Article
Biochemistry & Molecular Biology
Aurelie Marches, Emily Clement, Geraldine Alberola, Marie-Pierre Rols, Sarah Cousty, Michel Simon, Nofel Merbahi
Summary: This study suggests that helium-based CAP treatments can improve wound healing by stimulating keratinocyte migration. Long-term CAP treatments are cytotoxic, reducing keratinocyte migration and inducing oxidative stress. Short-term CAP treatments are not cytotoxic, do not affect keratinocyte proliferation and differentiation, and accelerate wound closure by improving keratinocyte migration in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Namkyung Kim, Seunghun Lee, Soyoung Lee, Jinjoo Kang, Young-Ae Choi, Jeongsu Park, Chul-Kyu Park, Dongwoo Khang, Sang-Hyun Kim
Summary: A cold atmospheric plasma (CAP) patch was developed for the treatment of skin diseases, especially psoriasis. The patch induces the opening of calcium channels in keratinocytes and generates ROS/RNS, improving psoriatic symptoms. It can be used as a combination therapy with existing drugs, reducing side effects.
Article
Biochemistry & Molecular Biology
Catarina Almeida-Ferreira, Rafael Silva-Teixeira, Ana Cristina Goncalves, Carlos Miguel Marto, Ana Bela Sarmento-Ribeiro, Francisco Caramelo, Maria Filomena Botelho, Mafalda Laranjo
Summary: This study evaluated the therapeutic potential of cold atmospheric plasma (CAP) in breast cancer cells with distinct histological features and found that apoptosis was the most prevalent type of cell death. In addition, CAP treatment inhibited cell replication ability and antioxidative activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physics, Applied
Maksudbek Yusupov, Debbie Dewaele, Pankaj Attri, Umedjon Khalilov, Frank Sobott, Annemie Bogaerts
Summary: This study unravels the possible mechanisms of oligosaccharide oxidation induced by cold atmospheric plasma (CAP), providing atomic-level insight into the onset of plasma-induced removal of biofilms.
PLASMA PROCESSES AND POLYMERS
(2023)
Review
Engineering, Chemical
Dominik Terefinko, Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, Aleksandra Klimczak, Pawel Pohl, Piotr Jamroz
Summary: Cold atmospheric pressure plasmas (CAPPs) have attracted increasing attention in the field of medicine, particularly in oncology. The selective anticancer characteristics of CAPP make it a promising application for treating skin cancers. Research on the effects of CAPP on skin cancers has provided insights into potential new treatments and the complex interactions between reactive species and cellular components.
PLASMA CHEMISTRY AND PLASMA PROCESSING
(2021)
Article
Biochemistry & Molecular Biology
Xiaolong Wang, Long Pang, Shuhui Yang, Liang Zou, Yuantao Zhang, Tong Zhao
Summary: Reactive molecular dynamics simulations were used to investigate the interactions between oxygen plasma species and chitin polymer, revealing that O and OH species can break important structural bonds of chitin and affect the inactivation mechanism of Candida albicans.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Engineering, Chemical
Zhitong Chen, Richard Obenchain, Richard E. Wirz
Summary: Researchers developed a single-electrode tiny plasma jet for clinical biomedical applications, studying the effect of voltage input and flow rate on the jet length and physical parameters. Interactions between the tiny plasma jet and different subjects showed an increase in ROS/RNS intensity as the distance decreased. These findings suggest the potential use of the tiny plasma jet device in clinical biomedical applications.
Article
Physics, Applied
Nishtha Gaur, Hirofumi Kurita, Jun-Seok Oh, Saki Miyachika, Masafumi Ito, Akira Mizuno, Allison J. Cowin, Sarah Allinson, Robert D. Short, Endre J. Szili
Summary: The study investigates the potential role of hydroxyl radicals in cold atmospheric plasma (CAP) jet treatment, showing correlation between CAP jet-induced DNA damage and the presence of hydroxyl radicals. A 'plasma screen' based on a hydrogel film is demonstrated to significantly reduce DNA damage while facilitating the delivery of hydrogen peroxide, which could be beneficial for applications focusing on DNA damage such as cancer treatment, as well as in situations where DNA damage should be minimized, such as open-wound treatment and dermatology.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Food Science & Technology
Yupan Zhu, Hangbo Xu, Dongjie Cui, Renwu Zhou, Yanping Wang, Aswathi Soni, Gale Brightwell, Jie Zhuang, Ruonan Ma, Zhen Jiao
Summary: This study investigated the effects of atmospheric cold plasma (ACP) treatment on the antioxidant pigment STX in S. aureus. Results showed that ACP treatment significantly decreased the survival rate of S. aureus and caused a decrease in STX content, making the bacteria more susceptible to hydrogen peroxide attack. ACP treatment also resulted in a decrease in cell membrane potential, accumulation of reactive oxygen species, and cell necrosis.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Food Science & Technology
Shanrui Li, Xi Yao, Xiaolong Wang, Shuqi Tian, Yuantao Zhang
Summary: This study used a Reactive Molecular Dynamics simulation to examine the interaction between reactive oxygen species (ROS) and aflatoxin B-1 (AFB(1)) in cold atmospheric plasma (CAP) decontamination. The simulation results showed that ROS can effectively reduce the toxicity of AFB(1) by reacting with its key structures. The findings provide valuable insights for the optimization of aflatoxin degradation in industrial applications.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Review
Physics, Applied
Wen Zhou, Xiuqing Wang, Xiaojing Huang
Summary: Cold atmospheric pressure plasmas (CAP) have wide applications in dentistry, including surface modification of dental materials, biofilm removal, disinfection, endodontic therapy, periodontitis treatment, wound healing, and head and neck cancer control.
PLASMA PROCESSES AND POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Sunil Kumar Dubey, Shraddha Parab, Amit Alexander, Mukta Agrawal, Vaishnav Pavan Kumar Achalla, Udit Narayan Pal, Murali Monohar Pandey, Prashant Kesharwani
Summary: Cold atmospheric plasma therapy is a novel, simple, non-invasive treatment approach mainly used in wound healing. It is distinct from blood plasma and is generated as the fourth state of matter through irradiation or electric field. This review emphasizes the application of cold plasma in wound healing, discussing wound types, healing process, and mechanisms of cold atmospheric plasma therapy.
PROCESS BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Helena Motaln, Nina Recek, Boris Rogelj
Summary: This review examines the potential use of cold atmospheric plasma in medicine, particularly its beneficial effects on tumor reduction in oncology. It discusses the cellular changes and impacts on main cellular processes, such as proliferation, migration, protein degradation, and various forms of cell death, especially in the oncology field of plasma medicine.
Article
Plant Sciences
Norrapon Vichiansan, Kanjanaporn Chatmaniwat, Marisa Sungkorn, Komgrit Leksakul, Poti Chaopaisarn, Dheerawan Boonyawan
Summary: This study demonstrates the feasibility of using plasma technology to promote tomato seed growth. Plasma-activated water containing NO3-, NO2-, and H2O2 ions was used to treat tomato seeds, resulting in a significant increase in yield. The optimal system settings were determined to be 20 W of power, 10 min of discharge duration, and 4 l/min of gas flow rate.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Engineering, Chemical
Weerasak Seelarat, Sujarinee Sangwanna, Teerapap Panklai, Natthaphon Chaosuan, Atipong Bootchanont, Chakkaphan Wattanawikkam, Ahkasit Subcharoen, Nuttapon Subcharoen, Nattapong Chanchula, Dheerawan Boonyawan, Porramain Porjai
Summary: The impact of cold plasma jet on fruiting body production and bioactive phytochemicals in blended Cordyceps militaris was evaluated. The results showed that CPJ treatment significantly increased the yield and nutritional value of blended C. militaris.
PLASMA CHEMISTRY AND PLASMA PROCESSING
(2023)
Article
Polymer Science
Pornchai Rachtanapun, Dheerawan Boonyawan, Rafael A. Auras, Gopinath Kasi
Summary: The use of SF6 plasma treatment improves the water resistance of Kraft paper. The optimal treatment conditions are 200 mTorr pressure, 50 Watts power, and 5 minutes treatment time. Increasing the treatment time enhances the contact angle, water absorption time, and Cobb test values of the paper, while the thickness and tensile strength remain relatively constant.
Article
Agronomy
Salit Supakitthanakorn, On-Uma Ruangwong, Choncharoen Sawangrat, Wimada Srisuwan, Dheerawan Boonyawan
Summary: Nonthermal atmospheric-pressure dielectric barrier discharge (DBD) plasma has the potential to control southern blight disease of lettuce by inhibiting fungal growth and reducing disease incidence and severity.
Article
Food Science & Technology
Sujarinee Sangwanna, Weerasak Seelarat, Teerapap Panklai, Natthaphon Chaosuan, Ahkasit Subcharoen, Nuttapon Subcharoen, Nattapong Chanchula, Tanapak Inyod, Thanaphat Toemarrom, Atipong Bootchanont, Chakkaphan Wattanawikkam, Sorapong Pavasupree, Dheerawan Boonyawan, Porramain Porjai
Summary: This study investigated the effects of different treatment times of an air atmospheric pressure plasma jet (APPJ) on the production of fruiting bodies and phytochemicals of white Cordyceps militaris. Results showed that optimal APPJ treatment significantly increased the fresh and dry weights of white C. militaris fruiting bodies. APPJ treatments also led to higher levels of cordycepin, adenosine, superoxide dismutase, glutathione S-transferase, and beta-glucan in the fruiting bodies, as well as enhanced antioxidant properties. However, carotenoid content decreased with APPJ treatment.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Engineering, Chemical
Pipath Poramapijitwat, Phuthidhorn Thana, Pongphun Sukum, Liangdeng Yu, Chakkrapong Kuensaen, Dheerawan Boonyawan
Summary: In this study, a non-thermal air plasma jet device was used to activate lactated Ringer's injection (LRI) for the in vitro inactivation of lung cancer cells. The results showed that plasma-activated LRI was able to effectively kill lung cancer cells while leaving non-cancerous cells unaffected. These findings not only contribute to the effective usage of plasma-activated LRI, but also advance the applications of plasma technology in the medical field.
PLASMA CHEMISTRY AND PLASMA PROCESSING
(2023)
Article
Plant Sciences
Sorapong Pavasupree, Nattapong Chanchula, Narittaya Nunya, Sirinya Kashima, Atipong Bootchanont, Chakkaphan Wattanawikkam, Russameeruk Noonuruk, Porramain Porjai
Summary: This study investigated the effects of titanium dioxide nanoparticles (TiO2 NPs) on the growth and antibacterial activity of Chrysanthemum indicum (C. indicum) cuttings in vitro culture. The results showed that the treatment with TiO2 NPs at concentrations of 10 and 20 mg/L had the most significant positive influence on plant growth parameters. The TiO2 NPs treatment also increased the contents of chlorophylls and carotenoids, enhanced the activity of antioxidant enzymes, and improved the antibacterial activity of the plants through phenolic compounds.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Multidisciplinary Sciences
Apichaya Sakulthai, Choncharoen Sawangrat, Duangporn Pichpol, Jutamart Kongkapan, Tiranun Srikanchai, Rangsun Charoensook, Phanumas Sojithamporn, Dheerawan Boonyawan
Summary: This research investigates the efficiency of cold plasma technology in enhancing the production and growth rates of Thai Native Chickens. The results show that cold plasma technology does not significantly affect chicken meat quality. It can help improve production and growth rates, reduce costs in the poultry industry while being safe and environmentally friendly.
SCIENTIFIC REPORTS
(2023)
Article
Polymer Science
Pongphun Sukum, Winita Punyodom, Somsak Dangtip, Pipath Poramapijitwat, Donraporn Daranarong, Thannaphat Jenvoraphot, Mudtorlep Nisoa, Chakkrapong Kuensaen, Dheerawan Boonyawan
Summary: The wound healing process can be disrupted by various factors, with inflammation playing a crucial role. Wound dressings made with PVA, CS, PEG, and Mangifera extract can effectively reduce infection and inflammation, providing an environment for faster healing. The use of plasma treatment improves the electrospinning of polymer solutions, resulting in enhanced properties of the electrospun nanofiber membrane, including increased viscosity, conductivity, and fiber diameter. Incorporating mangiferin extract further enhances the antimicrobial properties of the membrane and accelerates wound healing.
Article
Chemistry, Multidisciplinary
Salit Supakitthanakorn, On-Uma Ruangwong, Dheerawan Boonyawan
Summary: Non-thermal atmospheric pressure gliding arc, tesla coil, and dielectric barrier discharge plasmas were tested for their ability to inactivate Cercospora lactucae-sativa, the causative agent of leaf spot disease on lettuce. Results showed that dielectric barrier discharge plasma had the highest inhibitory effect on fungal growth, with 93.33% inhibition after 20 minutes of exposure. All three non-thermal plasmas completely inactivated fungal conidial germination after 5 minutes of exposure. Inoculation of treated conidia on lettuce showed that all three plasmas reduced the disease incidence and severity compared to the control. Therefore, these plasma technologies have potential for plant disease control.
APPLIED SCIENCES-BASEL
(2023)
Article
Polymer Science
Manasanan Namhongsa, Donraporn Daranarong, Robert Molloy, Sukunya Ross, Gareth M. Ross, Adisorn Tuantranont, Dheerawan Boonyawan, Jiraporn Tocharus, Sivanan Sivasinprasasn, Paul D. Topham, Brian J. Tighe, Winita Punyodom
Summary: In this study, two-component scaffolds consisting of a 3D-printed component and an electrospun fiber component were fabricated and treated with N-2-Ar plasma to enhance their surface properties. The plasma treatment significantly improved the surface roughness, wettability, and hydrophilicity of the scaffolds. The 3D-printed component provided mechanical strength, while the electrospun fiber component promoted cell attachment and proliferation. The designed scaffolds showed potential for supporting cell regeneration in biomedical applications.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Chonlada Bennett, Sawanya Ngamrung, Vithun Ano, Chanchai Umongno, Sugunya Mahatheeranont, Jaroon Jakmunee, Mudtorlep Nisoa, Komgrit Leksakul, Choncharoen Sawangrat, Dheerawan Boonyawan
Summary: The study compared the effects of pinhole plasma jet and gliding arc plasma in degrading the herbicide diuron in plasma activated solutions (PAS). The pinhole plasma jet system achieved over 50% degradation of diuron in 60 minutes, with pure Ar gas as the optimal plasma generation condition. The degradation products of diuron were identified via GC-MS. On the other hand, the gliding arc plasma system was not effective for herbicide degradation in PAS.
Article
Multidisciplinary Sciences
Preecha Changyom, Komgrit Leksakul, Dheerawan Boonyawan, Pongsawat Premphet, Norrapon Vichiansan
Summary: Complex multilayer film structures were fabricated using an angular DC magnetron co-sputtering system, and the optimization of the sputtering process was conducted. The results showed that the thickness and roughness of the sputtered films were significantly influenced by the sputtering time, substrate rotation speed, and sputtering voltage.
