Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB/BDNF signaling in the rat model of chronic unpredictable stress-induced depression

An update on NMDA antagonists in depression

(2019) Bartłomiej Pochwat et al.   Expert Review of Neurotherapeutics

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

The role of memantine in the treatment of major depressive disorder: Clinical efficacy and mechanisms of action

(2018) Meysam Amidfar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Intracerebroventricular streptozotocin impairs adult neurogenesis and cognitive functions via regulating neuroinflammation and insulin signaling in adult rats

(2018) Sandeep Kumar Mishra et al.   NEUROCHEMISTRY INTERNATIONAL

Effectiveness of memantine on depression-like behavior, memory deficits and brain mRNA levels of BDNF and TrkB in rats subjected to repeated unpredictable stress

(2018) Meysam Amidfar et al.   Pharmacological Reports

Glutamate, Glutamine and GABA Levels in Rat Brain Measured Using MRS, HPLC and NMR Methods in Study of Two Models of Autism

(2018) Elzbieta Zieminska et al.   Frontiers in Molecular Neuroscience

A brief history of the development of antidepressant drugs: From monoamines to glutamate.

(2015) Todd M. Hillhouse et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

PATHOPHYSIOLOGY OF DEPRESSION: DO WE HAVE ANY SOLID EVIDENCE OF INTEREST TO CLINICIANS?

(2015) GREGOR HASLER   World Psychiatry

Targeting of NMDA Receptors in the Treatment of Major Depression

(2014) Yong-Hui Dang et al.   CURRENT PHARMACEUTICAL DESIGN

Protection of streptozotocin induced insulin receptor dysfunction, neuroinflammation and amyloidogenesis in astrocytes by insulin

(2014) N. Rajasekar et al.   NEUROPHARMACOLOGY

N-Methyl D-Aspartate (NMDA) Receptor Antagonists and Memantine Treatment for Alzheimer’s Disease, Vascular Dementia and Parkinson’s Disease

(2013) David Olivares et al.   Current Alzheimer Research

BDNF prevents NMDA-induced toxicity in models of Huntington's disease: the effects are genotype specific and adenosine A2Areceptor is involved

(2013) Alberto Martire et al.   JOURNAL OF NEUROCHEMISTRY

Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats

(2013) Milind Geed et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Glial activation and post-synaptic neurotoxicity: The key events in Streptozotocin (ICV) induced memory impairment in rats

(2013) Shivika Rai et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Targeting the Glutamatergic System to Treat Major Depressive Disorder

(2012) Daniel C. Mathews et al.   DRUGS

Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways

(2012) Anthony Markham et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats

(2012) Shivika Rai et al.   JOURNAL OF NEUROIMMUNOLOGY

Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats

(2012) Gislaine Z. Réus et al.   METABOLIC BRAIN DISEASE

Using the rat forced swim test to assess antidepressant-like activity in rodents

(2012) David A Slattery et al.   Nature Protocols

Physiology and Pathology of Calcium Signaling in the Brain

(2012) Elisa Mitiko Kawamoto et al.   Frontiers in Pharmacology

Synaptic Mitochondrial Pathology in Alzheimer's Disease

(2011) Heng Du et al.   ANTIOXIDANTS & REDOX SIGNALING

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels

(2011) Alessandro Barbon et al.   NEUROCHEMISTRY INTERNATIONAL

Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis

(2011) Cheryl D. Conrad   REVIEWS IN THE NEUROSCIENCES

An update on the role of glutamate in the pathophysiology of depression

(2010) N. D. Mitchell et al.   ACTA PSYCHIATRICA SCANDINAVICA

Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment

(2010) Marianne H. Larsen et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: An NMDA receptor-independent mechanism

(2010) Cheng-Wei Lu et al.   NEUROCHEMISTRY INTERNATIONAL

Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression?

(2009) Gislaine Z. Réus et al.   BRAIN RESEARCH BULLETIN

NMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2

(2009) H. Girouard et al.   JOURNAL OF NEUROSCIENCE

The Role of AMPA receptor modulation in the treatment of neuropsychiatric diseases

(2008) Carlos A. Zarate et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial Dysfunction and Psychiatric Disorders

(2008) Gislaine T. Rezin et al.   NEUROCHEMICAL RESEARCH

Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex

(2008) Alessia Bachis et al.   NEUROSCIENCE LETTERS

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

(2008) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effects of memantine on mitochondrial function

(2007) Jenna McAllister et al.   BIOCHEMICAL PHARMACOLOGY

Stress and emotional memory retrieval: Effects of sex and cortisol response

(2007) Tony W. Buchanan et al.   NEUROBIOLOGY OF LEARNING AND MEMORY