan Wei, Zhiyong Qian, Xiawei Wei
Summary: The tumor microenvironment is crucial for tumorigenesis, metastasis, and drug resistance. Tumor-associated macrophages (TAMs) play a key role in creating a favorable environment for cancer cells, and nanoparticle-based drug delivery systems offer new approaches for targeting TAMs in cancer therapy. Strategies targeting TAMs with nanoparticles include blocking recruitment, promoting transformation, and diminishing existing TAMs to improve cancer treatment efficiency.
Article
Medicine, Research & Experimental
Zhengquan Wu, Ke Lei, Huaizhi Li, Jiali He, Enxian Shi
Summary: We established a prognostic model for melanoma related to M2-like tumor-associated macrophages and explored the role of VARS1 in melanoma progression and the development of immunotherapy resistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Darya Khantakova, Simone Brioschi, Martina Molgora
Summary: TREM2 is a receptor expressed in tumor-associated macrophages and is associated with tumor control and the tumor immune environment. Blocking or targeting TREM2 can improve tumor control, enhance immune response, and alter the tumor immune environment. Preclinical studies have paved the way for further investigation into TREM2 targeting therapies.
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Medicine, Research & Experimental
Xiao Wei, Jing Wang, Min Liang, Mingzhu Song
Summary: Tumor associated macrophages (TAMs) are a major obstacle in clinical cancer immunotherapy, but the use of nanomedicine targeted at TAMs shows promise in improving immunotherapy. This article first explains the mechanisms of tumor immunosuppression caused by TAMs, and then discusses the design, modification, and imaging techniques of nanomedicines targeting TAMs. The article summarizes the TAMs-targeting immunotherapeutic mechanisms based on functional nanomedicines and proposes challenges and perspectives for clinical translation.
Review
Oncology
Zijuan Zou, Hongfen Lin, Mengsen Li, Bo Lin
Summary: The chronic inflammation of tumor recruits TAMs to the TME and promotes polarization. Pro-inflammatory signals polarize macrophages to the M1 phenotype to enhance inflammation, while tumor inflammation changes the response to an anti-inflammatory response, altering macrophages from M1 to M2 to promote tumor progression. Hypoxia activates HIF in the TME, reprogramming macrophages to the M2 phenotype to support tumor development. Understanding the factors that drive phenotypic changes in TAMs in the inflammatory TME will aid in the development of cancer immunotherapy involving macrophages.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue, Long Chen, Yuan Su, Qiong Zhou
Summary: This study reveals the immune suppressive mechanism of C1q(+) TAMs and suggests that targeting C1q(+) TAMs effectively alleviates immunosuppression and enhances the efficacy of immune checkpoint blockade (ICB) therapy. The researchers also found that inhibition of FABP5 can weaken the anti-tumor effects of TAMs and improve the effectiveness of ICB therapy, indicating that C1q(+) TAMs have great potential as a therapeutic target for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Oncology
Shunyao Zhu, Ziyi Luo, Xixi Li, Xi Han, Senlin Shi, Ting Zhang
Summary: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment by secreting various factors that influence tumor growth and development. Different phenotypes of TAMs have distinct effects on tumors, making them an important target in tumor immunotherapy.
Article
Immunology
Diego Ulisse Pizzagalli, Joy Bordini, Diego Morone, Alain Pulfer, Pau Carrillo-Barbera, Benedikt Thelen, Kevin Ceni, Marcus Thelen, Rolf Krause, Santiago Fernandez Gonzalez
Summary: Two-photon intravital microscopy (2P-IVM) is widely used for studying cell-to-cell interactions in living organisms. However, technical artifacts affect the specificity of imaging channels for the cells of interest. In this study, CANCOL, a machine learning tool, was developed to automate cell tracking and improve tracking accuracy while reducing manual editing time.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G. Aragones, Jackson Liang Yao Li, Rodrigo Madurga, Jose M. Adrover, Alejandra Aroca-Crevillen, Sandra Martin-Salamanca, Alfonso Serrano del Valle, Sandra D. Castillo, Heidi C. E. Welch, Oliver Soehnlein, Mariona Graupera, Fatima Sanchez-Cabo, Alexander Zarbock, Thomas E. Smithgall, Mauro Di Pilato, Thorsten R. Mempel, Pierre-Louis Tharaux, Santiago F. Gonzalez, Angel Ayuso-Sacido, Lai Guan Ng, Gabriel F. Calvo, Ivan Gonzalez-Diaz, Fernando Diaz-de-Maria, Andres Hidalgo
Summary: Transcriptional and proteomic profiling of individual cells have provided cellular landscapes of tissues, but fail to capture dynamic scenarios. This study used live imaging to record morpho-kinetic parameters of leukocytes in active inflammation and built behavioural landscapes that identified leukocyte identities and revealed a continuum of neutrophil states. Mutant screening identified the kinase Fgr as a driver of pathogenic inflammation, and interfering with Fgr protected mice from inflammatory injury.
Article
Multidisciplinary Sciences
Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell, Kristopher R. Bosse, Andrew Kossenkov, Kai Tan, Michael D. Hogarty, John M. Maris, Chi V. Dang
Summary: By investigating inflammatory signaling pathways in neuroblastoma, researchers have identified heterogeneity in dsRNA sensing and intratumoral inflammatory signaling, which has significant implications for immunotherapeutic strategies in this aggressive childhood cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Konrad Patyra, Christoffer Lof, Holger Jaeschke, Hendrik Undeutsch, Huifei Sophia Zheng, Sofia Tyystjarvi, Kamila Pulawska, Milena Doroszko, Marcin Chrusciel, Britt-Marie Loo, Riikka Kurkijarvi, Fu-Ping Zhang, Chen-Che Jeff Huang, Claes Ohlsson, Andreina Kero, Matti Poutanen, Jorma Toppari, Ralf Paschke, Nafis Rahman, Ilpo Huhtaniemi, Jarmo Jaaskelainen, Jukka Kero
Summary: This study found that congenital hypothyroidism and hyperthyroidism have functional effects on adrenal gland development, steroidogenic activity, and adrenal medulla.
Review
Immunology
Diego Ulisse Pizzagalli, Alain Pulfer, Marcus Thelen, Rolf Krause, Santiago F. Gonzalez
Summary: This review discusses the importance of immune cell migration in inflammation and the use of intravital microscopy to visualize cell migration. The comprehensive classification of immune cell motility patterns observed in vivo and their relevance to the inflammatory process is still lacking. The review provides a definition and consensus naming for different cell actions, along with an overview of computational methods used for quantification, aiming to foster interdisciplinary research on the immune system using imaging data.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Margit Kaldmae, Thibault Vosselman, Xueying Zhong, Dilraj Lama, Gefei Chen, Mihkel Saluri, Nina Kronqvist, Jia Wei Siau, Aik Seng Ng, Farid J. Ghadessy, Pierre Sabatier, Borivoj Vojtesek, Medoune Sarr, Cagla Sahin, Nicklas Osterlund, Leopold L. Ilag, Venla A. Vaananen, Saikiran Sedimbi, Marie Arsenian-Henriksson, Roman A. Zubarev, Lennart Nilsson, Philip J. B. Koeck, Anna Rising, Axel Abelein, Nicolas Fritz, Jan Johansson, David P. Lane, Michael Landreh
Summary: Disordered proteins pose challenges to structural biology. Researchers have found that fusing the protein with a highly soluble spider silk domain can modulate its characteristics and enhance translation efficiency. This mechanism is of great significance for cancer treatment.
Article
Oncology
Adela Kiessling, Keerthana Ramanathan, Ola B. Nilsson, Luigi Notari, Stefanie Renken, Rolf Kiessling, Hans Gronlund, Stina L. Wickstrom
Summary: In the past decade, adoptive cell therapy has revolutionized cancer treatment. This study presents a novel strategy to deliver predicted neoantigens into autologous dendritic cells, resulting in the enrichment of tumor-specific CD8+ T cells. The enriched T cells demonstrate tumor specificity with limited recognition of non-tumor cells, and their tumor recognition and elimination capacity can be improved and preserved through further expansion.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lourdes Sainero-Alcolado, Judit Liano-Pons, Maria Victoria Ruiz-Perez, Marie Arsenian-Henriksson
Summary: The research field of cancer metabolism has been based on the Warburg effect for decades, but recently the key role of mitochondria in cancer development has been demonstrated. Mutations in oncogenes, tumor suppressor genes, and metabolic enzymes alter various mitochondrial pathways in tumors, leading to metabolic reprogramming that sustains rapid cell proliferation and the utilization of reactive oxygen species by cancer cells. The knowledge acquired on mitochondrial cancer metabolism is now being translated into clinical practice, where detailed analysis of tumors is necessary to develop more precise treatments. Drugs targeting metabolic mitochondrial enzymes have shown potential in precision medicine, but efficient personalized drugs remain challenging to develop and may require combination with other strategies.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Oncology
Stefanie Renken, Takahiro Nakajima, Isabelle Magalhaes, Jonas Mattsson, Andreas Lundqvist, Elias S. J. Arner, Rolf Kiessling, Stina Linnea Wickstrom
Summary: Auranofin can significantly reduce intracellular ROS accumulation in human cytotoxic lymphocytes ex vivo, preserving their antitumoral activity and increasing resistance to oxidative stress.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Neurosciences
Vassilis Stratoulias, Rocio Ruiz, Shigeaki Kanatani, Ahmed M. Osman, Lily Keane, Jose A. Armengol, Antonio Rodriguez-Moreno, Adriana-Natalia Murgoci, Irene Garcia-Dominguez, Isabel Alonso-Bellido, Fernando Gonzalez Ibanez, Katherine Picard, Guillermo Vazquez-Cabrera, Mercedes Posada-Perez, Nathalie Vernoux, Dario Tejera, Kathleen Grabert, Mathilde Cheray, Patricia Gonzalez-Rodriguez, Eva M. Perez-Villegas, Irene Martinez-Gallego, Alejandro Lastra-Romero, David Brodin, Javier Avila-Carino, Yang Cao, Mikko Airavaara, Per Uhlen, Michael T. Heneka, Marie-Eve Tremblay, Klas Blomgren, Jose L. Venero, Bertrand Joseph
Summary: The molecular diversity of microglia in the CNS has been described. The study shows that microglia expressing the enzyme ARG1 are enriched in phagocytic inclusions and play a role in hippocampal innervation and spine maturation in mice. ARG1-expressing microglia also influence cognition in a sex-dependent manner.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Kazunori Sunadome, Alek G. G. Erickson, Delf Kah, Ben Fabry, Csaba Adori, Polina Kameneva, Louis Faure, Shigeaki Kanatani, Marketa Kaucka, Ivar Dehnisch Ellstroem, Marketa Tesarova, Tomas Zikmund, Jozef Kaiser, Steven Edwards, Koichiro Maki, Taiji Adachi, Takuya Yamamoto, Kaj Fried, Igor Adameyko
Summary: The developing skeleton produces mechanical tension that guides the directional outgrowth of skeletal muscles. Formation of oriented myofibrils is crucial in musculoskeletal development. The mechanisms that control myocyte orientation and fusion for muscle directionality in adults are still unknown.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Isabel J. Bauer, Ping Fang, Katrin F. Lammle, Sofia Tyystjarvi, Dominik Alterauge, Dirk Baumjohann, Hongsup Yoon, Thomas Korn, Hartmut Wekerle, Naoto Kawakami
Summary: This study explores the impact of microbiota on T cell activation and their role in triggering CNS inflammation using intravital imaging. The results show that microbiota stimulation in the small intestine leads to calcium signaling in T cells, which is microbiota and MHC class II dependent. This stimulation induces the expression of Th17-axis genes in encephalitogenic T cells and facilitates their migration into the CNS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Mihkel Saluri, Axel Leppert, Genis Valentin Gese, Cagla Sahin, Dilraj Lama, Margit Kaldmae, Gefei Chen, Arne Elofsson, Timothy M. Allison, Marie Arsenian-Henriksson, Jan Johansson, David P. Lane, B. Martin Hallberg, Michael Landreh
Summary: This study examines the relationship between the self-assembly and chaperone activity of nucleophosmin 1 (NPM1). The results show that oligomerization of NPM1 modulates its ability to prevent amyloid formation, and fuzzy interactions between different regions of NPM1 contribute to its partially disordered oligomerization. Additionally, nucleolar proteins and RNAs regulate the association strength and chaperone activity of NPM1.
Article
Immunology
Stina L. Wickstrom, Arnika K. Wagner, Sina Fuchs, Marjet Elemans, Joanna Kritikou, Ramit Mehr, Klas Karre, H. Johansson, Hanna Brauner
Summary: The expression of MHC class I in the host influences NK cells, resulting in education and a repertoire of inhibitory MHC I-specific receptors. This repertoire skewing can be observed in the bone marrow during the early developmental stages of NK cells, suggesting that it is established during development.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang, Yong Liu, Monika Plescher, Javier Rodriguez, Oscar C. Bedoya-Reina, Paulo R. Jannig, Paula Valente-Silva, Meng Yu, Marie Arsenian Henriksson, Roman A. Zubarev, Anna Smed-Sorensen, Carolyn K. Suzuki, Jorge L. Ruas, Johan Holmberg, Catharina Larsson, C. Christofer Juhlin, Alex von Kriegsheim, Yihai Cao, Susanne Schlisio
Summary: This study reveals the oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcription and replication, and its connection to tumorigenesis in von Hippel-Lindau syndrome. The findings suggest that impaired mitochondrial biogenesis is linked to VHL tumorigenesis, and targeting mitochondria could sensitize therapy-resistant VHL tumors.