Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis

The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

(2020) Hiraku Takada et al.   Frontiers in Microbiology

A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes

(2020) Hedvig Tamman et al.   Nature Chemical Biology

A wealth of genotype-specific proteoforms fine-tunes hemoglobin scavenging by haptoglobin

(2020) Sem Tamara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel

(2020) Patrick Pausch et al.   Cell Reports

Make and Break the Alarmone: Regulation of (p)ppGpp Synthetase/Hydrolase Enzymes in Bacteria

(2019) Séverin Ronneau et al.   FEMS MICROBIOLOGY REVIEWS

Interaction studies on bacterial stringent response protein RelA with uncharged tRNA provide evidence for its prerequisite complex for ribosome binding

(2019) Gajraj Singh Kushwaha et al.   CURRENT GENETICS

The Rel stringent factor from Thermus thermophilus: crystallization and X-ray analysis

(2019) Katleen Van Nerom et al.   Acta Crystallographica Section F-Structural Biology Communications

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA

(2019) Kathryn Jane Turnbull et al.   Frontiers in Microbiology

Activation of the Stringent Response by Loading of RelA-tRNA Complexes at the Ribosomal A-Site

(2018) Kristoffer Skovbo Winther et al.   MOLECULAR CELL

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA

(2018) Pavel Kudrin et al.   NUCLEIC ACIDS RESEARCH

Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus

(2018) Fabio Lino Gratani et al.   PLoS Genetics

ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life

(2018) Victoriia Murina et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of (p)ppGpp hydrolysis by a conserved archetypal regulatory domain

(2018) Séverin Ronneau et al.   NUCLEIC ACIDS RESEARCH

Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor

(2017) Jelena Beljantseva et al.   Scientific Reports

HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGpp

(2017) Vallo Varik et al.   Scientific Reports

Ribosome dimerization is essential for the efficient regrowth of Bacillus subtilis

(2016) Genki Akanuma et al.   MICROBIOLOGY-SGM

Ribosome-dependent activation of stringent control

(2016) Alan Brown et al.   NATURE

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

(2016) Stefan Arenz et al.   NUCLEIC ACIDS RESEARCH

Ribosome•RelA structures reveal the mechanism of stringent response activation

(2016) Anna B Loveland et al.   eLife

Diversity in (p)ppGpp metabolism and effectors

(2015) Kuanqing Liu et al.   CURRENT OPINION IN MICROBIOLOGY

Many Means to a Common End: the Intricacies of (p)ppGpp Metabolism and Its Control of Bacterial Homeostasis

(2015) Anthony O. Gaca et al.   JOURNAL OF BACTERIOLOGY

Effects of amino acid starvation on RelA diffusive behavior in liveEscherichia coli

(2015) Wenting Li et al.   MOLECULAR MICROBIOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

The ribosome triggers the stringent response by RelA via a highly distorted tRNA

(2013) Xabier Agirrezabala et al.   EMBO REPORTS

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

(2012) Viktoriya Shyp et al.   EMBO REPORTS

Direct Regulation of GTP Homeostasis by (p)ppGpp: A Critical Component of Viability and Stress Resistance

(2012) Allison Kriel et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Expression of a small (p)ppGpp synthetase, YwaC, in the (p)ppGpp0mutant ofBacillus subtilistriggers YvyD-dependent dimerization of ribosome

(2012) Kazumi Tagami et al.   MicrobiologyOpen

The complex logic of stringent response regulation in Caulobacter crescentus: starvation signalling in an oligotrophic environment

(2011) Cara C. Boutte et al.   MOLECULAR MICROBIOLOGY

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

Single-molecule investigations of the stringent response machinery in living bacterial cells

(2011) B. P. English et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidelines for accurate EC50/IC50 estimation

(2010) J. L. Sebaugh   PHARMACEUTICAL STATISTICS

The Significance of EXDD and RXKD Motif Conservation in Rel Proteins

(2009) Mathew Sajish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY