Article
Biotechnology & Applied Microbiology
Shoichiro Kameoka, Daisuke Motooka, Satoshi Watanabe, Ryuichi Kubo, Nicolas Jung, Yuki Midorikawa, Natsuko O. Shinozaki, Yu Sawai, Aya K. Takeda, Shota Nakamura
Summary: The study compared 192 Japanese volunteers' fecal 16S analysis data using modified V1-V2 and standard V3-V4 primers. Results showed that the bacterial composition derived from the V34 region might differ from the actual abundance, suggesting that the modified V12 primer set is more desirable for analyzing the Japanese gut microbiota.
Article
Immunology
Yanyan Que, Man Cao, Jianquan He, Qiang Zhang, Qiongyun Chen, Changsheng Yan, Aiqiang Lin, Luxi Yang, Zezhen Wu, Dan Zhu, Fengwu Chen, Zhangran Chen, Chuanxing Xiao, Kaijian Hou, Bangzhou Zhang
Summary: Research shows significant differences in microbial diversity between individuals with type 2 diabetes mellitus (T2DM) and controls, but not in microbial alpha diversity. Various operational taxonomic units (OTUs) and bacterial genera with significant odds ratios for T2DM were identified. The microbial characteristics of T2DM can be applied to other studies, improving detection accuracy and disease specificity for T2DM through training on multiple research studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Li Xi, Yumin Song, Xinxi Qin, Jincheng Han, Yung-Fu Chang
Summary: By comparing the gut microbial composition of healthy and diarrheic giraffes, this study found that diarrhea significantly impacts the diversity and composition of the gut microbiota by increasing the proportion of pathogenic bacteria and decreasing beneficial bacteria. It also identified specific changes in bacterial phyla and genera, providing insights for establishing prevention and treatment strategies for diarrhea in giraffes.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Jie Huang, Shanshan Wei, Chuanhao Jiang, Zijun Xiao, Jian Liu, Weijun Peng, Bikui Zhang, Wenqun Li
Summary: This study reveals that an imbalance in the composition and function of the gut microbiota may be one of the etiological mechanisms underlying Doxorubicin-induced cardiotoxicity (DIC). The gut microbiota may serve as new targets for the treatment of cardiotoxicity and cardiovascular diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Ming -Han Li, Jin-Xin Meng, Wei Wang, Ma He, Zi-Yu Zhao, Ning Ma, Qing-Bo Lv, Yi-Feng Qin, Quan Zhao, Hong -Bo Ni, Xiao-Xuan Zhang
Summary: This study examined the diversity of bacteria and fungi in the gut microbiota of commercial broilers raised in cages. The results showed that the composition of the gut microbiota was influenced by age, with increasing richness and diversity as the broilers grew older. The gut microbiota had a unique structure in the early days after birth, and then underwent significant changes during periods of rapid growth and weight gain. Furthermore, certain bacteria and fungi played key roles in the gut microbiota of broilers, and their loss may impact the intestinal homeostasis of broilers.
Article
Ecology
Jiulin Chan, Daoqiang Geng, Binbin Pan, Qiming Zhang, Qianghua Xu
Summary: Hadal amphipods from different trenches showed distinct differences in gut microbial composition and functional potential. Microbe-microbe correlation analysis revealed that symbiont colonization was host-specific. The study also found enrichment of particular functional pathways in the gut microbiota of different isolated trench amphipods.
Article
Biotechnology & Applied Microbiology
Nitish Joat, Thi Thu Hao Van, Dragana Stanley, Robert J. Moore, Kapil Chousalkar
Summary: The study investigated the gut microbiota development in commercial layer chickens and found significant changes in the composition as the production stage transitioned. After 6 weeks of age, the richness and diversity of gut microbiota increased and stabilized.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Shimin Gu, Qiang Xie, Chen Chen, Chenglong Liu, Wentong Xue
Summary: This study used 16S rRNA sequencing to analyze the gut microbiota composition of peanut-allergic mice and found several bacterial groups that were significantly associated with peanut allergy, potentially serving as gut microbial signatures for peanut allergy.
Article
Biotechnology & Applied Microbiology
Dong Han, Hongmin Zhen, Xiaoyan Liu, Justyna Zulewska, Zhennai Yang
Summary: This study used both rRNA and gDNA sequencing on mouse cecal contents and found differences in microbial composition and functional predictions between the two methods. rRNA-derived sequencing improved identification capability of specific microorganisms and was more suitable for functional predictions.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaqing Yu, Wen Jiang, Russell Oliver Kosik, Yingchun Song, Qiong Luo, Tingting Qiao, Junyu Tong, Simin Liu, Chengwen Deng, Shanshan Qin, Zhongwei Lv, Dan Li
Summary: The study found that patients with thyroid carcinoma show significant changes in gut microbiota compared to healthy controls, with 70% of patients having increased levels of Proteobacteria-types. Microbiota analysis can distinguish thyroid carcinoma patients from healthy controls.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Infectious Diseases
Wenpei Shi, Yi Hu, Zhu Ning, Fan Xia, Meiying Wu, Yue O. O. Hu, Cheng Chen, Stefanie Prast-Nielsen, Biao Xu
Summary: There were significant differences in gut microbiota composition and metabolic pathways between tuberculosis patients and healthy controls. Antibiotic exposure was found to further reduce diversity and deplete beneficial bacteria in the gut microbiota of TB patients. Microbial functional analysis showed lower biosynthesis capacity of amino acids and fatty acids in TB patients compared to healthy controls.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Liang Dai, Yingjue Tang, Wenjun Zhou, Yanqi Dang, Qiaoli Sun, Zhipeng Tang, Mingzhe Zhu, Guang Ji
Summary: Mesalamine treatment partially restored the disrupted gut microbiota diversity and community composition in ulcerative colitis (UC) patients. Many genera and metabolites were significantly altered in UC group and reversed by mesalamine, indicating its beneficial role in modulating gut microbiota signature with correlated metabolites in different pathways as potential therapeutic targets and biomarkers for UC.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rui-Xue Huo, Yi-Jia Wang, Shao-Bin Hou, Wei Wang, Chun-Ze Zhang, Xue-Hua Wan
Summary: This study investigates the relationship between gut mucosal microbiota profiles and colorectal cancer (CRC) recurrence and patient prognosis. The researchers found spatial-specific patterns of gut mucosal microbiota profiles linked to CRC recurrence and patient prognosis. 17 bacterial genera/families were identified as potential biomarkers for CRC recurrence and patient prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Engineering, Environmental
Xiang Zeng, Zhijun Zeng, Qihua Wang, Wanting Liang, Yufeng Guo, Xia Huo
Summary: This study found that lead exposure is associated with significant alterations in the gut microbiota and metabolome of children. Lead concentrations in the blood and urine of children were higher in Guiyu. There were significant differences in microbiota and metabolites between the two regions.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nutrition & Dietetics
Chaonan Sun, Ling Chen, Huan Yang, Hongjiang Sun, Zhen Xie, Bei Zhao, Xuemei Jiang, Bi Qin, Zhu Shen
Summary: Through epidemiological investigation and animal experiments, researchers found differences in gastrointestinal symptoms between patients with psoriasis and the general population, along with changes in gut microbiota in psoriasis patients, and faster recovery in mice transplanted with healthy microbiota. These results preliminarily demonstrate the involvement of gut microbiota in psoriasis development and activity.
FRONTIERS IN NUTRITION
(2021)