Article
Immunology
Manchen Bao, Pan Zhang, Shulan Guo, Jianzhou Zou, Jun Ji, Xiaoqiang Ding, Xiaofang Yu
Summary: The abundance, composition, and function of gut microbiota were altered in peritoneal dialysis (PD) patients, leading to increased levels of p-cresyl sulfate (PCS), a uremic toxin. Targeting specific bacteria could decrease PCS levels, while preserving residual renal function could reduce indoxyl sulfate (IS) and trimethylamine-N-oxide (TMAO) levels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Dan Luo, Wenbo Zhao, Zhiming Lin, Jianhao Wu, Hongchun Lin, Yongjie Li, Jun Song, Jun Zhang, Hui Peng
Summary: Alterations in gut microbiota were observed in end-stage renal disease (ESRD) patients with or without dialysis. Dialysis reversed abnormal changes in certain bacterial genera in pre-dialysis patients. Functional predictions of microbial communities showed that peritoneal dialysis (PD) and hemodialysis (HD) altered signal transduction and metabolic pathways in ESRD patients. Certain gut bacteria were associated with cardiovascular mortality and peritonitis in ESRD patients. This study suggested a potential impact of gut bacteria on patient prognosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Tara E. Sutherland, Tovah N. Shaw, Rachel Lennon, Sarah E. Herrick, Dominik Rueckerl
Summary: Peritoneal dialysis initially benefits patients with chronic kidney disease, but long-term use may lead to significant pathology, increasing the risk of infection and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Tong Wu, Yuanyuan Qi, Shuang Ma, Lijie Zhang, Xinyu Pu, Kui Chen, Ying Zhao, Shenghua Sang, Jing Xiao
Summary: This study demonstrates that Roxadustat treatment can effectively and safely improve renal anemia and delay the decline of residual renal function (RRF) in patients new to peritoneal dialysis (PD).
Article
Urology & Nephrology
Luca Nardelli, Antonio Scalamogna, Elisa Cicero, Giuseppe Castellano
Summary: Compared to full-dose PD, incPD allows to reduce the time spent for managing dialysis, glucose exposure, economic cost, plastic waste, and water consumption.
JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Ruihua Liu, Hongjian Ye, Yuan Peng, Chunyan Yi, Jianxiong Lin, Haishan Wu, Xiangwen Diao, Haiping Mao, Fengxian Huang, Xiao Yang
Summary: This study aimed to evaluate the association between incremental initiation of peritoneal dialysis and mortality. The study found that patients in the incremental group had better survival and cardiovascular event-free survival during the first 6 years of dialysis compared to the full dose group. However, this advantage disappeared as dialysis vintage became longer. Additionally, the incremental group had lower all-cause and cardiovascular mortality rates compared to the full dose group.
JOURNAL OF NEPHROLOGY
(2023)
Article
Environmental Sciences
Aoyun Li, Yingli Wang, Jiayuan Hao, Lei Wang, Lingtong Quan, Kun Duan, Muhammad Fakhar-e-Alam Kulyar, Kalim Ullah, Jiabin Zhang, Yi Wu, Kun Li
Summary: The study revealed that exposure to Cr(VI) significantly decreased gut microbial diversity and altered microbial composition in chickens. Some bacterial taxa decreased significantly, while others increased during Cr(VI) exposure, leading to shifts in taxonomic composition.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Medicine, General & Internal
Nirong Gong, Chun Zhou, Jianxia Hu, Xiaohong Zhong, Zhixiu Yi, Tingting Zhang, Cong Yang, Yanhong Lin, Jianwei Tian, Xianhui Qin, Liping Hu, Jianping Jiang
Summary: This study aimed to investigate the relationship between dietary salt intake and residual renal function in peritoneal dialysis (PD) patients. The results showed a positive correlation between dietary sodium intake and sodium excretion. A high salt intake diet (salt intake >= 8 g/day) may lead to a faster decline of residual renal function in PD patients.
FRONTIERS IN MEDICINE
(2021)
Article
Plant Sciences
Wei Lin, Chen Jiang, Hangxing Yu, Lingling Wang, Jiaqi Li, Xinyue Liu, Lingyun Wang, Hongtao Yang
Summary: This study shows that Fushen Granule (FSG) improves nutritional status and quality of life by enriching beneficial bacteria associated with metabolism, making it a promising alternative treatment for patients with PDRP.
Review
Food Science & Technology
Do-Youn Jeong, Myeong Seon Ryu, Hee-Jong Yang, Sunmin Park
Summary: Fermented soybean paste, specifically Chungkookjang from Korea, has unique characteristics due to its short-term fermentation without salt and predominance of Bacilli. Different Bacillus species in different regions contribute to different functionalities and bioactive components of Chungkookjang. This fermented food has shown promising effects on memory function and inflammation reduction.
Article
Medicine, General & Internal
Kazuma Kobayashi, Toshikazu Ozeki, Hangsoo Kim, Masaki Imai, Hiroshi Kojima, Daiki Iguchi, Sosuke Fukui, Masafumi Suzuki, Yasuhiro Suzuki, Shoichi Maruyama, Yasuhiko Ito, Masashi Mizuno
Summary: This study found that membrane complement regulators are highly expressed on human peritoneal mesothelial cells, and the history of peritoneal dialysis might influence their expression. These findings suggest that mesothelial cells may alter the expression of complement regulators to protect the peritoneum, and the presence of peritoneal dialysis fluid may affect the homeostasis associated with the complement system.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, Research & Experimental
Sheng Chen, Jieshuang Jia, Huimin Guo, Nan Zhu
Summary: This meta-analysis evaluates the efficacy and safety of low glucose degradation product (GDP) peritoneal dialysis (PD) solutions in PD patients. The results show that low GDP solution preserves residual renal function, improves dialysis adequacy, and does not increase peritoneal solute transport rate and all-cause mortality.
INVESTIGACION CLINICA
(2022)
Review
Food Science & Technology
Denise Mafra, Julie A. Kemp, Natalia A. Borges, Michelle Wong, Peter Stenvinkel
Summary: Residual kidney function is associated with better quality of life and outcome for patients with chronic kidney disease (CKD), and strategies should be implemented to preserve kidney function. Gut dysbiosis due to increased uremic toxin production and endotoxemia is a major cause of kidney damage, and various strategies, including diet, medications, and faecal transplantation, have been proposed to modulate the gut microbiota in these patients. Modifying gut microbiota composition may mitigate chronic kidney damage and preserve residual kidney function, but the effects of diet on residual kidney function remain limited.
Article
Urology & Nephrology
Gabriele Claudino, Christiane Ishikawa Ramos, Laila Santos de Andrade, Natalia Barros Ferreira Pereira, Renata Rodrigues Teixeira, Gisselma Aliny Santos Muniz, Maria Carolina Bezerra Di Medeiros Leal, Lilian Cuppari
Summary: This study aimed to investigate the role of residual renal function on potassium intake and excretion in PD patients. The study found that non-anuric patients had lower dialysate potassium excretion, higher total potassium intake and potassium intake from fruit, and no difference in serum potassium and fecal potassium. In non-anuric patients, potassium intake correlated directly with urinary potassium.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Kenta Torigoe, Kumiko Muta, Kiyokazu Tsuji, Ayuko Yamashita, Miki Torigoe, Shinichi Abe, Yuki Ota, Hiroshi Mukae, Tomoya Nishino
Summary: Urinary levels of DKK-3 were found to be associated with the rate of renal function decline in PD patients, suggesting a potential role in identifying high-risk patients.
MEDICINA-LITHUANIA
(2021)