A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer
出版年份 2020 全文链接
标题
A hotspot for enhancing insulin receptor activation revealed by a conformation-specific allosteric aptamer
作者
关键词
-
出版物
NUCLEIC ACIDS RESEARCH
Volume 49, Issue 2, Pages 700-712
出版商
Oxford University Press (OUP)
发表日期
2020-12-16
DOI
10.1093/nar/gkaa1247
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application
- (2020) Ryosuke Ueki et al. Science Advances
- Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
- (2019) Aikaterini Alexaki et al. Scientific Reports
- Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis
- (2018) Giovanna Scapin et al. NATURE
- The signalling conformation of the insulin receptor ectodomain
- (2018) Felix Weis et al. Nature Communications
- Biochemical and cellular properties of insulin receptor signalling
- (2017) Rebecca A. Haeusler et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation
- (2016) Jean-Pierre Changeux et al. CELL
- Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor
- (2016) Alem W Kahsai et al. Nature Chemical Biology
- Aptamers as targeted therapeutics: current potential and challenges
- (2016) Jiehua Zhou et al. NATURE REVIEWS DRUG DISCOVERY
- Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain
- (2016) Tristan I. Croll et al. STRUCTURE
- 2-fluoro-RNA oligonucleotide CD40 targeted aptamers for the control of B lymphoma and bone-marrow aplasia
- (2015) Mario Martinez Soldevilla et al. BIOMATERIALS
- Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation
- (2015) Na-Oh Yunn et al. NUCLEIC ACIDS RESEARCH
- Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor
- (2015) Thale C. Jarvis et al. STRUCTURE
- DNA Aptamer Assembly as a Vascular Endothelial Growth Factor Receptor Agonist
- (2015) Vidhya Ramaswamy et al. Nucleic Acid Therapeutics
- Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand
- (2014) Amy D. Gelinas et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Allosteric targeting of receptor tyrosine kinases
- (2014) Frederik De Smet et al. NATURE BIOTECHNOLOGY
- Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity
- (2014) John A. Corbin et al. PLoS One
- Beyond antibodies: New affinity reagents to unlock the proteome
- (2014) Bridget Lollo et al. PROTEOMICS
- Insulin Receptor Signaling in Normal and Insulin-Resistant States
- (2014) J. Boucher et al. Cold Spring Harbor Perspectives in Biology
- Allostery in Disease and in Drug Discovery
- (2013) Ruth Nussinov et al. CELL
- Emerging paradigms in GPCR allostery: implications for drug discovery
- (2013) Denise Wootten et al. NATURE REVIEWS DRUG DISCOVERY
- Insulin Therapy and Hypoglycemia
- (2012) Anthony L. McCall ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
- Regulation of glucose transport by insulin: traffic control of GLUT4
- (2012) Dara Leto et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Aptamers as a Sensitive Tool to Detect Subtle Modifications in Therapeutic Proteins
- (2012) Ran Zichel et al. PLoS One
- Crystal structure of an RNA aptamer bound to thrombin
- (2008) S. B. Long et al. RNA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started